Strategies to Overcome Antigen Heterogeneity in CAR-T Cell Therapy by Bohan Zhang, Jiawen Wu, Hua Jiang, Min Zhou

“…These strategies include using combination therapy to increase the abundance of target antigens, optimizing the structure of CARs to enhance sensitivity to low-density antigens, developing multi-targeted CAR-T cells, and reprogramming the TME to activate endogenous immunity. …”
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Artificial Sweet Cherry miRNA 396 Promotes Early Flowering in Vernalization-Dependent Arabidopsis Edi-0 Ecotype by José Gaete-Loyola, Felipe Olivares, Gabriela M. Saavedra, Tiare Zúñiga, Roxana Mora, Ignacio Ríos, Gonzalo Valdovinos, Marion Barrera, Andrea Miyasaka Almeida, Humberto Prieto

“…MicroRNAs (miRNAs) play a crucial role in gene regulation during plant development and environmental interactions, and miR396’s role during flower development and vernalization has been described in some plant species, although not for sweet cherry dormancy. …”
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α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy by Kexin Zhang, Zhen Xu, Zexiu Xiao, Fei Cao, Jing Wang, Yuandong Xu, Winson M.J. Ma, Sihui Long, Gao-Feng Zha

“…To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (α-GalCer), a CD1d-binding glycolipid known to activate invariant natural killer T (iNKT) cells. …”
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Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases by Gabrielle M. Gentile, R. Eric Blue, Grant A. Goda, Bryan B. Guzman, Rachel A. Szymanski, Eunice Y. Lee, Nichlas M. Engels, Emma R. Hinkle, Hannah J. Wiedner, Aubriana N. Bishop, Jonathan T. Harrison, Hua Zhang, Xander H.T. Wehrens, Daniel Dominguez, Jimena Giudice

“…The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity. …”
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Genome-wide identification and gene expression analysis of the malate dehydrogenase (MDH) gene family in Eucalyptus grandis by Yifan Xing, Yifan Xing, Huiming Xu, Deming Yang, Lichuan Deng, Guolong Li, Guolong Li, Zhixin Zhao, Zhixin Zhao, Zhaohua Lu, Liuyin Ma, Guangyou Li

“…These results revealed that coordinated transcriptional reprogramming and protein interactions of EgMDHs were critical for nutrient stress adaptation. …”
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Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer by Yinghua Feng, Xiuli Zhang, Guangpeng Wang, Feiya Yang, Ruifang Li, Lu Yin, Dong Chen, Wenkuan Wang, Mingshuai Wang, Zhiyuan Hu, Yuan Sh, Nianzeng Xing

“…We also observed significant metabolic reprogramming and recurrent mutations linked to prostate-to-bone microenvironmental transitions. …”
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Multi-omics driven biomarker discovery and pathological insights into Pseudomonas aeruginosa pneumonia by Zhiwei Lin, Mingshan Xue, Mingqing Lu, Shuang Liu, Yueting Jiang, Qianyue Yang, Honghui Cui, Xia Huang, Zeguang Zheng, Baoqing Sun

“…The combined analysis revealed key interactions between local and systemic immune responses, indicating a reprogramming of host energy pathways to meet the heightened immune demands, contributing to disease progression. …”
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Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response by Ana J. Choi, Daniel J. Bennison, Esha Kulkarni, Hibah Azar, Haoyu Sun, Hanqi Li, Jonathan Bradshaw, Hui Wen Yeap, Nicholas Lim, Vishwas Mishra, Anna Crespo-Puig, Ewurabena A. Mills, Frances Davies, Shiranee Sriskandan, Avinash R. Shenoy

“…These are important frontline microbicidal drugs used against Gram-negative bacterial infections; therefore, understanding how resistance develops among sensitive strains is important. We show that aminoglycoside resistance is driven by the activation of the cell envelope stress response and transcriptional reprogramming via the CpxRA two-component system. …”
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Hypoxia-Induced Differences in the Expression of Pyruvate Dehydrogenase Kinase 1-Related Factors in the Renal Tissues and Renal Interstitial Fibroblast-like Cells of Yak (Bos Grunn... by Manlin Zhou, Jun Wang, Ruirui Cao, Fan Zhang, Xuehui Luo, Yiyuan Liao, Weiji Chen, Haie Ding, Xiao Tan, Zilin Qiao, Kun Yang

“…Mammals exposed to low oxygen in the plateau environment for a long time are prone to high-altitude disease, while yaks have been living in the plateau for generations do not develop kidney fibrosis caused by low oxygen. It has been suggested that metabolic reprogramming occurs in renal fibrosis and that pyruvate dehydrogenase kinase 1 (PDK1) plays a crucial role in metabolic reprogramming as an important node between glycolysis and the tricarboxylic acid cycle. …”
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Diagnosis and peculiarities of the treatment of pacemaker-mediated tachycardia by О.І. Семенюк, М.С. Сороківський, У.П. Черняга-Ройко, О.Й. Жарінов

“…The purpose of this article is to analyze a clinical case of pacemaker-mediated tachycardia. It can develop only in patients with dual-chamber or biventricular pacemakers and preserved ventriculoatrial conduction. …”
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Unraveling the nexus: Genomic instability and metabolism in cancer by Vaibhavi Gujar, Haojian Li, Tanya T. Paull, Carola A. Neumann, Urbain Weyemi

“…Although cancer drugs targeting DDR have received approval for treating various cancers, tumor cells often develop resistance to these therapies, owing to their ability to undergo energetic metabolic reprogramming. …”
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Dissecting the intratumoral microbiome landscape in lung cancer by Yan Zhao, Zhibo Yang, Dan Wu, Hai Zhao

“…By integrating findings from molecular epidemiology, multi-omics profiling, and preclinical models, this review provides a translational framework for leveraging the tumor-resident microbiota as both a within tumors, we may develop new microbiome-based strategies. These strategies could improve treatment outcomes and help overcome resistance to immunotherapy.…”
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Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges by Yuqi Xie, Xuan Wang, Wenquan Wang, Ning Pu, Liang Liu

“…Abstract The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, facilitating tumor cells to develop invasive traits and augmenting their migratory capabilities. …”
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ROS-Responsive Nanoplatforms for Targeted Tumor Immunomodulation: A Paradigm Shift in Precision Cancer Immunotherapy by Yuan-Yuan Fan, Hong Wu, Chuan Xu

“…Herein, we provide a framework for developing integrated therapeutic strategies to overcome the current limitations in cancer immunotherapy.…”
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Exploring the role of unconventional T cells in rheumatoid arthritis by Tangqing Xu, Hao Cai, Jianye Liu, Xingxing Mao, Yulong Chen, Minhao Chen, Youhua Wang

“…Recently, novel therapeutic strategies have been developed to target these subsets, including modulation of antigen presentation pathways, inhibition of pro-inflammatory signaling cascades, and reprogramming of cellular functionalities. …”
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Research progress on mechanisms of endocrine therapy resistance in prostate cancer by QI Zihao,  WANG Leijie, WU Linjie, BAI Xiaojie, FAN Jiuming, WANG Tiankun, HAN Yutong, YU Ying, GUO Zhongqiang, ZENG Xiantao

“…However, Most patients would developed into castration- resistant prostate cancer (CRPC), resulting in the resistant to ADT. …”
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The role of tumor-associated macrophages in lung cancer by Ronghao Zhu, Jing Huang, Fenhong Qian

“…Strategies aimed at inhibiting TAM recruitment, depleting TAMs, or reprogramming M2 to M1 are therefore highly promising. …”
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Trained immunity in the lung by Elina Idiiatullina, Dane Parker

“…Trained immunity represents a recent concept that elucidates the long-term reprogramming of innate immune cells, enabling them to adapt and respond more effectively to subsequent encounters with diverse pathogens. …”
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Dual function of Gasdermin E: pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity by Gulijiamali Kahaer, Sirun Pan, Chengcheng Yang, Wenchen Xie, Yan Lu

“…Current studies face three major challenges: elucidating the mechanisms underlying GSDME overexpression in HCC, clarifying the molecular hubs of pyroptosis-independent pro-tumor pathways, and developing precision strategies to control the functional switch of GSDME. …”
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Cisd2 delays atrial aging via a modulation of calcium homeostasis that mitigates atrial myopathy by Chi-Hsiao Yeh, Zhao-Qing Shen, Li-Hsien Chen, Carol Seah, Tsai-Yu Tzeng, Chien-Yi Tung, Wen-Tai Chiu, Cheng-Heng Kao, Ting-Fen Tsai

“…Finally, transcriptomic analysis reveals that Cisd2 protects the atrium from metabolic reprogramming and preserves into old age a transcriptomic profile resembling a youthful pattern, thereby safeguarding the atrium from age-related injury. …”
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