Intercellular communication between extracellular vesicles from conditioned macrophages and breast cancer cells drives endocrine therapy resistance by María C. Rodriguez-Baili, Miguel Palma-Cobo, César G. Prucca, María Yáñez-Mó, German A. Gil

“…Importantly, treated cells developed a stem-like phenotype, characterized by a larger CD44High/CD24Low subpopulation and improved spheroid-forming ability. …”
Get full text

Enhanced cadmium tolerance in perennial ryegrass via exogenous application of Enterobacter hormaechei strain X20 by Shujie Liao, Yu Ling, Ya Gao, Guangjing Ma, Xiaoning Li, Liang Chen, Longxing Hu, Yan Xie

“…The utilization of plant growth-promoting rhizobacteria (PGPR) emerges as a promising strategy for mitigating the adverse effects of heavy metal stress on plant health and development. This study investigates the effectiveness of Enterobacter hormaechei X20 in enhancing Cd tolerance in perennial ryegrass, a species renowned for its phytoremediation potential. …”
Get full text

Glutamine potentiates cefoperazone-sulbactam activity against Pseudomonas aeruginosa by increasing membrane permeability and cellular uptake by Jiao Xiang, Xin Wang, Huiyin Lin, Lifen Yang, Xiaoxia Huang, Yuetao Chen, Yingyue Zeng, Shaohua Li, Xianliang Zhao, Shiwen Wang, Yuan Tao, Huanzhe Fu, Zhengqi Shi, Kuihai Wu, Xuanxian Peng, Hui Li, Jin Tang, Zhuanggui Chen

“…Glutamine slows the development of SCF resistance, delays the post-antibiotic effect, and reduces mutation frequency. …”
Get full text

Uncovering SPP1+ Macrophage, Neutrophils and Their Related Diagnostic Biomarkers in Intracranial Aneurysm and Subarachnoid Hemorrhage by Jie H, Wang B, Zhang J, Wang X, Song X, Yang F, Fu C, Dong B, Yan F

“…Furthermore, HIF1α regulon was enriched in SPP1+ Macrophage, mediating inflammation and metabolic reprogramming, which contributed to IA progression. Integrated MR analysis identified CD36 as a risk factor for both IA and SAH, and it has been recognized as an effective blood biomarker for SAH. …”
Get full text

Fibroblast Growth Factor Receptor 4 Promotes Triple‐Negative Breast Cancer Progression via Regulating Fatty Acid Metabolism Through the AKT/RYR2 Signaling by Jinhui Ye, Song Wu, Qiang Quan, Feng Ye, Jinhui Zhang, Cailu Song, Yidan Fan, Huijiao Cao, Hailin Tang, Jianfu Zhao

“…Previous studies have found that fibroblast growth factor receptor 4 (FGFR4) plays a crucial role in tumor development and metastasis. However, the potential role and underlying mechanisms of FGFR4 in the progression of TNBC remain unclear. …”
Get full text

Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Interestingly, the bidirectional influence of CSCs and TME leads to an epigenetic reprogramming which sustains malignant transformation. …”
Get full text

Myeloid subsets impede the efficacy of anti-PD1 therapy in patients with advanced gastric cancer (WJOG10417GTR study) by Naoki Takahashi, Hirokazu Shoji, Kengo Nagashima, Hiroshi Imazeki, Narikazu Boku, Takeshi Kawakami, Kei Muro, Takeru Wakatsuki, Chie Kudo-Saito, Yukiya Narita, Kai Tsugaru, Yusuke Amanuma, Naohiro Okano, Yoshiyuki Yamamoto, Rika Kizawa, Kazunori Aoki

“…Targeting them may be useful as diagnostic biomarkers to predict potential anti-PD1 therapeutic efficacy, and also as therapeutic targets for accelerating the development of new drugs to improve clinical outcomes in immunotherapy for GC.…”
Get full text

Physiological, transcriptomic and metabolomic analyses reveal the mechanism of CuO and silicon nanoparticles involved in Polygonatum kingianum response to root rot by Xi Xu, Jinpeng Wan, Guizhou Liu, Chengkai Lu, Xinyu Mao, Jinglin Wu, Hanying Liu, Yong Ding, Peng Xu

“…Abstract Background Copper oxide nanoparticles (CuNPs) and silicon nanoparticles (SiNPs) play a crucial role in enhancing plant growth and development under stress conditions, making them valuable tools in sustainable agriculture. …”
Get full text

Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

“…These changes in macrophage composition and function promoted effector T cell exhaustion and the development of MASH-associated hepatocellular carcinoma in Tgfbr1-deficient mice. …”
Get full text

Single-cell sequencing and machine learning reveal the role of dioxin-interacting genes in HCC prognosis and immune microenvironment by Senyan Wang, Qi Liu, Xiaoyan Sun, Minghui Hou, Wenjuan Wei, Hao Song, Jing Xu, Danyang Lu, Jing Fu, Xiaofang Zhao, Hongyang Wang

“…Although the carcinogenic potential of dioxins is well recognized, the molecular mechanisms driving hepatocellular carcinoma (HCC) development remain poorly understood. To address this gap, single-cell and bulk transcriptomic analyses, combined with machine learning, identified dioxin-interacting differentially expressed genes (DI-DEGs) associated with immune evasion, metabolic reprogramming, and cell cycle regulation in HCC. …”
Get full text

Mitochondrial Unfolded Protein Response (mtUPR) Activation Improves Pathological Alterations in Cellular Models of Ethylmalonic Encephalopathy by José Manuel Romero-Domínguez, Paula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, Diana Reche-López, Ana Romero-González, Mónica Álvarez-Córdoba, Alejandra López-Cabrera, Marta Castro De Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, Angeles Aroca, José A. Sánchez-Alcázar

“…Ethylmalonic encephalopathy (EE) is a serious metabolic disorder that usually appears in early childhood development and the effects are seen primarily in the brain, gastrointestinal tract, and peripheral vessels. …”
Get full text

An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord by Fu-Lu Dong, Lina Yu, Pei-Da Feng, Jin-Xuan Ren, Xue-Hui Bai, Jia-Qi Lin, De-Li Cao, Yu-Tao Deng, Yan Zhang, Hui-Hui Shen, Hao Gong, Wen-Xing Sun, Dong-Qiu Chi, Yixiao Mei, Longfei Ma, Ming-Zhe Yin, Meng-Na Li, Peng-Fei Zhang, Nan Hu, Bing-Lin Zhou, Ying Liu, Xuan-Jie Zheng, Yi-Fan Chen, Da Zhong, Yuan-Xiang Tao, Min Yan, Bao-Chun Jiang

“…Abstract Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling in the dorsal root ganglia (DRG) and spinal cord (SC) drive the development and maintenance of neuropathic pain (NP). …”
Get full text

Proteomic characterization of the pseudocapsule of clear cell renal cell carcinoma in VHL disease reveals a distinct microenvironment at the tumor boundary zone by Tobias Feilen, Manuel Rogg, Grigor Andreev, Niko Pinter, Maximilian Wess, Anna L. Kössinger, Nastasja Diel, Elke Neumann-Haefelin, Athina Ganner, Markus Grabbert, Christoph Schell, Oliver Schilling

“…Further, tumor proteomes reflected canonical VHL-driven metabolic reprogramming, including upregulated glycolysis and hypoxia markers, suppressed aerobic metabolism, and dysregulated fatty acid metabolism. …”
Get full text

Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis by Chengcheng Zhang, Zhijing Rao, Xiangyang Zhan, Jingru Qin, Lu Yang, Qianqian Yin, Junqing Ji, Xiaoxue Zhao, Yiyi Liu, Zhanhui Lu, Guoying Wang, Xingshuai Huang, Wenbo Shi, Wan Su, Zhongqi Wang

“…Metabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment. …”
Get full text

Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…To further dig into the impact of lactate in tumor microenvironment, we evaluated the effect of this metabolite on mesenchymal stromal cells (MSCs) reprogramming. Results Our results show an activation of a cancer-associated phenotype (CAF) related to mineralized matrix formation and early fibrosis development. …”
Get full text

Diagnosis and prognosis prediction of gastric cancer by high-performance serum lipidome fingerprints by Ze-Rong Cai, Wen Wang, Di Chen, Hao-Jie Chen, Yan Hu, Xiao-Jing Luo, Yi-Ting Wang, Yi-Qian Pan, Hai-Yu Mo, Shu-Yu Luo, Kun Liao, Zhao-Lei Zeng, Shan-Shan Li, Xin-Yuan Guan, Xin-Juan Fan, Hai-long Piao, Rui-Hua Xu, Huai-Qiang Ju

“…Liquid biopsy combined with machine learning will provide new insights into diagnostic strategies of GC. Lipid metabolism reprogramming plays a crucial role in the initiation and development of tumors. …”
Get full text

Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer by Zheng Yuan, Kai Fang, Xinsheng Miao, Yan Zhang, Menghui Gu, Wei Xu, Hao Li, Dawei Zhu, Jiahui Zhou, Jian Sun, Xinhua Gu

“…Over time, cancer cells can develop mechanisms to resist the toxic effects of chemo-therapy drugs, leading to reduced sensitivity or complete insensitivity to these agents. …”
Get full text

Entinostat in combination with nivolumab for patients with advanced cholangiocarcinoma: a phase 2 clinical trial by Elsa Hallab, Jennifer N. Durham, Rosalind Walker, Leslie Cope, Soren Charmsaz, Nicole E. Gross, Dimitrios N. Sidiropoulos, Alexei Hernandez, James Leatherman, Sarah Mitchell, Mark Yarchoan, Won Jin Ho, Nilofer S. Azad, Marina Baretti

“…CyTOF profiling of PBMCs revealed that the HDAC inhibitor mediated immune reprogramming seen in the PDAC was not consistently reproduced for both myeloid and T cell compartments in CCA. …”
Get full text

Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa by Haoan He, Chao Lv, Yuhong Xie, Wei Li, Wei Li, Wei Li, Zihang Ling, Zihang Ling, Zihang Ling, Bin Cheng, Bin Cheng, Bin Cheng, Xiaoan Tao, Xiaoan Tao, Xiaoan Tao

“…These insights support the development of novel carnosine-based interventions to preserve oral mucosal function, prevent age-related oral diseases, and improve oral health in the aging population, thereby advancing healthy aging.…”
Get full text

The role and therapeutic potential of glucose metabolism in multidrug resistance of cancer by Qijing Wang, Kai Li, Liang Li, Qin Li, Yanyu Qi, Kai Liu, Hang Yuan, Ping Lin

“…The molecular mechanisms for cancer cells developing MDR are complex and largely unclarified. …”
Get full text