Targeting tumor angiogenesis and metabolism: a new perspective in pediatric thoracic tumor therapy by Yong Lv, Fanke Shu, Dengke Luo, Ru Jia, YiDong Huang, Chang Xu

“…Both processes play key roles in pediatric thoracic tumor development. Therefore, targeting tumor vasculature could be an important therapeutic strategy, and exploring the molecular mechanisms of metabolic reprogramming may provide a theoretical foundation for targeted treatment. …”
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Mitosis gives a brief window of opportunity for a change in gene transcription. by Richard P Halley-Stott, Jerome Jullien, Vincent Pasque, John Gurdon

“…They support the general principle that a temporary access of cytoplasmic factors to genes during mitosis may facilitate somatic cell nuclear reprogramming and the acquisition of new cell fates in normal development.…”
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Haoya Wang Et Al.: Circadian Rhythm Disruption Promotes Tumor Progression Through Upregulated Glycolysis by Haoya Wang, Di Wu, Jie Li, Binghe Zhao, Lu Liu, Xinxin Wang

“…ABSTRACT Background Aberrant activation of glycolysis (Warburg effect) constitutes a key metabolic reprogramming feature in malignant tumors, serving as a critical mechanism facilitating tumor development. …”
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Unraveling the Complex Nexus of Macrophage Metabolism, Periodontitis, and Associated Comorbidities by Zihan Zhang, Yi Liu, Tian Yu, Zhen Liu

“…Macrophages play a pivotal role in the development and progression of periodontitis, and the feasibility of targeting them therapeutically has been established. …”
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Lost in translation: pluripotent stem cell‐derived hematopoiesis by Mania Ackermann, Steffi Liebhaber, Jan‐Henning Klusmann, Nico Lachmann

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Illuminating the future of diabetes treatment: Autologous CiPSC-derived islets take center stage by Ying Lou

“…The discussion highlights the scientific rationale behind chemical reprogramming, the development of functional islets, the novel transplantation strategy, and the remarkable clinical outcomes observed in their first patient. …”
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An increase in reactive oxygen species underlies neonatal cerebellum repair by Anna Pakula, Salsabiel El Nagar, N Sumru Bayin, Jens Bager Christensen, Daniel Stephen, Adam James Reid, Richard P Koche, Alexandra L Joyner

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Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications by Seung-Ick Oh, Chang Kyu Lee, Kyung Jin Cho, Kyung-Ok Lee, Ssang-Goo Cho, Sunghoi Hong

“…In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.…”
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Histone acetylation modulators in breast cancer by Xueying Yuan, Jeffrey M. Rosen

“…Aberrant epigenetic reprogramming such as dysregulation of histone acetylation has been associated with the development of breast cancer. …”
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Exosome-mediated ferroptosis in the tumor microenvironment: from molecular mechanisms to clinical application by Na Liu, Tianqing Wu, Guohu Han, Minbin Chen

“…Abstract Ferroptosis in the tumor microenvironment (TME) plays a crucial role in the development, metastasis, immune escape, and drug resistance of various types of cancer. …”
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Research Progress on Glycolysis in the Pathogenesis of Asthma by Luo J, Ge X

“…The findings aim to inform future studies and contribute to the development of asthma-related precision medicine. A deeper understanding of the interplay between glycolysis and the development and progression of asthma may facilitate the development of innovative therapeutic approaches for this complex condition.Keywords: asthma, glycolysis, immune cells, precision medicine, programmed cell death…”
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Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons by Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour

“…This new strategy paves the way to develop more disease-relevant models by establishing reprogramming-free patient-specific dopaminergic cell models for drug screening and/or target validation for neurodegenerative diseases.…”
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Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion by Zhao-Di Yuan, Wei-Ning Zhu, Ke-Zhi Liu, Zhan-Peng Huang, Yan-Chuang Han

“…Although innovative technologies for somatic cell reprogramming and transdifferentiation provide new strategies for the research of translational medicine, including disease modeling, drug screening, artificial organ development, and cell therapy, recipient safety remains a concern due to the use of exogenous transcription factors during induction. …”
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Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos by Lihong Liu, Siyao Ha, Dan Cao, MingQing Li, Zhiling Li

“…This impairment might underpin the mechanism that impacts embryonic development. Collectively, our study not only verified the crucial role of MERVL in embryonic development but also probed its regulatory function in DNA methylation reprogramming, thereby laying a solid foundation for further investigations into MERVL's role.…”
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A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research by Sára Kálmán, Edit Hathy, János M. Réthelyi

“…Neuronal differentiation of induced pluripotent stem cells and direct reprogramming represent powerful methods for modeling the development of neurons in vitro. …”
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Metabolism and Immune Suppressive Response in Liver Cancer by Patrizio Caini, Vinicio Carloni

“…Hepatocellular carcinoma (HCC) constitutes more than 90% of the primary tumor of the liver. Metabolic reprogramming is decisive in promoting HCC development. …”
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Targeting glutamine metabolism as a potential target for cancer treatment by Wenxuan Zou, Zitao Han, Zihan Wang, Qian Liu

“…Abstract Metabolic reprogramming is a hallmark of cancer cells, and the advent of “glutamine addiction” in numerous tumors signifies a pivotal advancement for precision-targeted therapy. …”
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Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. by Michael K Skinner, Matthew D Anway, Marina I Savenkova, Andrea C Gore, David Crews

“…These observations demonstrate that an embryonic exposure to an environmental compound appears to promote a reprogramming of brain development that correlates with transgenerational sex-specific alterations in the brain transcriptomes and behavior. …”
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Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues by Carmen Unzu, Marc Friedli, Alexis Bosman, Marisa E. Jaconi, Barbara E. Wildhaber, Anne-Laure Rougemont

“…Random integration of transgenes and the use of potent protooncogenes such as myc might be a risk factor for malignant tumor development if hepatocytes are used for reprogramming. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. …”
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