A new class of human CpG Island promoters with primate-specific repeats by K. Naga Mohan, Anuhya Anne, Lov Kumar, J. Richard Chaillet

“…In summary, the incorporation of TRs in certain CGI promoters in mammalian evolution results in the unique ability to acquire methylation during human embryonic development and resist reprogramming to a pluripotent stem cell state with an effect on gene expression.…”
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Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation by Li Liu, Qingqing Zhao, Daigang Xiong, Dan Li, Jie Du, Yunfei Huang, Yan Yang, Rui Chen

“…Abstract Metabolic reprogramming is widely recognized as a hallmark of malignant tumors, and the targeting of metabolism has emerged as an appealing approach for cancer treatment. …”
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M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair by Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan

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Smart biomimetic “nano-med-fireman” blocking inflammation and lactate metabolism crosstalk for normalized spatiotemporal photo-immunotherapy by Honglin Huang, Ningxi Li, Li Zeng, Qianyi Zeng, Ziman Yang, Jinyang Shen, Xiaodan Wei, Hong Yang, Dengfeng Wang, Yiyao Liu, Chunhui Wu

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Unraveling the immune evasion mechanisms in the tumor microenvironment of head and neck squamous cell carcinoma by Xuri Zhao, Yaping Zhu, Youya He, Weiyan Gu, Qi Zhou, Bei Jin, Shenguo Chen, Haisheng Lin

“…This framework provides a theoretical foundation for the development of multi-targeted combination therapies and offers innovative strategies to overcome immune evasion. …”
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Metabolomic and Molecular Mechanisms of Glycerol Supplementation in Regulating the Reproductive Function of Kazakh Ewes in the Non-Breeding Season by Ying Nan, Baihui Jiang, Xingdong Qi, Cuifang Ye, Mengting Xie, Zongsheng Zhao

“…This study reveals the central role of metabolic reprogramming in regulating seasonal reproduction in ruminants.…”
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Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation by Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo

“…NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming. This study aimed to examine the molecular mechanisms underlying the involvement of NSUN2 in immune evasion and metabolic reprogramming of HCC. …”
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Challenges in the preclinical design and assessment of CAR-T cells by Radu Tomai, Radu Tomai, Javier De Las Rivas, Bogdan Fetica, Bogdan Fetica, Rui Bergantim, Rui Bergantim, Rui Bergantim, Rui Bergantim, Brankica Filipic, Zarko Gagic, Katarina Nikolic, Diana Gulei, Diana Gulei, David Kegyes, David Kegyes, Madalina Nistor, Madalina Nistor, Ximena Maria Muresan, Ximena Maria Muresan, Diana Cenariu, Diana Cenariu, Richard Feder, Richard Feder, Mariana Pavel-Tanasa, Andrei Cianga, Adrian Bogdan Tigu, Adrian Bogdan Tigu, Raluca Munteanu, Raluca Munteanu, Alina Tanase, Hermann Einsele, Hermann Einsele, Hermann Einsele, Ciprian Tomuleasa, Ciprian Tomuleasa

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Targeting mitochondria: a novel approach for treating platinum-resistant ovarian cancer by Xin Cui, Juan Xu, Xuemei Jia

“…Platinum-based chemotherapy is the first-line treatment for ovarian cancer; however, a majority of patients with ovarian cancer experience relapse and develop platinum resistance following initial treatment. …”
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Mapping the Interactome of KRAS and Its G12C/D/V Mutants by Integrating TurboID Proximity Labeling with Quantitative Proteomics by Jiangwei Song, Busong Wang, Mingjie Zou, Haiyuan Zhou, Yibing Ding, Wei Ren, Lei Fang, Jingzi Zhang

“…The study further lays a foundation for developing mutation-specific strategies to counteract KRAS oncogenic signaling.…”
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Rapid generation of secondary fibroblasts through teratoma formation by Sang Mi Cho, Jung Sun Park, Byungkuk Min, Sujin Kwon, Yong-Kook Kang

“…Our results showed that the TOFs retained the capability to mediate cellular reprogramming, similar to that of regular secondary fibroblasts.…”
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Genetic Variation and Metabolic Basis of Kidney Cancer: New Opportunities for Targeted Therapy by M. F. Urmantsev, R. I. Tavabilov, M. R. Bakeev

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Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism by Meng Yu, Xianjuan Zhang, Zhifei Wang, Shan Wang, Jun Li, Huan Huang, Xu Li, Chen Wang, Wen Shen, Weiwei Sun, Jie Yu, Wanming Zhang, Yunyang Wang, Bin Wang

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Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration by Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi

“…Abstract The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect the development of various diseases. However, the relationship between metabolic reprogramming and intervertebral disc degeneration (IVDD) remains unclear. …”
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Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis by Chenyang Hu, Shenghua Zhang, Fugang Duan, Xinmei Huang, Jing Huang, Zhu Zhu, Xiaoning Mo, Weiyan Xu, Lina Wu, Zhimin Fan, Xiaoyan Qiu

“…Conclusions These findings suggest that SIA-IgG, by enhancing glycolysis and the lactate cycle, induces metabolic reprogramming and thereby promotes the development of TNBC, making it a promising target for targeted therapy in TNBC.…”
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Effects of anesthetics on development of gynecological cancer by Yingxiang Cheng, Yunzhi Wu, Lingzhong Xu

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Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer by Lizhuo Zhang, Qingqing Feng, Chuanming Zheng, Yuanqiang Li, Xinyang Ge, Tiefeng Jin, Gaofeng Hu, Zhuo Tan, Jiafeng Wang, Jiajie Xu, Liehao Jiang, Dan Wang, Zhangguo Ying, Xiao Zhao, Keman Cheng, Qinglin Li, Minghua Ge

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A model for accelerating a life cycle of research and development based on example of development of genetic cell re-programming by L. A. Tsvetkova

“…An analysis was conducted of a model for accelerating the life cycle of research and development, as well as temporary parameters for transforming fundamental industrial perspective using an example of reprogramming technologies for obtaining induced pluripotent stem cells. …”
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Generation of footprint-free human induced pluripotent stem cell line (SCIKFi001-B) from cGMP grade umbilical cord-derived mesenchymal stem cells (UC-MSCs) using episomal-plasmid b... by Marchella Tohari, Ricky Sanjaya, Siska Yuliana Sari, Bintang Tedjobagaskara, Andrian Ibnu Faisal, Matheus Alvin Prawira, Anggia Oktaviani Dwi Putri, Naufalia Faza, Harry Murti, Halida P. Widyastuti

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Influences of metabolism and lipid homeostasis on regulatory vs. conventional T cells and implications for autoimmunity by Madison A. Nguyen, Sarah S. Lee, Sarah S. Lee, Craig M. Walsh, Craig M. Walsh, Craig M. Walsh

“…This suppressive nature of regulatory T cells is largely due to their metabolic profiles determined by metabolic reprogramming upon activation and subsequent differentiation. …”
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