Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma by Yiran Guo, Tianhe Jiang, Sen Liang, Anhe Wang, Jieling Li, Yi Jia, Qi Li, Jian Yin, Shuo Bai, Junbai Li

“…Here an injected peptide gel with in situ immunostimulatory functions is developed to coordinate the regulation of glutamine metabolism and chemodynamic therapy for overcoming these postoperative obstacles. …”
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Immunocytes in the tumor microenvironment: recent updates and interconnections by Jiyao Yu, Jiyao Yu, Li Fu, Li Fu, Rui Wu, Rui Wu, Linyi Che, Linyi Che, Guodong Liu, Qinwen Ran, Zhiwei Xia, Xisong Liang, Xisong Liang, Guanjian Zhao

“…By integrating recent molecular insights and clinical advancements, the review underscores the importance of deciphering the interplay between immunocytes and the TME to develop more effective cancer immunotherapies.…”
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Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities by Meimei Wang, Yaping Xiao, Jie Miao, Xin Zhang, Meng Liu, Longchao Zhu, Hongxin Liu, Xiaoyan Shen, Jihui Wang, Biao Xie, Di Wang

“…The goal is to provide a theoretical framework and translational roadmap for developing synergistic anti-tumor therapies.…”
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Itaconic Acid: A Regulator of Immune Responses and Inflammatory Metabolism by Kai Ma, Pei Zhou, Wei Zhang, Liwu Zeng, Kaixiong Tao, Peng Zhang

“…In immune regulation, itaconate regulates macrophage function through a variety of mechanisms, including metabolic reprogramming, polarization regulation, inhibition of cytokine production, and regulation of oxidative stress. …”
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PRMT1-mediated methylation of UBE2m promoting calcium oxalate crystal-induced kidney injury by inhibiting fatty acid metabolism by Tianhui Yuan, Zehua Ye, Shuqin Mei, Miao Zhang, Ming Wu, Fangyou Lin, Weimin Yu, Wei Li, Xiangjun Zhou, Fan Cheng

“…In this study, mice with specific deletion or overexpression of PRMT1 in tubular epithelial cells were developed, and a CaOx crystal-induced kidney injury mouse model was established. …”
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Unveiling tumor-infiltrating immune cell-driven immune-mediated drug resistance in clear cell renal cell carcinoma: prognostic insights and therapeutic strategies by Jifeng Yang, Yixuan Xing, Jiusong Luan, Wenbo Yang, Xin Zhang, Yanhua Tian, Haisong Zhang

“…Significant metabolic reprogramming, including lipid and sulfur metabolism, and distinct genomic alterations, such as BAP1 mutations, were linked to TIIC score. …”
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Leukotriene Involvement in the Insulin Receptor Pathway and Macrophage Profiles in Muscles from Type 1 Diabetic Mice by João Pedro Tôrres Guimarães, Luciano Ribeiro Filgueiras, Joilson Oliveira Martins, Sonia Jancar

“…Although T1D can be corrected by insulin administration, over time T1D patients can develop insulin resistance that hinders glycemic control. …”
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Modular and signal-responsive transcriptional regulation using CRISPRi-aided genetic switches in Escherichia coli by Seong Keun Kim, Seung-Gyun Woo, Jun-Hong Park, Seung-Goo Lee, Dae-Hee Lee

“…However, existing regulatory tools are often limited by issues such as leaky transcription and insufficient tunability, particularly in high-expression or complex genetic contexts. This study aimed to develop a CRISPRi-aided genetic switch platform that overcomes these limitations and expands the functionality of transcriptional regulation tools in synthetic biology. …”
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USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness by Zhenlei Zhang, Xiujie Yu, Liqi Wen, Jia’nan Wang, Zhufeng Li, Yu Zhang, Jiayu Cheng, Ronglin Kan, Wanting Zhang, Yan Shen, Shukai Yuan, Li Zhao

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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. Lipid metabolic reprogramming, a hallmark of tumor progression, contributes to acquired drug resistance in various malignant tumors. …”
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UBE2G2 inhibits vasculogenic mimicry and metastasis of uveal melanoma by promoting ubiquitination of LGALS3BP by Andi Zhao, Chenyu Zhou, Jinjing Li, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen

“…Furthermore, UBE2G2 inhibits oncogenic phenotypes by inactivating intracellular PI3K/AKT signaling and reprogramming the tumor microenvironment. Therefore, targeting intercellular and intracellular molecular mechanisms of the hypoxia–UBE2G2–LGALS3BP axis may contribute to developing various therapeutic strategies for UM.…”
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Feruloyl-amides as natural antimicrobials for crop and food protection by Denise Dozio, Sharmila Ghosh, Daniele Alessandro Consolini, Josè Luis Ermini Starna, Loris Pinto, Federico Baruzzi, Martina Letizia Contente, Andrea Pinto, Paolo Cortesi, Salvatore Princiotto, Andrea Kunova, Sabrina Dallavalle

“…Abstract Background Plants have developed multiple chemical defence responses against pathogen attacks. …”
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A programmable platelet theranostic platform for adaptive multi-stage delivery and synergistic immunotherapy in atherosclerosis by Yi Li, Xueping Li, Ting Chen, Jian Li, Ji Qi, Wen Li

“…Abstract Macrophages, along with the inflammatory and maladaptive immune responses they trigger, play crucial roles in the progression and rupture of atherosclerosis. We develop an adaptable platelet-protein platform tailored for the targeted delivery of both antioxidant nanocatalysts and TRAF6 inhibitor to advance synergistic therapy for atherosclerosis. …”
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Seasonal adaptation strategies of heteroblastic foliage in Pinus massoniana seedlings: insights into sugar composition, osmotic regulation, and protective enzyme mechanisms by Haoyun Wang, Shuangqin Xie, Hongyang He, Yingying Xu, Feng Wu

“…As such, a theoretical framework is developed to better understand key traits that enable conifer species to adapt to environmental stressors associated with changing climates.…”
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A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers by Mary C. Bedard, Cosette M. Rivera-Cruz, Tafadzwa Chihanga, Andrew VonHandorf, Alice L. Tang, Chad Zender, Matthew T. Weirauch, Robert Ferris, Trisha M. Wise-Draper, Mike Adam, Susanne I. Wells

“…We hypothesize that distinct epithelial cell populations and reprogramming in HPV− versus HPV+ HNSCC represent important components of the pro-tumor environment. …”
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Immunomodulatory exosomes loaded chitosan methacryloyl hydrogel combined with pro-chondrogenic microspheres for promoting articular cartilage regeneration by Ruoyu Liang, Zhaoxu Li, Qu Xu, Shengtao Wang, Dongxu Chen, Peng Gui, Mingzhou Chen, Wei Peng, Jian Su

“…Therefore, there is a need to develop innovative hydrogel systems with immunomodulatory capabilities that promote a favorable environment for cartilage regeneration. …”
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Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy by Ying Wang, Jiayao Yan, Lin Li, Tianran Chen, Jingyi Guo, Lei Lei, Siwen Wu, Lijing Zhu, Xiaotong Chen, Baorui Liu

“…Here, we identify a MSLN-targeting designed ankyrin repeat protein (DARPin) M7, which specifically binds to the protease-sensitive C-terminal region of MSLN. Furthermore, we develop two auristatin-based DARPin-drug conjugates (DARPin-DCs), M7A-DC and M7GA-DC. …”
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Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma by Qian Chengqun, Wang Xijun, Fan Yangyang, Yang Xiaoqin, Cheng Min, Xu Jun

“…Methods A prognostic model was developed using random survival forests (RSF), with performance evaluated through concordance index (C-index) and survival analysis. …”
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Iron Deficiency in Tomatoes Reversed by <i>Pseudomonas</i> Strains: A Synergistic Role of Siderophores and Plant Gene Activation by Belén Montero-Palmero, Jose A. Lucas, Blanca Montalbán, Ana García-Villaraco, Javier Gutierrez-Mañero, Beatriz Ramos-Solano

“…In view of these results, both strains are effective candidates to develop biofertilizers.…”
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Cancer-associated fibroblasts in clear cell renal cell carcinoma: functional heterogeneity, tumor microenvironment crosstalk, and therapeutic opportunities by Man Wang, Yuanzhuo Zhao, Kangchun Xu, Chao Liu, Hui Zhong, You Wu, Ke Zhang, Shanzhai Wei

“…Furthermore, heterogeneous CAFs facilitate tumor growth through metabolic reprogramming and modulate immune suppression by driving the M2 polarization of tumor-associated macrophages (TAMs) and the expansion of regulatory T cells (Tregs), which promote a multilayered immunosuppressive network. …”
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