Decoupling model descriptions from execution: a modular paradigm for extensible neurosimulation with EDEN by Sotirios Panagiotou, Rene Miedema, Dimitrios Soudris, Christos Strydis, Christos Strydis

“…This architecture enhances flexibility and extensibility by enabling seamless integration of multiple backends, including hardware accelerators, without extensive reprogramming. Through the use of NeuroML, simulation developers can focus on high-performance execution, while model users benefit from improved portability without the need to implement custom simulation engines. …”
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Plant growth-promoting endophytic bacteria: a sustainable solution for climate change and environmental stresses in agriculture by Zabihullah Sherzad, Noor Agha Nawakht, Faridullah Sherzad

“…Abstract Climate change poses significant challenges to plant production, food security, and ecosystem stability. Developing new varieties through breeding is indeed expensive, time-consuming, taking longer to commercialize and less successful. …”
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An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. by Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A Parkhitko

“…To elaborate these causes, we recently developed a series of Drosophila insulin-like receptor (dInr) mutants with single amino acid substitutions that extend lifespan but differentially affect insulin sensitivity, growth and reproduction. …”
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Advocating the role of trained immunity in the pathogenesis of ME/CFS: a mini review by Bart Humer, Willem A. Dik, Marjan A. Versnel

“…Trained immune cells undergo long term epigenetic reprogramming, which leads to changes in chromatin accessibility, metabolism, and results in a hyperresponsive phenotype. …”
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SGLT2 inhibitors as metabolic modulators: beyond glycemic control in type 2 diabetes by Qian Wu, Jian Zhang, Fuli Zhang, Dongnan Li

“…SGLT2is promote urinary glucose excretion, leading to a negative energy balance that triggers lipid metabolic reprogramming and fuel switching in the body. This process significantly reduces visceral fat deposition and improves insulin resistance and the inflammatory status. …”
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Systematic proteomic and small RNA profiling of extracellular vesicles from cattle infected with a naturally occurring buparvaquone-resistant strain of Theileria annulata and from... by Yijun Chai, Jin Che, Jinming Wang, Guiquan Guan, Hong Yin

“…Results Our analysis identified 2580 proteins and 6635 miRNAs in EVs derived from T. annulata-infected bovine serum and immune cell types, many of which are implicated in parasite development, host invasion, and immune modulation. Significant alterations were observed in the EV cargo from infected sera, including enrichment of vesicular proteins and miRNAs associated with immune regulation, metabolic reprogramming, and host–pathogen interactions. …”
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Gasdermin E links tumor cell-intrinsic nucleic acid signaling to proinflammatory cell death for successful checkpoint inhibitor cancer immunotherapy by Stefan Enssle, Anna Sax, Peter May, Nadia El Khawanky, Nardine Soliman, Markus Perl, Julius C. Enssle, Karsten Krey, Jürgen Ruland, Andreas Pichlmair, Florian Bassermann, Hendrik Poeck, Simon Heidegger

“…A deeper understanding of these pathways may allow for the development of novel combined modality approaches to improve ICI treatment responses in cancer patients.…”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…Crucially, Piezo1/ITGB1 overexpression promoted cancer development by suppressing apoptosis and enhancing proliferation. …”
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Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses by Dan Zheng, Dan Zheng, Xuan Pu, Xuan Pu, XuHui Deng, XuHui Deng, Cui Liu, Cui Liu, SiJun Li, SiJun Li

“…Subsequently, prognostic and diagnostic models have been developed using machine learning techniques. Specifically, the prognostic model utilized the least absolute shrinkage and selection operator (LASSO) Cox regression, whereas the diagnostic model was built using the Random Forest (RF) algorithm. …”
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AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma by Xufeng Yao, Qian Chai, Yuhao Ma, Guomeng Li, Tiantian Jia, Xiaohang Zhang, Tao Xia, Xiaozheng Wei, Xueyi Feng, Yanke Zhang, Yaqiang Zhang, Xueqin Wang, Danye Han, Zongwei Li, Lei Zhao, Qian Dai

“…However, the role of AFF4 in glycolysis and LUAD development remains unidentified. Methods AFF4 expression was assessed in LUAD cells and tissues using bioinformatics analysis, western blotting, and immunohistochemical staining. …”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Abstract Background The role of lipid metabolic reprogramming in the development of various types of cancer has already been established. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…The process of metabolic reprogramming, with a specific emphasis on lipid metabolism, is instrumental in the progression of HCC. …”
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METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism by Xinyu Jia, Shan Liu, Chunan Sun, Manni Zhu, Qi Yuan, Min Wang, Tingting Xu, Zhengxia Wang, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang

“…Mechanistically, METTL16 could regulate lung epithelial mitochondrial function by participating in the reprogramming of glutamine metabolism. Our study characterized the role of the METTL16/GOT2/glutamine axis in the occurrence and development of COPD, and emphasized the potential value of METTL16 and glutamine in the therapy of chronic airway inflammation in smoking-induced COPD.…”
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Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

“…Finally, the active DNA demethylation activity of DNMT3A has now emerged as a new potential target for therapeutic development to prevent EMT and metastasis of cancer cells. …”
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Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells by Oleg Chen, Olena Vovk, Nikita Polishchuk, Oksana Mayevska, Galyna Shuvayeva, Melike Demir, Vasyl Lukiyanchuk, Leoni A. Kunz-Schughart, Anna Dubrovska, Oleh Stasyk

“…<i>Purpose:</i> The development of acquired resistance to arginine deprivation therapy (ADT) is a major barrier to its efficacy. …”
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ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy by Christoph Huber, Christian Stocker, Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Alexander Rau, Andreas Katopodis, Anais Zurbach, Dario Reichenstein

“…These findings support the clinical development of ANV600 as both a monotherapy and a combination therapy in cancer immunotherapy.…”
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Gestational Inulin Supplementation in Low-/High-Fat Sow Diets: Effects on Growth Performance, Lipid Metabolism, and Meat Quality of Offspring Pigs by Pan Zhou, Yachao Wu, Jianbo Shen, Tao Duan, Long Che, Yong Zhang, Yang Zhao, Honglin Yan

“…This study provides novel mechanistic insights into how maternal dietary fiber nutrition programs offspring development through epigenetic reprogramming.…”
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RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α by Hao Liu, Yongqin Tang, Anshu Singh, Joaquim Vong, Julio Cordero, Arthur Mathes, Rui Gao, Yanhan Jia, Boyan K. Garvalov, Till Acker, Gernot Poschet, Rüdiger Hell, Marc A. Schneider, Joerg Heineke, Thomas Wieland, Guillermo Barreto, Adelheid Cerwenka, Michael Potente, Sofia-Iris Bibli, Rajkumar Savai, Gergana Dobreva

“…Abstract Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. …”
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Dysregulated macrophage immunity in Helicobacter pylori infection: unveiling mechanistic insights and therapeutic implications by Miao Xiang, Miao Xiang, Panpan Li, Panpan Li, Xiaofei Yue, Linlin Liu, Linlin Liu, Linjing Wang, Nengjin Sun, Nengjin Sun, Kaile Wang, Kaile Wang, Yuying Zhang, Hongyan Wang, Hongyan Wang

“…It is strongly linked to gastritis, ulcers, and the development of malignant tumors. Macrophages, as one of the key components of the innate immune system, play a crucial role in maintaining immune homeostasis through a range of functions, including pathogen phagocytosis, antigen recognition and presentation, inflammation regulation and tumor immune surveillance. …”
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A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation by Shuya Wang, Xianlei Sun, Qingxuan Xin, Jianxiang Shi, Jin Li, Huilin Zhang, Mengjiao Xue, Fanxiang Yin, Zan Qiu, Xiaoqian Wang, Nannan Sun, Yingmei Li, Yaoyao Chen, Liyan Fu, Chaoqi Li, Shaohua Yan, Xian Zhao, Bolin Jue, Yanxia Gao, Baohong Yue, Bo Qin, Yong Jiang, Rongqun Guo

“…Excess copper impaired immune homeostasis and hematopoietic development. Then, we developed a map of the immune landscape of patients with WD. …”
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