The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes by Tongguo Shi, Huan Zhang, Yueqiu Chen

“…Abstract N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role in the development and progression of various diseases, including cancer, through its regulation of RNA degradation, stabilization, splicing, and cap-independent translation. …”
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Overcoming Immune Barriers in Allogeneic CAR-NK Therapy: From Multiplex Gene Editing to AI-Driven Precision Design by Hyunyoung Kim

“…In addition, we discuss functional enhancements such as IL-15 pathway activation, KIR modulation, and transcriptional reprogramming (e.g., FOXO1 knockout) to improve persistence and antitumor activity. …”
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Multidimensional insights into exosomes in hepatocellular carcinoma: from genesis to clinical application by Xiang Zhang, Cheng Zhang, Zheng Zhang, Xuan Zhang

“…Moreover, exosomes contribute to the establishment of pre-metastatic niches by remodeling distant organ microenvironments—inducing hypoxia, metabolic reprogramming, and angiogenesis—which collectively create favorable conditions for tumor cell colonization. …”
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Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets by Elena Codrici, Ana-Maria Enciu, Ionela-Daniela Popescu, Simona Mihai, Cristiana Tanase

“…Such niches are being increasingly recognized as key regulators involved in multiple stages of disease progression, therapy resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development of frontline interventions in clinical oncology. …”
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Unique cellular interactions between pancreatic cancer cells and the omentum. by Valerya Feygenzon, Shelly Loewenstein, Nir Lubezky, Metsada Pasmanic-Chor, Osnat Sher, Joseph M Klausner, Guy Lahat

“…They imply that omental fat secreted factors induce cellular reprogramming of pancreatic cancer cells, resulting in increased tumor aggressiveness. …”
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New Insights into Monocyte-Derived Macrophages in Glioblastoma by Xuetong Li, Wei Gao, Xinmiao Long, Minghua Wu

“…This functional diversity is shaped by tumor-specific genetic alterations and metabolic reprogramming. Therapeutic approaches focusing on MDMs include inhibiting their recruitment, enhancing phagocytic activity, employing genetically engineered macrophage, and modulating metabolic pathways. …”
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Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword by Sina Kamrani, Reza Naseramini, Pouria Khani, Zahra Sadat Razavi, Hamed Afkhami, Mohammad Reza Atashzar, Farzad Nasri, Sajad Alavimanesh, Farzane Saeidi, Hossein Ronaghi

“…This review investigates the role of MSCs in the development and progression of MM.…”
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Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities by Shuoyang Hu, Jirun Xu, Weiyan Cui, Haoran Jin, Xiaoyu Wang, Yasen Maimaitiyiming

“…Multiple myeloma (MM) remains an incurable hematologic malignancy due to the inevitable development of drug resistance, particularly in relapsed or refractory cases. …”
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Spotlight on USP30: structure, function, disease and target inhibition by Jiapeng Du, Yiyang Gao, Guoqing Xue, Zhuoyue Zhao, Ying Yang, Peng Chu, Xingping Duan

“…Pharmacological inhibition of USP30, using agents such as S3, MF-094, and FT3967385, enhances ubiquitination and reactivates mitophagy, indicating potential therapeutic benefits in preclinical models. The development of USP30-targeted therapies holds promise but also faces challenges. …”
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Alveolar epithelial cell dysfunction and epithelial-mesenchymal transition in pulmonary fibrosis pathogenesis by Caopei Zheng, Caopei Zheng, Ling Zhang, Ling Zhang, Yuqing Sun, Yuqing Sun, Yingmin Ma, Yulin Zhang, Yulin Zhang, Yulin Zhang

“…It also highlights emerging regulators, including metabolic reprogramming, exosomal miRNA trafficking, and immune-epithelial interactions. …”
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Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunothera... by Yingli Luo, Maoyuan Linghu, Xianyu Luo, Dongdong Li, Jilong Wang, Shaojun Peng, Yinchu Ma

“…Consequently, a nanoformulation containing metal sulfide of FeS and GSDMD plasmid (NPFeS/GD) had been developed to effectively augment antitumor immune responses through dual activation of immunogenic PANoptosis and ferroptosis, as well as reprogramming immunosuppressive effects via H2S amplification. …”
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Insights of cellular and molecular changes in sugarcane response to oxidative signaling by Lucas Felipe Silva, Kellya F. M. Barreto, Helaine Cristiane Silva, Iara Dantas de Souza, Carlos H. S. G. Meneses, Adriana F. Uchôa, Katia C. Scortecci

“…Abstract Main conclusion Significant changes in the proteome highlight essential metabolic adaptations for development and oxidative signaling induced by the treatment of young sugarcane plants with hydrogen peroxide. …”
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Oxygen level alters energy metabolism in bovine preimplantation embryos by Nina Boskovic, Marilin Ivask, Gamze Yazgeldi Gunaydin, Barış Yaşar, Shintaro Katayama, Andres Salumets, Tõnis Org, Ants Kurg, Karolina Lundin, Timo Tuuri, Carsten O. Daub, Juha Kere

“…In ultrahypoxia conditions only 4.6% of embryos developed up to blastocyst stage. Transcriptomic profiles showed that normoxic conditions slowed down oocyte transcript degradation which is a prerequisite for reprogramming of the embryonic cell lineages. …”
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Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells by Hidehiro Toh, Hiroaki Okae, Kenjiro Shirane, Tetsuya Sato, Hirotaka Hamada, Chie Kikutake, Daisuke Saito, Takahiro Arima, Hiroyuki Sasaki, Mikita Suyama

“…Abstract Background The placenta is essential for nutrient exchange and hormone production between the mother and the developing fetus and serves as an invaluable model for epigenetic research. …”
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A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis by Qi Zhang, Shengchao Ma, Xue Kang, Yi Liu, Fei Ma, Feifei Yu, Xiaolan Luo, Guizhong Li, Yinju Hao, Huiping Zhang, Bin Liu, Yideng Jiang

“…In vivo assay indicated that HA-ML@ES NPs with long circulation and plaque accumulation efficiently attenuate endothelial cell dysfunction by inhibiting glycolysis and restore cholesterol flow homeostasis in macrophage by reprogramming macrophage phenotype, which finally attenuated the development of atherosclerosis. …”
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Overcoming cancer treatment resistance: Unraveling the role of cancer-associated fibroblasts by Xiaoyuan Wang, Yinuo Zhou, Yingzhuo Wang, Jiaxin Yang, Zhengqian Li, Fuliang Liu, Anni Wang, Zhenhao Gao, Chen Wu, Hang Yin

“…Besides, we summarize recent clinical trials in CAF-targeted therapies. The development of resistance involves physical barrier formation, metabolic reprogramming, exosome release, DNA repair, bypass pathway activation, multidrug resistance protein upregulation, and immune checkpoint inhibition. …”
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The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness by Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng

“…TFEB/TFE3 deletion restores B cell development, GC formation in Peyer’s patches and TI humoral immunity, but not TD humoral immunity in the absence of Rag-GTPases. …”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…PTMs associated with cancer can be exploited to better understand the underlying molecular mechanisms of this heterogeneous and chameleonic disease, find new biomarkers of cancer progression and prognosis, personalize oncotherapies, and discover new targets for drug development.…”
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Emerging trends and knowledge networks in pan-cancer sorafenib resistance: a 20-year bibliometric investigation by Qiong Zhou, Rui Wang

“…Future research priorities should include biomarker-driven clinical trials, the development of nanoparticle delivery systems, and the clinical translation of combination therapy strategies. …”
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Cofilin in Cancer: A Molecular Review of Its Role in Tumor Plasticity and Progression by J. Renukadevi, D. S. Mridula, K. Nimithasree, V. Sanjay

“…Future research should focus on the development of selective inhibitors and personalized treatment strategies to leverage cofilin as a target in precision oncology.…”
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