Platelets in cancer and immunotherapy: functional dynamics and therapeutic opportunities by Changjing Cai, Yiting Liu, Ruohuang Lu, Xudong Fan, Shan Zeng, Pingping Gan

“…This work offers essential insights for reprogramming platelets to shift their function from tumor promotion to tumor suppression, providing a foundation for the development of novel immunotherapeutic strategies and related research.…”
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The malignant dialogue between cancer-associated fibroblasts and osteosarcoma cells: microenvironment-mediated drug resistance and therapeutic targets by Xiufeng Wang, Cong Luo, Danying Zhang

“…Challenges like CAF plasticity and biomarker development are discussed, alongside future directions for precision targeting in OS.…”
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Innate immune memory in macrophage differentiation and cardiovascular diseases by Yukiteru Nakayama, Katsuhito Fujiu

“…Advancing the understanding of these processes could facilitate the development of novel approaches to control inflammatory diseases and immune-related disorders.…”
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Induction of Pluripotency in Adult Equine Fibroblasts without c-MYC by Khodadad Khodadadi, Huseyin Sumer, Maryam Pashaiasl, Susan Lim, Mark Williamson, Paul J. Verma

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Constructing Cell-Specific Causal Networks of Individual Cells for Depicting Dynamical Biological Processes by Xinzhe Huang, Luonan Chen, Xiaoping Liu

“…It also enables the construction of context-specific GRNs to identify key regulators of fate transitions for diverse processes such as cellular reprogramming and development. Furthermore, SiCNet can delineate the intricate dynamic regulatory processes involved in development, providing deep insights into the mechanisms governing cellular transitions and the gene regulation across developmental stages.…”
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Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities by Lan Huang, Xuemei Chen, Meina Yan, Ze Xiang, Jian Wu

“…Epigenetic alterations and metabolic reprogramming are prominent characteristics of tumors. …”
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Regulatory role and therapeutic prospect of lactate modification in cancer by Mengdi Sun, Kejing Wang, Fang Lu, Donghua Yu, Shumin Liu

“…PTMs play a crucial role in processes such as signal transduction, epigenetics, and disease development. Lactylation is a newly discovered PTM that, due to its close association with lactate—the end product of glycolytic metabolism—provides a new perspective on the connection between cellular metabolic reprogramming and epigenetic regulation. …”
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Purine metabolism-associated key genes depict the immune landscape in gout patients by Lin-na Li, Hao Wang, Lu-shan Xiao, Wei-nan Lai

“…Therefore, our study made an urgent appeal to due attention to the underlying crosstalk among purine metabolism, immune responses, and tumor development in gout patients.…”
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Single-cell RNA sequencing reveals key regulators and differentiation trajectory of iPSC-derived cardiomyocytes by Lu Li, Dandan Li, Jiahong Wang, Yong Dai

“…Abstract Cardiac differentiation of human pluripotent stem cells is not only a new strategy of regenerative therapy for cardiovascular disease treatment but also provides unique opportunities for the study of in vitro disease models and human heart development. To elucidate the dynamic gene regulatory networks and pivotal regulators involved in the cardiomyocyte differentiation process, we conducted an analysis of single-cell RNA sequencing data obtained from the reprogramming of two human induced pluripotent stem cell (iPSC) lines into cardiomyocytes. …”
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Neuroprotection Mechanisms in Cerebral Hypothermia (Review) by Oleg A. Shevelev, Marina V. Petrova, Shavkat Kh. Saidov, Nadezhda A. Khodorovich, Pranil Pradkhan

“…The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.The concept of hypothermic pre-conditioning based on the development of typical nonspecific reactions for the formation of the cytoprotective phenotype of neurons due to potentially dangerous stimuli, such as ischemia, reperfusion, and hypothermia, was used to explain the effects of low temperatures. …”
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Targeting the hallmarks of aging: mechanisms and therapeutic opportunities by Fumihiro Sanada, Shinichiro Hayashi, Ryuichi Morishita

“…Advances in regenerative medicine, gene editing, and organ cross-talk modulation are also contributing to the development of personalized, multi-targeted anti-aging therapies. …”
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Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma by H. Degroote, A. Van Dierendonck, A. Geerts, H. Van Vlierberghe, L. Devisscher

“…The heterogeneity of TAM subtypes and their origin and dynamic phenotype during the initiation and progression of HCC has been partially unraveled and forms the base for the development of therapeutic agents. Current approaches are aimed at decreasing the population of TAMs by depleting macrophages present in the tumor, blocking the recruitment of bone marrow-derived monocytes, and/or functionally reprogramming TAMs to antitumoral behavior. …”
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Tumour-infiltrating lymphocyte therapy landscape: prospects and challenges by Arkadiusz Z Dudek, Jeffrey Johnson, Ruqin Chen, Ali Rezazadeh

“…This review comprehensively examines the historical development, biology, clinical efficacy, safety and limitations of TIL therapy. …”
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Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics by Jung-Yu Kan, Hsiao-Chen Lee, Ming-Feng Hou, Hung-Pei Tsai, Shu-Fang Jian, Chao-Yuan Chang, Pei-Hsun Tsai, Yi-Shiuan Lin, Ying-Ming Tsai, Kuan-Li Wu, Yung-Chi Huang, Ya-Ling Hsu

“…Our findings revealed an increase in metabolic-related genes within the cancer cells, with the hub gene Dlat (Dihydrolipoamide S-Acetyltransferase) showing a significant association with the development of lung metastatic tumors. Upregulation of Dlat led to the reprogramming of fatty acid utilization, markedly enhancing the bioenergetic capacity of cancer cells. …”
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Knowledge mapping of trained immunity/innate immune memory: Insights from two decades of studies by Jiacheng He, Hongxia Cui, Guoqian Jiang, Lijun Fang, Jianlei Hao

“…The current research focus encompasses immune memory, nonspecific effects, epigenetics, metabolic reprogramming, BCG vaccine, and the development of trained immunity-based vaccines. …”
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METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m6A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis by Sa Li, Jiajie Hao, Guangliang Hong, Hongzhi Dong, He Liu, Lingmei Jin, Zhihao Zhang, Haoyu Wu, Mingli Hu, Rujin Huang, Guanzheng Luo, Jiangping He, Jiekai Chen, Kaixin Wu

“…Abstract N6-methyladenosine (m6A) plays crucial roles in development and cellular reprogramming. During embryonic development, pluripotency transitions from a naïve to a primed state, and modeling the reverse primed-to-naïve transition (PNT) provides a valuable framework for investigating pluripotency regulation. …”
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Phosphofructokinase-1 redefined: a metabolic hub orchestrating cancer hallmarks through multi-dimensional control networks by Rong Yuan, Junqi Wang, Shengkang Zhang, Zhaojun Xu, Lan Song

“…The isoform-specific modification networks unveil novel targets for developing diagnostic biomarkers and tissue-selective therapeutic strategies. …”
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Research progress on the role and mechanisms of microglia in inflammatory diseases of central nervous system by YU Kai, SHUAI Zhewei, HUANG Hongjun, LUO Yan

“…In recent years, with the rapid development of frontier biotechnology such as single-cell sequencing, proteinomics and gene editing, important progress has been made in understanding the molecular mechanism by which microglia participate in CNS inflammatory diseases, especially in the activation of inflammatory corpuscles, epigenetic modifications, and metabolic reprogramming. …”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation. by Arne W Mould, Marc A J Morgan, Andrew C Nelson, Elizabeth K Bikoff, Elizabeth J Robertson

“…Recent studies demonstrate that the zinc finger transcriptional repressor Blimp1/Prdm1 plays an essential role governing postnatal reprogramming of intestinal enterocytes during this period. …”
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The complement system in human pregnancy and preeclampsia by Vijay Kumar, John H. Stewart

“…For a successful pregnancy, maternal immune reprogramming is crucial because the developing embryo is considered a semi-allograft. …”
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