Transcriptome Analysis and CFEM Gene Overexpression in <i>Metschnikowia bicuspidata</i> Under Hemocyte and Iron Ion Stress by Bingnan Zuo, Xiaodong Li, Ji Zhang, Bingyu Li, Na Sun, Fang Liang

“…This work elucidates how <i>M. bicuspidata</i> employs metabolic reprogramming, oxidative stress responses, and CFEM-mediated iron regulation to establish infection, providing critical insights for developing targeted control strategies against milky disease.…”
Get full text

Low-Temperature Stress-Induced Hepatic Injury in Darkbarbel Catfish (<i>Pelteobagrus vachelli</i>): Mediated by Gut–Liver Axis Dysregulation by Amei Liu, Guoqing Duan, Libo Yang, Yuting Hu, Huaxing Zhou, Huan Wang

“…Collectively, this study delineates the interplay between hepatic metabolic reprogramming and gut microbiota dysbiosis during cold adaptation in <i>P. vachelli</i>, establishing a theoretical framework for developing gut–liver axis-targeted strategies to augment cold tolerance in aquatic species.…”
Get full text

Multi-omics reveals the polyethylene terephthalate carcinogenicity: Cancer progression and immune microenvironment by Kangping Yang, Xianhuan Zhou, Kai Wu, Jiaqiang Wu, Chunxia Huang, Liang Yang

“…This work provides critical insights for developing prevention strategies against pollutant-driven malignancies, bridging molecular toxicology with clinical cancer biology.…”
Get full text

A lipid metabolism-related gene signature predicts prognosis after tamoxifen treatment in ER + breast cancer and reflects tumor microenvironment heterogeneity through single-cell a... by Linxiaoxi Ma, Bei Qian, Chen Peng, Gang Liu, Hao Shen

“…Conclusion The signature captures lipid metabolic reprogramming and immunosuppression, providing a biomarker for prognosis and precision therapy in tamoxifen-treated ER + breast cancer.…”
Get full text

USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma by Yongkang Xu, Jiayu Zeng, Kan Liu, Dan Li, Shenglan Huang, Shumin Fu, Mao Ye, Si Tao, Jianbing Wu

“…Xenograft models in nude mice were developed to verify the role of the USP11/SREBF1 axis in lipogenesis and tumor growth in vivo. …”
Get full text

Omics-based evaluation of m6A modification patterns in uveal melanoma and their prognostic implications by Xiaohui Shi, Xiao Zhu, Dongpei Li

“…Background: Epigenetic reprogramming plays a crucial role in the progression of uveal melanoma (UM). …”
Get full text

Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma by Qian Liu, Jiayu Zhu, Guzalinuer Abulizi, Ayshamgul Hasim

“…Abstract Background Reprogramming of cellular metabolism is a pivotal mechanism employed by tumor cells to facilitate cell growth, proliferation, and differentiation, thereby propelling the progression of cancer. …”
Get full text

EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency. by Christine T Styles, Quentin Bazot, Gillian A Parker, Robert E White, Kostas Paschos, Martin J Allday

“…In vitro, about 20 days after infection with EBV lacking functional EBNA3A and EBNA3C, cells develop a PC-like phenotype. Together, these data suggest that EBNA3A and EBNA3C have evolved to prevent differentiation to PCs after infection by EBV, thus favouring long-term latency in MBC and asymptomatic persistence.…”
Get full text

Immunohistochemical study of uveal melanoma and its cellular microenvironment by S. V. Saakyan, L. A. Katargina, E. B. Myakoshina, G. P. Zakharova, I. P. Khoroshilova–Maslova, A. M. Maibogin

“…The data obtained will make it possible to further evaluate the significance of individual immune cells (in particular, T-cytotoxic CD28+ lymphocytes) in the pathogenesis of uveal melanoma in order to develop targeted effects, substantiate new immunotherapeutic approaches to the treatment of primary tumors and reprogramming altered immune cells.…”
Get full text

ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation by Yan Rong, Yu‐Ke Wu, Yingyan Chen, Qing Liu, Leilei Ai, Yun‐Wen Wu, Yezhang Zhu, Yin‐Li Zhang, Chengkan Liu, Yerong Ma, Xiaomei Tong, Jiamin Jin, Xiaoxuan Li, Yan Zhou, Shu‐Yan Ji, Songying Zhang, Heng‐Yu Fan

“…In addition to this known function, it is found that ZAR1/2 is required for oocyte epigenetic maturation and zygotic reprogramming. Zar1/2‐deleted oocytes exhibited reduced levels of multiple histone modifications and of the expression of corresponding histone modifiers, along with over‐condensed chromatin, leading to compromised minor zygotic genome activation and deficient embryo development following fertilization. …”
Get full text

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages by Antonio Sica, Marta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D'Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Donatella Del Bufalo

“…Tumor-derived interleukin-1β has been identified as the effector cytokine of bcl-2-dependent macrophage reprogramming, according to reduced tumor growth, decreased number of M2-polarized tumor-associated macrophages and increased number of infiltrating CD4+IFNγ+ and CD8+IFNγ+ effector T lymphocytes, which we observed in response to in vivo treatment with the IL-1 receptor antagonist kineret. …”
Get full text

Effect of Mesenchymal Stem Cell–Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells by Jiabin Liang, Sihang Cheng, Qide Song, Yukuan Tang, Qian Wang, Hanwei Chen, Jie Feng, Lin Yang, Shunli Li, Zhiwei Wang, Jinghui Fan, Chen Huang

“…Introduction: Advanced glycation end products (AGEs) play a critical role in the development of vascular diseases in diabetes. Although stem cell therapies often involve exposure to AGEs, the impact of this environment on extracellular vesicles (EVs) and endothelial cell metabolism remains unclear. …”
Get full text

Acetylation at lysine 27 on maternal H3.3 regulates minor zygotic genome activation by Jiaming Zhang, Xuanwen Li, Qi Zhao, Jingzhang Ji, Hongdi Cui, Weibo Hou, Xinyu Wang, Entong Song, Songling Xiao, Shukuan Ling, Shaorong Gao, Xiaoyu Liu, Duancheng Wen, Qingran Kong

“…These findings demonstrate that mH3.3-mediated parental chromatin reprogramming is essential for orchestrating minor ZGA.…”
Get full text

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer by Yang Li, Pedram Yadollahi, Fonma N. Essien, Vasanta Putluri, Chandra Shekar R. Ambati, Karthik Reddy Kami Reddy, Abu Hena Mostafa Kamal, Nagireddy Putluri, Lama M. Abdurrahman, Maria E. Ruiz Echartea, Keenan J. Ernste, Akshar J. Trivedi, Jonathan Vazquez-Perez, William H. Hudson, William K. Decker, Rutulkumar Patel, Abdullah. A. Osman, Farrah Kheradmand, Stephen Y. Lai, Jeffrey N. Myers, Heath D. Skinner, Cristian Coarfa, Kwangwon Lee, Antrix Jain, Anna Malovannaya, Mitchell J. Frederick, Vlad C. Sandulache

“…We sought to determine whether smoke itself can modulate aggressive tumor behavior in head and neck squamous cell carcinoma (HNSCC) through reprogramming of the cellular reductive state. Methods Using established human and murine HNSCC cell lines and syngeneic mouse models, we utilized conventional western blotting, steady state and flux metabolomics, RNA sequencing, quantitative proteomics and flow cytometry to analyze the impact of smoke exposure on HNSCC tumor biology and anti-tumor immunity. …”
Get full text

Metabolic alterations and immune heterogeneity in gastric cancer metastasis by Rui Zeng, Zhihao Lin, Feiyan Feng, Yanyan Li, Weiwei Liu, Wenting He, Yongjun Huang, Xingtao Lin, Yan Mei, Hongmei Wu, Qingling Zhang

“…Summary: Cellular metabolic reprogramming supports tumor proliferation, invasion, and metastasis by enhancing resistance to stress and immune clearance. …”
Get full text

Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery by Qin Xu, Bing Wang, Yang He, Zening Zheng, Jiaxin Zhang, Jizong Jiang, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Yongzhuo Huang

“…Moreover, CDX-LIPO promoted M1-macrophage polarization and facilitated mTOR-mediated reprogramming of glucose metabolism in glioma.Conclusion This study developed a potential combinatory therapeutic strategy by regulation of TIME and a ‘three-birds-one-stone’-like glioma-targeting drug delivery system.…”
Get full text

Multiomic analysis of lactylation and mitochondria-related genes in hepatocellular carcinoma identified MRPL3 as a new prognostic biomarker by Wenya Xing, Yuanzi Zhou, Qiuzi Long, Nan Yi, Gaoyuan Wang, Rongwei Shi, Jinlong Huang, Xindong Yin, Taiyang Zhu, Shibing Cao

“…Prognostic outcomes and pathway enrichment were analyzed across the identified clusters. Additionally, we developed a prognostic model based on LMRGs, examining its implications for survival, immune response, and drug sensitivity. …”
Get full text

Pathophysiology‐Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain by Wenkai Wang, Yan Wang, Xinle Huang, Peng Wu, Lanlan Li, Yang Zhang, Yihui Chen, Zhiyu Chen, Changqing Li, Yue Zhou, Jianxiang Zhang

“…By packaging AD peptide into PPTN, a combination nano‐analgesic APTN is developed. Besides potentiated anti‐hyperalgesic effects due to site‐specific delivery and on‐demand release of AD peptide at target sites, APTN simultaneously inhibits neuroinflammation and promotes nerve regeneration by reprogramming macrophages via regulating MAPK/NF‐kB signaling pathways and NLRP3 inflammasome activation, thus affording synergistic efficacies in treating nerve injury‐induced neuropathic pain.…”
Get full text

The SlDLK2 receptor, involved in the control of arbuscular mycorrhizal symbiosis, regulates hormonal balance in roots by Martín Ramos-Alvelo, Nuria Molinero-Rosales, María Isabel Tamayo-Navarrete, Sanja Ćavar Zeljković, Sanja Ćavar Zeljković, Petr Tarkowski, Petr Tarkowski, José Manuel García-Garrido, Tania Ho-Plágaro

“…Transcriptional reprogramming and hormonal regulation are necessary for the formation of the arbuscules. …”
Get full text

Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations by Joseph Nhyira Obisi, Abike Ndidiamaka Josephine Abimbola, Oluwasegun Adesina Babaleye, Peter Kwame Atidoglo, Saviour God’swealth Usin, Eudora Obioma Nwanaforo, Faith Sutu Patrick-Inezi, Ilemobayo Victor Fasogbon, Joseph Chimezie, Christianah Adebimpe Dare, Oluwadoyinsayemi Oluwadamilare Kuti, Daniel Ejim Uti, Humphrey Chukwudi Omeoga

“…As such, CSCs have become focal points in developing advanced cancer therapies. This review highlights progress in CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, and nanoparticle-based drug delivery systems. …”
Get full text