Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…We begin with a focused overview of tumour metabolic reprogramming and the enzymology of lactylation, establishing the biochemical context for its regulatory functions. …”
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Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux by Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan

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GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway by Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang

“…Treatment with GLS1 inhibitors or knockdown of GLS1 alleviates osteogenic reprogramming. In contrast, glutamate administration boosts the development of arterial calcification. …”
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HNCDrugResDb: a platform for deciphering drug resistance in head and neck cancers by Akhina Palollathil, Revathy Nandakumar, Mukhtar Ahmed, Anoop Kumar G. Velikkakath, Mahammad Nisar, Muhammad Nisar, Rex Devasahayam Arokia Balaya, Sakshi Sanjay Parate, Vidyarashmi Hanehalli, Althaf Mahin, Rohan Thomas Mathew, Rohan Shetty, Jalaluddin Akbar Kandel Codi, Amjesh Revikumar, Manavalan Vijayakumar, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju

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Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer by Jing Li, Haojun Huang, Renxian Xie, Rongying Yang, Haitao Wang, Li Wan

“…By elucidating the dynamic crosstalk between Tregs and the ovarian TME, this review provides a framework for developing novel immunotherapies to overcome Treg-mediated immunosuppression and improve clinical outcomes.…”
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Urea cycle dysregulation: a new frontier in cancer metabolism and immune evasion by Yiyi Shou, Ruiqi Liu, Hao Xiong, Keke Xu, Xiaoyan Chen, Luanluan Huang, Yitian Zhang, Hailong Sheng, Haibo Zhang, Yanwei Lu

“…Abstract Cancer cells experience metabolic reprogramming to enhance the synthesis of nitrogen and carbon, facilitating the production of macromolecules essential for tumor proliferation and growth. …”
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Classification of the LC4 Primarily-like Cell Line—Recapitulating a CDK4 Overexpressing Immune Evasive HIV-HCV-Induced HCC by Janine Kah, Lisa Staffeldt, Tassilo Volz, Kornelius Schulze, Asmus Heumann, Götz Rövenstrunk, Meike Goebel, Sven Peine, Maura Dandri, Stefan Lüth

“…HCC is characterized by high heterogeneity and, subsequently, adaptation by developing resistance to current treatments. Applying individualized models is crucial to understanding the potential of approved therapies. …”
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Fin Cells as a Promising Seed Cell Source for Sustainable Fish Meat Cultivation by Zongyun Du, Jihui Lao, Yuyan Jiang, Jingyu Liu, Shili Liu, Jianbo Zheng, Fei Li, Yongyi Jia, Zhimin Gu, Jun Chen, Xiao Huang

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Innate epithelial and functional differences in airway epithelium of children with acute wheeze by Kevin Looi, Kevin Looi, Kevin Looi, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Saraya Harrison, Saraya Harrison, Stephen M. Stick, Peter LeSouef, Peter LeSouef, Peter LeSouef, Ingrid A. Laing, Ingrid A. Laing, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic

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Construction of a Dataset for All Expressed Transcripts for Alzheimer’s Disease Research by Zhenyu Huang, Bocheng Shi, Xuechen Mu, Siyu Qiao, Gangyi Xiao, Yan Wang, Ying Xu

“…This work supports future research into gene regulation and metabolic reprogramming in AD and serves as a foundation for exploring novel therapeutic targets.…”
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A nicotinamide metabolism-related gene signature for predicting immunotherapy response and prognosis in lung adenocarcinoma patients by Meng Wang, Wei Li, Fang Zhou, Zheng Wang, Xiaoteng Jia, Xingpeng Han

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A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> by Dorien Dams, Célia Pas, Agnieszka Latka, Zuzanna Drulis-Kawa, Lars Fieseler, Yves Briers

“…<b>Conclusions:</b> This work lays the groundwork for a scalable platform for the development of engineered tailocins, marking an important step towards making R2 tailocins a practical therapeutic tool for targeted bacterial infections.…”
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Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modula... by Fei Xia, Yuqian Lu, Zipeng Gong, Qingchao Tu, Shuntao Liang, Chen Wang, HaiLu Yao, LinYing Zhong, Yuanfeng Fu, Pengbo Guo, Yichong Hou, Xinyu Zhou, Li Zou, Licheng Gan, Weiqi Chen, Jiawei Yan, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Chen Pan, Xiaomei Tao, Jigang Wang, Qingfeng Du, Chong Qiu

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TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway by Qianyi Qi, Bairong Chen, Jinran Wu, Jing Xu, Hongyi Bao, Kangfeng Jin, Lin Chen, Guang Zhu, Feng Wang

“…Background tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies. …”
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Lactic acid metabolism: gynecological cancer's Achilles’ heel by Ting Zhang, Wenchao Zhou, Tingyu Fan, Yuwei Yuan, Xing Tang, Qunfeng Zhang, Juan Zou, Yukun Li

“…Abstract Lactic acid is significantly expressed in many cancers, including gynecological cancer, and has become a key regulator of the proliferation, development, metastasis and invasion of these cancers. …”
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Advances in liver engineering with cell, scaffold, and vascularization by Chunyan Liu, Yulian Wang, Xuqian Zhou, Lei Dong

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Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune... by Yuwei Sun, Wenyang Nie, Zhikai Xiahou, Xiaojing Wang, Wenjia Liu, Zongkai Liu, Zhiheng Lin, Zhaidong Liu

“…The findings underscored the importance of developing specific therapeutic targets, targeting metabolic reprogramming, and overcoming immune evasion, providing new theoretical foundations.…”
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Multi-omics analysis reveals Jianpi formula-derived bioactive peptide-YG-22 potentially inhibited colorectal cancer via regulating epigenetic reprogram and signal pathway regulatio... by Jun Wang, Jun Wang, Lijuan Zhu, Yuanyuan Li, Mingming Ding, Xiyu Wang, Bo Xiong, Hongyu Chen, Lisheng Chang, Wenli Chen, Bo Han, Jun Lu, Qin Shi

“…Furthermore, this study also lays the foundation for further development of peptide-based therapies and highlights the value of combining traditional and modern therapeutic strategies for CRC management.…”
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Emerging Insights into Sall4’s Role in Cardiac Regenerative Medicine by Jianchang Yang

“…Recent research highlights Sall4’s emerging roles in modulating cardiac progenitors and cellular reprogramming, linking its functions to early heart development and regenerative medicine. …”
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Advances in modeling cellular state dynamics: integrating omics data and predictive techniques by Sungwon Jung

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