Genome Editing Redefines Precision Medicine in the Cardiovascular Field by Elda Dzilic, Harald Lahm, Martina Dreßen, Marcus-André Deutsch, Rüdiger Lange, Sean M. Wu, Markus Krane, Stefanie A. Doppler

“…We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. …”
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Resistance to neoadjuvant chemotherapy in breast cancers: a metabolic perspective by Manon Desgres, Melis Poyraz, Buse Sari, François P. Duhoux, Cédric van Marcke, Cyril Corbet

“…Emerging evidence highlights tumor metabolic reprogramming as a key non-genetic mechanism contributing to NAC resistance. …”
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Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance by Michelle Amantéa Sugimoto, Juliana Priscila Vago, Mauro Martins Teixeira, Lirlândia Pires Sousa

“…The combination of these mechanisms results in an effective resolution of inflammation, pointing to AnxA1 as a promising tool for the development of new therapeutic strategies to treat inflammatory diseases.…”
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Mitigating methane emissions and promoting acetogenesis in ruminant livestock by Rehema Iddi Mrutu, Abdussamad Muhammad Abdussamad, Kabir Mustapha Umar, Adnan Abdulhamid, Natalie G. Farny, Natalie G. Farny

“…Such manipulation includes the genetic reprogramming of methanogens for reductive acetogenesis. …”
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Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances by Meidan Wang, Rui Xing, Liqun Wang, Mingyue Pan, Ruoyun Zhang, Ting Li, Weiqiang Sun, Jing Zhou

“…However, a major limitation of radiotherapy is the development of resistance, which compromises treatment efficacy. …”
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Cancer-associated fibroblasts: dual roles from senescence sentinels to death regulators and new dimensions in therapy by Guixiang Ruan, Xiang Wang, Huiyi Ou, Huiyi Ou, Duancheng Guo, Duancheng Guo, Duancheng Guo

“…This review provides a comprehensive analysis of CAFs functions and their potential as therapeutic targets, offering valuable insights into the development of novel anti-cancer strategies.…”
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Temporal metabolomics of pea seedlings reveals primary and secondary metabolism dynamics under varying light intensity by Jong Sung Lee, Yu–Mi Shin, Ye Jin Kim, Sang Un Park, Sun-Hwa Ha, HanGyeol Lee, Ji-Eun Ra, Hyung Wook Kwon, Woo Duck Seo, Jae Kwang Kim

“…These findings provide insights into metabolic reprogramming in pea seedlings and inform strategies for enhancing their growth and nutritional quality. …”
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Mitochondrial metabolic regulation of macrophage polarization in osteomyelitis and other orthopedic disorders: mechanisms and therapeutic opportunities by Jinglin Li, Lin Zhang, Jiaze Peng, Chuntao Zhao, Wenguang Li, Yang Yu, Xianpeng Huang, Fuyin Yang, Xuan Deng, Xuxu Yang, Tao Zhang, Jiachen Peng, Jiachen Peng

“…However, how mitochondrial metabolism regulates macrophage polarization to affect the pathological mechanisms of osteomyelitis, and how to develop novel therapeutic strategies based on this mechanism, remain critical scientific questions to be addressed. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…IntroductionAntibiotic overuse has caused the development of bacterial resistance, which is a major threat to public health. …”
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The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma by Yu Gu, Zhihui Zhang, Hao Huang, Wenyong Zhu, Hongjia Liu, Rongxin Zhang, Nan Weng, Xiao Sun

“…Based on medical imaging data, we developed a radiomics tool, RCSP (Radiogenomics-based CXCL9/SPP1 Polarity), to assist in non-invasively predicting the CS polarity in HCC patients.ConclusionOur research sheds light on the regulatory roles of SPP1+ TAMs and CXCL9+ TAMs in the micro-environment and provides new therapeutic targets or insights for the reprogramming of targeted macrophages in HCC.…”
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Bacterial wilt pathogen induced spatial shifts of root-associated microbiome and metabolome of potatoes by Xianjun Lai, Zhouhua He, Shuyan Wang, Feng Zhang, Haiyan Wang, Xiyao Wang, Shifeng Liu, Lang Yan

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O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma by Sijia Fang, Guoqing Zhu, Yi Xie, Miao Ding, Ni Zhen, Jiabei Zhu, Siwei Mao, Xiaochen Tang, Han Wu, Qi Zhang, Aijia Zhang, Xin Ni, Qiuhui Pan, Ji Ma

“…However, the mechanism by which glutamine is involved in the development of HB remains unclear. Our study identified glutamine metabolism as a crucial factor in the development of HB. …”
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A Brief History of Cell Culture: From Harrison to Organs-on-a-Chip by Lincoln Gozzi Moro, Lucas Pires Guarnier, Maurício Fogaça Azevedo, Julia Amanda Rodrigues Fracasso, Marco Aurélio Lucio, Mateus Vidigal de Castro, Marlon Lemos Dias, Francislaine Aparecida dos Reis Lívero, João Tadeu Ribeiro-Paes

“…Finally, we discussed the future directions for cell culture research that may accelerate the development of more effective and personalized treatments.…”
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Centromere Protein F in Tumor Biology: Cancer's Achilles Heel by Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han

“…Methods A comprehensive review and analysis of domestic and international research literature related to CENP‐F were conducted, focusing on its role in tumorigenesis, development, and as a therapeutic target. Results CENP‐F acts as an oncogene and can maintain or promote the malignant phenotype of tumor cells through multiple mechanisms, including regulating signaling pathways related to cell proliferation and apoptosis, promoting metabolic reprogramming, angiogenesis, and tumor cell invasion and metastasis. …”
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Near-infrared fatty acid molecular probe for image-guided surgery of glioblastoma by Meedie Ali, Pavlo Khodakivskyi, Ioannis Ntafoulis, Koen T. H. van der Kuil, Kranthi M. Panth, Arno Roos, Aleksey Yevtodiyenko, Kevin P. Francis, Zhenyu Gao, Martine L. M. Lamfers, Clemens W. G. M. Löwik, Laura Mezzanotte, Elena A. Goun

“…Abstract Metabolic reprogramming is considered a major driving factor in cancer growth and yet it remains challenging to monitor in vivo uptake of fatty acids, which are essential energy sources for many tumor types. …”
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Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer by Zhenhong Li, Xinzou Fan, Fan Gao, Shengguang Pan, Xiao Ma, Hao Cheng, Hiroko Nakatsukasa, Wei Zhang, Dunfang Zhang

“…Lastly, in the context of cancer development, this review summarizes the dual role of fructose in tumors, both pro- and anti-tumor effects. …”
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Drought-tolerant fungal microbes, Aspergillus oryzae and Aspergillus fumigatus, elevate physiohormonal and antioxidant responses of maize under drought stress by Kiran Niaz, Mamoona Rauf, Muhammad Arif, Muhammad Hamayun, Humaira Gul, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu

“…In addition, the enhanced adventitious root development at the root/stem interface, and elongated main root development optimum stomatal activity of SAB- and CBW-inoculated maize plants were observed under drought stress. …”
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Fenaminosulf Promotes Growth and Gall Formation in <i>Zizania latifolia</i> Through Modulation of Physiological and Molecular Pathways by Chaohong Ding, Ruifang Ma, Liqiu Wang, Xinyan Lan, Limin Chen, Jinxing Zhu, Lailiang Wang

“…Transcriptomic analysis provided mechanistic insights, revealing extensive gene expression reprogramming, especially under high FM treatment (5 g/L). …”
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Higher sperm H3K4me3 levels are associated with idiopathic recurrent pregnancy loss by Delna Irani, Deepshikha Arya, Deepti Tandon, Vandana Bansal, Anushree Patil, Dipty Singh

“…A fraction of H3K4me3 enrichment is now known to resist embryonic epigenetic reprogramming; and hence, such elevated levels in the sperm would question its developmental competence leading to RPL pathology. …”
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Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies by Jiaqian Song, Wei Zhang, Deqiang Wang

“…This review aims to systematically analyze the core molecular mechanism of GM affecting tumor development and explore the precise intervention strategies guided by clinical translation. …”
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