Tracing the development of CAR-T cell design: from concept to next-generation platforms by Ahdab A. Alsaieedi, Ahdab A. Alsaieedi, Kawther A. Zaher

“…This review elucidates the fundamental rationale behind CAR-T cell development and addresses key biological challenges encountered. …”
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Assessing in-vitro models for microglial development and fetal programming: a critical review by Steven Schepanski, Steven Schepanski, Gonza B. Ngoumou, Gonza B. Ngoumou, Claudia Buss, Claudia Buss, Claudia Buss, Claudia Buss, Georg Seifert, Georg Seifert

“…This review evaluates in-vitro models for studying how maternal influences during pregnancy impact the development of offspring microglia, the immune cells of the central nervous system. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…Specifically, we focus on the role of succinylation modification mediated by SIRT5 in tumor progression, highlighting how desuccinylation by SIRT5 modulates tumor development and delineating the underlying mechanisms involved.…”
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Early rumen development in calves: Biological processes and nutritional strategies—A mini-review by M.H. Ghaffari, H.M. Hammon, C. Koch

“…The transformation of the reticulo-rumen (hereafter rumen) from a monogastric state to a functional rumen during early calf development is driven by complex transcriptional reprogramming and changes in metabolic pathways. …”
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Role and molecular mechanism of epigenetic regulation during the development and pathogenesis of plant pathogenic fungi by SUN Ziyue, TAO Zeng

“…Increasing evidence suggests that epigenetic regulation plays a crucial role in transcriptional reprogramming of plant pathogenic fungal genes, which affects their development, environmental stress response, biosynthesis of secondary metabolites and pathogenicity. …”
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Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development by Guoming Chen, Bonan Chen, Yilin Wu, Hao Nie, Zilan Zhong, Shuyang Yang, Rui Qin, Wei Kang, Cheng Zhang, Ning Wang, Yibin Feng

“…Importantly, CAFs have been implicated in the pathogenesis of tumor cachexia through their ability to modulate inflammation, metabolic reprogramming, and immune responses. Given the intricate interplay between the TME, CAFs, and cachexia, understanding the mechanisms underlying these interactions is essential for developing effective therapeutic strategies to mitigate cachexia and improve patient outcomes. …”
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Human T-cell leukemia virus type 1: oncogenic potential and vaccine development strategies by Jorge Vasconez-Gonzalez, Isaac A. Suárez-Sangucho, Esteban Acosta-Muñoz, Luis Paz y Miño, Domenic Borja-Mendoza, John Altamirano Alexander-Castillo, Julia Saa, Natasha Salazar-Calvopiña, Paúl Cárdenas, Andrés López-Cortés, Esteban Ortiz-Prado

“…Among the key risk factors for ATLL development are high proviral load, reduced anti-Tax immune responses, and elevated levels of soluble interleukin-2 receptor. …”
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Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes by Shoupeng Ding, Chunxiao Huang, Jinghua Gao, Chun Bi, Yuyang Zhou, Zihan Cai

“…Conclusions Our findings reveal that TCM–DEGs critically regulate TB progression through immune–metabolic reprogramming and cell–cell communication networks. The developed diagnostic model and molecular subtyping strategy enable precise TB–LTBI differentiation and inform immunotherapy optimization.…”
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Research progress on the role of histone acetylation regulatory factors during the early embryonic development in animals by LI Xiaoteng, ZHAO Panpan, ZHANG Kun

“…Following sperm-egg fusion, animal embryos undergo severe epigenetic reprogramming during the early development, encompassing DNA methylation, histone modification, as well as chromatin remodeling, to ensure that highly differentiated gametes form totipotent embryonic cells upon fertilization. …”
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Plant Signaling Hormones and Transcription Factors: Key Regulators of Plant Responses to Growth, Development, and Stress by Ayomi S. Thilakarathne, Fei Liu, Zhongwei Zou

“…Plants constantly encounter a wide range of biotic and abiotic stresses that adversely affect their growth, development, and productivity. Phytohormones such as abscisic acid, jasmonic acid, salicylic acid, and ethylene serve as crucial regulators, integrating internal and external signals to mediate stress responses while also coordinating key developmental processes, including seed germination, root and shoot growth, flowering, and senescence. …”
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Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health by Aron Moazamian, Fabrice Saez, Joël R. Drevet, Robert John Aitken, Parviz Gharagozloo

“…We discuss how this lesion can disrupt key epigenetic mechanisms such as DNA methylation, histone modifications, and small non-coding RNAs, thereby influencing fertilization outcomes, embryo development, and offspring health. We propose that the interplay between oxidative DNA damage and epigenetic reprogramming is further exacerbated by aging in both the paternal and maternal germlines, creating a “perfect storm” that increases the risk of heritable (epi)mutations. …”
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Proteomic profiling reveals important regulators of photosynthate accumulation in wheat leaves during grain development by Wanting Li, Xiangrui Liu, Zeyu Shi, Yifei Wang, Wenqiang Tang, Huimin Ren, Baowen Zhang

“…Abstract Background Wheat yield potential is intrinsically linked to the efficiency of photosynthetic carbon fixation and subsequent allocation to developing grains. While leaves are recognized as the dominant source of photosynthate, the molecular drivers governing temporal shifts in source tissue function during grain filling remain unresolved, leaving a critical gap in knowledge about the proteomic reprogramming underlying natural developmental transitions. …”
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Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3 by Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou

“…Together, these findings provide new insights into MFN1's role in regulating epigenetic reprogramming during preimplantation embryo development.…”
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Phytomers, collet and founder cells: a “universal” plant embryonic body plan from a developmental, molecular, and evolutionary perspective by Prakash Venglat, Perumal Vijayan, Timothy F. Sharbel, Abidur Rahman, Abidur Rahman, Karen Tanino

“…This conceptual model is grounded in a Reprogramming Potential (RP) involving an activation (RP1+) -suppression (RP1-) switch (RP1+/RP1-), which integrates embryonic development in a stepwise manner across diverse embryophytes. …”
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DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos. by Jia Tao, Yu Zhang, Xiaoyuan Zuo, Renyun Hong, Hui Li, Xing Liu, Weiping Huang, Zubing Cao, Yunhai Zhang

“…Incomplete epigenetic reprogramming of the genome of donor cells causes poor early and full-term developmental efficiency of somatic cell nuclear transfer (SCNT) embryos. …”
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Exploring the Interplay between the Warburg Effect and Glucolipotoxicity in Cancer Development: A Novel Perspective on Cancer Etiology by Maher Monir Akl, Amr Ahmed

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Advances in the mechanism of small extracellular vesicles promoting the development of hepatocellular carcinoma through multi-network fusion by Xiaoying Yuan, Defa Huang, Liang Peng, Yilong Lin, Lijuan Wang, Jiawei Yan, Youming Qiu, Chenggui Song, Qi Wang

“…Such communication facilitates TME reprogramming, pro-angiogenic phenotypic shifts, and therapy resistance development. …”
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Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer by Kouta Niizuma, Toshinobu Nishimura, Jonathan Villanueva, Laura Amaya, Jonas L. Fowler, Taichi Isobe, Yusuke Nakauchi, Brandon Saavedra, Haojun Xu, Mahito Nakanishi, Adam C. Wilkinson, Kyle M. Loh, Joseph B. Shrager, Hiromitsu Nakauchi

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Improving porcine in vitro blastocyst development using fetal bovine serum, amino acids, and insulin-transferrin-selenium by Ba Anh My LE, Lien Boi Linh NGUYEN, Chi Thien LAM, Nhat-Thinh NGUYEN, Ngoc Thao Vy NGUYEN, Van Thuan NGUYEN, Hong-Thuy BUI

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Interference of estrogen signaling by endocrine disruptors in male and female cells: Potential implications of BPS and PFOS in human development by Giulia Gaggi, Andrea Di Credico, Sandra Bibbò, Barbara Corneo, Alberto Ferlin, Angela Di Baldassarre, Barbara Ghinassi

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