Revisiting TAM polarization: beyond M1- and M2-type TAM toward clinical precision in macrophage-targeted therapy by Qingqing Wang, Wenxue Ma

“…However, inconsistencies and mischaracterizations in the literature regarding TAM classification have led to confusion in the field, potentially impeding the development of effective macrophage-targeted immunotherapies. …”
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The role of tenascin-C in tumor microenvironments and its potential as a therapeutic target by Yaran Wang, Xiaohui Wen, Chao Su, Yanyi You, Ziqing Jiang, Qin Fan, Daoqi Zhu

“…The tumor microenvironment (TME) plays a pivotal role in cancer development and progression, and comprises various cellular and non-cellular components that interact with tumor cells. …”
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Research progress on cholesterol metabolism and tumor therapy by Zewen Chu, Lei Fang, Yanwei Xiang, Yue Ding

“…Cholesterol metabolism is involved in bile acid production and steroid hormone biosynthesis and is closely linked to the reprogramming of endogenous and exogenous cellular signals within the tumor microenvironment. …”
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Decidualization and Related Pregnancy Complications by Jing Tong, Shijian Lv, Jieqiong Yang, Hongwanyu Li, Weiya Li, Cong Zhang, Dandan Shi

“…Human decidualization involves some amount of signaling molecules and pathways as well as genetic reprogramming, which is driven by the postovulatory rise in progesterone levels and local cyclic adenosine monophosphate production. …”
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Non-parenchymal cells: key targets for modulating chronic liver diseases by Tongwang Yang, Zhiyun Gu, Juan Feng, Juanjuan Shan, Cheng Qian, Na Zhuang

“…These approaches provide valuable insights into halting CLD progression and advancing the development of innovative antifibrotic therapies.…”
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Melatonin: a natural guardian in cancer treatment by Yurou Cao, Hang Zhang, Xubin Chen, Conghui Li, Jingxin Chen

“…Mechanistically, melatonin inhibits tumor development through epigenetic regulation, metabolic reprogramming, immune micro-environment, and regulation of important signaling pathways (PI3K/AKT). …”
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Thymic Self-Antigen Expression for the Design of a Negative/Tolerogenic Self-Vaccine against Type 1 Diabetes by Aziz Alami Chentoufi, Vincent Geenen

“…Based on the close homology and cross-tolerance between insulin, the primary T1D autoantigen, and IGF-2, the dominant self-antigen of the insulin family, a novel type of vaccination, so-called “negative/tolerogenic self-vaccination”, is currently developed for prevention and cure of T1D. If this approach were found to be effective for reprogramming immunological tolerance in T1D, it could pave the way for the design of negative self-vaccines against autoimmune endocrine diseases, as well as other organ-specific autoimmune diseases.…”
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Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches by Linda K. Do, Hyun Min Lee, Yun-Sok Ha, Chan-Hyeong Lee, Jiyeon Kim

“…Summary: Metabolic reprogramming is a hallmark of malignant transformation. …”
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Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

“…Two iPSC lines were characterised in detail. Reprogramming was performed by transfection with non-integrating episomal vectors expressing the OCT4, SOX2, KLF4, LIN28, L-MYC and mp53DD proteins. …”
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Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer by Hussein Sabit, Sama Abouelnour, Bassel M. Hassen, Salma Magdy, Ahmed Yasser, Al-Hassan Soliman Wadan, Shaimaa Abdel-Ghany, Faisal Radwan, Amany I. Alqosaibi, Hala Hafiz, Ohaad F. A. Awlya, Borros Arneth

“…Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic and ERβ exhibiting tumor-suppressive properties. …”
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DNA storage: The future direction for medical cold data storage by Peilin Shen, Yukui Zheng, CongYu Zhang, Shuo Li, Yongru Chen, Yongsong Chen, Yuchen Liu, Zhiming Cai

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The lactylation modification of proteins plays a critical role in tumor progression by Dehao Yi, Ke Zhou, Yinlong Pan, Huazhong Cai, Pan Huang, Pan Huang

“…Lactylation modifications have been shown to be a novel type of protein post-translational modifications (PTMs), providing a new perspective for understanding the interaction between cellular metabolic reprogramming and epigenetic regulation. Studies have shown that lactylation plays an important role in the occurrence, development, angiogenesis, invasion and metastasis of tumors. …”
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Epigenetics and Herbs: Potential Therapeutic Strategies for Osteoarthritis of the Knee by Zheng Y, Wang J, Wang L, Zheng Y, Qi W

“…Programmed cell death (PCD) of chondrocytes plays a central role in the development of knee osteoarthritis, and epigenetics provides new explanations for this complex biological process. …”
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Research progress on mechanisms of tumor immune microenvironment and gastrointestinal resistance to immunotherapy: mini review by Zheng Zhang, Yangping Wu

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Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance by Xue Yang, Yang Gu

“…Overcoming translational barriers and integrating multifunctional nanocarriers with immunomodulatory approaches, metabolic regulation, and artificial intelligence–based design may facilitate the development of advanced precision therapies for cervical cancer through the combined application of bioorthogonal chemistry and nanotechnology.…”
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Cytoplasmic injection of circular plasmids allows targeted expression in mammalian embryos by Khursheed Iqbal, Brigitte Barg-Kues, Sandra Broll, Jürgen Bode, Heiner Niemann, Wilfried A. Kues

“…This approach allows an experimental access to reprogramming events in early mammalian embryos.…”
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Tumor microenvironment-responsive nanoplatforms for enhanced cancer immunotherapy: Advances and synergistic strategies by Jie Wu, Xiangdong Xue, Haijing Qu

“…Furthermore, we elucidate synergistic mechanisms of TME-responsive nanosystems empowering immunotherapy: i) subcellular organelle-specific delivery, ii) TME remodeling, iii) immunometabolic reprogramming and iv) lymph node drainage regulation. …”
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Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives by Kaihuan Zhou, Qianqian Qin, Junyu Lu

“…Main body By integrating classical theories with recent research advancements, we provide a comprehensive analysis of how inflammatory mediators, metabolic reprogramming, oxidative stress, and immune dysregulation synergistically drive ARDS onset and progression. …”
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System for Simultaneous Control of Multiple Unmanned Aerial Vehicles by Yehor Zheliazkov

“…Nowadays, airspace is a strategically important resource for both national security and economic development. The state is responsible for its efficient use and safety. …”
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A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease by Carmen Sevilla-Ortega, Alba Angelina, Leticia Martín-Cruz, Mario Pérez-Diego, Angel Maldonado, Begoña Lavín, Beatriz Marcos-Ramiro, Luis Pérez de Llano, Auba Gayá, Francisco X. Real, Laura Conejero, José Luis Subiza, Oscar Palomares

“…Abstract Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. …”
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