A Universal Strategy of Anti‐Tumor mRNA Vaccine by Harnessing “Off‐the‐Shelf” Immunity by Jiayan Fu, Shuangqi Wu, Nengcheng Bao, Lili Wu, Huiru Qu, Zhechao Wang, Haiyang Dong, Jian Wu, Yongfeng Jin

“…In vitro test indicated that this mRNA vaccine reprogrammed tumor cells that can be recognized and killed by OVA‐specific cytotoxic T lymphocytes (CTLs). …”
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Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth by Yu Zhou, Yuan Yuan, Minghui Liu, Xiuting Hu, Yiming Quan, Xi Chen

“…In the present study, we developed an alternative strategy to silence the so-called untargetable and undruggable KRAS gene by employing exosome-mediated siRNA delivery. …”
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Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy by Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang

“…Abstract Small cell lung cancer (SCLC) is an extremely aggressive and highly malignant type of lung cancer that frequently develops resistance and recurrence following initial treatment. …”
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siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy by Yunfei Yi, Zhangwen Peng, Yuanqi Liu, Huisong Hao, Liu Yu, Simin Wen, Shengjie Sun, Jianlin Shi, Meiying Wu, Lin Mei

“…Among tumor microenvironment (TME), the entire metabolic characteristics of tumor-resident cells are reprogrammed to benefit the expansion of tumor cells, which count on glutamine in large part to fuel the tricarboxylic acid cycle for energy generation and anabolic metabolism support. …”
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Human induced pluripotent stem cell–derived therapies for regeneration after central nervous system injury by Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles W. Plant

“…Considering the non-regenerative nature of the mature central nervous system, the concept that “blank” cells could be reprogrammed and functionally integrated into host neural networks remained intriguing. …”
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The role of macrophage polarization in ovarian cancer: from molecular mechanism to therapeutic potentials by Chenchen Xu, Jiyu Chen, Mi Tan, Qingqing Tan

“…Continued research in this domain is essential to develop robust therapeutic frameworks that can mitigate the immunosuppressive TME and enhance the efficacy of existing and novel cancer therapies.…”
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A ‘two-missile’ nanoplatform for targeting triple-negative breast cancer: prodrug activation and immune enhancement by Haiping Hu, Shuaiguang Li, Yao Zhou, Hui Lv, Zhonghua Dong, Yujia Wang, Juzheng Sheng, Xue Wang, Wenfei Fan, Wei Xu

“…In addition, the platform's accompanying CRISPR/Cas9 system can reprogram tumor cells by down-regulating CD47 expression, enhancing macrophage recognition and phagocytosis activity, which in turn amplifies the efficacy of ensuing immunotherapy. …”
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Matrix-bound EGF promotes malignant phenotypes of breast cancer organoids in the biomimetic ECM of alginate by Xue-Yu Chen, Meng-Yuan Wang, Xin Shu, Jun Li, Ruizhi Tang, Xi-Qiu Liu

“…., GOT2), and finally to reprogram breast cancer energy metabolism. This system would represent a new paradigm of cancer progression studies using in vitro 3D organoids in a biomimetic ECM, in order to develop novel therapeutic strategies and evaluate preclinical treatments.…”
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Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance by Xiaoqing Sun, Caiqin Wang, Jianghua Cao, Jing Li, Gang Ma, Xianqiu Wu, Peng Sun, Yu Wang, Jiajia Huang, Robert Peter Gale, Zhiming Li

“…Introduction: Patients with mantle cell lymphoma (MCL) frequently develop resistance to ibrutinib. Lymphoma-associated macrophages (LAMs) may play a causal role in this resistance but remain underexplored in current literature. …”
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Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency by Yingzhen Gao, Siyu He, Xiaoyan Meng, Kun Zheng, Heyang Cui, Yikun Cheng, Xinyuan Shen, Yuanfang Zhai, Binbin Zou, Fang Wang, Hongyi Li, Pengzhou Kong, Yanqiang Wang, Xuefei Feng, Bin Yang, Ruifang Sun, Yongsheng Meng, Enwei Xu, Yanlin Guo, Ning Ding, Weimin Zhang, Xiaolong Cheng, Lunzhi Dai, Yongping Cui, Ling Zhang

“…A robust subtype prediction model was developed and validated across two independent cohorts. …”
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Regulation of proliferative potential: insights into key signaling cascades and te-lomerase functions by O. Tolok, Kh. Malysheva

“…These factors not only reprogram somatic cells into induced pluripotent stem cells (iPSCs) but also enhance regenerative capabilities, making them indispensable tools for tissue engineering and regenerative medicine. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. …”
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Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer by Wenyi Yan, Yujing Xuan, Ruimin Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

“…<b>Conclusions:</b> VVL-GL7 reprograms the immunosuppressive tumor microenvironment and synergizes with anti-PD-1 antibodies to overcome resistance in pancreatic cancer.…”
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HER2-Targeted Nanoliposome Therapy Activates Immune Response by Converting Cold to Hot Breast Tumors by Quan Sun MS, Ying Zhu PhD, Dongli Zhao MS, Lili Yang MS, Siyu Zhang MS, Changxin Huang PhD

“…Conclusion Our HER2-targeted nanoliposomes effectively reprogrammed cold tumors by dual activation of innate (STING pathway) and adaptive (viral peptide-driven TCR diversity) immunity. …”
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