PATJ regulates cell stress responses and vascular remodeling post-stroke by Mengqi Zhang, Wei I. Jiang, Kajsa Arkelius, Raymond A. Swanson, Dengke K. Ma, Neel S. Singhal

“…PATJ KO cells demonstrated transcriptional reprogramming based on RNA sequencing analysis, and identified dysregulation in genes central to vascular development, stress response, and metabolism, including RUNX1, HEY1, NUPR1, and HK2. …”
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Causal role of immune cells in head and neck squamous cell carcinoma by Panshu Xu, Zhenxing Zhang, Haoran Zhu, Conglin Hu, Yukang Ying

“…Abstract Chronic inflammation, immune cell infiltration, and metabolic reprogramming play a crucial role in the development of head and neck squamous cell carcinoma (HNSCC). …”
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Alternative splicing fine-tunes prey shift of Coccinellini lady beetles to non-target insect by Xuefei Tang, Xinhui Xia, Yuqi Liu, Xiyao Hong, Yuhao Huang, Guannan Li, Yuansen Liang, Xueqing Wang, Hong Pang, Yuchen Yang

“…The DSGs were primarily associated with energy derivation, organ formation and development, chemosensation and immune responses, which may promote tolerance of lady beetles to nutrient deprivation and pathogen challenges induced by prey shift. …”
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Mitigating salt stress in maize using Ecklonia maxima seaweed extracts by B.C. Pienaar, B.M. Majeke, M.F. Wittenberg, A.E. Adetunji, L. Nephali, F. Tugizimana, M.S. Rafudeen

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Descondensación de la heterocromatina en bovinos criollos portadores de la translocación Robertsoniana (rob1; 29). Acción del inductor 5-azacitidina-C Heterochromatin decondesation... by Rody Artigas, Wanda Iriarte, Leticia de Soto, Andrés Iriarte, Silvia Llambí, Miguel de Bethencourt, Alicia Postiglioni

“…A correlation between hypometilated regions and decondensed of facultative (conditional) heterochromatin is related with genomic instability, and epigenetic reprogramming.…”
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Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice by Xiuli Chen, Shenzhen Huang, Li Wang, Kan Liu, Haiying Wu

“…Additionally, PS-NPs induced sex-specific transcriptional reprogramming and metabolic disruptions in the offspring. …”
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Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology by Yifei Ge, Lixue Jiang, Chengru Yang, Qingfu Dong, Chengwu Tang, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Yi Xu, Xiangyu Zhong

“…These insights offer a novel perspective on tumor biology and provide a foundation for the development of more efficacious cancer therapies.…”
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Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha by Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou

“…These findings provide the first evidence that dietary ALA supplementation mitigates anesthesia‐induced neurotoxicity via PGC‐1α‐mediated metabolic reprogramming, highlighting its potential as a perioperative dietary intervention to reduce neurodevelopmental risks in pediatric populations.…”
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Metabolomic analysis of grapes and leaves from symptomatic and asymptomatic Vitis vinifera grapevines with Esca disease by Florent Weiller, Inês Diniz, Diana Pimentel, Alexander Erban, Pedro Reis, Flávio Soares, Cecília Rego, Joachim Kopka, Ana Margarida Fortes

“…Altogether this study, identified putative metabolic markers associated with Esca disease in plants with different symptomatology and contributed to a physiological understanding of this fungal disease that could help in the development of mitigation strategies for its spread.…”
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Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis by Xiaowei Wei, Yutong Ge, Yaolin Zheng, Sunyan Zhao, Yuhan Zhou, Yuhan Chang, Nuofan Wang, Xiumei Wang, Juan Zhang, Xuanchang Zhang, Liqiao Hu, Youhua Tan, Qiong Jia

“…In summary, this study uncovers previously unappreciated roles of hybrid EMT and cell membrane tension in ferroptosis, which not only predict the treatment efficacy but also potentiate the development of new ferroptosis‐based targeted therapeutic strategies.…”
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The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with... by Kathrin K Geyer, Umar H Niazi, David Duval, Céline Cosseau, Chad Tomlinson, Iain W Chalmers, Martin T Swain, David J Cutress, Utibe Bickham-Wright, Sabrina E Munshi, Christoph Grunau, Timothy P Yoshino, Karl F Hoffmann

“…Finally, we provide preliminary evidence for parasite-mediated host epigenetic reprogramming in the schistosome/snail system, as demonstrated by the increase in Bgdnmt1 and Bgmbd2/3 transcript abundance following Bge (B. glabrata embryonic cell line) exposure to parasite larval transformation products (LTP).…”
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Biofilm Formation of <i>Pseudomonas aeruginosa</i> in Cystic Fibrosis: Mechanisms of Persistence, Adaptation, and Pathogenesis by Dayana Borisova, Tsvetelina Paunova-Krasteva, Tanya Strateva, Stoyanka Stoitsova

“…Elucidating the molecular mechanisms driving persistence, hypermutability, and biofilm resilience is critical for the development of effective therapeutic strategies targeting chronic <i>P. aeruginosa</i> infections in CF.…”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…The single-cell transcriptome and bioinformatics analyses provided insights into the mechanisms driving MVI, potentially aiding the development of targeted diagnostic and therapeutic strategies. …”
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Metabolic phenotype of adult mice offspring obtained from different variants of embryo transfer by M. V. Anisimova, Ya. Gong, N. S. Yudin, Yu. M. Moshkin, L. A. Gerlinskaya

“…Assisted reproductive technologies (ART) increasingly occupy the study of human reproduction. In addition, in developed countries they contribute to breeding of more than 50 % of cattle. …”
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Metabolomic profiles underlying gout flares: a prospective study of people with gout by Zhen Liu, Hui Zhang, Rui Li, Can Wang, Jie Lu, Nicola Dalbeth, Lin Han, Changgui Li, Lingling Cui, Huiyong Yin, Wenyan Sun, Haibing Chen

“…Participants in the intercritical group were prospectively followed and analysed according to the development of gout flares (recurrent flare group) or no gout flare (no flare group) over 1 year. …”
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Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses by Charley Comer, Kian Cotton, Christopher Edwards, Xiaoyang Dai, Sara Badodi, Roberto Buccafusca, Chris Bennett, Andrew Peet, Alice Williams, David Michod, Elena Bochukova, Maria Victoria Niklison-Chirou

“…Lipid metabolism reprogramming, characterized by increased cholesterol synthesis, lipid uptake and the activation of de novo lipogenesis, is a newly identified hallmark of cancers. …”
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Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells by Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki

“…Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vitamin C (VitC) improves the prognosis of colorectal cancer by reprogramming the cancer epigenome and limiting chemotherapeutic drug resistance events. …”
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Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective by Zhang Hongchao, Francisco Javier Cubero, Zhao Gang, Xu Jin, Liu Qian, Shao Wentao, Gu Aihua

“…Early-life exposure to environmental chemicals may exert a "programming effect" on hepatic development and metabolic function by disrupting nuclear receptor signaling, impairing mitochondrial homeostasis, inducing epigenetic reprogramming, and mediating liver-extrahepatic organ crosstalk, thereby significantly increasing the risk of MASLD in adulthood. …”
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ATRX, OLIG2, MGMT, and IDH2 in Glioblastoma: Essential Molecular Mechanisms and Therapeutic Significance by Andrea Pop-Crisan, Radu Pirlog, Lavinia-Lorena Pruteanu, Constantin Busuioc, Ovidiu-Laurean Pop, Deo Prakash Pandey, Cornelia Braicu, Ioana Berindan-Neagoe

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PB101, a VEGF- and PlGF-targeting decoy protein, enhances antitumor immunity and suppresses tumor progression and metastasis by Eun-Jin Go, Hannah Yang, Seung Joon Lee, Hyun Gul Yang, Jin A. Shin, Won Suk Lee, Hye Seong Lim, Hong Jae Chon, Chan Kim

“…PB101 induced robust reprogramming of antitumor immunity and activates intratumoral CD8+ T cells. …”
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