The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…When the immune system of plants is activated upon pathogen infection during their growth and development, cellular transcriptional reprogramming occurs to regulate the expression of defense-related genes. …”
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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism by Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang

“…Additionally, a xenograft mouse model was developed for in vivo validation. Results TP53 and RB1 mutations were associated with cisplatin concentration-dependent phenotypic transformation, with A549/DDP cells acquiring a more aggressive SCLC-like phenotype (In the article we call the A549/DDPSCLC cells). …”
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Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1 by Yanling Zhang, Yafei Cao, Xia Wu, Zhenghui Chen, Bowen Chen, Anhui Wang, Yanshen Guo, Wei Chen, Ruolan Xue, Zihua Liu, Yuanpei Li, Tian Li, Ruiqin Cheng, Ning Zhou, Jing Li, Yuan Liu, Xiaohui Zhao, Huixin Luo, Ming Xu, Houhua Li, Yiqun Geng

“…Abstract Deep understanding of sugar metabolite-protein interactions should provide implications on sugar metabolic reprogramming in human physiopathology. Although tremendous efforts have been made for determining individual event, global profiling of such interactome remains challenging. …”
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Ecophysiological transition mediated by hybridization in a hybrid pine species complex by Zhi-Chao Li, Chao-Qun Xu, Wei Zhao, Shuai Nie, Yu-Tao Bao, Hui Liu, Zhen Xing, Jian-Feng Mao, Xiao-Ru Wang

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Trained immunity: novel perspectives in diabetes and associated complications by Yukun Liu, Yukun Liu, Yanqi Lei, Yanqi Lei, Yanqi Lei, Yanqi Lei, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Changfang Luo, Changfang Luo, Changfang Luo, Changfang Luo, Qiming Gong, Qiming Gong, Qiming Gong, Qiming Gong, Yanqun Li, Yanqun Li, Yanqun Li, Yanqun Li, Yong Xu, Yong Xu, Yong Xu, Yong Xu, Wei Huang, Wei Huang, Wei Huang, Wei Huang

“…Recent studies have revealed that the innate immune system possesses the capacity to develop “trained immunity” via metabolic and epigenetic reprogramming, leading to non-specific memory responses distinct from the memory traditionally attributed exclusively to adaptive immunity. …”
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The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy by Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Xin Su, Zigan Li, Yuxuan Cai, Tangbin Hu, Maoxiao Feng, Xiaoyan Liu, Ming Xia, Jun Tai, Yana Zhang, Yunshan Wang, Mo Wang

“…Furthermore, the review highlights the influence of immunometabolic reprogramming on immune cell function and plaque phenotype, illustrating how metabolic states shape inflammatory outcomes. …”
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Spatially resolved proteomics surveys the chemo‐refractory proteins related to high‐grade serous ovarian cancer by Linyuan Fan, Yi Liu, Haichao Zhou, Yang Feng, Guangyi Jiang, Guixue Hou, Zhihan Cao, Zhiguo Zheng, Lu Sun, Hao Chen, Yuefei Zhang, Weiran Chen, Yun Xi, Benliang Cheng, Qinghai Yang, Yan Ren, Jianqing Zhu, Siqi Liu

“…TS analysis revealed conserved tissue architecture across CP response groups, whereas CS mapping revealed pretreatment metabolic reprogramming (rather than proliferation) as the defining feature of chemo‐resistant tumours, challenging current resistance paradigms. …”
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Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis by Han Gao, Zhongyi Sun, Xingxing Hu, Weiwei Song, Yuan Liu, Menglin Zou, Menglin Zou, Minghui Zhu, Zhenshun Cheng, Zhenshun Cheng, Zhenshun Cheng

“…A prognostic signature was developed using LASSO regression, and time-dependent receiver operating characteristic (ROC) curves were generated to evaluate predictive performance. …”
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Use of constitutive and inducible oncogene-containing iPSCs as surrogates for transgenic mice to study breast oncogenesis by Christine Nguyen, Julie P. T. Nguyen, Arnav P. Modi, Ihsaan Ahmad, Sarah C. Petrova, Stuart D. Ferrell, Sabrina R. Wilhelm, Yin Ye, Dorthe Schaue, Sanford H. Barsky

“…When injected orthotopically, select iPSC clones, either constitutive or inducible, no longer expressed their exogenous pluripotency reprogramming factors but expressed their oncogenic transgene (PyVT or ErbB2) and participated in both breast ontogenesis and subsequent oncogenesis. …”
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Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitiv... by Karyn Lewis, Valeria Fernandez Vallone, Adam Dordevic, Johannes Kern, Harald Stachelscheid, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen, Christian Schinke

“…Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. Each line was characterized to confirm markers of the undifferentiated state, differentiation potential, genomic integrity, identity verification and reprogramming vector removal. …”
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Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer by Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen

“…Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. …”
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Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma by Fu Wang, Haoyu You, Huahua Liu, Zhuoran Qi, Xuan Shi, Zhiping Jin, Qingyang Zhong, Taotao Liu, Xizhong Shen, Sergii Rudiuk, Jimin Zhu, Tao Sun, Chen Jiang

“…Leveraging small interfering RNA (siRNA) technology, we developed a novel glutathione-responsive nano-platform HPssPT (HA/PEIss@siPtpn2) to silence PTPN2 and enhance immunotherapy efficacy in hepatocellular carcinoma (HCC). …”
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Modulation of Brain Kynurenic Acid by N-Acetylcysteine Prevents Cognitive Impairment and Muscular Weakness Induced by Cisplatin in Female Rats by Teminijesu Dorcas Aremu, Daniela Ramírez Ortega, Tonali Blanco Ayala, Dinora Fabiola González Esquivel, Benjamín Pineda, Gonzalo Pérez de la Cruz, Alelí Salazar, Itamar Flores, Karla F. Meza-Sosa, Laura Sánchez Chapul, Edgar Rangel-López, Saúl Gómez-Manzo, Adrián Márquez Navarro, Gabriel Roldán Roldán, Verónica Pérez de la Cruz

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Decoding stress specific transcriptional regulation by causality aware Graph-Transformer deep learning by Umesh Bhati, Akanksha Sharma, Sagar Gupta, Anchit Kumar, Upendra Kumar Pradhan, Ravi Shankar

“…Cells respond to environmental stimuli through transcriptional reprogramming orchestrated by transcription factors (TFs) which interpret cis-regulatory DNA sequences to determine the timing and locations of gene expression. …”
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3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…Collectively, the local stiff niches may drive the emergence of CSCs through epigenetic and metabolic reprogramming in PDAC mechanobiology. This provides new insights for developing more precise therapeutic strategies targeting PDAC mechanical heterogeneity.…”
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PDGFR-β/Cav1-induced autophagy via mTOR/FIP200/ATG13 activation in cancer-associated fibroblasts promotes the malignant progression of breast cancer by Lifang Zhang, Keqin Wang, Jianbo Zhang, Xianzhe Qian, Xiaoan Zhang, Yi Wang, Quan Hu, Ziyi Zhan, Wending Hu, Hui Lin, Xiaoming Liu, Lixia Xiong

“…This enhances glycolysis and lactate efflux from CAFs to the TME, facilitating breast cancer development…”
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Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker by Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

“…While dysregulated cell death mechanisms and metabolic reprogramming are hallmarks of cancer progression, the interplay between fatty acid metabolism and cell death pathway regulation in neuroblastoma remains incompletely understood. …”
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Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition by Tzu‐Lei Kuo, Ya‐Chin Hou, Yan‐Shen Shan, Li‐Tzong Chen, Wen‐Chun Hung

“…Compared to the tumours developed in mice with K‐ras mutation and Tp53 deficiency (KPC mice), KAR tumours exhibited increased immune cell infiltration and reduced stromal activation. …”
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Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma by Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang

“…BackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. …”
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MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer by Yixuan Wang, Mu Qiao, Jing Guo, Ying Xie, Meilin Hu, Xin Li, Sheng Wang, Jingjing Wang, Jingya Wang, Ziyi Peng, Mengqi Wang, Hao Cheng, Tiantian Li, Linchuang Jia, Danchen Su, Huanhuan Liu, Kexin Hu, Xinyang Li, Wenjing Li, Di Wu, Zhe Zhang, Jianing Han, Ruiyang Bai, Funan Zhou, Zhiqiang Liu

“…Mechanistic analysis revealed that MKRN1 interacts with Aspartate/Glutamate Carrier 1 (AGC1), facilitating degradation of AGC1 via K11- and K29-linked ubiquitination, thereby affecting mitochondrial function including energy metabolism and antioxidant responses. Through reprogramming of metabolic genes, this process enhances the expression of heat shock protein HSPD1 and HSP90AA1, while reducing oxidative stress, ultimately contributing to the development of Oxa resistance in CRC cells. …”
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