The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics by Xinzhen Che, Yixin Zhang, Xiqi Chen, Guangdong Xie, Jinling Li, Chengchao Xu, Chunhua Zhang, Yong Zhu, Xinyu Yang

“…We clarify the molecular switching role of lactylation in regulating macrophage polarization under pathological settings by integrating current developments in epigenetic regulation and metabolic reprogramming. …”
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Warburg effect and lactylation in cancer: mechanisms for chemoresistance by Wenjie Zhang, Min Xia, Jiahui Li, Gaohua Liu, Yan Sun, Xisha Chen, Jing Zhong

“…Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic strategies. Importantly, existing studies have demonstrated that glucose metabolic reprogramming, commonly referred to as the Warburg effect or aerobic glycolysis, is a major contributor to chemoresistance. …”
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Exploring the prognostic significance and therapeutic potential of SUCLG2 in prostate cancer by Bao Hua, Qing Yang, Shangqing Song, Wenfeng Li, Bin Xu, Yufei Gu

“…Our study underscores the importance of metabolic pathways in PCa pathogenesis and paves the way for the development of targeted therapies, thus contributing to personalized medicine in PCa management.…”
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Identify key transcript factors of adipocyte differentiation in abdominal fat of broilers based on ATAC-seq and RNA-seq by Xiaoying Liu, Chaohui Wang, Xi Sun, Zhihao Qiao, Xiaojun Yang, Yanli Liu

“…Understanding the molecular mechanisms underlying AFT development is essential for informed breeding strategies. …”
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Unveiling the Cuproptosis in Colitis and Colitis-Related Carcinogenesis: A Multifaceted Player and Immune Moderator by Jingwen Liu, Hairuo Huang, Xiaojie Zhang, Yang Shen, DeMing Jiang, Shurong Hu, Shuyan Li, Zelin Yan, Wen Hu, Jinhua Luo, Haibo Yao, Yan Chen, Bufu Tang

“…Emerging evidence indicates that copper metabolism and cuproptosis may exert dual regulatory effects within pathological cellular environments, specifically modulating oxidative stress responses, metabolic reprogramming, and immunotherapeutic efficacy. An appropriate level of copper may promote disease progression and exert synergistic effects, but exceeding a certain threshold, copper can inhibit disease development by inducing cuproptosis in pathological cells. …”
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Liquid-liquid phase separation: an emerging perspective on the tumorigenesis, progression, and treatment of tumors by Qin Jian, Qin Jian, Qi Xu, Sirui Xiang, Rongrong Wang, Chuchu Wang, Boxun Zhang, Ruli Li, Junzhi Lin, Chuan Zheng, Chuan Zheng

“…The above insights drive the innovation of LLPS-based tumor therapeutic strategies and the development of targeted antitumor drugs.…”
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The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology by Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Mustafa M. Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha

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Induced Pluripotent Stem Cell for the Study and Treatment of Sickle Cell Anemia by Luiza Cunha Junqueira Reis, Virgínia Picanço-Castro, Bárbara Cristina Martins Fernandes Paes, Olívia Ambrozini Pereira, Isabela Gerdes Gyuricza, Fabiano Tófoli de Araújo, Mariana Morato-Marques, Lílian Figueiredo Moreira, Everton de Brito Oliveira Costa, Tálita Pollyanna Moreira dos Santos, Dimas Tadeu Covas, Lygia da Veiga Pereira Carramaschi, Elisa Maria de Sousa Russo

“…Then, episomal vectors were used for reprogramming peripheral blood mononuclear cells to obtain integration-free iPSC. …”
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Molecular mechanisms of glucose metabolism disorders in tumors of the female reproductive system by E. Yu. Kovaleva, R. R. Kantimirova, T. K. Gunina, E. V. Vlasenko, D. O. Salychin, D. S. Khulagova, A. Kochkin, V. A. Mamatkova, N. S. Zhakov, G. K. Bezmaternykh, E. Yu. Fomenko, A. A. Mullagalieva, F. S. Ali, R. N. Imanova

“…In gynecologic malignancies (GMs), including ovarian cancer (OC), endometrial cancer (EC), and cervical cancer (CC), metabolic reprogramming occurs to support tumor growth, invasion, metastasis, and drug resistance. …”
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Cancer stem cells: landscape, challenges and emerging therapeutic innovations by Haksoo Lee, Byeongsoo Kim, Junhyeong Park, Sujin Park, Gaeun Yoo, Soomin Yum, Wooseok Kang, Jae-Myung Lee, HyeSook Youn, BuHyun Youn

“…Moving forward, an integrative approach combining metabolic reprogramming, immunomodulation, and targeted inhibition of CSC vulnerabilities is essential for developing effective CSC-directed therapies. …”
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New Insights into Potential Therapeutic Targets for Neuroendocrine Prostate Cancer: From Bench to Clinic by Maoping Cai, Fengtao Zheng, Yang-Zi Ren, Chuqian Zhen, Dujiang Fu, Xian-Lu Song, Qing Li, Yuanyuan Qu, Zhe-Sheng Chen, Shan-Chao Zhao

“…Neuroendocrine prostate cancer (NEPC), an aggressive and highly malignant subtype of castration-resistant prostate cancer (CRPC), arises through drug resistance mechanisms involving genomic alterations, epigenetic remodeling, tumor microenvironment (TME) reprogramming, and lineage plasticity. A hallmark of NEPC is its independence from the androgen receptor (AR) pathway, evidenced by diminished or absent AR expression—a key barrier to effective clinical management. …”
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ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP by Liang Sun, Ting Lu, Linhua Jiang, Huihui Yao, Qixuan Xu, Jie Sun, Xiaoqin Yang, Songbing He, Xinguo Zhu

“…Abstract Metabolic reprogramming is considered one of the hallmarks of cancer in which cancer cells reprogram some of their metabolic cascades, mostly driven by the specific chemical microenvironment in cancer tissues. …”
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Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products by Chen G, Zhang Y, Zhou Y, Luo H, Guan H, An B

“…Their inhibitory effects on these processes suggest valuable directions for the development of more effective HCC therapeutic strategies. …”
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Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer by Ling Shi, Feng Qiu, Chao Shi, Guohua Zhang, Feng Yu

“…However, the inevitable development of resistance remains a formidable challenge, necessitating deeper insights into its molecular underpinnings. …”
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Proteomic profiling reveals common and region-specific protein signatures underlying tumor heterogeneity in cholangiocarcinoma by Sirinya Sitthirak, Sittiruk Roytrakul, Arporn Wangwiwatsin, Nisana Namwat, Poramate Klanrit, Hasaya Dokduang, Prakasit Sa-ngiamwibool, Attapol Titapan, Apiwat Jareanrat, Vasin Thanasukarn, Natcha Khuntikeo, Luke Boulter, Watcharin Loilome

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Biofilm formation by the host microbiota: a protective shield against immunity and its implication in cancer by Elena Montanari, Giancarla Bernardo, Valentino Le Noci, Martina Anselmi, Serenella M. Pupa, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini

“…Addressing this intricate relationship holds promises for innovative therapeutic approaches aimed at reprogramming the microbiota-cancer axis for better clinical outcomes. …”
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The role of programmed cell death in renal cancer: a bibliometric perspective (1998–2024) by Liang Hong, Chun Zhao, Tingping Wu, Xiaorong Hu, Xueyao Li, Lu Li

“…Keyword and cluster analyses demonstrated a shift from earlier apoptosis- and angiogenesis-focused studies toward intersections of metabolic reprogramming, immune infiltration, and newer cell death modalities (e.g., ferroptosis, pyroptosis). …”
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Iron–Immune Crosstalk at the Maternal–Fetal Interface: Emerging Mechanisms in the Pathogenesis of Preeclampsia by Jieyan Zhong, Ruhe Jiang, Nan Liu, Qingqing Cai, Qi Cao, Yan Du, Hongbo Zhao

“…Finally, we highlight promising therapeutic strategies targeting the iron–immune axis, encompassing three key modalities—iron chelation therapy, precision immunomodulation, and metabolic reprogramming interventions—which may offer novel avenues for PE prevention and treatment.…”
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Ginkgolic acid inhibits CD8+ T cell activation and induces ferroptosis by lactate dehydrogenase A to exert immunosuppressive effect by Sai Zhang, Zhuyuan Si, Mingkun Liu, Wenjuan Hao, Tong Xia, Zeyang Liu, Gang Du, Bin Jin

“…In the context of the development of transplant oncology, it is of great clinical significance to find a drug with both antitumor and immunosuppressive effects for liver transplantation patients with hepatocellular carcinoma (HCC). …”
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TNBC-derived Gal3BP/Gal3 complex induces immunosuppression through CD45 receptor by Annat Raiter, Julia Lipovetsky, Asaf Stenbac, Ido Lubin, Rinat Yerushalmi

“…Proteins expressed by EVs play a role in reprogramming the tumor microenvironment and impeding effective responses to immunotherapy. …”
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