Secondary metabolites as biostimulants in salt stressed plants: mechanisms of oxidative defense and signal transduction by Muhammad Ikram, Burhan Khalid, Maria Batool, Maaz Ullah, Jiang Zitong, Abdul Rauf, Muhammad Junaid Rao, Haseeb Ur Rehman, Jie Kuai, Zhenghua Xu, Jie Zhao, Jing Wang, Guangsheng Zhou, Bo Wang

“…Elucidating the intricate mechanisms by which SMs operate as biostimulants not only advances our understanding of plant stress responses but also paves the way for developing sustainable agricultural practices aimed at improving crop resilience in saline environments. …”
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Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration by Wenshuai Li, Qichen Shen, Tong Tong, Hongsen Tian, Xiaowei Lian, Haoli Wang, Ke Yang, Zhanqiu Dai, Yijun Li, Xianhua Chen, Qingqing Wang, Dan Yang, Feng Wang, Feng Hao, Linfeng Wang

“…Bone regeneration is a complex and coordinated physiological process, and the different stages of this process have corresponding microenvironments to support cell development and physiological activities. However, biological scaffolds that provide different three-dimensional environments during different stages of bone regeneration are lacking. …”
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An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis by Liming Gong, Yanhong Liu, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang

“…Abstract Breast cancer as a “cold” tumor presents an immunosuppressive microenvironment and inferior T-lymphocyte infiltration, leading to poor efficacy of immune checkpoint blockade (ICB) therapies. It is urgent to develop new effective combination treatment strategies. …”
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Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth by L Recalde-Percaz, I de la Guia-Lopez, P Linzoain-Agos, A Noguera-Castells, M Rodrigo-Faus, P Jauregui, A Lopez-Plana, P Fernández-Nogueira, M Iniesta-González, M Cueto-Remacha, S Manzano, R Alonso, N Moragas, C Baquero, N Palao, E Dalla, FX Avilés-Jurado, I Vilaseca, X León-Vintró, M Camacho, G Fuster, J Alcaraz, J Aguirre-Ghiso, P Gascón, A Porras, A Gutiérrez-Uzquiza, N Carbó, P Bragado

“…Therefore, we conclude that the TGFβ1-NRP2 axis is a new key dormancy-awakening inducer that promotes DTCs proliferation and lung metastasis development.…”
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Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells by Hong-Thu Pham, Florence Perold, Yannicke Pijoff, Nathalie Doerflinger, Sylvie Rival-Gervier, Maëlle Givelet, Anaïs Moulin, Manon Ressaire, Emilie Da Silva Fernandes, Valeska Bidault, Luc Jouneau, Véronique Duranthon, Florence Wianny, Bertrand Pain, Ingrid Plotton, Thierry Joly, Marielle Afanassieff, Pierre Savatier, Nathalie Beaujean

“…These chimeric embryos can develop into fetuses and newborn rabbits, with iPSCs contributing up to 100 % to certain organs. …”
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Generation of the human iPSC line ESi132-A from a patient with retinitis pigmentosa caused by a mutation in the PRPF31 gene by Estefanía Caballano Infantes, Laurie Clauzon, Berta de la Cerda Haynes, Francisco Díaz-Corrales

“…In this study, peripheral blood mononuclear cells from a patient carrying a heterozygous mutation in PRPF31 were reprogrammed to generate the human iPSC line ESi132-A. …”
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Human induced pluripotent stem cell line (FDHSi005-A) derived from a patient with a deep intronic variant in the GNE gene by Kexin Jiao, Jialong Zhang, Ningning Wang, Xingyu Gu, Xuechun Chang, Xingyu Xia, Bochen Zhu, Mingshi Gao, Nachuan Cheng, Chongbo Zhao, Jianying Xi, Wenhua Zhu

“…Importantly, we identified that these iPSCs possess the same specific mutations as the patient, making them a robust model for studying GNE myopathy and developing potential therapeutic interventions.…”
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Establishing an induced pluripotent stem cell bank using urine cells from pediatric patients with neurogenetic diseases by Hien Bao Dieu Thai, WonWoo Jung, Sol Choi, Woo Joong Kim, JangSup Moon, ByungChan Lim

“…Conclusion Here we used UCs to successfully develop an early-onset neurogenetic disease iPSC bank that offers an efficient protocol for expanding patient accessibility in pediatric neurogenetic research.…”
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Design and Construction of a GSM Based Led Scrolling Message Display Board. by Tumuhimbise Jasper Kanze

“…The aim of this project is to develop a moving sign board which empowers the user to remotely change the scrolling message by sending SMS using GSM to a pre-registered phone number. …”
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Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment by Xiaoru Zhang, Xiaguo Fu, Wanying Chen, Peng Chen, He Zhu, Bo Yang, Jianming Liang, Feng Zeng

“…To address these pathological features, we developed a core–shell nanoplatform consisting of silver-modified ceria nanoparticles loaded with celastrol (Ag-CeNP@Cel). …”
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Construction and Validation of an Oxidative Phosphorylation Signature in High-Grade Glioma and Potential Inhibitors Screening by Hanwen Lu, Wenpeng Zhao, Bingchang Zhang, Yuanyuan Xie, Jiawei He, Huiying Yang, Zhanxiang Wang

“…Despite current treatment options, the prognosis for glioma patients remains poor. Metabolic reprograming has emerged as a crucial aspect of tumorigenesis, and the oxidative phosphorylation pathway has received increasing attention as a promising target for cancer treatment. …”
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Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy by Hongjian Li, Yating Hu, Jingxuan Li, Jia He, Guocan Yu, Jiasheng Wang, Xin Lin

“…Single-cell RNA sequencing revealed that the vaccination reprograms endogenous T cells, enhancing their cytotoxicity and inducing a memory-like phenotype. …”
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Prospect of Stem Cells in Bone Tissue Engineering: A Review by Azizeh-Mitra Yousefi, Paul F. James, Rosa Akbarzadeh, Aswati Subramanian, Conor Flavin, Hassane Oudadesse

“…These cells are another attractive stem cell source because of their ability to be reprogramed, allowing the generation of multiple cell types from a single cell. …”
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Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues by Rodrigo Machado, Sebastián Moschen, Gabriela Conti, Sergio A. González, Máximo Rivarola, Claudio Gómez, Horacio Esteban Hopp, Paula Fernández

“…These insights facilitate breeding programs focused on developing HLB-tolerant citrus cultivars, contributing to the long-term sustainability and resilience of global citrus production.…”
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Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis by Liangzi Yin, Liangzi Yin, Chenglin Sun, Junjie Zhang, Yan Li, Yansheng Wang, Yansheng Wang, Lunhao Bai, Zeming Lei, Zeming Lei

“…Specifically, we analyze how wear particle-induced inflammation reprograms these signaling networks to exacerbate osteolytic activity. …”
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DelaySSA: stochastic simulation of biochemical systems and gene regulatory networks with or without time delays. by Ziyan Jin, Xinyi Zhou, Zhaoyuan Fang

“…To address these challenges, we have developed DelaySSA, an R package that implements currently available algorithms for SSA with or without delays. …”
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Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy by Anna Ochalek, Karolina Szczesna, Paolo Petazzi, Julianna Kobolak, Andras Dinnyes

“…Currently, many protocols for generation of various neuronal subtypes are being developed; however, most of them still require further optimization. …”
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Mitochondrial Ribosomal Protein Family in Cancers: Mechanistic Insights and Therapeutic Implications by Qian Chen, Yingli Zhang, Jin‐Jian Lu, Ting Li

“…We further explore the underlying reasons for the diverse functions of MRPs, their implications in cellular signaling and tumor immunity, and consider the prospects for developing MRP inhibitors as therapeutic strategies. …”
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CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma by Shuyao Zhang, Hong Jiang, Chengkuan Zhao, Yanli Lei, Shaojie Liu, Chengcheng Xu, Xiaoshan Chen, Danling Zheng, Xiaolong Wu, Xinyue Lin, Wang Chen, Yun Chen, Jianxiang Huang, XiaoLong Wei, Yihui Huang, Chaoxian Lin

“…To address this, we developed an innovative siRNA-based therapeutic approach targeting CXCL12 in CAFs. …”
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Dual Targeting Biomimetic Carrier‐Free Nanosystems for Photo‐Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re‐Polarization by Guanghe Xue, Huimei Jiang, Zhenhua Song, Yifan Zhao, Wen Gao, Bai Lv, Jie Cao

“…Here, dual‐targeting biomimetic carrier‐free nanomaterials (BSA‐MTX‐CyI nanosystem, BMC) is developed for synergistic photo‐chemotherapy of RA. …”
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