Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis by Hugang Zhang, Jiaxin Jia, Hanyu Liu, Haobo Han, Quanshun Li

“…The combination of APPC/pHO-1 and NIR can effectively reprogram the cellular metabolism and repolarize the macrophages and fibroblast-like synoviocytes, thereby inhibiting inflammation by suppressing glycolysis. …”
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IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment by Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo, Sho-Jen Cheng, Yung-Chieh Chen, Shiu-Wen Huang, Hsing-Jien Kung, Cheng-Yu Chen

“…For clinical translation, we developed a novel CHOL-PEG-SPIO-IL-19 nanoparticles to target IL-19 expression in glioblastoma tissue. …”
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NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma by Guoyin Li, Guoyin Li, Yukui Zhao, Yubo He, Zhaoqiang Qian, Xiaoyan Li, Zewen Song, Zhiqiang Liu

“…A prognostic model (SRRS) was developed via LASSO regression and validated across cohorts.ResultsSMC4 was significantly overexpressed in glioma tissues, with higher expression correlating with advanced tumor grades and poorer patient survival (AUC > 0.82). …”
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Multi-omics dissection of tumor microenvironment-mediated drug resistance: mechanisms and therapeutic reprogramming by Fanghua Chen, Fanghua Chen, Yuandong Fu, Yuandong Fu, Gaigai Bai, Gaigai Bai, Junjun Qiu, Junjun Qiu, Keqin Hua, Keqin Hua

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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…However, challenges such as the complexity of drug development and metabolic interactions must be overcome. …”
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The multifaceted roles of BAF60 subunits in muscle: regulation of differentiation, reprogramming, and metabolic homeostasis by Yaoxia Liu, Zhen Fan, Yang Zhai, Yang Zhai, Haotian Huang, Ruifeng Shi, Tao Wang, Tao Wang

“…Muscle development and metabolic homeostasis are critical aspects of human health. …”
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Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential by Peng Dai, Jing Feng, Yanyan Dong, Shujing Zhang, Jianghong Cao, Xiaopeng Cui, Xueliang Qin, Shiming Yang, Daguang Fan

“…Abstract Metabolic reprogramming is an important cancer hallmark. Recent studies have indicated that lipid metabolic reprogramming play a potential role in the development of hepatocellular carcinoma (HCC). …”
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Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy by Kun Huang, Ying Han, Yihong Chen, Hong Shen, Shan Zeng, Changjing Cai

“…These regulators provide a theoretical basis and research direction for the development of new strategies and targets in cancer therapy based on tumor metabolic reprogramming.…”
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Combination strategies of gut microbiota in cancer therapy through metabolic reprogramming and immune remodeling by Lixuan Wang, Weibo Jiang, Manshi Yang, Quezhu Danzeng, Shiyu Liu, Mengying Cui

“…Abstract Over the past decade, there has been a qualitative improvement in the understanding of gut microbiota in cancer development and treatment. Gut microbiota regulates metabolic reprogramming that occurs in the competition between tumor cells and immune cells for essential nutrients in the tumor microenvironment (TME). …”
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Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance by Lanyue Zhang, Jiangnan Zhao, Chunyu Su, Jianxi Wu, Lai Jiang, Hao Chi, Qin Wang

“…Metabolic reprogramming is a hallmark of ovarian cancer, enabling tumor progression, immune evasion and drug resistance. …”
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Coordination acid-engineered Prussian Blue affects glycometabolic reprogramming in microglia for epileptic treatment by Yao Zhao, Feixiang Chen, Chen Chen, Yuling Yang, Luo Wang, Jiaqi Zhu, Xin Wang, Yanyan Liu, Jing Ding

“…This study, utilizing single-nucleus RNA sequencing data from temporal lobe epilepsy (TLE) patients, reveals that reactive oxygen species (ROS) stabilize hypoxia-inducible factor 1-alpha (HIF-1α), thereby inducing glycometabolic reprogramming in microglia and driving the development of a pro-inflammatory phenotype. …”
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Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia by Jeremy B. Ducharme, Daria Neyroud, Martin M. Schonk, Miguel A. Gutierrez-Monreal, Zhiguang Huo, Haley O. Tucker, Karyn A. Esser, Sarah M. Judge, Andrew R. Judge

“…These findings thus implicate cancer/disease-specific functions of FOXP1 in the disruption and reprograming of the skeletal-muscle circadian transcriptome, which may contribute to muscle wasting and the development of cachexia.…”
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PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity by Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov

“…Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression by Shi-Bing Li, Li Yuan, Qian-Ying Zhu, Gong Zhang, Yuan-Tao Liu, Ming-Hui Gao, Fei Han, Zhi-Rui Lin, Hua Zhang, Lin-Quan Tang, Li Sun, Qing-Yu He, Er-Wei Song, Lawrence S. Young, Yu-Chun Li, Hai-Qiang Mai, Mu-Sheng Zeng, Qian Zhong

“…Accumulating evidence suggests that persistent IFN-Is and a subset of IFN-stimulated genes (ISGs) might promote tumor development, but the regulation of mRNA translation and lipid metabolism during this process remains unknown. …”
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer by Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung

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Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface by Lukas Broich, Hannah Wullenkord, Maria Kaukab Osman, Yang Fu, Mathias Müsken, Peter Reuther, Mark Brönstrup, Christian Sieben

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Mapping the landscape of metabolic reprogramming research in lung cancer: a bibliometric and visualized analysis by Song Han, Jialu Li, Feng Jiang, Qingtong Shi

“…Conclusions This bibliometric analysis maps the research landscape of metabolic reprogramming in lung cancer, identifying influential contributors and emerging research themes. …”
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Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor by Krzysztof Ciura, Olimpia Sobota, Aleksandra Chorążewska, Daniel Krowarsch, Natalia Porębska, Łukasz Opaliński

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Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming by Xi Zhang, Yue Liu, Yueyu Dai, Lingna An, Fangyuan Zhong, Shifeng Lou

“…Furthermore, we co-cultured AFA with CAR-T cells during the preparation stage and multianalyses of differentiation characteristics, metabolic profiling, and RNA sequencing revealed that AFA induce comprehensive metabolism remodeling and fate reprogramming. Based on it, we finally identified the antitumor efficacy of AFA-pretreatment CAR-T compared with negative-control CAR-T.Results We identified that AFA blocked the T-cell receptor (TCR) and phosphoinositide 3-kinase-protein kinase B-mechanistic target of rapamycin signaling pathways, induced metabolic reprogramming and modulated T-cell differentiation. …”
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Generation of bovine iPSCs from fetal fibroblasts for in vitro myogenesis and cultured meat by Kaiana Recchia, Methi Wathikthinnakon, Fabiana Fernandes Bressan, Fabiana Fernandes Bressan, Kristine Freude

“…Bovine induced pluripotent stem cells (biPSCs) represent a promising alternative due to their capacity for self-renewal and developmental plasticity.MethodsThis study utilized both lentiviral (integrating) and episomal (non-integrating) reprogramming strategies to generate biPSCs suitable for myogenic differentiation. …”
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