Regulation of α-Ketoglutarate levels by Myc affects metabolism and demethylation in porcine early embryos by Ran Ding, Yongfeng Zhou, Qi Zhang, Xiangjie Kong, Qi Li, Sheng Zhang, Yibing Chen, Xinglan An, Ziyi Li

“…The Myc family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of Myc in porcine early embryonic development is not fully understood. …”
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Induction of microspore embryogenesis in bread wheat by mannitol pre-treatment is associated with the disruption of endogenous hormone balance and substantial accumulation of auxin... by Agnieszka Springer, Monika Krzewska, Ewa Dubas, Przemysław Kopeć, Lenka Plačková, Karel Doležal, Dorota Weigt, Iwona Żur

“…The balance between endogenous phytohormones must be altered to induce microspore reprogramming from the classical pollen-formation pathway to embryogenic development, but too extensive changes may be detrimental. …”
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The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant by Judith Gronbach, Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci, Rory E. Morty, Tobias Reicherzer, Harald Ehrhardt

“…The therapeutic potential of mesenchymal stromal cells (MSCs)—also known as mesenchymal stem cells—has attracted much attention during the recent years due to their anti-inflammatory activities and their secretion of growth and development-promoting factors. Based on a molecular understanding, this review summarizes the positive actions of exogenous umbilical cord-derived MSCs on the immature lung and brain and the therapeutic potential of reprogramming resident MSCs. …”
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Recapitulating hypoxic metabolism in cartilaginous organoids via adaptive cell-matrix interactions enhances histone lactylation and cartilage regeneration by Boguang Yang, Zhuo Li, Zhengmeng Yang, Pengchao Zhao, Sien Lin, Jiahao Wu, Wei Liu, Xuefeng Yang, Xian Xie, Zhixian Zong, Yuanning Lyu, Zhinan Yang, Gang Li, To Ngai, Kunyu Zhang, Liming Bian

“…Our findings reveal how matrix biophysical cues influence cellular development, metabolic reprogramming, and epigenetic modifications.…”
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Pathogenic Mechanisms of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Associated Hepatocellular Carcinoma by Toru Nakamura, Atsutaka Masuda, Dan Nakano, Keisuke Amano, Tomoya Sano, Masahito Nakano, Takumi Kawaguchi

“…In addition, MASLD has been reported to enhance the development of HCC in patients with chronic viral hepatitis infection. …”
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Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets by Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen

“…., fibroblast activation protein+ CAFs), epigenetic reprogramming toward antitumor phenotypes, and inhibition of CXCL12/CXCR4 or transforming growth factor‐beta signaling pathways. …”
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Targeting Sepsis: Disease Tolerance, Immune Resilience, and Compartmentalized Immunity by Alexis Garduno, Ignacio Martín-Loeches

“…This review explores the burden of sepsis on organ-specific immune dysregulation, immune resilience, and epigenetic reprogramming, emphasizing translational challenges and opportunities. …”
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Image-guided optimization of current steering in STN-DBS for Parkinson's disease by Atsushi Umemura, Atsushi Umemura, Hideki Mizuno, Mina Maki, Atsuo Masago

“…An alternative stimulation program was developed using Stimview™ XT, a patient-specific image-guided interface, without altering pulse width or frequency. …”
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Emerging Mechanistic Insights and Therapeutic Strategies for Pulmonary Arterial Hypertension: A Focus on Right Ventricular Dysfunction and Novel Treatment Pathways by Masab Mansoor, Andrew F. Ibrahim

“…Emerging therapies such as JAK-STAT inhibitors, metabolic reprogramming agents, and mesenchymal stromal cell-derived extracellular vesicles (EVs) show promise in preclinical and early clinical trials. …”
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer by Eslam Mohamed, Juan R. Cubillos-Ruiz, Paulo C. Rodriguez

“…Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. …”
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Mechanism and application of copper-based nanomedicines in activating tumor immunity through oxidative stress modulation by Cong Xia, Zirun Luo, Zhen Feng, Qianshi Zhang, Chenglai Xia

“…The modulation of oxidative stress in the tumor microenvironment (TME) by metals presents novel breakthroughs for metalloimmunotherapy, particularly in enhancing immune responses, optimizing immune cell function, and reprogramming the immunosuppressive TME. Copper, a transition metal closely associated with tumor development, acts as an immune activator to enhance immune responses through oxidative stress. …”
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Extracellular vesicle-based drug delivery systems in cancer by Ruotong Huang, Jiajun Zhu, Ru Fan, Yiting Tang, Lianlong Hu, HaeJu Lee, Shuying Chen

“…We review the extracellular vesicles’ development, drug loading techniques, and discuss their potential in clinical applications to provide new avenues for precise and targeted treatment strategies. …”
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Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis by Guoqing Li, Xiaoling Zhou, Wenhan Li, Qiulei Wu, Tong Liu, Lin Huang, Xiaoli Liu, Jing Zhao, Xiaohan Xu, Linjuan Xu, Zehua Wang, Lanqing Gong, Liqiong Cai, Jing Cai

“…Using a patient-derived omentum-macrophage co-culture system, we demonstrated that tumor-derived EVs stimulate lipid release from omental adipocytes, which macrophages subsequently internalize through CD36-dependent uptake to drive lipid accumulation. This metabolic reprogramming culminated in cellular senescence, as evidenced by classical biomarkers including SA-β-galactosidase activity, elevated p16-INK4A and p53 levels, and the development of a matrix metalloproteinase-enriched senescence-associated secretory phenotype. …”
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MS4A7 based metabolic gene signature as a prognostic predictor in lung adenocarcinoma by Yan Jiang, Zhengyu Shu, Lei Cheng, Lei Cheng, Haowei Wang, Taiping He, Liwen Fu, Chao Zhao, Xuefei Li, Weicheng Zeng, Weicheng Zeng

“…MS4A7+ macrophages, characterized by distinct metabolic reprogramming and immune interactions, are pivotal in shaping LUAD progression and immune response. …”
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Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells. by Foad J Rouhani, Serena Nik-Zainal, Arthur Wuster, Yilong Li, Nathalie Conte, Hiroko Koike-Yusa, Natsuhiko Kumasaka, Ludovic Vallier, Kosuke Yusa, Allan Bradley

“…The mutation rate in the human genome has recently been measured to be 50-70 de novo single nucleotide variants (SNVs) between generations. During development mutations accumulate in somatic cells so that an organism is a mosaic. …”
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Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics by Rayana L. Bighetti-Trevisan, Lucas O. Sousa, Rogerio M. Castilho, Luciana O. Almeida

“…The endowed resistance mechanisms of CSC are mainly attributed to several factors including cellular quiescence, accumulation of ABC transporters, disruption of apoptosis, epigenetic reprogramming, and metabolism. There is a current need to develop new therapeutic drugs capable of targeting CSC to overcome tumor resistance. …”
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Visualization of the relationship between metabolism and lung diseases from the perspective of bibliometric analysis: research trends and future prospects by Ming-Yan Wang, Xing-Yu Mo, Meng-Xu Yi, Hong-Yan Lu

“…Current research trends highlight a shift toward investigating metabolic reprogramming of immune cells in the context of lung diseases. …”
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Landscape of TET2 Mutations: From Hematological Malignancies to Solid Tumors by Zoë L. Hawking, James M. Allan

“…Thus, it is not surprising that loss or attenuation of TET enzymes is implicated in genomic hypermethylation and transcriptional reprogramming that drives cancer development. Somatic mutations in TET2 are observed in the bone marrow of 5%–10% of healthy adults over 65 years of age, imparting a hematopoietic stem cell advantage and subsequent clonal hematopoiesis of indeterminate potential (CHIP), a condition which is associated with increased risk of myeloid malignancy. …”
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INSTRUMENTAL TREATMENT OF AMBLYOPIA by B. F. Lavrent’ev, V. V. Rozhentsov

“…To develop a device with broad functionality for treatment amblyopia. methods. …”
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Features of aminothiol metabolism and progression of breast cancer by A. V. Markovsky

“…Imbalance of aminothiol metabolism is a potential risk factor for malignant transformation of cells and caner development, including breast cancer, which is the most commonly diagnosed cancer in the world. …”
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