Replicative Senescence in Mesenchymal Stem Cells: An In Vitro Study on Mitochondrial Dynamics and Metabolic Alterations by Beatrice Casorati, Isabella Zafferri, Sara Castiglioni, Jeanette A. Maier

“…These mitochondrial defects play a role in metabolic reprogramming in senescent bMSCs. Our findings underscore the intricate interplay between ROS, mitochondrial dysfunction, and replicative senescence, offering valuable insights to guide the development of therapeutic strategies for preserving MSC functionality in aging and MSC-based therapies.…”
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Extracellular matrix stiffness: mechanisms in tumor progression and therapeutic potential in cancer by Meiling Zhang, Bin Zhang

“…The quantity and cross-linking status of stromal components are primary determinants of tissue stiffness. During tumor development, ECM stiffness not only serves as a barrier to hinder drug delivery but also promotes cancer progression by inducing mechanical stimulation that activates cell membrane receptors and mechanical sensors. …”
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From Target Prediction to Mechanistic Insights: Revealing Air Pollution-Driven Mechanisms in Endometrial Cancer via Interpretable Machine Learning and Molecular Docking by Hongyao Liu, Yueqing Zou

“…These findings reveal potential mechanisms linking air pollution to EC and support the development of biomarkers for high-exposure populations. …”
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The role and challenges of intratumoral microbiota in colorectal cancer immunotherapy by Miao Hao, Haiming Xu, Min Li, Dan Jiao

“…Colorectal cancer (CRC) is the third most common malignant tumor globally, and its development is closely related to interactions between the host and microbes. …”
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Latency, microenvironment, and the priming of a precancerous senescent cell for malignant transformation by April Kirkendoll

“…Most of the altered cells never develop into cancers, and it is unknown what may trigger malignancy. …”
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THE INFLUENCE OF PROPIONATE ON THE SPECTRUM OF LONG-CHAIN FATTY ACIDS IN CERVICAL CELLS DURING DIS- AND NEOPLASTIC TRANSFORMATION by E. V. Kayukova, T. E. Belokrinitskaya, P. P. Tereshkov

“…Background. Metabolic reprogramming of tumor cells is one of the leading links in carcinogenesis. …”
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The role and function of lncRNA in ageing-associated liver diseases by Peyman Kheirandish Zarandi, Mohsen Ghiasi, Mohammad Heiat

“…LncRNAs exert a major influence on the progression of age-related liver diseases through the regulation of cell proliferation, necrosis, apoptosis, senescence, and metabolic reprogramming. A concise overview of the current understanding of lncRNAs and their potential impact on the development of age-related liver diseases will be provided in this mini-review.…”
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Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms by Mincong Shu, Yuhan Liu, Jianbin Wang

“…We summarize how these PTMs participate in the metabolic reprogramming of SSP. It helps us better understand the molecular mechanisms and physiological significance of the PTM network in serine synthetic metabolism, providing guidance for subsequent research and development in the future.…”
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Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner by Hong Hu, Yishuai Huang, Jiafeng Li, Ruijie Liu, Honglei Li, Meng Cai, Hao Chen, Ning Wang, Shuo Yang, Kaikai Wang, Lei Teng, Huailei Liu

“…Methionine (Met) is an essential amino acid in human metabolism and plays a crucial role in the development of glioma. However, the role of Met metabolism in the formation of the tumor immunosuppression microenvironment remains uncertain. …”
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Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma by Haikun Yang, Yuan Chen, Yuan Chen, Zheng Zhou, Yanjing Wang, Peng Li, Yang Li

“…BackgroundUbiquitination, a critical post-translational modification, plays a pivotal role in regulating protein stability and activity, influencing various aspects of cancer development, including metabolic reprogramming, immune evasion, and tumor progression. …”
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Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models by Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda

“…Transient IL-12 expression was responsible for a favorable reprogramming of the tumor immune microenvironment, longer persistence of transferred T lymphocytes in vivo, and the development of immunity to endogenous antigens following primary tumor eradication. …”
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Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer by Mary Lee, George T Chen, Eric Puttock, Kehui Wang, Robert A Edwards, Marian L Waterman, John Lowengrub

“…Abstract Cell‐intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. …”
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Regenerative Therapy for Chronic Heart Failure: Prospects for the Use of Cellular and Acellular Technologies by I. S. Dolgopolov, M. Yu. Rykov, V. V. Osadchij

“…Many researchers have reported direct reprogramming of the heart in vivo in animal and human cells. …”
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Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing by Tomoki Yanagi, Shean Fu Phen, Jonah Ayala, Deniz Ece Aydin, Susanna Jaramillo, David M. Truong

“…Abstract Background Inducible gene expression circuits enable precise control over target gene activation and are widely used in direct reprogramming. However, their usability is often compromised by DNA methylation-induced silencing, especially in iPSCs. …”
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Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis by Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao

“…Subsequently, a tryptophan metabolism-related signature was developed using an integrated machine-learning approach. …”
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Ca2+-dependent cytoplasmic and nuclear phosphorylation of STOP1 by CPK21 and CPK23 confers ALMT1-dependent aluminum resistance by Hongrui Cao, Rongxiu Cui, Huan Guo, Qiuchen Xia, Jianing Zhang, Wenxin Liu, Zhong-Bao Yang

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Immunomodulatory Effects of Halichondrin Isolated from Marine Sponges and Its Synthetic Analogs in Oncological Applications by Dinusha Shiromala Dissanayake, Dineth Pramuditha Nagahawatta, Jung-Suck Lee, You-Jin Jeon

“…This review explores the mechanisms underlying the immunomodulatory activity of halichondrin and its analogs in cancer therapy, along with their clinical applications and potential for future drug development.…”
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Chimeric Antigen Receptor-Modified Immune Cells for Eradication of HIV Reservoirs by Guo-Fen Re, Bei-Bei Tang, Jing Kou, Chen Hong, Yi-Qun Kuang

“…This article reviews the latent characteristics of HIV, the development of CAR molecules, and the strategies for reprogramming T cells and NK cells with CARs, and aims to clear the HIV reservoirs and related potential problems.…”
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Tumor-derived vesicles in immune modulation: focus on signaling pathways by Fei Yin, Yangfang He, Yue Qiao, Yan Yan

“…We also examine emerging therapeutic approaches aimed at disrupting EV-mediated pathways, offering promising avenues for the development of novel EV-based cancer immunotherapy.…”
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Microbiota recruitment for brain cancer management by Ruty Mehrian-Shai

“…Therefore, understanding the bidirectional dynamics of the gut-brain-tumor axis is essential for the development of microbiome-informed therapies. Despite these promising insights, several challenges remain. …”
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