27-Hydroxycholesterol in cancer development and drug resistance by Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska, Yuan Guo, Sihe Zhang

“…This review offers an updated role of 27HC in cancer biology, setting the stage for future research and the development of targeted therapeutics.…”
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Drug-tolerant persister cell in cancer: reversibility, microenvironmental interplay, and therapeutic strategies by Haifeng Li, Wenlong Xu, Wenqi Cheng, Guanxiao Yu, Dongmei Tang, Dongmei Tang

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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer by Tianyue Sun, Yan Chen, Ying-Xuan Chen

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Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system by Dapeng Li, Dapeng Li, Yuanfan Li, Yuanfan Li, Jie Cang, Xianwen Yan, Feipeng Wu, Xuan Sun, Wenchao Zhang

“…Its treatment is complicated by chemotherapy-induced toxicity and limited induction of immunogenic cell death (ICD).MethodsTo address these challenges, we developed a pH-responsive, multi-component nanoparticle system designed to co-deliver doxorubicin (DOX), monophosphoryl lipid A (MPLA), and a PD-1/PD-L1-targeting peptide, integrated with the immune-modulating polymer PEG-PC7A. …”
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The Generation of Two Induced Pluripotent Cell Lines from Patients with an Atypical Familial Form of Lung Fibrosis by Eid Al-Mutairy, Somaya M. Al Qattan, Faiqa Imtiaz, Azizah AlAnazi, Angela Inglis, Rana Al-Rabiah, Reem S. Al-Hejailan

“…<b><i>Results</i></b>: We show that the reprogrammed cells carry mutations in the calcium-binding protein genes S100A3 and S100A13, leading to diminished protein expression, thus mimicking the patients’ cells. …”
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Endothelial Cpt1a Inhibits Neonatal Hyperoxia‐Induced Pulmonary Vascular Remodeling by Repressing Endothelial‐Mesenchymal Transition by Xiaoyun Li, Katy Hegarty, Fanjie Lin, Jason L. Chang, Amro Abdalla, Karthik Dhanabalan, Sergey O. Solomevich, Wenliang Song, Karim Roder, Chenrui Yao, Wenju Lu, Peter Carmeliet, Gaurav Choudhary, Phyllis A. Dennery, Hongwei Yao

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The Role of Cholesterol Metabolism and Its Regulation in Tumor Development by Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao

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The correlation between obesity and the occurrence and development of breast cancer by Jun-Jie Hu, Qi-Yue Zhang, Zhi-Chun Yang

“…Abstract This study reviews the mechanisms by which obesity affects the development and progression of breast cancer (BC). The association between obesity and BC is mainly due to three aspects: disruption of glycolipid metabolism, abnormal cell function and imbalance of adipokine levels. …”
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Role of TRAP1 Protein in the Development and Progression of Glioblastoma by I. F. Gareev, A. S. Yasinskaya, S. A. Roumiantsev, A. A. Bukhvostov

“…The role of TRAP1 lies in enhancing or suppressing oxidative phosphorylation, with the impact of such regulation on tumor development and progression being a matter of ongoing debate. …”
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Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA by Shan Huang, Yuanyuan Liu, Manyu Zhao, Tao Wang, Lihua Mao, Ting Wang, Chunyuan Guo, Wentao Huang, Zimei Peng, Zhen Zhang, Rui Jiang, Xinrui Ma, Nimei Shen, Jun Rao, Xing Wang, Zhi Zheng, Lixiao Chen

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Persistent lineage plasticity driving lung cancer development and progression by Fanchen Meng, Jianyu Li, Zhijun Xia, Qinglin Wang, Qinhong Sun, Siwei Wang, Lin Xu, Rong Yin

“…Clinically, tumours can shift between these states, reflecting lineage plasticity—the reprogramming of differentiated cells to alternate identities. …”
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Effects and mechanisms of aflatoxin B1 on oocytes and embryo development by Lang Li, Yangyong Dong, Jiafu Zhao, Yuemin Li, Zhenzhen Wang, Bin Liu, Jingyi Chen, Tongyao Wang, Huihui Gao, Xiong Xiao, Yongju Zhao, Xiaoyan Qiu

“…This cascade ultimately impedes oocyte maturation and compromises embryonic developmental competence. This study provides novel insights into the reproductive toxicity of AFB1 and establishes a scientific foundation for developing effective preventative and therapeutic strategies.…”
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Transcription Factors Involved in Plant Stress and Growth and Development: NAC by Chenjia Zheng, Qin Yang, Xin Wang, Yu Chen, Ruoyu He, Xinmeng Li, Huanhuan Pan, Renying Zhuo, Tongbao Qu, Wenmin Qiu

“…This review systematically analyses the multidimensional regulatory mechanisms of NAC transcription factors in developmental processes such as cell wall remodelling, root system architecture, leaf senescence and fruit ripening, and reveals their molecular basis for responding to biotic/abiotic stresses through strategies such as hormone signalling integration (ABA, SA, JA, etc.), antioxidant defence activation and metabolic reprogramming. …”
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Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis by Peize Yu, Peize Yu, Qikai Zhong, Qikai Zhong, Xinlei Wang, Xinlei Wang, Yifang Liu, Qiang Liu, Qiang Liu, Yuqiang Zhang, Jiawei Lu, Yang Dong, Cong-hui Han, Cong-hui Han

“…ATP1A1, a core gene, was associated with metabolic reprogramming and chemotherapy sensitivity across multiple cancers. …”
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Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring by Meihua Zhang, Munan Ma, Jinping Wang, Yijun Wang, Xinrui Yang, Songtao Fu

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The musculotendinous interface: insights into development, injury, and recovery for military medical applications by Alex T. Adams, Alex T. Adams, Zachary G. Davis, Zachary G. Davis, Kyle F. Browder, Kyle F. Browder, Christopher L. Dearth, Christopher L. Dearth, Stephen M. Goldman, Stephen M. Goldman

“…Based on these insights, the review discusses promising therapeutic approaches for treating these injuries, such as anabolic agents, metabolic reprogramming, scaffold or cell-based therapies, and physical therapy. …”
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Development of an accurate breast cancer detection classifier based on platelet RNA by Wenlong Xie, Jie Hu, Zehang Zhao, Huixin Lu, Yu Han, Boan Li, Zhong Ouyang

“…Abstract Platelets possess cancer-induced reprogramming properties, thereby contributing to RNA profile alterations and further cancer progression, while the former is considered a promising biosource for cancer detection. …”
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Developments in the study of the role of lactate metabolism in the genesis and progression of thyroid cancer by Lei Shi, Lei Shi, Lei Shi, Xuyang Zhong, Jiafeng Liu, Yong Ying, Zibing Liao, Jin Liu, Liwen Zhao, Jianing Zhong, Jianing Zhong, Xiangtai Zeng, Xiangtai Zeng

“…Lactate metabolism and lactylation modification roles in carcinogenesis and development have garnered more interest in recent years. …”
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Cell lineage specification and its regulation mechanisms during mammalian preimplantation development by WANG Han, ZHAO Panpan, ZHANG Kun

“…In developmental biology, chromatin reprogramming, degradation of maternal factor, and embryo genomic activation take place after fertilization. …”
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Emerging role of microglia in the developing dopaminergic system: Perturbation by early life stress by Kaijie She, Naijun Yuan, Minyi Huang, Wenjun Zhu, Manshi Tang, Qingyu Ma, Jiaxu Chen

“…These conditions, primarily involving abnormal development and damage of the dopaminergic system, pose significant public health challenges. …”
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