Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…Moreover, there is compelling evidence indicating that cancer cells develop a unique microenvironment through adaptive metabolic reprogramming, which aberrantly modulates host immunity to evade immunosurveillance. …”
Get full text

Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer by Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou, Xingdang Liu

“…Abstract Background Alanine Serine Cysteine transporter 2 (ASCT2/SLC1A5) is a key glutamine transporter in cancer cells and has been shown in a variety of cancers to promote tumor growth by reprogramming glutamine metabolism and altering the tumor microenvironment. …”
Get full text

Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions by Zhifa Ling, Xiaoli Zeng, Qiaoyan Luo, Xue Li, Lijun Cui

“…This will provide theoretical advances for the development of an accurate therapeutic system that considers tissue homeostasis.…”
Get full text

Role of metabolic dysfunction-associated fatty liver disease in atrial fibrillation and heart failure: molecular and clinical aspects by Jamie Cheung, Bernard Man-Yung Cheung, Kai-Hang Yiu, Kai-Hang Yiu, Kai-Hang Yiu, Hung-Fat Tse, Hung-Fat Tse, Yap-Hang Chan, Yap-Hang Chan, Yap-Hang Chan, Yap-Hang Chan

“…MASLD, AF, and HF are associated with immune system activation, including the reprogramming of immune cells and the establishment of immune memory. …”
Get full text

LOX-1 rewires glutamine ammonia metabolism to drive liver fibrosis by Ruihua Huang, Hanyu Cui, Mohammed Abdulaziz Yahya Ali Alshami, Chuankui Fu, Wei Jiang, Mingyuan Cai, Shuhan Zhou, Xiaoyun Zhu, Changping Hu

“…LOX-1 deletion reversed the development of liver fibrosis. We further verified that LOX-1 drove liver fibrosis by reprogramming glutamine metabolism through mediating isoform switching of glutaminase (GLS). …”
Get full text

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling by Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang

“…Moreover, an arithmetic model is developed that integrates N‐glycan expression patterns, which effectively distinguishes tumors from NATs, reflecting metabolic reprogramming in cancer. …”
Get full text

Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women by Qiyuan Chang, Senlan Wang, Qingyun Mai, Canquan Zhou

“…Conclusions In conclusion, our findings indicate that obesity exacerbates inflammation and oxidative stress in PCOS women, adversely affecting oocyte development and IVF/ICSI outcomes. In contrast, non-PCOS women exhibit protective metabolic and inflammatory adaptations. …”
Get full text

Heterochromatin decondesation in Creole cattle carrier of Robertsonian franslocation (rob 1; 29). Action of 5–azacytidine–C Descondensación de la heterocromatina en bovinos cri... by Postiglioni Alicia, Iriarte Wanda, Iriarte Andrés, Llambí Silvia, De Soto Leticia, Artigas Rody, De Betancourth Miguel

“…It is also described a delay on embryo development in front of normal ones. The action of 5–aza–C, as an hypomethylated agent, could permitted to decondensate the constitutive or facultative heterochromatin. …”
Get full text

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

“…Viewed through the lens of metabolic reprogramming, these pathways highlight how shifts in glucose, lipid, and amino acid metabolism support the cellular functions essential for liver repair and regeneration. …”
Get full text

Integrated analysis of a miRNA-mRNA network related to immunity and metabolism in Macrobrachium rosenbergii infected with decapod iridescent virus 1 by Yu-Kun Jie, Jing-Wen Hao, Cui Liu, Jun-Jun Yan, Tian-Tian Ye, Ji-Lun Meng, Yu-Tong Zheng, Guo-Yuan Zou, Hong-Tuo Fu, Zhi-Min Gu

“…Further research suggests that PI3K-mediated immune responses may be activated by DEMs such as miR-236–5p, miR-130a-3p, and miR-365–5p, while metabolic reprogramming may be activated by DEMs such as miR-279–3p, miR-142–5p, and miR-705–5p. …”
Get full text

Transcriptomic Analysis Reveals That the Photosynthesis and Carotenoid Metabolism Pathway Is Involved in the Salinity Stress Response in <i>Brassica rapa</i> L. ssp. <i>Pekinensis<... by Jin Jia, Fengshuo Wang, Mengmeng Yuan, Zhiying Wang, Zhe Qin, Xiaoli Zhang, Yutao Shao, Haixia Pei

“…Salinity stress is a major abiotic factor that adversely affects plant growth and development. This study investigated the physiological and molecular responses of <i>Brassica rapa</i> L. ssp. …”
Get full text

Dynamic metabolomic changes in Pochonia chlamydosporia’s parasitism of Parascaris equorum eggs by Luyao Hao, Fengmiao Zhao, Hongyou Liu, Chengyu Ma, Yuan Ma, Zhengyi Li, Wei Wei, Rui Wang

“…These findings clarify that P. chlamydosporia coordinates a metabolic cascade—from energy reprogramming to host defense evasion—to complete parasitism, providing novel targets for biocontrol agent development.…”
Get full text

Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

“…Carcinogenesis is a complex, multidimensional molecular process leading to cancer development, and in recent years, the role of nerves in the pathogenesis of various malignancies has been increasingly recognized. …”
Get full text

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications by Andrés Caicedo, Pedro M. Aponte, Francisco Cabrera, Carmen Hidalgo, Maroun Khoury

“…The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. …”
Get full text

Bioinformatics-Driven Investigations of Signature Biomarkers for Triple-Negative Breast Cancer by Shristi Handa, Sanjeev Puri, Mary Chatterjee, Veena Puri

“…It is one of the most common types of cancer in women posing serious health concerns globally. Recent developments and discovery of specific prognostic biomarkers have enabled its application toward developing personalized therapies. …”
Get full text

Dynamic crosstalk between amino acid metabolism and cancer drug efficacy: From mechanisms to therapeutic opportunities by Mengyi Zhu, Changping Wang, Dianwen Song

“…This review explores the interplay between DDR, amino acid metabolism, and nanomedicine, emphasizing metabolic reprogramming to enhance genotoxic therapies. By integrating cancer metabolism and precision medicine, we propose targeting amino acid pathways to improve DNA repair and develop next-generation nanomedicine, bridging basic research, and clinical applications for advanced cancer therapy.…”
Get full text

PLIN1 suppresses glioma progression through regulating lipid metabolism by Kui Luo, Kai Zhuang, Hao Wu, Yuanbing Chen, Yi Liu, Fan Yang, Zhifei Wang

“…Abstract Glioma is a common and destructive brain tumor, which is highly heterogeneous with poor prognosis. Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. …”
Get full text

Hematopoietic stem cell state and fate in trained immunity by Weinian Liao, Xiaodong Zai, Jun Zhang, Junjie Xu

“…Abstract Trained immunity serves as a de facto memory for innate immune responses, resulting in long-term functional reprogramming of innate immune cells. It enhances resistance to pathogens and augments immunosurveillance under physiological conditions. …”
Get full text

LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER

“…Previously, we have developed a branched organoid system embedded in collagen matrices that robustly recapitulates the phenotypic heterogeneity seen in both murine and human PDAC1,2. …”
Get full text

Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation by Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

“…Through systematic analysis of the long‐term effects of virus infection‐induced epigenetic reprogramming in HCC development and progression, combined with multi‐omics data to construct HCC risk prediction models, our findings provide scientific evidence for the development of early screening and precision treatment strategies. …”
Get full text