Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma by Jiafen Xie, Xiaoming Wang

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Checklist for Professional Communication: A Path to a Healthy Personality, Reflective Mindfulness, and Self-Development Management by Bahaudin G. Mujtaba, Chance Meyer

“…The reality is that the human mind is a complex biological machine that is programmed and reprogrammed from the time of one’s conception until the day we die. …”
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Free Methylglyoxal and Lactate Produced and Released by Cultured Cancer and Non-Cancer Cells: Implications for Tumor Growth and Development by Dominique Belpomme, Philippe Irigaray, Jean-Marc Alberto, Clément Poletti, Charlotte Hinault-Boyer, Stéphanie Lacomme

“…From this data, we propose that in malignant tumors, both cancer and fibroblastic stromal cells may contribute to tumor growth and development by producing via glycolysis both free MG and D-lactate, which, in addition to L-lactate, may be part of the core hallmark of cell metabolic reprogramming in cancer.…”
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Machine learning-based integration develops a metabolism-derived consensus model for improving immunotherapy in pancreatic cancer by Yang Song, Cheng Yang, Jie Min, Lei Hua, Haichuan Su, Ting Zhao, Yongdong Guo, Ronglin Wang, Jingjie Shi, Peixiang Ma, Junqiang Li

“…PAC cells undergo metabolic reprogramming, which is thought to modulate the tumor microenvironment (TME) and affect immunotherapy outcomes. …”
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Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics by Gina Chia-Yi Chu, Leland W.K. Chung, Murali Gururajan, Chia-Ling Hsieh, Sajni Josson, Srinivas Nandana, Shian-Ying Sung, Ruoxiang Wang, Jason Boyang Wu, Haiyen E. Zhau

“…This article describes cell signaling network of metastatic prostate cancer (PCa) to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics. The article focuses on our recent progress in the understanding of: 1) The plasticity and dynamics of tumor–stroma interaction; 2) The significance of epigenetic reprogramming in conferring cancer growth, invasion and metastasis; 3) New insights on altered junctional communication affecting PCa bone and brain metastases; 4) Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy; 5) Genetic-based therapy to co-target tumor and bone stroma; 6) PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis; 7) The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis; and 8) Characterization of imprinting cluster of microRNA, in tumor–stroma interaction. …”
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Multi-omics analysis of gestational PM2.5 exposure induces abnormal cardiac metabolism and development in offspring by Li Tian, Qinglin Sun, Jianong Lv, Shiqian Liu, Kexin Zhang, Yang Li, Zhiwei Sun, Lili Cao, Junchao Duan

“…This study aimed to investigate the effects of gestational PM2.5 exposure on offspring cardiac development and to elucidate the potential mechanisms involved. …”
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Non-canonical nuclear function of glutaminase cooperates with Wnt signaling to drive EMT during neural crest development by Nioosha Nekooie Marnany, Alwyn Dady, Isabelle Duband-Goulet, Frédéric Relaix, Roberto Motterlini, Roberta Foresti, Sylvie Dufour, Jean-Loup Duband

“…Abstract Metabolic reprograming has been linked to epithelial-to-mesenchymal transition (EMT) in cancer cells, but how it influences EMT in normal cells remains largely unknown. …”
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Quality assessment strategy development and analytical method selection of GMP grade biological drugs for gene and cell therapy by Quan-en Yang, Nicole Lee, Nicole Johnson, Jennifer Hong, Jenny (Qinghua) Zhao, Xiulian Sun, Jian Zhang

“…Biological drugs with gene and cell therapy potentials, including natural or rationally created biomacromolecules, recombinant proteins/enzymes, gene-carrying DNA/RNA fragments, oncolytic viruses, plasmid and viral vectors or other gene delivering vehicles with specific therapeutic genes and gene manipulation tools, and genetically modified and reprogrammed human cells comprise a large fraction of drug development candidates in modern precision and regeneration medicine. …”
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Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms by Jianfeng Wu, Siqi Huang, Lihao Chen, Yinghong Yang, Shunhan Zhang, Jiajia Xian, Jiajia Xian, Xiaoyan Ma, Xiaoyan Ma, Furong Ma, Shaoying Li, Shaoying Li, Yi Yang, Yingjun Xie, Xiaofang Sun

“…These patient-derived iPSCs were reprogrammed from somatic cells and subsequently characterized. …”
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Novel multi-omics analysis revealing metabolic heterogeneity of breast cancer cell and subsequent development of associated prognostic signature by Peng Zhang, Cuicui Li, Fen Li, Jiezhong Wu, Kunpeng Hu, He Huang

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Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia by Huynh Cao, Jeffrey Xiao, David J. Baylink, Vinh Nguyen, Nathan Shim, Jae Lee, Dave J. R. Mallari, Samiksha Wasnik, Saied Mirshahidi, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Yi Xu

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Prospects of emerging 3D bioprinting technologies: major technology components, technology developers, and end users—Part I by Prasanta K. Ghosh

“…Advancements in technologies such as cellular reprogramming hold the potential to enhance the development of superior bioinks, thereby enabling the fabrication of 3D bioprinted tissues. 3D bioprinting technology offers significant benefits across research, personalized medicine, and other applications. …”
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Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cells. by Mariana de Napoles, Tatyana Nesterova, Neil Brockdorff

“…<h4>Principal findings/methodology</h4>We present evidence that the epigenetic reprogramming of the inactive X-chromosome is initiated earlier than was previously thought, around the time that primordial germ cells (PGCs) migrate through the hindgut. …”
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A high throughput assay for phosphoribosylformylglycinamidine synthase by Nandini Sharma, Yuka Otsuka, Louis Scampavia, Timothy P. Spicer, Jarrod B. French

“…Metabolic reprogramming of purine biosynthesis is a hallmark of cancer metabolism and represents a critical vulnerability. …”
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Investigating how dengue virus-induced metabolic changes affect the host immune response and how to develop Immunomodulatory strategies by Fatemeh Amini Chermahini, Pooria Mohammadi Arvejeh, Francesco M. Marincola, Sajjad Ahmad, Ramtin Naderian, Omid Pajand, Majid Eslami, Maliheh Hasannia, Samira Sanami

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Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis by Xinping Huang, Hailong Shu, Man Xu, Weixiao Ke, Wanting Chen, Wenbin Huang, Hai Wang, Yifan Zhu, Yongxia Yang

“…Conclusion Taurine metabolic reprogramming can serve as a potential marker for early breast cancer diagnosis. …”
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A pathogen effector HaRxL10 hijacks the circadian clock component CHE to perturb both plant development and immunity by Mengyao Fu, Yaoyu Zhou, Xin Zhang, Keyi Yang, Yufeng Xu, Xingwei Wang, Zhaodan Chen, Yu Wang, Yabo Shi, Lin Ma, Hanguang Liu, Yuhua Deng, Shujing Cheng, Jinfang Chu, Jingyi Song, Tongjun Sun, Yuanchao Wang, Wei Wang, Mian Zhou

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Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications by Qiang Zeng, Junfeng Tao, Lilu Qin, Yong Zeng, Zhong Liu, Mingxian Xu, Linshan Zeng

“…LASSO regression models were developed for risk stratification, and model accuracy was evaluated using time-dependent ROC curves. …”
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The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription by Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang

“…Abstract Metabolic processes and epigenetic reprogramming are intricately interconnected; however, their mechanistic interplay remains unclear. …”
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Transcriptome and 2-DE proteome analyses reveal defense-associated development in the leaf galls induced by psyllids on Machilus japonica var. kusanoi by Tin-Han Shih, Jian-Liang Chen, Meng-Yuan Huang

“…During infection, secondary metabolites are synthesized to mitigate the oxidative stress whereas growth and cellular processes in infected tissues are reprogrammed. Although the regulatory networks of growth-related phytohormones are recognized as the main component in gall formation, other factors like oxidative stress might also being critical in gall development. …”
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