Nanosize Non‐Viral Gene Therapy Reverses Senescence Reprograming Driven by PBRM1 Deficiency to Suppress iCCA Progression by Xiwen Wu, Yi Zhang, Yuan Ding, Jiali Yang, Zimin Song, Shuirong Lin, Ruhe Zhang, Jun Wu, Shunli Shen

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Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming by Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao

“…The purified circRNA demonstrates exceptional performance in induced pluripotent stem cells (iPSCs) reprogramming, achieving over 300% reprogramming efficiency with just three OSKMLN circRNA transfection treatments. …”
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Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers by Arnaud Millet, Khaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Fabienne Thomas, Marie-Hélène Laverriere, Edouard Girard, Gael Roth

“…Among the various strategies that have been developed to target these cells, the blockade of the colony-stimulating factor 1 receptor (CSF-1R) receptor is one of the most promising ones. …”
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Cooperative CCL2/CCR2 and HGF/MET signaling enhances breast cancer growth and invasion associated with metabolic reprogramming by Wei Fang, Yuuka Kozai, Diana S. Acevedo, Rebecca Brodine, Haasini S. Gorrepati, Nizhoni Arviso, Paige Cote, Alala Thompson, Zachary Gerdes, Ashley Espinoza, Nick Bergeron, Audrey Brownfield, Nikki Cheng

“…By understanding the mechanisms regulating DCIS progression, we may develop tailored strategies to improve treatment. …”
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The impact of the tumor microenvironment on macrophages by Man Xiao, Xiaoduan Li

“…We also summarize the development of immunotherapies targeting TAMs, which have shown promising results in clinical trials.…”
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Regulatory role of transcription factor c-Myc in the pathogenesis of psoriasis by Yue Cao, Xu-Ping Niu, Kai-Ming Zhang

“…C-Myc is also involved in the induction of metabolic reprogramming of cells in the development of psoriasis, thus exacerbating the excessive proliferation of psoriatic epidermis. …”
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Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets by Hao Xiong, Ruiqi Liu, Keke Xu, Xiaoyan Chen, Luanluan Huang, Yiyi Shou, Yumei Huang, Hailong Sheng, Yanwei Lu, Haibo Zhang

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AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo by Marina Pavlou, Marlene Probst, Lew Kaplan, Elizaveta Filippova, Aric R Prieve, Fred Rieke, Thomas A Reh

“…These results represent a key step forward in developing a cellular reprogramming approach for regenerative medicine in the CNS.…”
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The Mechanism and Dynamic Regulation of Epithelial to Mesenchymal Transition in Ovarian Cancer by Pande Kadek Aditya Prayudi, I Gde Sastra Winata, I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, Kade Yudi Saspriyana, Ketut Suwiyoga

“…The net result of this cellular reprogramming is the acquisition of mesenchymal phenotypes with increased invasive and metastatic potential, stemness properties and chemoresistance. …”
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Naphthenic Acid Fraction Components-Induced Metabolic and Mitochondrial Alterations in Rat Hepatoma Cells: Monitoring Metabolic Reprogramming with Tryptophan–Kynurenine Ratio by Laiba Jamshed, Amica Marie-Lucas, Genevieve A. Perono, Gregg T. Tomy, Jim J. Petrik, Richard A. Frank, L. Mark Hewitt, Philippe J. Thomas, Alison C. Holloway

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Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues by Xiaocui Zhong, Mamona Bilal, Yanqiu Zhou, Xiaojia Yang, Zuchao Qin, Qibing Li, Yang Yang, Ting-Li Han, Ting-Li Han, Min Li

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Molecular Regulation of Antioxidant Defense and Metabolic Reprogramming in Xiaozhan Rice Genotypes: Differential Roles of Salicylic Acid and Melatonin Under Salt Stress by Yang Wu, Yongbo Duan, Xifan Luo, Mingjun Li, Hengjie Gao, Wei Zhu, Fei Zhao, Jian Liu, Wenzhong Zhang

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Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer by Jin Su Kim, Chan Hee Park, Eunyoung Kim, Hee Seung Lee, Jinyoung Lee, Jeehoon Kim, Eun Hee Kam, Sanghee Nam, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Sangwoo Kim, Galam Leem, Seungmin Bang

“…Methods We established 3D organoid cultures using patient-derived conditionally reprogrammed cell (CRC) lines, originally cultured under 2D conditions. …”
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Reprogrammed human lateral ganglionic eminence precursors generate striatal neurons and restore motor function in a rat model of Huntington’s disease by Amy McCaughey-Chapman, Anne Lieke Burgers, Catharina Combrinck, Laura Marriott, David Gordon, Bronwen Connor

“…Methods hiLGEPs were derived by direct reprogramming of adult human dermal fibroblasts (aHDFs) using chemically modified mRNA (cmRNA) and a defined reprogramming medium. hiLGEPs were differentiated in vitro using an optimised striatal differentiation medium. …”
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The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome by Lan Luo, Xiaoli Zhuang, Lin Fu, Ziyuan Dong, Shuyuan Yi, Kan Wang, Yu Jiang, Ju Zhao, Xiaofang Yang, Feilong Hei

“…Understanding their complex pathophysiological mechanisms is crucial for developing new preventive and therapeutic strategies. …”
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Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1 by Debayan Mukherjee, Erminia Romano, Richard Walshaw, Leo A. H. Zeef, Antonia Banyard, Stephen J. Kitcatt, Eleanor J. Cheadle, Karoliina Tuomela, Swati Pendharkar, Aws Al-Deka, Beatrice Salerno, Sophie Raby, Ian G. Mills, Jamie Honeychurch, Tim M. Illidge

“…Using diverse preclinical tumor models of prostate and bladder cancer, including an autochthonous prostate tumor (Pten−/−/trp53−/−) that respond poorly to radiation therapy (RT) and anti-PD-L1 combinations, the key drivers of this resistance within the TME were profiled and used to develop rationalized combination therapies that simultaneously enhance activation of anti-cancer T cell responses and reprogram the immunosuppressive TME. …”
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METTL1-driven nucleotide metabolism reprograms the immune microenvironment in hepatocellular carcinoma: a multi-omics approach for prognostic biomarker discovery by Xie Weng, Yangyue Huang, Zhuoya Fu, Xingli Liu, Fuli Xie, Jiale Wang, Qiaohua Zhu, Dayong Zheng, Dayong Zheng

“…The findings provide novel insights into HCC pathogenesis and pave the way for developing personalized therapeutic strategies based on targeting METTL1 and its associated metabolic pathways.…”
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Metabolic reprogramming signature predicts prognosis and immune landscape in small cell lung cancer: MOCS2 validation and implications for personalized therapy by Junyan Wang, Panpan Sun, Fan Zhang, Yu Xu, Shenghu Guo

“…IntroductionSmall cell lung cancer (SCLC) remains a leading cause of cancer mortality worldwide, characterized by rapid progression and poor clinical outcomes, and the function of metabolic reprogramming remains unclear in SCLC.MethodsWe performed multi-omics analysis using public SCLC datasets, analyzing single-cell RNA sequencing to identify metabolic reprogramming patterns between chemotherapy-resistant and sensitive samples. …”
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TISSUE REGENERATION AND ONCOGENESIS-SIMILARITIES AND DIFFERENCES by V. A. Tkachuk

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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…These advances in uncovering the intricacies of lipid metabolism and TAMs have yielded new insights on tumor development and treatment. In this review, we aim to provide an update on the current understanding of the lipid metabolic reprogramming made by TAMs to adapt to the harsh tumor microenvironment (TME). …”
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