Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis by Fan Chen, Yi Han, Jingwu Yue, Hui Zhang, Luyang Tian, Zhifa Cao, Mengwen Zhu, Wenjia Wang, Yan Meng, Liwei An, Feng Li, Huanhu Zhang, Wenqi Bai, Yanfeng Xi, Zaisheng Ye, Shi Jiao, Zhaocai Zhou

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<i>OsVPS16</i> Deficiency Enhances Salinity Tolerance in Rice by Regulating Ion Homeostasis, Antioxidant Activity, and Stress-Responsive Gene Expression by Juan Liu, Mingming Tang, Yun Lu, Huimin Yan, Yang Liu, Yongrun Cao, Xiaohua Song, Qiuyuan Liu, Xin Ji

“…Collectively, comprehensive physiological and molecular analyses demonstrated that the loss of <i>OsVPS16</i> improves rice salt tolerance through multiple mechanisms, including the regulation of K⁺/Na⁺ homeostasis, the modulation of antioxidant enzyme activities, and the transcriptional reprogramming of stress-responsive genes. This study not only elucidates the function of a novel salt stress response gene in rice, but also provides valuable genetic resources for developing salt-tolerant rice cultivars through molecular breeding approaches.…”
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Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation by Luting Yang, Chunqing Hu, Xiaowen Chen, Mengru Sun, Jie Zhang, Zhe Feng, Tingting Cui, Ruyi Zhu, Xin Zhang, Yanxin Xiao, Ye Gong, Yang Yang, Qian Zhang, Yaling Zhang, Yaping Yan

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Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling by Shi‐Bing Li, Yan‐Yan Liu, Li Yuan, Ming‐Fang Ji, Ao Zhang, Hui‐Yu Li, Lin‐Quan Tang, Shuo‐Gui Fang, Hua Zhang, Shan Xing, Man‐Zhi Li, Qian Zhong, Shao‐Jun Lin, Wan‐Li Liu, Peng Huang, Yi‐Xin Zeng, Yu‐Ming Zheng, Zhi‐Qiang Ling, Jian‐Hua Sui, Mu‐Sheng Zeng

“…Abstract Metabolic reprogramming plays important roles in development and progression of nasopharyngeal carcinoma (NPC), but the underlying mechanism has not been completely defined. …”
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Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity by Yanting Zhou, Guobo Shen, Xikun Zhou, Jing Li

“…Studies have shown that the tumor microenvironment (TME) mediates tumor development and recruits neutrophils into tumors to become tumor-associated neutrophils (TANs), an important part of TME, and achieve extended lifespan. …”
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Roles of WRKY Transcription Factors in Response to Sri Lankan Cassava Mosaic Virus Infection in Susceptible and Tolerant Cassava Cultivars by Somruthai Chaowongdee, Nattachai Vannatim, Srihunsa Malichan, Nattakorn Kuncharoen, Pumipat Tongyoo, Wanwisa Siriwan

“…This study highlights the crucial roles of WRKYs in transcriptional reprogramming, innate immunity, and responses to geminivirus infections in cassava, providing valuable insights to enhance disease resistance in cassava and, potentially, other crops.…”
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SLC50A1 inhibits the doxorubicin sensitivity in hepatocellular carcinoma cells through regulating the tumor glycolysis by Ganggang Wang, Wenzhi Jin, Lianmei Zhang, Meiyuan Dong, Xin Zhang, Zhijie Zhou, Xiaoliang Wang

“…Abstract Metabolic reprogramming has been found to be closely associated with the occurrence and development of hepatocellular carcinoma (HCC). …”
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miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis by Yixuan Wang, Houkun Zhou, Ying Liu, Xingyu Zhao, Shuhao Wang, Zhenhua Lin

“…Quinone oxidoreductase (NQO1), a cytosolic flavoprotein, is important for reprogramming cancer cell metabolism. Therefore, NQO1’s function in aerobic glycolysis and impact on colorectal cancer (CRC) development and progression was investigated. …”
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Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation. by Fiona L Cousins, Alison Murray, Arantza Esnal, Douglas A Gibson, Hilary O D Critchley, Philippa T K Saunders

“…<h4>Methodology</h4>A modified mouse model of menses was developed to focus on the events occurring within the uterine lining during endometrial shedding/repair. …”
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PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation by Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R. Billiar, Haichao Wang, Lizhi Cao, Jianxin Jiang, Daolin Tang

“…Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. …”
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Regulation of <i>Bombyx mori</i>–BmNPV Protein Interactions: Study Strategies and Molecular Mechanisms by Dan Guo, Bowen Liu, Mingxing Cui, Heying Qian, Gang Li

“…Furthermore, we elaborate on the molecular regulatory networks of Bombyx mori nucleopolyhedrovirus (BmNPV) from multiple perspectives: apoptosis and cell cycle regulation; viral protein invasion and trafficking; non-coding RNA-mediated modulation; metabolic reprogramming; and host immune evasion. These insights reveal the dynamic interplay between viral replication and host defense mechanisms. …”
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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers by Syed K. Hasan, Sundarraj Jayakumar, Eliezer Espina Barroso, Anup Jha, Gianfranco Catalano, Santosh K. Sandur, Nelida I. Noguera

“…However, the persistent or aberrant activation of Nrf2 in cancer cells has been implicated in tumor progression, metabolic reprogramming, and resistance to chemotherapy and radiotherapy. …”
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Reversible proliferative arrest induced by rapid depletion of RNase MRP by Yuan Liu, Shiyang He, Kawon Pyo, Reuben Franklin, Ibrahim B. Maaz, Chen Cai, Kriti Shah, Sihem Cheloufi, William F. Marzluff, Jernej Murn

“…Abstract Cellular quiescence is a state of reversible proliferative arrest that plays essential roles in development, resistance to stress, aging, and longevity of organisms. …”
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Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway by Bei Wang, Zixuan Wang, Zini Zhou, Gui Liu, Zhenyuan Jiang, Mingyue Zheng, Wei Geng

“…Abstract Metabolic reprogramming plays a pivotal role in the development and progression of tumors. …”
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Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial by Bridget Young, J Perry, Caroline McCarthy, Stefano Fedele, R Shaw, Frances Sherratt, Albert Jiménez-Tomàs, R Kuruvilla, M W Ho, M Daunt, S Moorhouse

“…We explored the perspectives of those screened or invited to join an early phase clinical trial (the SAVER trial: Sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia). …”
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LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity by Patricia Garcia-Rodriguez, Patricia Garcia-Rodriguez, Laura Hidalgo, Miguel Angel Rodriguez-Milla, Beatriz Somovilla-Crespo, Javier Garcia-Castro, Javier Garcia-Castro

“…LIN28, a highly conserved RNA-binding protein that acts as a posttranscriptional modulator, plays a vital role in the regulation of T-cell development, reprogramming, and immune activity in infectious diseases and T-cell-based immunotherapies. …”
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Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? by Aranka Brockmueller, Constanze Buhrmann, Amir Reza Moravejolahkami, Mehdi Shakibaei

“…Background: Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle factors, is very often associated with functional plasticity during its development. In addition, the malignant plasticity of CRC cells underscores one of their survival abilities to functionally adapt to specific stresses, including inflammation, that occur during carcinogenesis. …”
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The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype by Ben Topham, Barry Hock, Elisabeth Phillips, George Wiggins, Margaret Currie

“…Innate priming offers a novel target for development of cancer immunotherapy and improved prognosis of disease, but also raises the risk of exacerbating existing inflammatory pathologies. …”
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Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies by Abdullah Jabri, Bader Taftafa, Abdulaziz Mhannayeh, Mohamed Alsharif, Tasnim Abbad, Sana Ahmed, Eman A. Alshehri, Abdulrahman Elsalti, Jibran Khan, Tanveer Ahmad Mir, Ahmed Yaqinuddin

“…In particular, the combined use of various bioengineering strategies and cellular reprogramming approaches has facilitated the development of various models. …”
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ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment by Xiaoying Wang, Keqing Yang, Bin Yang, Rui Wang, Yongliang Zhu, Tianhui Pan

“…Additionally, we identified a small-molecule ANKRD22 upregulator that could aid in the development of novel therapeutics targeting TAM remodeling.…”
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