The Role of the CPT Family in Cancer: Searching for New Therapeutic Strategies by Yanxia Duan, Jiaxin Liu, Ailin Li, Chang Liu, Guang Shu, Gang Yin

“…Therefore, we look at molecular structural properties of the CPT family, the roles they play in tumorigenesis and development, the target drugs, and the possible regulatory roles of CPTs in energy metabolism reprogramming to help understand the current state of CPT family research and to search for new therapeutic strategies.…”
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Research progress on the advantages, mechanisms and design strategies of nanomaterials for immunomodulatory angiogenesis by Yuxiao Luo, Xiaohe Zhou, Jiling Xie, Ziwei Chen, Yupeng Wu, Zedong Lan, Liangjiao Chen

“…This review provides a theoretical basis for an in-depth understanding of NMs and immunomodulatory vascularization for tissue regeneration to optimize the design strategy, rational development and clinical application of NMs in the field of immunovascularization.…”
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Regulation of dendritic cell biology by amino acids and their transporters by Shanlin Chen, Gongwei Li, Zihao Jiang, Yuekang Xu, Adila Aipire, Jinyao Li

“…Therefore, dysregulation of amino acid metabolism can cause metabolic reprogramming of DCs, leading to or accelerating the occurrence of various immunological disorders, like type 1 diabetes, rheumatoid arthritis, and cancer. …”
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Neutrophil extracellular traps in tumor metabolism and microenvironment by Zhanrui Liu, Yuanyao Dou, Conghua Lu, Rui Han, Yong He

“…These include the interaction of NETs with tumor mitochondria, their effect on redox states within tumors, their involvement in metabolic reprogramming, and their contribution to angiogenesis in tumors. …”
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Advancing veterinary vaccines design through trained immunity insights by Xin Wang, Xin Wang, Xin Wang, Xin Wang, Guohua Yu, Guohua Yu, Guohua Yu

“…Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. …”
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Unravelling the pathways driving tumour growth and resistance by Abraham Ubhenin, Joshua Ikebuiro, Osayemwenre Erharuyi, Yusuf Abdulmalik, Tyem Danjuma

“…Previously thought to be a genetic disease caused by DNA abnormalities, recent research demonstrates the critical role of metabolic reprogramming in cancer development. Cancer cells experience severe metabolic changes in the tumour microenvironment (TME), which include nutritional deprivation, hypoxia, and low pH. …”
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IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming by Anbo Gao, Juan Zou, Tian Zeng, Mei Qin, Xing Tang, Ting Yi, Guangming Song, Jie Zhong, Yuhuan Zeng, Wenchao Zhou, Qin Gao, Qunfeng Zhang, Juan Zhang, Yukun Li

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Molecular and epigenetic pathogenesis of germ cell tumors by Melanie R. Müller, Margaretha A. Skowron, Peter Albers, Daniel Nettersheim

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Peptide Drug: Design and Clinical Applications by Yaqi Han, YunKui Zhang, Han Li, Zhongliang Ma, Yanmao Wang

“…They exert critical roles in disease‐associated metabolic reprogramming and immune modulation by activating cell signaling pathways, regulating metabolic processes, and immune cell functions. …”
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulationResearch in context by Xuguang Li, Nobuaki Shiraki, Takami Watanabe, Rikako Fukui, Kyohei Furukawa, Yusuke Kato, Yuri Nakahara, Shoen Kume, Akashi Taguchi, Youichiro Wada, Dwina Juliana Warman, Kenji Saito, Haruyo Nakajima-Adachi, Satoshi Hachimura, Hisanori Kato, Huijuan Jia

“…Interpretation: Short-term maternal MD during foetal pancreatic development can induce lasting metabolic reprogramming in offspring. …”
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Macrophages and tumor progression: on the way to macrophage-specific therapy by N. V. Cherdyntseva, I. V. Mitrofanova, M. A. Buldakov, M. N. Stakheeva, M. R. Patysheva, M. V. Zavjalova, J. G. Kzhyshkowska

“…Approaches of simultaneous alteration of cancer stem cells and TAM to abolish chemoresistance and inhibit tumor progression are promising. Strategies for reprogramming of macrophages to switch off towards the antitumor phenotype are developing.Thus, an extremely wide range of regulatory and effector activity and high functional plasticity of macrophages promise the development of macrophage-targeted therapeutic agents to modulate relationships between tumor and microenvironment to prevent the tumor progression.…”
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MicroRNA-7 as a multifaceted regulator of tumor glycolytic metabolism: Mechanistic insights and therapeutic perspectives by Yiling Zhu, Jiayi Zhang, Xu Zhao, Mengmeng Guo, Chao Chen, Ya Zhou, Lin Xu

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Energy metabolism in cardiovascular diseases: unlocking the hidden powerhouse of cardiac pathophysiology by Li Chen, Mingtai Chen, Xinrui Yang, Yuanli Hu, Caiwei Qiu, Youyou Fu, Xiaoyu Lan, Gang Luo, Qiuyu Liu, Mengnan Liu

“…Major outstanding questions pertain to the dynamic regulation of metabolic reprogramming and its complex interplay with mitochondrial dysfunction. …”
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Targeting the crosstalk between glutamine metabolism and tumor immune microenvironment for lung cancer immunotherapy by Jingyang Li, Li Xiang, Shaohui Wang, Yingrui Zhang, Shiyi Zhao, Di Zhang, Xianli Meng, Yi Zhang, Jin‐Ming Lin

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Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects... by Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

“…Although advances in cancer therapies and early detection have improved the overall survival of patients, patients still develop resistance or cancer recurrence. Thus, the development of novel therapies that can affect multiple mechanisms of drug resistance and cell survival is ideal for the treatment of advanced and metastatic cancers. …”
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Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation by Samprita Das, Uri Manor

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Dual Roles of SIRT7 Inhibition by Oroxylin A Reprogram HSCs Fate: PRMT5 Succinylation-Driven Senescence and Ecto-Calreticulin-Dependent NK Cell Immune Clearance in Liver Fibrosis by Junrui Wang, Haoyuan Tian, Yuanyuan Gao, Xinran Qiu, Zhengyang Bao, Danli Zhao, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Haibo Cheng, Jiangjuan Shao

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TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis by Xinxing Wang, Mingze Ma, Shuai Shao, Xianwen Xu, Chuan Qin, Ruxin Gao, Zhenhai Zhang

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The Role of the Hexosamine-Sialic Acid Metabolic Pathway Mediated by GFPT1/NANS in c-Myc-Driven Hepatocellular CarcinomaSummary by Shiguan Wang, Pan Han, Ping Mi, Chunxue Wang, Miao Lu, Xinying Li, Bowen Xu, Haoran Wang, Yingchen Gao, Yanlei Hou, Xueying Tan, Jinyuan Liang, Xue Ding, Yan Zhang, Tingguo Zhang, Detian Yuan, Lei Gao, Cuijuan Zhang

“…Background & Aims: Hepatocellular carcinoma (HCC) frequently involves metabolic reprogramming, which promotes oncogenesis and metastasis. …”
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Analysing the loss of embryogenic competence in long-term cell lines of Solanum betaceum Cav.: involvement of miR827, phosphate and sugar by Daniela Cordeiro, Jorge Canhoto, Sandra Correia

“…Therefore, there is a great interest in understanding the gene regulatory networks underlying cell reprogramming during this process. Accordingly, SE in Solanum betaceum Cav. …”
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