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Direct Cardiac Reprogramming: Progress and Promise
Published 2018-01-01“…Finally, we discuss the development of safer reprogramming approaches for future clinical application.…”
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Trajectories of macrophage ontogeny and reprogramming in cancer
Published 2025-05-01“…Dicer1 inactivation interfered with this trajectory and stalled TAMs at an intermediate state, impeding immunosuppressive and M2-like TAM development. This reprogramming translated into enhanced response to antiangiogenic immunotherapy in an orthotopic lung cancer model. …”
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Advances in the Study of Metabolic Reprogramming in Gastric Cancer
Published 2025-05-01“…Methods Recent research has demonstrated that metabolic reprogramming—including alterations in glucose, lipid, and amino‐acid metabolism—plays a critical role in both the development and progression of this disease. …”
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Advances in MicroRNA-Mediated Reprogramming Technology
Published 2012-01-01“…Several approaches for ESC-specific miRNA-mediated reprogramming have been developed using cancer and somatic cells to generate ESC-like cells with similarity to iPSCs and/or hESCs. …”
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Post-translational modifications and the reprogramming of tumor metabolism
Published 2025-05-01“…Abstract Metabolic reprogramming occurs alongside tumor development. As cancers advance from precancerous lesions to locally invasive tumors and then to metastatic tumors, metabolic patterns exhibit distinct changes, including mutations in metabolic enzymes and modifications in the activity of metabolic regulatory proteins. …”
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Transcriptional reprogramming in oral squamous cell carcinoma
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The role of macrophage metabolic reprogramming in myocardial infarction
Published 2024-11-01“…This review summarizes the phenomenon of metabolic reprogramming in macrophages after MI and its impact on the regulation of inflammation and tissue repair after MI, providing more perspectives and scientific evidence for the development of macrophage-targeted therapeutic strategies.…”
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Metabolic Reprogramming in Melanoma: An Epigenetic Point of View
Published 2025-06-01“…Metabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. …”
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Somatic cell reprogramming for Parkinson's disease treatment
Published 2025-03-01“…In recent years, novel therapeutic strategies have been developed, such as cell reprogramming, trying to generate more DA in PD treatment. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
Published 2024-12-01“…Abstract Background The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross‐talk between the immune system and insulin‐producing beta cells, has hindered the development of effective disease‐modifying therapies. …”
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CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice
Published 2021-07-01“…We have previously identified somatic cell nuclear transfer-reprogramming resistant genes (SRRGs) that are highly enriched for genes essential for spermatogenesis, although many of them remain uncharacterized in knockout (KO) mice. …”
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Epigenetic reprogramming in mouse and human primordial germ cells
Published 2024-12-01“…Recent findings related to these processes provide a comprehensive overview of germline epigenetic reprogramming and its importance in mouse and human PGC development. …”
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Metabolic reprogramming in lung cancer and its clinical implication
Published 2024-12-01“…This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. …”
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Reprogramming Heritage: An Approach for the Automatization in the Adaptative Reuse of Buildings
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Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors
Published 2025-05-01“…This review discusses the molecular mechanisms by which hypoxia regulates angiogenesis and metabolic reprogramming in vascular tumors, highlighting the intricate link between these processes, and explores potential therapeutic strategies to target these pathways in order to develop effective treatment strategies for patients.…”
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Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm
Published 2024-11-01“…The limitation of the current management is that most patients can only be followed up until the AAA diameter increases to a threshold, and surgical intervention is recommended. The development of preventive and curative drugs for AAA is urgently needed. …”
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Engineering fibroblast with reprogramming and spheronization for bone defect repair
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PKM2-mediated metabolic reprogramming of microglia in neuroinflammation
Published 2025-04-01“…Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. …”
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Cellular Reprogramming Using Defined Factors and MicroRNAs
Published 2016-01-01“…Induced pluripotent stem (iPS) cells have been recently developed using defined reprogramming factors such as Nanog, Klf5, Oct3/4 (Pou5f1), Sox2, and Myc. …”
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Metabolic reprogramming of macrophages in the context of type 2 diabetes
Published 2024-10-01“…Macrophages play a crucial role in this context, influencing both the development and progression of insulin resistance. These innate immune cells respond to inflammatory stimuli and reprogram their metabolism, directly impacting the pathophysiology of T2D. …”
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