Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia by Nguyet Le, Sherine Awad, Isabella Palazzo, Thanh Hoang, Seth Blackshaw

Subjects: Get full text

Proline-driven metabolic reprogramming promotes skeletal muscle hypertrophy and oxidative myofiber specification in porcine offspring: a stage-optimized maternal nutritional interv... by Jun Huang, Kaidi Ma, Junyi Wu, Shuangbo Huang, Zihao Huang, Yujiao Chen, Shijian Zhou, Hefeng Luo, Chengquan Tan

“…Supplementation with Pro during G20–114 reprogrammed offspring skeletal muscle development through STAT3-CCND1-mediated myoblast proliferation, enhanced mitochondrial bioenergetics, and oxidative fiber specification. …”
Get full text

Author Correction: CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice by Most Sumona Akter, Masashi Hada, Daiki Shikata, Gen Watanabe, Atsuo Ogura, Shogo Matoba

Get full text

Corrigendum: 5-azacytidine promotes microspore embryogenesis initiation by decreasing global DNA methylation, but prevents subsequent embryo development in rapeseed and barley by María-Teresa Solís, Ahmed-Abdalla El-Tantawy, Vanesa Cano, María C. Risueño, Pilar S. Testillano

Get full text

Targeting Glycolytic Reprogramming in Cholangiocarcinoma: A Novel Approach for Metabolic Therapy by Hao L, Li S, Peng Q, Zhang J, Deng J, Hu X

“…Recently, metabolic reprogramming in cancer cells has emerged as a hallmark of the disease. …”
Get full text

Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives by Yan Zhang, Wancheng Li, Jubao Niu, Zeyang Fan, Xin Li, Xin Li, Hui Zhang, Hui Zhang

“…As a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of driver genes, modifying key functional proteins, triggering mitochondrial metabolism abnormality, and remodeling the tumor microenvironment. …”
Get full text

Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1 by Jethro Lundie-Brown, Francesca Puletti, Anna Philpott, Roberta Azzarelli

“…By integrating these perspectives, this review provides a comprehensive overview of the diverse roles of ASCL1 in development, reprogramming and cancer, offering insights into its molecular functions and therapeutic potential.…”
Get full text

Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation by Dawei Zhang, Changming Liang, Chengwei Wu, Michael Hawanga, Senlin Wan, Lishuai Xu, Xu Zhang, Yongchun Liu, Fangshuai Hu, Mengyun Wang, Xiaoming Wang, Li Xu, Xiaoxu Huang

Get full text

The crucial role of metabolic reprogramming in driving macrophage conversion in kidney disease by Na Gong, Wenjuan Wang, Yifei Fu, Xumin Zheng, Xinru Guo, Yuhao Chen, Yan Chen, Shengchun Zheng, Guangyan Cai

Get full text

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia by Gonçalo Regalo, Achim Leutz

“…Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans‐differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans‐differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development.…”
Get full text

Advancements in Müller Glia Reprogramming: Pioneering Approaches for Retinal Neuron Regeneration by Yuyan Zhou, Song Qin, Haixiang Wu

“…Müller glia exhibit a remarkable regenerative capacity in zebrafish through spontaneous reprogramming post-injury but remain limited in mammals. …”
Get full text

Metabolic reprogramming in viral infections: the interplay of glucose metabolism and immune responses by Mahmoud Darweesh, Mahmoud Darweesh, Saeed Mohammadi, Mina Rahmati, Moosa Al-Hamadani, Ahmed Al-Harrasi

“…This review explores the mechanisms of metabolic reprogramming during viral infections, with a specific emphasis on glucose metabolism. …”
Get full text

Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury by Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius

“…We hypothesize that reprogramming the skeletal muscle to an embryonic-like state may preserve its reinnervation capability following PNI. …”
Get full text

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming by Mengjia Li, Hengchao Zhang, Xiuyun Wu, Mengqi Yu, Qianqian Yang, Lei Sun, Wei Li, Zhongxing Jiang, Fumin Xue, Ting Wang, Xiuli An, Lixiang Chen

“…Here, utilizing the human erythropoiesis system, we present an evidence of IDH1-mediated chromatin state reprogramming besides its well-characterized metabolism effects. …”
Get full text

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? by Lise Van Wyngene, Jolien Vandewalle, Claude Libert

“…It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. …”
Get full text

A new era in melanoma immunotherapy: focus on DCs metabolic reprogramming by Mina Afrashteh Nour, Mansour Rajabivahid, Marjan Sadat Seyed Mehdi, Safa Tahmasebi, Sepideh Nasirzadeh Dashtgol, Mahmoud Dehghani-Ghorbi, Ahmad Ghorbani Vanan, Farid Ghorbaninezhad

“…This contribution reviews the metabolic reprogramming of DCs as a new approach for melanoma immunotherapy.…”
Get full text

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy by Yingying Lv, Zongshang Li, Shutong Liu, Zhaokai Zhou, Jinling Song, Yuhao Ba, Siyuan Weng, Anning Zuo, Hui Xu, Peng Luo, Quan Cheng, Chuhan Zhang, Jingyuan Ning, Yukang Chen, Yuyuan Zhang, Zaoqu Liu, Xinwei Han

“…This review summarizes the latest developments in multifaceted metabolic checkpoints, with a focus on how metabolic checkpoints modulate immunological consequences and cancer progression. …”
Get full text

Reprogrammed Cell‐based Therapy for Liver Disease: From Lab to Clinic by Amir Mehdizadeh, Masoud Darabi

“…Furthermore, advances in cellular reprogramming highlight the need for developing and evaluating novel standards addressing clinical research interests in this field.…”
Get full text

Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment by Seung Woo Kim, Chan Woo Kim, Young-Ah Moon, Hong Seok Kim

Get full text

Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis by Amir Barzegar Behrooz, Hamid Latifi-Navid, Narges Zolfaghari, Somayeh Piroozmand, Ahmad Pour-Rashidi, Mahsa Bourbour, Fatemeh Jusheghani, Mahmoud Aghaei, Negar Azarpira, Fatemeh Mollasalehi, Sedigheh Alamdar, Ahmad Nasimian, Jabar Lotfi, Shahla Shojaei, Elham Nazar, Saeid Ghavami

“…However, metabolic reprogramming has emerged as a key driver of GB progression and invasiveness. …”
Get full text