Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Targeting this metabolic pathway offers a promising strategy for the development of new therapeutic approaches, particularly for overcoming drug resistance and improving outcomes in patients with advanced prostate cancer.…”
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Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells by Xiaoyu Yang, Ailing Kang, Yuanyue Lu, Yafeng Li, Lili Guo, Rongshan Li, Xiaoshuang Zhou

“…Hypoxia-reoxygenated HK-2 cells are accompanied by altered metabolisms such as disturbance of amino acid and nucleotide metabolism, dysregulation of lipid metabolism, increased glycolysis, and metabolic reprogramming, which manifests as a shift in energy metabolism from FAO to glycolysis.Conclusion The development of IRI-induced AKI in HK-2 cells is accompanied by the disturbance of amino acid, nucleotide, and tricarboxylic acid cycle metabolism and specifically metabolic reprogramming of FAO to glycolytic conversion. …”
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Single-cell sequencing and spatial transcriptomics reveal the evolution of glucose metabolism in hepatocellular carcinoma and identify G6PD as a potential therapeutic target by Deyang Xi, Deyang Xi, Yinshuang Yang, Jiayi Guo, Jiayi Guo, Mengjiao Wang, Mengjiao Wang, Xuebing Yan, Chunyang Li

“…BackgroundGlucose metabolism reprogramming provides significant insights into the development and progression of malignant tumors. …”
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Uncovering the research evolution and hotspots of metabolism in renal cell carcinoma over the last decade by Yifan Liu, Junzhe He, Donghao Lyu, Xinyue Yang, Haoyu Zhang, Siqi Tu, Yuntao Yao, Maodong Wei, Yuanan Li, Zihui Zhao, Runzhi Huang, Bingnan Lu, Xiao Xu, Xiuwu Pan

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CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts by Shannon Chiang, Keilah Garcia Netto, John Kokkinos, Koroush S. Haghighi, Aparna S. Raina, Janet Youkhana, Omali Pitiyarachchi, Quach Truong, Daniel Wenholz, John Wilkinson, Olivier Laczka, Xiang Li, Vina R. Aldilla, Naresh Kumar, David Goldstein, George Sharbeen, Phoebe A. Phillips

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Potential effects of PFAS exposure on trained immunity: From mechanisms to health risks by Jingle Qiu, Xia Huo, Yifeng Dai, Yu Huang, Xijin Xu

“…There is growing evidence that PFAS exposure may disrupt trained immunity—a novel form of innate immune memory driven by epigenetic and metabolic reprogramming—thereby enhancing immune responses upon re-exposure to pathogens. …”
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Navigating Metabolic Challenges in Ovarian Cancer: Insights and Innovations in Drug Repurposing by Sara Mikhael, Georges Daoud

“…In recent years, the role of metabolic reprogramming in OC has emerged as a key factor driving tumor progression, therapy resistance, and poor clinical outcomes. …”
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Identification of M0 macrophage associated lipid metabolism genes for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma by Huanjie Zhou, Ming Lao, Zhengui Liang, Huiliu Zhao, Ying Wang, Qiongqing Huang, Chao Ou

“…Abstract Purpose Liver cancer prognosis is associated with M0 macrophages and lipid metabolism reprogramming; however, the prognostic role of M0 macrophage-related lipid metabolism genes in hepatocellular carcinoma (HCC) remains unclear. …”
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Glycan dysregulation as one of major metabolic subtypes is associated with TERC overexpression and poor outcomes in cervical cancer by Yanlei Dong, Xinyuan Zhang, Jingjie Zhao, Qingzhen Hou, Yunhai Yu, Yu Wu, Xing Shi, Lina Wang, Dawei Xu

“…BackgroundMetabolic reprogramming is an important hallmark of cervical cancer (CC), and extensive studies have provided important information for translational and clinical oncology. …”
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Bioengineer mesenchymal stem cell for treatment of glioma by IL‐12 mediated microenvironment reprogramming and nCD47‐SLAMF7 mediated phagocytosis regulation of macrophages by Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu

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MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3/NADH-CoQ axis for OA treatment by Jingdi Zhan, Jing Zou, Qiming Pang, Zhuolin Chen, Junyan Liu, Senrui Liu, Chengcheng Du, Jiacheng Liu, Weikang Zhao, Lili Dong, Wei Huang

“…Methods Inspired by the immune memory of the adaptive immune system, we developed an engineered strategy to impart OA-specific immune memory to MSCs-EVs. …”
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Emerging roles for fatty acid oxidation in cancer by Jialin Ma, Shuxian Wang, Pingfeng Zhang, Sihao Zheng, Xiangpan Li, Juanjuan Li, Huadong Pei

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Single-cell RNA sequencing provides new insights into the interaction between astrocytes and neurons after spinal cord injury in mice by Zhi Tang, Hengyang Lu, Xiao Yang, Mao Wu, Junfeng Yang, Shaoshuo Li, Heng Liu, Junkang Zhou, Bin Tang, Xinyao Du, Fei Xu, Yang Shao, Jianwei Wang

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Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) by Xiaogang He, Haoming Shu, Tian Xu, Minhui Yu, Honglin Li, Yanru Hu, Jiajun Mo, Chunxiang Ai

“…<b>Conclusions:</b> Based on our results of multiomics, <i>pck2</i>, and <i>ldh</i> played main roles in crisping molecular mechanisms in driving the initial metabolic reprogram. Moreover, the addition of the crisping package further activated the ErbB signaling pathway and downstream MAPK signaling pathway to strengthen immune response, promoting muscle fiber development and growth. …”
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Amino acid metabolism-mediated immune cell fate and function in pigs by Liuqin He, Shunshun Jin, Tiejun Li, Yulong Yin

“…The transport, sensing, and mobilization of amino acids drive metabolic reprogramming to support these processes. Therefore, this review focuses on the influence of amino acids on the fate and function of immune cells across development, homeostasis, activation, and effector phases, highlighting the underlying mechanisms. …”
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Targeting Mitochondrial Quality Control for the Treatment of Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Therapy by Wanjuan Pei, Ling Dai, Mingxiao Li, Sihui Cao, Yili Xiao, Yan Yang, Minghao Ma, Minjie Deng, Yang Mo, Mi Liu

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Metabolism and epigenetics in cancer: toward personalized treatment by Xiaoman Zhang, Dequan Liu, Sulan Yin, Yaru Gao, Xiaorui Li, Guangzhen Wu

“…In this review, we have summarized the metabolic and epigenetic regulatory networks in cancer development, including glycolipid metabolic reprograming, the role of metabolites produced by the glut flora and tumor microenvironment, and key epigenetic drivers such as non-coding RNAs (ncRNAs). …”
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Metabolic rewiring in keratinocytes by miR‐31‐5p identifies therapeutic intervention for psoriasis by Mao‐Jie Wang, Huan‐Jie Huang, Yong‐Yue Xu, Harmjan Vos, Can Gulersonmez, Edwin Stigter, Johan Gerritsen, Marc Pages Gallego, Robert van Es, Li Li, Hao Deng, Lin Han, Run‐Yue Huang, Chuan‐Jian Lu, Boudewijn MT Burgering

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Navigating the nano-bio immune interface: advancements and challenges in CNS nanotherapeutics by Chantalle Moulton, Anna Baroni, Erica Quagliarini, Lucia Leone, Lucia Leone, Luca Digiacomo, Marta Morotti, Marta Morotti, Giulio Caracciolo, Maria Vittoria Podda, Maria Vittoria Podda, Ennio Tasciotti, Ennio Tasciotti

“…While challenges remain, advancements in NPs engineering and design have led to the development of NPs using diverse strategies to overcome these challenges. …”
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MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation by Chihiro Hosoda, Seiji Mitani, Asuka Sakata, Shogo Kasuda, Yu Onodera, Yoko Takabayashi, Midori Shima, Kohei Tatsumi

“…Therefore, we aimed to generate CD34-positive cells by the reprogramming of endothelial cells (ECs). Methods: Based on previous reports, seven candidate chemical compounds were selected to reprogram human umbilical vein ECs (HUVECs) to CD34-positive cells. …”
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