Research trends of protein palmitoylation in cancer from 2004 to 2024: a bibliometric and visualization analysis by Yufeng Peng, Kewei Peng, Yi Wang, Luyao Li, Yuefei Lu

“…Research hotspots have shifted from early mechanistic studies to cancer-specific applications, particularly in areas such as tumor immune evasion, metabolic reprogramming, and therapeutic strategies, where significant progress has been made.ConclusionFuture efforts should concentrate on three primary directions: constructing high-resolution pan-cancer palmitoylation site maps to unveil subtype-specific modification patterns; developing subtype-selective inhibitors targeting the ZDHHC enzyme family to overcome the toxicity limitations of current broad-spectrum inhibitors; and establishing international research alliances to integrate China’s high productivity with the United States’ translational expertise, thereby bridging regional disparities between basic research and clinical innovation, ultimately advancing palmitoylation regulatory networks toward precision therapeutic strategies.…”
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Insights into the roles of macrophages in Klebsiella pneumoniae infections: a comprehensive review by Yangguang Li, Xuanheng Li, Wenqi Wu, Peizhao Liu, Juanhan Liu, Haiyang Jiang, Liting Deng, Chujun Ni, Xiuwen Wu, Yun Zhao, Jianan Ren

“…Insights gained from this analysis may inform the development of novel immunomodulatory approaches to augment conventional antimicrobial therapies, potentially transforming the clinical management of KP infections. …”
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation by Konstantin Budagyan, Alexa C. Cannon, Adam Chatoff, Dorothy Benton, Alison M. Kurimchak, Daniela Araiza-Olivera, Anastasiia Gerasimova, Nathaniel W. Snyder, James S. Duncan, Cristina Uribe-Alvarez, Jonathan Chernoff

“…Finally, ACSS2 plays a critical role in early KRAS G12V adenoma development, unlike in KRAS G12D adenomas. These findings highlight mutation-specific metabolic reprogramming in KRAS-driven CRC and identify ACSS2 as a potential therapeutic target.…”
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Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/N... by Sajid Javed, Leanne Marsay, Alice Wareham, Kuiama S Lewandowski, Ann Williams, Michael J Dennis, Sally Sharpe, Richard Vipond, Nigel Silman, Graham Ball, Karen E Kempsell

“…Further data refinements identified groups of key markers showing group-specific expression patterns, with a substantial reprogramming event evident at the four to six week interval. …”
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Targeting Resistance Pathways in Breast Cancer Through Precision Oncology: Nanotechnology and Immune Modulation Approaches by Hussein Sabit, Sanaa Rashwan, Yasser Albrahim, Al-Hassan Soliman Wadan, Faisal Radwan, Amany I. Alqosaibi, Shaimaa Abdel-Ghany, Borros Arneth

“…Resistance mechanisms—such as metabolic reprogramming, tumor heterogeneity, immune evasion, autophagy, and the role of cancer stem cells—are critically examined. …”
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Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer by Rawan Al-Faze, Hoda A. Ahmed, Mohamed A. El-Atawy, Hayat Zagloul, Eida M. Alshammari, Mariusz Jaremko, Abdul-Hamid Emwas, Gehan M. Nabil, Demiana H. Hanna

“…Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. …”
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Loss of <i>Myostatin</i> Shapes the Transcriptomic and Epigenetic Landscapes Across Multiple Muscle Types in Cattle by Chao Hai, Xuefei Liu, Chunling Bai, Guanghua Su, Lei Yang, Guangpeng Li

“…<i>Myostatin</i> (<i>MSTN</i>) is a critical regulator of muscle development. This study aimed to investigate the transcriptional and epigenetic mechanisms by which <i>MSTN</i> gene editing affects skeletal, cardiac, and smooth muscle function in cattle. …”
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Multi‐Omic Analysis Reveals a Lipid Metabolism Gene Signature and Predicts Prognosis and Chemotherapy Response in Thyroid Carcinoma by Yuqin Tu, Yanchen Chen, Linlong Mo, Guiling Yan, Jingling Xie, Xinyao Ji, Shu Chen, Changchun Niu, Pu Liao

“…ABSTRACT Objective Lipid metabolic reprogramming is closely intertwined with the development and progression of thyroid carcinoma (TC); however, its specific mechanism remains elusive. …”
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Mapping Disorders with Neurological Features Through Mitochondrial Impairment Pathways: Insights from Genetic Evidence by Anna Makridou, Evangelie Sintou, Sofia Chatzianagnosti, Iasonas Dermitzakis, Sofia Gargani, Maria Eleni Manthou, Paschalis Theotokis

“…This approach offers a conceptual framework that connects molecular findings to clinical practice, supporting more precise diagnostic strategies and the development of targeted therapies. Advances in whole-exome sequencing, pharmacogenomic profiling, mitochondrial gene editing, metabolic reprogramming, and replacement therapy—promise individualized therapeutic approaches, although hurdles including heteroplasmy, tissue specificity, and delivery challenges must be overcome. …”
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Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages by Eric Deutsch, Michele Mondini, Pauline Hamon, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Ruy A Louzada, Raphaël Corre, Corinne Dupuy

“…The antitumor effect of Duox1−/− macrophages was associated with a significant increase in IFNγ production by both lymphoid and myeloid immune cells.Conclusions Our data indicate that DUOX1 is a new target for macrophage reprogramming and suggest that DUOX1 inhibition in macrophages combined with RT is a new therapeutic strategy for the management of cancers.…”
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Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage Embryos by Ning Wang, Fang Le, Qi-Tao Zhan, Li Li, Min-Yue Dong, Guo-Lian Ding, Chen-Ming Xu, Shi-Wen Jiang, He-Feng Huang, Fan Jin

“…By function of selection, parts of the changes could be recovered in late embryo development.…”
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Mechanistic Insight into Serine Flux Regulation through Nanoscale Organization of Glucose and Serine Transporters by Substrate Probe-Based Direct Stochastic Optical Reconstruction... by Pengwei Jiang, Hao Hou, Jiaqi Wang, Xumin Wang, Yaqi Wang, Simin Liu, Junling Chen, Hongda Wang, Feng Liang

“…This work establishes a fundamental link between transporter spatial assembly and tumor serine metabolic reprogramming, providing a new perspective to better understand SerT dysfunction in tumor metabolic reprogramming, offering novel therapeutic avenues for targeting serine metabolism in cancer.…”
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Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma by Yuxiang Chi, Yuxiang Chi, Guoyuan Ma, Qiang Liu, Qiang Liu, Yunzhi Xiang, Yunzhi Xiang, Defeng Liu, Jiajun Du, Jiajun Du

“…BackgroundMetabolic reprogramming within the tumor microenvironment plays a pivotal role in tumor progression and therapeutic responses. …”
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Regulation of ovarian cancer by protein post-translational modifications by Qiugang Zhu, Huimin Zhou, Feiting Xie

“…This review discusses the latest developments in the study of protein PTMs in ovarian cancer and introduces pharmacological approaches that target these modifications as therapeutic strategies.…”
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Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experi... by Wang Yao, Dong-Ming Hua, Ying-Ru Zhang, Yi-Yang Zhao, Ying Feng, Zhao-Zhou Zhang, Zhong-Ya Ni, Hai-dong Guo, Yun-Feng Guan, Yan Wang

“…Abstract Background Chronic stress is a risk factor for the development of colorectal cancer (CRC). Xiao-chai-hu-tang (XCHT) is a traditional Chinese medicine prescription and has been widely used to treat chronic stress-related diseases and cancer. …”
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Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

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In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Impairs the Ability of Mice to Clear a <i>Pseudomonas aeruginosa</i> Infection in Adulthood by Victoria R. Stephens, Julia K. Bohannon, Kaylon L. Bruner-Tran, Xenia D. Davis, Mary A. Oliver, Margaret A. McBride, Sharareh Ameli, Jelonia T. Rumph, Jennifer A. Gaddy, Edward R. Sherwood, Kevin G. Osteen

“…Herein, we hypothesize that in utero exposure to TCDD induces developmental reprogramming of the innate immune system that subsequently impacts the adult response to infection. …”
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Integrative transcriptomic-physiological analysis deciphers nitrogen-mediated carbon reallocation balancing growth and flavonoid metabolism in Epimedium pubescens by Shangnian Liu, Shangnian Liu, Xiaojing An, Xiaojing An, Chaoqun Xu, Dongmei He, Xianen Li, Caixia Chen, Baolin Guo, De Xu, Juan Huang

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Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli by Jing Sun, Yiming Liu, Jiashen Chang, Ying Liu, Luqi Li, Ran Jiang, Yihan Luo, Shuo Yang, Mei Yang, Xinglong Wang, Juan Wang, Xi Xia, Kangkang Guo, Zengqi Yang, Dongyang Ye

“…This study discovered that exogenous adenosine can effectively restore the sensitivity of tet(X3)-positive Escherichia coli to tigecycline through metabolic reprogramming based on a non-targeted metabolomics strategy. …”
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Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model by Shin-Yi Liu, Shin-Yi Liu, Shin-Yi Liu, Yung-Ju Yeh, Yung-Ju Yeh, Ting-Yin Xue, Ting-Yin Xue, Fei-Hung Hsieh, Fei-Hung Hsieh, Ya-Wun Wu, Ya-Wun Wu, Meng-Zhen Wu, Meng-Zhen Wu, Wei-Jing Li, Wei-Jing Li, Jun-Chieh J. Tsay, Jun-Chieh J. Tsay, Shu-Yao Tsai, Chung-Ming Huang, Chung-Ming Huang, Hen-Hong Chang, Hen-Hong Chang, Hui-Chen Chen, Chun-Ping Lin, Gregory J. Tsay, Gregory J. Tsay, Gregory J. Tsay

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