N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…On one hand, m7G modification-associated modulate tumour progression and affect malignant biological characteristics, including sustained proliferation signalling, resistance to cell death, activation of invasion and metastasis, reprogramming of energy metabolism, genome instability, and immune evasion. …”
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Exploring Alternative Splicing in Response to Salinity: A Tissue-Level Comparative Analysis Using <i>Arabidopsis thaliana</i> Public Transcriptomic Data by Jesús Hernández-Urrieta, José Miguel Álvarez, José Antonio O’Brien

“…Plants responses to salinity involve multiple regulatory layers, from transcriptome reprogramming to proteomic and metabolomic changes. Alternative splicing (AS) plays a role in coordinating the response to salinity, yet its extent, tissue, and condition specificity, remain poorly understood aspects. …”
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Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting by Fei Yin, Yangfang He, Jian Li, Yuan Gao

“…These treatments would be directed specifically against the selective elimination or reprogramming of senescent cells to restore immune homeostasis. …”
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Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns. by Jian Tajbakhsh, Arkadiusz Gertych, W Samuel Fagg, Seigo Hatada, Jeffrey H Fair

“…The genome organization in pluripotent cells undergoing the first steps of differentiation is highly relevant to the reprogramming process in differentiation. Considering this fact, chromatin texture patterns that identify cells at the very early stage of lineage commitment could serve as valuable tools in the selection of optimal cell phenotypes for regenerative medicine applications. …”
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The Good, the Bad, and the Epigenetic: Stress-Induced Metabolite Regulation and Transgenerational Effects by Saida Ibragić, Sabina Dahija, Erna Karalija

“…To survive and adapt, they undergo complex metabolic reprogramming by redirecting carbon and nitrogen fluxes toward the biosynthesis of protective secondary metabolites such as phenylpropanoids, flavonoids, and lignin. …”
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Astrocytes: Therapeutic targets for stroke by Jingxiu Li, Keyuan Gao, Lili Wang, Jiayue Wang, Mian Qin, Xinrui Wang, Kai Lian, Chao Li, Shan’e Gao, Chenxi Sun

“…These astrocyte-targeting strategies are categorized into traditional small-molecule drugs, microRNAs (miRNAs), stem cell-based therapies, cellular reprogramming, hydrogels, and extracellular vesicles. …”
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Parity influences postpartum adaptations in the maternal gut microbiota by Zharkyn Jarmukhanov, Elizaveta Vinogradova, Nurislam Mukhanbetzhanov, Samat Kozhakhmetov, Deniza Khassenbekova, Almagul Kushugulova

“…Functional analysis revealed distinct metabolic reprogramming patterns, including increased amino acid biosynthesis and modified fermentation pathways supporting postpartum recovery. …”
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CYP51A1 in health and disease: from sterol metabolism to regulated cell death by Fangquan Chen, RuiRui Liang, Jieting Zhang, Rui Kang, Daolin Tang, Jiao Liu

“…Although well-characterized as an antifungal drug target in microorganisms, the roles of human CYP51A1 in development, cell death regulation, and disease pathogenesis remain underexplored. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Senescent cells display distinct epigenetic signatures, such as DNA hypermethylation and histone modifications, which can be targeted to enhance senolytic efficacy. Epigenetic reprogramming strategies, such as induced pluripotent stem cells, may further complement senolytics by rejuvenating aged cells. …”
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Single-cell multi-omics delineates the dynamics of distinct epigenetic codes coordinating mouse gastrulation by Mingzhu Fu, Long Pang, Zhenwei Wu, Mei Wang, Jin Jin, Shanshan Ai, Xin Li

“…Abstract Gastrulation represents a crucial stage in embryonic development and is tightly controlled by a complex network involving epigenetic reprogramming. …”
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Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? by Jana Karbanová, Kristina Thamm, Christine A. Fargeas, Ilker A. Deniz, Aurelio Lorico, Denis Corbeil

“…We will further discuss the molecular and cellular characteristics of prominin-1, notably those that have a direct effect on the release of prominin-1+ EVs, a process that might be directly implicated in donor cell reprogramming of stem and cancer stem cells. Prominin-1+ EVs also mediate intercellular communication during embryonic development and adult homeostasis in healthy individuals, while disseminating biological information during diseases. …”
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TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies by Lianshuai Zhang, Xianyuan Xiang, Yahui Li, Guojun Bu, Xiao-Fen Chen

“…Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological development and tissue damages. TREM2 binds diverse ligands and activates downstream pathways that regulate microglial phagocytosis, inflammatory responses, and metabolic reprogramming. …”
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Trained immunity in diabetes: emerging targets for cardiovascular complications by Yanan Bai, Jianglan Wu, Weixiong Jian, Weixiong Jian

“…Diabetes can induce trained immunity in bone marrow progenitor cells and myeloid cells, thus promoting the long-term development of AS. This article first introduces the concept and molecular mechanisms of trained immunity, with particular emphasis on metabolic and epigenetic reprogramming, which plays a crucial role in sustaining chronic inflammation during trained immunity. …”
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Identification of metabolic biomarkers in idiopathic pulmonary arterial hypertension using targeted metabolomics and bioinformatics analysis by Chuang Yang, Yi-Hang Liu, Hai-Kuo Zheng

“…Abstract Pulmonary arterial hypertension (PAH) is a life-threatening disease with a poor prognosis, and metabolic abnormalities play a critical role in its development. This study used metabolomics, machine learning algorithms and bioinformatics to screen for potential metabolic biomarkers associated with the diagnosis of PAH. …”
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Deciphering the tumor immune microenvironment: Microscale measurements for precision detection and multidimensional analysis by Lu Wang, Fan Yin, Rongping Luo, Fengqi Dong, Jianxin Lyu, Zhen Wang, Yi Zhang

“…Furthermore, the review discusses the impact of cancer metabolic reprogramming on the TIME and the potential of new biomarkers for predicting responses to immunotherapy. …”
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Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics by Yin Le, Shicong Zhu, Hongling Peng, Zhihua Wang

“…While the PI3K-Akt signaling pathway and metabolic reprogramming are known to play crucial roles in B-ALL, the interactions between lipid metabolism, immune pathways, and drug resistance remain unclear. …”
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Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection by Marta Pawłowska, Jarosław Nuszkiewicz, Dorian Julian Jarek, Alina Woźniak

“…It also discusses metabolic reprogramming as a factor that modifies the levels of cell-sensitizing polyunsaturated fatty acids (PUFAs), iron dysregulation, and oxidative stress in aggressive cancers and inflammatory diseases such as sepsis, tuberculosis, and COVID-19. …”
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Mitochondrial metabolism and cancer therapeutic innovation by Hongxiang Du, Tianhan Xu, Sihui Yu, Sufang Wu, Jiawen Zhang

“…In cancer, mitochondria orchestrate multiple cellular processes critical to tumor development. Metabolic reprogramming enables cancer cells to exploit aerobic glycolysis, glutamine metabolism, and lipid alterations, supporting uncontrolled growth, survival, and treatment resistance. …”
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m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets by Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye

“…In CRC, m5C modification affects cancer cell proliferation, migration, invasion, drug resistance, and immunotherapy resistance by regulating RNA stability, metabolic reprogramming, signalling pathway activation, and immune escape. …”
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Application of Modeling and Simulation in a Self-Reprogrammable Prototype of a Manufacturing System by Rodrigo Ferro, João Victor P. de Oliveira, Gabrielly A. Cordeiro, Robert E. C. Ordóñez

“…To validate this approach, a prototype capable of interacting with a simulation model was developed. In the event of a failure that compromises product delivery conditions, the simulation model is activated to reprogram the production system’s operating parameters, ensuring compliance with initial production requirements and minimizing the impact of disruptions. …”
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