Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasia by Yufeng Liu, Chun Yan, Yushan Li, Ruoxing Zhou, Xiaoyu Lin, Qiong Meng, Sitao Li, Limei Zhong, Yanfang Tan, Wangkai Liu

“…Conclusion These findings enhance the understanding of the BPD immune microenvironment and lay the foundation for developing targeted immunomodulatory therapies. Highlights Single‐cell sequencing revealed immune cell profiles in bronchopulmonary dysplasia (BPD). …”
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Metabolic pathway activation and immune microenvironment features in non-small cell lung cancer: insights from single-cell transcriptomics by Yanru Liu, Yanru Liu, Yanru Liu, Hanmin Liu, Hanmin Liu, Ying Xiong, Ying Xiong

“…Given that lung cancer is a leading cause of cancer-related deaths globally and NSCLC accounts for the majority of lung cancer cases, understanding the relationship between TME and metabolic pathways in NSCLC is crucial for developing new treatment strategies.MethodsFinally, machine learning algorithms were employed to construct a risk signature with strong predictive power across multiple independent cohorts. …”
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Harnessing delta-like ligand 3: bridging biomarker discovery to next-generation immunotherapies in refractory small cell lung cancer by Kangkang Ji, Kangkang Ji, Lin Guo, Dianbao Zuo, Mingqian Feng, Xin Chen, Zhenggang Zhao, Jing Tang, Guoping Chen

“…Together, these developments signal a transformative era in SCLC treatment, where molecular diagnostics and engineered immunotherapies converge to address unmet clinical needs.…”
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Integrated transcriptomics and machine learning reveal REN as a dual regulator of tumor stemness and NK cell evasion in Wilms tumor progression by Qingfei Cao, Junyi Li, Yunfei Zou, Changwen Xu, Huihui Tang, Meixue Chen

“…A novel Cancer Stemness Prognostic Index (CSPI) was developed using machine learning algorithms to stratify WT patients by risk and histological subtype. …”
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Transcriptome atlas of Striga germination: Implications for managing an intractable parasitic plant by Gilles Irafasha, Sylvia Mutinda, Fredrick Mobegi, Brett Hale, George Omwenga, Asela J. Wijeratne, Susann Wicke, Emily S. Bellis, Steven Runo

“…Results showed that germination proceeds immediately after SL perception and is marked by a wave of transcriptional reprogramming to allow for metabolic processes of energy mobilization. …”
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Constructing a Glioblastoma Prognostic Model Related to Fatty Acid Metabolism Using Machine Learning and Identifying F13A1 as a Potential Target by Yushu Liu, Hui Deng, Ping Song, Mengxian Zhang

“…<b>Conclusions:</b> The prognostic model developed here helps us to further enhance our understanding of FAM in GBM and provides a compelling avenue for the clinical prediction of patient prognosis and treatment. …”
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Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells by Umberto Miglio, Enrico Berrino, Daniele Avanzato, Ivan Molineris, Valentina Miano, Melissa Milan, Letizia Lanzetti, Eugenio Morelli, James M. Hughes, Michele De Bortoli, Anna Sapino, Tiziana Venesio

“…We investigated the effects of targeting L1-MET in eight cancer cell lines derived from breast, lung, and gastrointestinal cancers, as well as in non-transformed human fibroblasts and lymphocytes, using specifically developed modified antisense oligonucleotides. Inhibition of L1-MET resulted in decreased cell viability, increased apoptosis, and gene expression profile reprogramming in cancer cells, including significant downregulation of MET and epidermal growth factor receptor (EGFR) proteins. …”
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Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects by Xiaoyang Liu, Jia Dong, Zhongshu Wu, Jiarong Cui, Yixin Zheng, Min Zhou

“…Colchicine (Col), the most prescribed medication for GA, exhibits anti-inflammatory effects but is associated with significant side effects. Here, we developed an oral microalgae-based hydrogel system (Eug-Col@Fucar) utilizing Fucar to load the Eug-Col complex, aiming to synergistically reduce UA levels and alleviate inflammation in GA treatment. …”
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Metabolically Engineered Extracellular Vesicles Released From a Composite Hydrogel Delivery System Regulate the Microenvironment for Periprosthetic Osteolysis Treatment by Chenchen Wang, Jiang Ju, Chao Fu, Bingbo Bao, Tianhui Ren, Yanan Li, Yuan Wang, Sheng Han, Yuan Wang, Xuan Huang, Hongxing Hu, Xianyou Zheng

“…DS‐EVs demonstrated specific macrophage tropism, effectively reprogramming macrophage polarisation from pro‐inflammatory M1 to regenerative M2 phenotypes. …”
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Ferroptosis: a novel pharmacological mechanism against multiple myeloma by Jingbo Shi, Yitong Lu, Wenjian Wei, Guodong Ma, Changnian Li, Lulu Li, Yaru Wang, Yan Wang, Ruirong Xu, Siyuan Cui

“…Prioritize developing biomarkers and ferroptosis inducers to advance novel ferroptosis-targeting anticancer compounds.…”
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Mechanisms of host-bacterial interactions during Escherichia coli or Staphylococcus aureus infection of mammary epithelial cells by Zhengge Zhao, Zhiming Hou, Jianmin Chai, Chunfang Li, Tingyu Liu, Jianming Li, Shuyi Zhang, Lei Zhang, Yabin Ma

“…These findings provide new insights into the pathogenesis of mastitis and provide a theoretical basis for developing targeted prevention and control strategies.…”
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Generation and characterization of induced pluripotent stem cells of small apes by Yusuke Hamazaki, Hiroto Akuta, Hikaru Suzuki, Hideyuki Tanabe, Kenji Ichiyanagi, Takuya Imamura, Masanori Imamura, Masanori Imamura, Masanori Imamura

“…Using Sendai virus-based stealth RNA vectors, we generated 31 reprogrammed cell lines, five of which were developed into transgene-free induced pluripotent stem cells. …”
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Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein by Kenneth W Hance, Nicolas Torres, María Victoria Regge, Florencia Secchiari, Adrián David Friedrich, Raúl Germán Spallanzani, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Núñez, Jessica Mariel Sierra, Andrea Ziblat, María Cecilia Santilli, Nicolás Gilio, Evangelina Almada, Constanza Lauche, Romina Pardo, Carolina Inés Domaica, Mercedes Beatriz Fuertes, Kevin Patrick Madauss, Israel S Gloger, Vanesa Zylberman, Fernando Alberto Goldbaum, Norberto Walter Zwirner

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Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer by Zhengfang Liang, Fengwei Nong, Fengwei Nong, Zhenjie Li, Runmin Chen, Haoxu Zhao, Yongping Huang, Yongping Huang

“…A taurine metabolic dysregulation index (TMs) was developed using TCGA cohorts, with survival modeling and machine learning methodologies deployed to assess its prognostic utility. …”
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Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility by Yifei Hu, Shunjie Zheng, Jing Xu, Yufang Zhao, Jianbao Wang, Zenghui Fang, Lanfang Zhou

“…Although maternal gut microbiota undergoes significant remodeling during pregnancy, the specific mechanisms governing GDM-induced microbial reprogramming in offspring and its implications for susceptibility to infections remain unclear. …”
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Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance by Minhan Jin, Minhan Jin, Yuhui Wang, Mingze Song, Wenfei Guo, Shirong Li, Zeqing Pu

“…Finding effective targets is important to develop new treatments for lung cancer. As a member of Group 4A of the nuclear receptor subfamily, Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) is an immediate early gene that encodes a transcription factor that plays a regulatory role when the cell and tissue microenvironment changes. …”
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The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study by Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng, Puhua Zeng

“…The identification of pleiotropic genetic variants also offers insights for developing shared biomarkers and therapeutic targets across malignancies.…”
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Identification and validation of synergistic drug strategies targeting macrophage polarization in triple-negative breast cancer via single-cell transcriptomics and deep learning by Qi Qi, Wenhao Yang, Liang Li, Yuheng Tang, Yongzhi Chen, Hui Wang, Sun Yingjie, Jialin Shi, Samina Gul, Wenru Tang, Jianyu Pang, Xiaoli Xie

“…Finasteride significantly enhanced doxorubicin efficacy ex vivo and in vivo by reprogramming the TME, reducing M2 macrophage infiltration while promoting an M1 phenotype. …”
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Drought priming-induced low temperature stress tolerance in wheat: insight into stress memory dynamics by Yi Wang, Lihao Zheng, Jiamin Song, Jian Cai, Qin Zhou, Yingxin Zhong, Dong Jiang, Xiao Wang

“…These physiological advantages were tightly linked to transcriptional reprogramming of carbohydrate metabolism, antioxidant defense, and hormone signaling pathways, suggesting that drought priming establishes a long-term molecular and metabolic memory that enhances stress tolerance. …”
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Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival by Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni

“…This effect is, at least partially, induced by stem-cell driving events coordinated by the reprogramming transcription factors Oct4 and Sox2 that lead to open chromatin states. …”
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