NIR-responsive tissue-adaptive hydrogel for accelerating healing of seawater-immersed wounds by Rui Ma, Li Xu, Ze Li, Sicheng Li, Ye Liu, Guiwen Qu, Kang Chen, Canwen Chen, Luqiao Huang, Yitian Teng, Xinxin Huang, Shuanghong Yang, Qingchuan Li, Jinjian Huang, Jianan Ren, Xiuwen Wu

“…Although a number of dynamically adhesive hydrogels have developed recently, these gels are often composed of dynamic networks, which lead to insufficient mechanical strength and short-term protection for wound surfaces. …”
Get full text

Boosting anti-tumor immunity with TILT-517 oncolytic adenovirus and checkpoint blockade in renal cell carcinoma by Victor Arias, Tatiana V. Kudling, James H.A. Clubb, Elise Jirovec, Santeri A. Pakola, Mirte Van der Heijden, Saru Basnet, Dafne C.A. Quixabeira, Lyna Haybout, Nea Ojala, Susanna Grönberg-Vähä-Koskela, Anna Kanerva, Antti Rannikko, João M. Santos, Victor Cervera-Carrascon, Otto Hemminki, Akseli Hemminki

“…This approach also seeks to activate infiltrating immune cells, thereby reprogramming the immune landscape characteristic of renal cell carcinoma tumors. …”
Get full text

An injectable gambogic acid loaded nanocomposite hydrogel enhances antitumor effect by reshaping immunosuppressive tumor microenvironment by Dan Lei, Wanru Wang, Jianhang Zhao, Yingling Zhou, Ying Chen, Juanjuan Dai, Yuling Qiu, Haoyue Qi, Chunhua Li, Boyao Liang, Baorui Liu, Qin Wang, Rutian Li

“…To minimize side effects, combining gambogic acid (GA) with delivery systems such as nanohydrogels to develop an in situ vaccine system (ISV) shows great promise. …”
Get full text

Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination by Cancan Qi, Zhaoli Liu, Gizem Kilic, Andrei S. Sarlea, Priya A. Debisarun, Xuan Liu, Yonatan Ayalew Mekonnen, Wenchao Li, Martin Grasshoff, Ahmed Alaswad, Apostolos Petkoglou, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu

“…Abstract Background Epigenetic reprogramming shapes immune memory in both innate (trained immunity) and adaptive immune cells following Bacillus Calmette-Guérin (BCG) vaccination. …”
Get full text

Synergistic HER2-scFv mediated immunotherapy with targeted gemcitabine delivery harnessing biomimetic composite nanoparticles for enhanced metastatic tumor therapy by Xinan Wang, Wenhui Chu, Fuyu Du, Hongyu Fan, Zixuan Ye, Yaru Xue, Xianghan Zhang, Peng Yang, Yuqiong Xia, Zhihui Chen, Pengbo Ning

“…In response, PLGA nanoparticles with engineered modified macrophage membrane coating was designed to develop a novel gene reprogramming biomimetic drug-loading nanoplatform. …”
Get full text

Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis by Rutao Li, Na Li, Qianqian Yang, Xing Tong, Wei Wang, Chang Li, Jun Zhao, Dong Jiang, Haitao Huang, Chen Fang, Kai Xie, Jiamin Yuan, Shaomu Chen, Guangbin Li, Haitao Luo, Zhibo Gao, Dongfang Wu, Xiaoli Cui, Wei Jiang, Lingchuan Guo, Haitao Ma, Yu Feng

“…Abstract Background Understanding the stepwise progression of esophageal squamous cell carcinoma (ESCC) is crucial for developing customized strategies for early detection and optimal clinical management. …”
Get full text

Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma by Zhang J, Xu Y, Ni X, Mao Z, Xiao H, Chen M, Lin Y, Pan J, Zhang B, Zhang L, Zheng X, Song G, Ge N

“…This establishes PBK as a dual-purpose biomarker for prognostic stratification and immunotherapy resistance prediction, providing a mechanistic rationale for developing PBK-targeted therapies in HCC.Keywords: PDZ-binding kinase, bioinformatics, prognosis, cancer immunotherapy, hepatocellular carcinoma…”
Get full text

Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway by Jiale Cai, Xinya Zheng, Xiongbo Luo, Wenli Cui, Xinrui Ma, Shuyi Xu, Lanya Fu, Jiaqi Zhang, Yizhou Xu, Yunlun Li, Ye He, Xianghai Wang, Jiasong Guo

“…Moreover, this study highlights the importance of considering cell-specific roles of RhoA in SCI repair and provides a foundation for developing targeted therapies aimed at microglial metabolic reprogramming. …”
Get full text

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI by Xiaoxiao Hu, Fang Jia, Lili Li, Wuzhen Chen, Leyi Zhang, Jun Pan, Sangsang Zhu, Zhen Wang, Jian Huang

“…Objectives: High body mass index (BMI), encompassing overweight and obesity, is a well-established risk factor for developing breast cancer (BC). The underlying mechanisms linking elevated BMI to increased BC risk involve metabolic reprogramming and chronic inflammatory microenvironments regulated by cellular networks within breast white adipose tissue (WAT). …”
Get full text

3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment by Yipei Yang, Zhenyu Yao, Yuanyi Sun, Yangyi Nie, Yuanchi Zhang, Ziyue Li, Zhiheng Luo, Wenjing Zhang, Xiao Wang, Yuhan Du, Wei Zhang, Ling Qin, Hongxun Sang, Yuxiao Lai

Get full text

Targeting RARγ Decreases Immunosuppressive Macrophage Polarization and Reduces Tumor Growth by Jihyeon Park, Jisun Oh, Sang-Hyun Min, Ji Hoon Yu, Jong-Sup Bae, Hui-Jeon Jeon

“…These findings suggest that targeting RARγ reprograms immunosuppressive macrophages and mitigates the tumor-promoting effects of TAMs, highlighting RARγ as a promising therapeutic target for developing novel anti-cancer strategies.…”
Get full text

Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research by Filipa Esteves, David Brito, Ana Teresa Rajado, Nádia Silva, Joana Apolónio, Vânia Palma Roberto, Raquel P. Andrade, Sofia Calado, Maria Leonor Faleiro, Carlos Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Sónia Simãoa, Natércia Joaquim, Rui Miranda, António Pêgas, Daniela Marques Raposo, Ana Sardo, Inês Araújo, Clévio Nóbrega, Pedro Castelo-Branco, José Bragança

“…Here, we describe ABCRIi001-A, a hiPSC line generated from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female enrolled in a study for development of an ageing score (ALFA Score). PBMCs were reprogrammed using three Sendai virus-based reprogramming vectors (hKOS, hc-Myc, and hKlf4). …”
Get full text

System-Level Mathematical Macro-Models of Logic MEMS Gates by А. А. Solovev, E. F. Pevtsov, V. A. Kolchuzhin

“…The relevance of the study is due to the rapid development of microelectromechanical systems (MEMS), which are used as logic elements due to low power consumption, high reliability and the ability to reprogram during operation. …”
Get full text

Progress in the application of the synergistic effects of nanomaterials and bacteria in tumor therapy by Ran Yin, Haiying Jin, Jing Yu, Lijun Shao, Xiaoli Yu

“…It will also provide a prospective outlook on future development.…”
Get full text

The Small Non-Coding RNA Profile of Human and Mouse Sperm by Yoon Sing Yap, Pasquale Patrizio, Luisa Cimmino, Konstantinos Sdrimas, Aristeidis G. Telonis

“…Diet, exercise, and environmental exposures have a direct effect on small RNA levels in spermatozoa, and this differential abundance can reprogram the development of the embryo. Offsprings of fathers with different lifestyles can have different phenotypes, including altered metabolism or behavior. …”
Get full text

Bone marrow microenvironment in myelodysplastic neoplasms: insights into pathogenesis, biomarkers, and therapeutic targets by Forouzan Bahmani, Maryam Shayanmanesh, Mahdi Safari, Amirarsalan Alaei, Yasaman Pouriafar, Zahra Rasti, Farhad Zaker, Shahrbano Rostami, Fatemeh Damerchiloo, Majid Safa

“…The pathogenesis of MDS is influenced by intrinsic factors, such as genetic insults, and extrinsic factors, including altered bone marrow microenvironment (BMM) composition and architecture. BMM is reprogrammed in MDS, initially to prevent the development of the disease but eventually to provide a survival advantage to dysplastic cells. …”
Get full text

Key events in the process of sex determination and differentiation in early chicken embryos by Xiaoqian Lv, Changhua Sun, Xin Liu, Guanzheng Liu, Wei Gong, Hongwu Qian, Zeyu Li, Jun Wu, Xilin Zhu, Jiuzhou Song, Yingjie Niu, Hongyan Sun, Wei Han, Guo hong Chen, Kai Jin, Bichun Li, Qisheng Zuo

“…This phenotypic and molecular shift underscores the ability of metabolic and epigenetic modulators to reprogram ovarian development towards a male-like pattern, preserving male sexual characteristics. …”
Get full text

Advancements in understanding tumor-resident bacteria and their application in cancer therapy by Yi-Chen Luo, Xiu-Ting Huang, Rui Wang, Yu-Jing Lin, Jia-Xin Sun, Ke-Feng Li, De-Yun Wang, Yan Yan, Yong-Kang Qiao

“…As a result, this review provides new insights to guide future investigations and support the development of microbiota-based interventions in oncology.…”
Get full text

The role of intestinal macrophage polarization in colitis-associated colon cancer by Yujie Deng, Xiaobing Jia, Liu Liu, Qiao He, Lei Liu

“…The combination of immunotherapy with reprogrammed macrophages and anti-tumor drugs may provide an effective means for enhancing the therapeutic effect. …”
Get full text

Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration by Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Haimei Liang, Haimei Liang, Haimei Liang, Haimei Liang, Xiangling Qin, Xiangling Qin, Xiangling Qin, Xiangling Qin, Yuemi Mo, Yuemi Mo, Yuemi Mo, Yuemi Mo, Shiyi Chen, Shiyi Chen, Shiyi Chen, Shiyi Chen, Jinling Xie, Jinling Xie, Jinling Xie, Jinling Xie, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao, Erwei Hao, Zhengcai Du, Zhengcai Du, Zhengcai Du, Zhengcai Du

“…By bridging fundamental discoveries with translational applications, this review establishes Hippo/YAP as a compelling therapeutic target and provides a theoretical foundation for developing innovative CRC therapies.…”
Get full text