Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming by Liang Liu, Han Wang, Han Wang, Juan Zhou, Jing Lu, Yan Zhang, Haiyan Liu, Li Lu

“…However, the involvement of Nar in DFU development remains poorly understood.MethodsThe polarization traits of bone marrow derived macrophages (BMDMs) with indicated treatments were determined by flow cytometry, immunofluorescence staining, western blot and qRT-PCR. …”
Get full text

TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy by Marialaura Giannaccari, Chiara Florindi, Nora Bloise, Francesco Moccia, Francesco Lodola, Livia Visai

“…TRP channels are involved in critical steps of cancer-related metabolic reprogramming by influencing intracellular Ca2+ signaling. …”
Get full text

Network pharmacological investigation and experimental verification of the peel of Zea mays L. regulating metabolic reprogramming in the treatment of diabetic nephropathy by Andong Wang, Yuru Yang, Yaonan He, Guangtong Chen, Bai Ling, Bai Ling, Xiaotian Cheng, Xiaotian Cheng

“…The effects and mechanisms of YMP on metabolic reprogramming are largely unknown.MethodsThe components of YMP were systematically identified using UPLC-Q-TOF-MS/MS. …”
Get full text

PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2 by Yang Xuejing, Feng Huijing, Kim Jonghwa, Ti Gang, Wang Lin, Wang Kun, Song Dong

“…Mitochondrial division and glycolytic reprogramming play important roles in tumor development. …”
Get full text

M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation by Juan Ji, Shaoying Yang, Yongxin Xu, Qian He, Qian Liang, Guijuan Feng, Yunfei Xia, Mei Yang, Yuting Huang, Junling Yang, Chen Dong, Rui Zhao, Yunan Wang, Genkai Guo, Xiaoqi Sha, Jing Li, Yuehua Guo, Zhifeng Gu

“…The abnormal phenotype and function of macrophages participate in the development of SLE. The targeted delivery to reprogram macrophage in SLE has been a long-standing challenge. …”
Get full text

MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism by Zhuolin Chen, Qiming Pang, Jingdi Zhan, Junyan Liu, Weikang Zhao, Lili Dong, Wei Huang

“…Furthermore, we utilized proteomics and transcriptomics analysis to reveal that the hydrogel accomplished macrophage metabolic reprogramming by regulating mitochondrial function and energy metabolism, thereby reducing inflammation. …”
Get full text

Thyroid hormones inhibit tumor progression and enhance the antitumor activity of lenvatinib in hepatocellular carcinoma via reprogramming glucose metabolism by Chun‑Cheng Yang, Yu-Chuan Yan, Guo‑Qiang Pan, Guang-Xiao Meng, Xiao Zhang, Lun-Jie Yan, Zi-Niu Ding, Dong-Xu Wang, Rui-Zhe Li, Guang-Zhen Li, Zhao‑Ru Dong, Tao Li

Get full text

Sequential Targeting Chondroitin Sulfate‐Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages by Caifeng Deng, Yongbing Xiao, Xuan Zhao, Hui Li, Yuxiao Chen, Kelong Ai, Ting Jiang, Jie Wei, Xiaoyuan Chen, Guanghua Lei, Chao Zeng

“…Here, a self‐assembling, licofelone‐loaded nanoparticle (termed LCF‐CSBN), comprising chondroitin sulfate and bilirubin joined by an ethylenediamine linker, is developed to selectively reprogram lipid metabolism in macrophage activation. …”
Get full text

NK cell-derived artificial extracellular vesicles elicit potent anti-tumor efficacy and tumor microenvironment reprogramming capability by Xinyue Zhou, Hang Yuan, Xinyue Zhu, Yangli Liu, Jinmin Xiao, Xueting Xie, Linlin Che, Cheng Fang, Chao Yao, Dan Hu, Yufu Zhou, Lixin Wang, Chenyuan Gong, Shiguo Zhu

Get full text

Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming by Xiaonan Huang, Zhen Hu, Weilong Shang, Juan Chen, Qiwen Hu, Yumin Zhou, Ruolan Ding, Jing Yin, Mengyang Li, He Liu, Jianxiong Dou, Huagang Peng, Yifan Rao, Lu Liu, Yuting Wang, Li Tan, Yuhua Yang, Jianghong Wu, Chuan Xiao, Yi Yang, Xiancai Rao

“…They exhibit promising application in developing bioproducts such as vaccine, drug‐delivery system and anticancer agent. …”
Get full text

Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs) by Ruiping Chen, Wenxiu Xie, Baomei Cai, Yue Qin, Chuman Wu, Wenyi Zhou, Chunhua Zhou, Shengyong Yu, Junqi Kuang, Bin Yang, Mingyi Zhao, Ping Zhu

“…In order to verify that the CiPSCs were indeed reprogrammed from mouse embryonic fibroblasts (MEFs), and further explore the underlying mechanisms, FSP-tdTomato mice were used to construct a fluorescent protein-tracking system of MEFs, for revealing the process of CiPSC reprogramming. …”
Get full text

DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…Abstract Objective Lipid metabolic reprogramming enables tumor cells to acquire malignant phenotypes, including enhanced proliferative capacity, migratory potential, and invasive properties. …”
Get full text

Cinobufagin Inhibits Invasion and Migration of Non-Small Cell Lung Cancer via Regulating Glucose Metabolism Reprogramming in Tumor-Associated Macrophages by Sun Y, Yang H, Mei X, Xia J, Feng L, Gao J, Jiang W, Jiang M, Hao X, Feng Y, Lian Y

Get full text

KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation by Shenyu Sun, Ling Ding, Karla Paniagua, Xian Wang, Yufei Huang, Mario A. Flores, Shou-Jiang Gao

“…ABSTRACT RNA alternative splicing is a fundamental cellular process implicated in cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of multiple human malignancies, including Kaposi’s sarcoma (KS), remains a significant concern, particularly in AIDS patients. …”
Get full text

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions by Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li

Get full text

Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity by Valentina Russo, Deny Menghini, Marco Mainardi, Marco Mainardi, Danilo Fintini, Alessia Aureli, Nicoletta Gianni, Lucilla Ravà, Maria Alessia Rea, Gabriele Scozia, Chiara Spiezia, Gaia Scabia, Giulia Furini, Stefano Vicari, Stefano Vicari, Stefano Cianfarani, Stefano Cianfarani, Margherita Maffei, Melania Manco

Get full text

E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis by Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lu

“…Abstract Macrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction‐associated steatohepatitis(MASH). …”
Get full text

Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma by Qixin Zhao, Shenglu Liu, Tao Bi, Ting Wang, Lei Chen, Juan Huang, Xuemei Yang, Xiyu Dai, Zengjin Liu, Qin Sun

Get full text

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation by Zhaoxuan Wang, Cheng Wang, Cheng Wang, Shilei Zhao, Chundong Gu

“…A prognostic model was developed based on GPCR signaling genes using least absolute shrinkage and selection operator (LASSO) analysis and Cox regression. …”
Get full text

Reprogramming tumor-associated macrophages using STING or TLR agonists: a promising strategy to enhance immunotherapy in hormone-dependent cancers by Rosario Garcia-Campelo, Fernando Torres Andón, Victor Sacristan Santos, Alba Pensado-López, Silvia Antolin Novoa, Rosa Señaris Rodriguez

“…In this line of research, Al-Janabi et al have recently developed lipid nanoparticles decorated with antibodies that bind to the folate receptor-beta overexpressed in perivascular TAMs and loaded with a STING agonist (cGAMP) for the reprogramming of these TAMs. …”
Get full text