Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences by Qi Shao, Simin Chen, Yuxiao Zheng, Wenxiu Xu, Jiahui Chen, Wei Shao, Qingguo Wang, Changxiang Li, Xueqian Wang

“…Microglia-mediated metabolic reprogramming is recognized as an important driver of inflammation. …”
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MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids by Akanksha Gupta, Arpit Mehrotra, Abhilasha Sood, Bunty Sharma, Vikas Yadav, Ginpreet Kaur, Katrin Sak, Shakti Ranjan Satapathy, Hardeep Singh Tuli

“…We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies.…”
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The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer by Mengqi Deng, Mengqi Deng, Ruiye Yang, Ruiye Yang, Junyi Jiang, Jinxu Zhang, Junqi He, Junqi He, Jinwei Miao, Jinwei Miao

“…This review discusses the complex processes of HGSOC metastasis, focusing on peritoneal immune suppression, stromal reprogramming, and the role of circulating tumor cells in blood-based spread. …”
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Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs by Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao

“…Future studies should integrate advanced technologies to decode the spatiotemporal dynamics of miRNA regulation within the TME and develop optimised nanodelivery systems for stable and targeted miRNA delivery, advancing clinical applications in PC treatment.…”
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Resynthesis of synthetic biology techniques: combining engineered bacteria with other antitumour therapies by Xueke Chang, Xueke Chang, Xiaolin Liu, Xiumei Wang, Lin Ma, Jing Liang, Yan Li

“…Worldwide cancer mortality rates underscore the pressing need to identify and develop novel anticancer therapies to supplement traditional cancer treatments. …”
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Mechanism of crosstalk between DNA methylation and histone acetylation and related advances in diagnosis and treatment of premature ovarian failure by Jing Li, Qianhui Liao, Yurou Guo, Jiaheng Zhang, Ruyi Zhang, Qiyu Liu, Huiping Liu

“…Additionally, non-coding RNAs form regulatory hubs by constructing competing endogenous RNA networks that integrate oxidative stress and developmental signaling pathways. These mechanisms provide new insights into the pathological basis of POF, identify potential biomarkers, and offer a theoretical framework for deciphering targeted intervention strategies and developing precision epigenetic therapies to delay POF progression.…”
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Metabolic mechanisms of immunotherapy resistance by Luis Cabezón-Gutiérrez, Magda Palka-Kotlowska, Sara Custodio-Cabello, Beatriz Chacón-Ovejero, Vilma Pacheco-Barcia

“…Understanding how tumor metabolism shapes the immune microenvironment is essential for developing effective therapeutic strategies. This review examines key metabolic pathways influencing immunotherapy resistance, including glucose, lipid, and amino acid metabolism. …”
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Lysine methyltransferase 2D deficiency drives complete response to pembrolizumab in PD-L1-High cholangiocarcinoma: a case report and review of literature by Xiaofang Li, Xiaofang Li, Liao Wang, Liao Wang, Shuang Li, Shuang Li

“…Conventional biomarkers like PD-L1 expression show limited predictive value, creating an urgent need for novel therapeutic targets in this aggressive malignancy.Case presentationWe describe a stage IV ICC patient with PD-L1 positivity and a somatic KMT2D mutation (p.R5303C) who attained sustained complete remission after pembrolizumab treatment, despite developing severe multi-organ immune-related adverse events (irAEs) including hepatitis, pneumonitis, and thrombocytopenia. …”
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Comprehensive analysis of metabolism-related gene biomarkers reveals their impact on the diagnosis and prognosis of triple-negative breast cancer by Weibin Ren, Yuyun Yu, Tao Wang, Xueyao Wang, Kunkai Su, Yanbo Wang, Wenjie Tang, Miaomiao Liu, Yanhui Zhang, Long Yang, Hongyan Diao

“…A prognostic model incorporating these genes was developed and validated in an independent patient cohort. …”
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Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy by Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping, Tingbo Liang

“…Improvement of chemotherapeutic efficacy by targeting tumor-associated macrophage and reprograming tumor microenvironment to enhance their efficacy may become a promising strategy. …”
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Adaptive Evolution and Transcriptomic Specialization of P450 Detoxification Genes in the Colorado Potato Beetle Across Developmental Stages and Tissues by Hang Zhou, Ziqi Cheng, Jiejing Tang, Yueqi Lu, Yang Mei, Xi Chen

“…Using RNA-seq data from 65 datasets, we identified significant transcriptional reprogramming during key developmental transitions, particularly from egg to first instar larva and from third instar larva to adult, reflecting critical biological processes, including feeding initiation and metamorphosis. …”
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The Ferroptosis–Mitochondrial Axis in Depression: Unraveling the Feedforward Loop of Oxidative Stress, Metabolic Homeostasis Dysregulation, and Neuroinflammation by Xu Liu, Qiang Luo, Yulong Zhao, Peng Ren, Yu Jin, Junjie Zhou

“…Prefrontal–hippocampal metabolomics reveal paradoxical metabolic reprogramming with glycolytic compensation suppressing mitochondrial biogenesis (via PGC-1α/TFAM downregulation), trapping neurons in bioenergetic crisis. …”
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Nano-orchestrated magnetotactic-like navigation for electromagnetic theranostics and immune enhancement via photoautotrophic oxygenation, mild hyperthermia, and ferroptosis by Chi-Hung Hsiao, Yung-Wei Lin, Chia-Hung Liu, Yan-Ting Chen, Hieu Trung Nguyen, Andrew E.-Y. Chuang

“…Moreover, the multimodal CHL-GCS-IO NPs reprogrammed the TME, facilitating immune activation by promoting macrophage polarization towards the proinflammatory M1 phenotype, engaging cytotoxic T cells and natural killer cells, programmed death ligand 1 (PD-L1) downregulation, and driving dendritic cell reprogramming towards improved antigen presentation. …”
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Global research landscape of antiangiogenic therapy for colorectal cancer: a bibliometric analysis of mechanistic insights and clinical advancements by Ke-Qiang Hou, Jia-Ming Wu, Jie Chen

“…Keyword evolution reflects a shift from angiogenesis mechanisms to clinical validation of treatments like FOLFIRI with bevacizumab, with a current focus on tumor microenvironment reprogramming and precision survival analytics (2020-2024, burst intensity 6.66). …”
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Biomarkers for modeling of cancer-specifc tumor-associated macrophages ex vivo by T. S. Sudarskikh, I. V. Larionova, M. A. Rakina, J. G. Kzhyshkowska

“…Our model system is valuable to examine agents reprogramming key TAM pro-tumoral activities, and for the reproducible analysis of mechanistic events that program tolerogenic status of TAMs towards cancer cells.…”
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Metabolic Engineering of <i>Escherichia coli</i> Nissle 1917 for the Production of Heparosan Using Mixed Carbon Sources by Fangqi Shao, Ruiji Wu, Zheng-Jun Li

“…Its biosynthesis holds significant importance for achieving the chemoenzymatic synthesis of heparin. Here, we developed a systematic metabolic engineering strategy in <i>Escherichia coli</i> Nissle 1917 to establish an efficient heparosan production platform. …”
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Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine by Yilin Meng, Lu Sui, Ligeer Che, Zihang Jin, Yutong Ma, Li Sun

“…Moreover, epigenetic reprogramming is expected for the complete treatment of renal fibrosis. …”
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Macrophage-driven exosomes regulate the progression of cardiovascular disease by Liao Qi, De-Zhu Luo, HuLi Li, JianWen Yan, WenJie He

“…Future studies need to further explore the biological properties of exosomes and develop more efficient, economical, and straightforward isolation methods. …”
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miR-124 coordinates metabolic regulators acting at early stages of human neurogenesis by Geurim Son, Yongwoo Na, Yongsung Kim, Ji-Hoon Son, Gregory D. Clemenson, Simon T. Schafer, Jong-Yeon Yoo, Sarah L. Parylak, Apua Paquola, Hyunsu Do, Dayeon Kim, Insook Ahn, Mingyu Ju, Chanhee S. Kang, Younghee Ju, Eunji Jung, Aidan H. McDonald, Youngjin Park, Gilhyun Kim, Se-Bum Paik, Junho Hur, Joon Kim, Yong-Mahn Han, Seung-Hee Lee, Fred H. Gage, Jong-Seo Kim, Jinju Han

“…Abstract Metabolic dysregulation of neurons is associated with diverse human brain disorders. Metabolic reprogramming occurs during neuronal differentiation, but it is not fully understood which molecules regulate metabolic changes at the early stages of neurogenesis. …”
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Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos by Xiaoyang Ge, Xiaole Yu, Zhixin Liu, Jiachen Yuan, Aizhi Qin, Ye Wang, Yanli Chen, Wenqiang Qin, Yumeng Liu, Xingxing Liu, Yaping Zhou, Peng Wang, Jincheng Yang, Hao Liu, Zihao Zhao, Mengke Hu, Yixin Zhang, Susu Sun, Luis Herrera-Estrella, Lam-Son Phan Tran, Xuwu Sun, Fuguang Li

“…To evaluate the results of these analyses, we functionally characterized the potential roles of two representative marker genes, AATP1 and DOX2, in the regulation of cotton somatic embryo development. A publicly available web-based resource database ( https://cotton.cricaas.com.cn/somaticembryo/ ) in this study provides convenience for future studies of the expression patterns of marker genes at specific developmental stages during the process of SE in cotton.…”
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