DDR1 promotes LoVo cell proliferation by regulating energy metabolism by Xiong Bin, Xie Zehui, Song Feixue, Chen Huiling, Wang Xiaojuan, Jin Zhengxu, Han Tiyun, Li Yi, Zhang Dekui

“…Whether it participates in cellular metabolic reprogramming and regulates CRC initiation and progression remains unclear. …”
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Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos by Zaheer Haider, Safeer Ullah, Tahir Muhammad, Chalani Dilshani Perera, Muhammad Tayyab Khan, Asif Jan, Seung-Eun Lee, Seo-Hyun Lee, Sung Woo Kim, Muhammad Idrees, Muhammad Idrees, Il-Keun Kong, Il-Keun Kong, Il-Keun Kong

“…In conclusion, MA impacted the EGA reprogramming and development of cloned bovine embryos via probable activation of TERT. …”
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Target neutrophil heterogeneity and plasticity in cancer by Ye Feng, Guang Liu, Haiqing Li, Lin Cheng

“…The potential of targeting and engineering neutrophil as a therapeutic avenue for cancer treatment is further underscored, including the use of senolytic agents, metabolic inhibitors, and reprogramming strategies. Finally, future research directions are proposed to further elucidate the mechanisms underlying neutrophil heterogeneity and plasticity, with the aim of developing novel therapeutic approaches to modulate neutrophil function in cancer.…”
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Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer by Chunyu Zhang, Zhiwei Miao, Yan Xu, Tongguo Shi

“…Cholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. …”
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Generation, characterization, and validation of two human induced pluripotent stem cell lines from the peripheral blood of young and older adults by Dongli Yang, Jun Chen, Jerry H. Juratli, Andre Monteiro da Rocha, Allison Schley, Nadia R. Sutton

“…Aging is a leading risk factor for the development of age-related diseases. However, how aging impacts human induced pluripotent stem cell (hiPSC) reprogramming, age-related epigenetic memory post-reprogramming, differentiation, and its potential applicability to cardiovascular regenerative medicine remains underexplored. …”
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Mechanisms of Acute Kidney Injury–Chronic Kidney Disease Transition: Unraveling Maladaptive Repair and Therapeutic Opportunities by Dongxue Xu, Xiaoyu Zhang, Jingjing Pang, Yiming Li, Zhiyong Peng

“…Central to this transition are mechanisms such as epigenetic reprogramming, G2/M cell-cycle arrest, cellular senescence, mitochondrial dysfunction, metabolism reprogramming, and cell death, which collectively drive the progression of CKD. …”
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Drug Discovery Models and Toxicity Testing Using Embryonic and Induced Pluripotent Stem-Cell-Derived Cardiac and Neuronal Cells by Rahul S. Deshmukh, Krisztián A Kovács, András Dinnyés

“…Two important limitations for research application of embryonic stem cells (ESCs), namely, ethical and immunological issues, can be circumvented using iPSCs. Since the development of first iPSCs, tremendous effort has been directed to the development of methods to increase the efficiency of the process and to reduce the extent of genomic modifications associated with the reprogramming procedure. …”
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Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer by Yuxin Ji, Ruonan Li, Guohui Tang, Yuhan Xiao, Ruyin Ye, Jiwen Shi, Chenchen Geng, Ruorong Ran, Chengle Zhu, Wenrui Wang, Changjie Chen, Qingling Yang

“…Abstract Breast cancer (BC) is the most prevalent and highly heterogeneous malignancy affecting females worldwide, and its development is closely linked to metabolic reprogramming. …”
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Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E by Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong

“…We quantitatively appraised the PM traits of diverse cell subsets via scoring algorithms such as AUCell and Ucell. Moreover, cell development and cell-cell interaction analysis elucidated the alterations in TME induced by PM dysregulation. …”
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Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology by Romualdo Sciorio, Luca Tramontano, Giuseppe Gullo, Steven Fleming

“…However, the long-term health implications for offspring remain uncertain. Epigenetic reprogramming during early embryogenesis is essential for proper embryo development and can be changed by ART-related conditions. …”
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Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer by Chiara M. S. Herzog, Elisa Redl, James Barrett, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Julia Tevini, Roland Lang, Barbara Kofler, Martin Widschwendter

“…Results Our findings offer insights into the association of functionally enriched groups of age-related DNAme changes with cancer, identify sites perturbed earliest during carcinogenesis, as well as those distinct between cancer and reprogramming that could inform strategies to prevent teratoma formation upon in vivo reprogramming. …”
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Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy by E. M. Samoilova, V. A. Kalsin, N. M. Kushnir, D. A. Chistyakov, A. V. Troitskiy, V. P. Baklaushev

“…This review deals with basic molecular mechanisms for maintaining the pluripotent state of embryonic/induced stem and reprogrammed somatic cells, as well as with currently existing reprogramming strategies. …”
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Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…Abstract Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the metabolic fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, and proliferation compared to normal cells. …”
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Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord. by Atsushi Yamazaki, Seiji Shiozawa, Yuko Koushige, Hirotaka Kondo, Hisashi Shibuya, Kazuya Edamura

“…This study contributes to the development of veterinary regenerative medicine by using canine iPSCs.…”
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Gut dysbiosis in cancer immunotherapy: microbiota-mediated resistance and emerging treatments by Liza Eiman, Khadija Moazzam, Sumaira Anjum, Humera Kausar, Elham Abdullatif M. Sharif, Wisam Nabeel Ibrahim

“…Disruption in the gut microbial populations and diversity, known as dysbiosis, has been linked with the development of chronic inflammation, oncogenesis, angiogenesis and metastasis. …”
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An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. by Elizabeth J Radford, Elvira Isganaitis, Josep Jimenez-Chillaron, Joshua Schroeder, Michael Molla, Simon Andrews, Nathalie Didier, Marika Charalambous, Kirsten McEwen, Giovanna Marazzi, David Sassoon, Mary-Elizabeth Patti, Anne C Ferguson-Smith

“…Nor do we find any evidence that the epigenetic reprogramming of ICRs in the germline is susceptible to nutritional restriction. …”
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Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health by Amelia Cuarenta

“…Epigenetic mechanisms have increasingly been of interest to understand how environmental factors contribute to reprogramming the brain and alter risk and resilience to developing psychiatric disorders. …”
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Metabolic Profiles of Serum and Ovarian Tissue in Taihe Black-Boned Silky Fowl During the Early and Peak Laying Periods by Xuan Huang, Shibao Li, Zhaozheng Yin

“…Egg production is a complex biological process closely linked to ovarian development and metabolic adaptation in laying hens. …”
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Metabolic Profiling Reveals Diagnostic Biomarkers for Distinguishing Myocarditis From Acute Myocardial Infarction by Yuting Chen, Xiu Liu, Chengying Hong, Shunyao Xu, Linling He, Zhenmi Liu, Huaisheng Chen, Yaowang Lin

“…Conclusions: In conclusion, patients experiencing AMI and MC undergo significant metabolic reprogramming. Metabolites exhibiting abnormal expression in peripheral blood hold diagnostic value for distinguishing between AMI and MC in clinical settings. 11-cis-retinol proved to be the pivotal biomarker for AMI, potentially aiding in the development of a robust predictive model for distinguishing between MC and AMI in clinical settings.…”
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SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers by Jianfa Li, Yincong Chen, Zhicong Chen, Anbang He, Haibiao Xie, Qiaoxiao Zhang, Zhiming Cai, Yuchen Liu, Weiren Huang

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