Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation by Didi Shan, Hongxu Wang, Jianing Li, Yu Wang, Fuchen Liu

“…This iPSC cell line retains the patient’s genetic information, making it a valuable model for studying disease mechanisms and developing novel therapies.…”
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All-Natural Gelatin-Based Nanoemulsion Loaded with TLR 7/8 Agonist for Efficient Modulation of Macrophage Polarization for Immunotherapy by Ritabrita Goswami, Ahmed Nabawy, Mingdi Jiang, Yagiz Anil Cicek, Muhammad Aamir Hassan, Harini Nagaraj, Xianzhi Zhang, Vincent M Rotello

“…Tumor-associated macrophages (TAMs) often adopt a tumor-promoting M2-like phenotype, aiding tumor progression and immune evasion. Reprogramming TAMs to a tumoricidal M1-like phenotype is an emerging target for cancer immunotherapy. …”
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Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease by Ping Huang, Yibin Li, M. I. Nasser, Huiming Guo, Huanlei Huang, Mingyi Zhao, Ping Zhu

“…In this context, it is necessary to develop a minimally invasive method to create induced pluripotent stem cells (iPSCs). …”
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Recent progress in stem cell and immune cell-based interventions for aging and age-related disorders by Li He, Donglei Han, Fenfen Zong, Yan Zhang, Zhongyang Han, Zenghui Xu, Zenghui Xu, Zenghui Xu

“…The extension of human lifespan has intensified the demand for developing more effective strategies to enhance quality of life. …”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

“…Epigenetic marks play vital roles in transcriptional reprogramming during the development of DCM. The current study is aimed to profile genome-wide DNA (hydroxy)methylation patterns in the hearts of control and streptozotocin (STZ)-induced diabetic rats and decipher the effect of modulation of DNA methylation by alpha-ketoglutarate (AKG), a TET enzyme cofactor, on the progression of DCM. …”
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Exploring physiological and molecular dynamics of drought stress responses in plants: challenges and future directions by Sajad Ali, Rakeeb Ahmad Mir, Md Azizul Haque, Danishuddin, Mohammed A. Almalki, Mohammad Alfredan, Ashraf Khalifa, Henda Mahmoudi, Mohammad Shahid, Anshika Tyagi, Zahoor Ahmad Mir

“…Next, we focused on how plants sense drought and undergo biochemical reprogramming from root to shoot to regulate diverse adaptive traits. …”
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KYNU is a potential metabolic-related biomarker for nasopharyngeal carcinoma by Raman spectroscopy, metabolomics, and transcriptomics analysis by Ziman Wu, Haiyan Yang, Yafei Xu, Xiang Ji, Dayang Chen, Chuang Zhang, Mingjie Liang, Xinying Li, Xiuming Zhang, Dan Xiong

“…Abstract Background Nasopharyngeal carcinoma (NPC) is a malignant tumor with high incidence in Southeast Asia and Southern China, characterized by difficulties in early diagnosis and high recurrence rates after treatment. Metabolic reprogramming plays a crucial role in the development and progression of tumors. …”
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Structural and Functional Insights into a Novel <i>Aspergillus ochraceus</i> Polysaccharide from the Weddell Sea: Implications for Melanoma Immunotherapy In Vitro by Jiale Hao, Kouame kra Wilfred Armel, Pengcheng Gao, Jinglei Wang, Weibin Zhang, Kexin Du, Qi Li, Huishu Gao, Guangli Yu, Guoyun Li

“…Immunotherapy is a transformative strategy in oncology, yet the development of novel immunomodulatory agents remains essential. …”
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The potential of ME1 in guiding immunotherapeutic strategies for ovarian cancer: insights from pan-cancer research by Jiahui Wei, Ming Wang, Shuiqing Xu, Paizigul Tusufuhan, Yumei Wu

“…It may signify a metabolic reprogramming that supplies energy for tumor progression and immunotherapy, offering valuable insights for the development of personalized therapies.…”
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Differential Expression of miRNAs Between Young-Onset and Late-Onset Indian Colorectal Carcinoma Patients by Sumaiya Moiz, Barsha Saha, Varsha Mondal, Debarati Bishnu, Biswajit Das, Bodhisattva Bose, Soumen Das, Nirmalya Banerjee, Amitava Dutta, Krishti Chatterjee, Srikanta Goswami, Soma Mukhopadhyay, Sudarshana Basu

“…Experimentally validated targets of the above miRNAs were compared with differentially expressed genes in the TCGA dataset to identify targets with physiological significance in EOCRC development. Our analysis revealed metabolic reprogramming, downregulation of anoikis-regulating pathways, and changes in tissue morphogenesis, potentially leading to anchorage-independent growth and progression of epithelial-mesenchymal transition (EMT). …”
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Pathogenic KCNH2-G53S variant in the PAS domain influences the electrophysiological phenotype in long QT syndrome type 2 by Dasom Mun, Ji-Young Kang, Malgeum Park, Gyeongseo Yoo, Nuri Yun, YouMi Hwang, YouMi Hwang, Boyoung Joung

“…Transcriptomic analysis of KCNH2G53S hiPSC-CMs revealed 3,857 differentially expressed genes, highlighting significant changes in pathways related to LQT2 development. Action potential duration was significantly longer in KCNH2G53S hiPSC-CMs than in control (545.3 ± 176.3 ms vs. 339.9 ± 44.5 ms; P = 0.019). …”
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Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control by Mary Philip, Mary K Washington, Joseph T Roland, Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman

“…Cancer vaccines are an attractive strategy to boost patient immune responses, but less is known about whether and how immunization can induce long-term tumor immune reprogramming and arrest cancer progression. We developed a clinically relevant genetic cancer mouse model in which hepatocytes sporadically undergo oncogenic transformation. …”
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Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes by Farhan Ullah Khan, Puregmaa Khongorzul, Denis Gris, Abdelaziz Amrani

“…However, the mechanisms involved in reprogramming DCs to adopt tolerogenic or immunogenic signatures are not fully known. …”
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Metabolomic Profiling Reveals PGPR-Driven Drought Tolerance in Contrasting <i>Brassica juncea</i> Genotypes by Asha Rani Sheoran, Nita Lakra, Baljeet Singh Saharan, Annu Luhach, Yogesh K. Ahlawat, Rosa Porcel, Jose M. Mulet, Prabhakar Singh

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Fatty acid metabolism-related risk signature revealing the immune landscape of neuroblastoma and predicting overall survival in pediatric neuroblastoma patients by Shizun Wang, Dan Zhang, Ming Ge, Nijia Zhang, Wei Yang, Yuqin Liu

“…Abstract Background Tumor metabolic reprogramming is a hallmark in cancer cells, wherein fatty acid metabolism assumes a pivotal role in energy supply and the provision of diverse biosynthetic precursors. …”
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Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia by Yinyin Xie, Qinghua Zeng, Zhiwei Chen, Jiachun Song, Fuhui Wang, Dan Liu, Xiaojian Sun, Yuanliang Zhang, Qiuhua Huang

“…These findings highlight the dominant role of sphingolipid metabolism in BCR::ABL1-induced metabolic reprogramming in CML.…”
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Itaconate: A Nexus Metabolite Fueling <i>Leishmania</i> Survival Through Lipid Metabolism Modulation by Ayyoub Kihel, Hajar El Filaly, Dounia Darif, Aicha Assouab, Myriam Riyad, Imane Nait Irahal, Khadija Akarid

“…<i>Leishmania</i> mainly infects macrophages, where metabolic reprogramming shapes their plasticity (M1/M2), affecting the host’s resistance or susceptibility to infection. …”
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The integrated multi-omics analysis unravels distinct roles of Malvaceae-derived protein hydrolysate and its molecular fraction in modulating tomato resilience under limited nitrog... by Sonia Monterisi, Monica Yorlady Alzate Zuluaga, Biancamaria Senizza, Mariateresa Cardarelli, Youssef Rouphael, Giuseppe Colla, Luigi Lucini, Stefano Cesco, Youry Pii

“…Multi-omics analysis showed that C impacted N metabolism upregulating nitrate transporters (NRT1) and promoting metabolic reprogramming, whereas F2 primarily influenced hormonal signalling and Circadian rhythm. …”
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Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status by Yuko Miyagoe-Suzuki, Takashi Nishiyama, Miho Nakamura, Asako Narita, Fusako Takemura, Satoru Masuda, Narihiro Minami, Kumiko Murayama, Hirofumi Komaki, Yu-ichi Goto, Shin’ichi Takeda

“…Three to eight percent of female carriers of Duchenne muscular dystrophy (DMD) develop dystrophic symptoms ranging from mild muscle weakness to a rapidly progressive DMD-like muscular dystrophy due to skewed inactivation of X chromosomes during early development. …”
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Therapeutic Effects of GLP-1 Receptor Agonists and DPP-4 Inhibitors in Neuropathic Pain: Mechanisms and Clinical Implications by Yaswanth Kuthati, Venkata Naga Goutham Davuluri, Chih-Shung Wong

“…To address this limitation, GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors (DPP-4is) were developed and have demonstrated potency in clinical practice. …”
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