Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials by Taylor Gardner, Jacob Duncan, Griffin K. Hughes, Ryan McIntire, Brooke Gardner, Andriana Peña, Chase Ladd, Kelsey Snider, Ryan Ottwell, Jordan Tuia, Alyson Haslam, Vinay Prasad, Matt Vassar

Get full text

Development of a Scalable Extraction Process for Anthocyanins of Haskap Berry (<i>Lonicera caerulea</i>) by Damith Costa, H.P. Vasantha Rupasinghe

Get full text

Pedagogical conditions for ensuring continuity in the development of coherent speech in older preschool children and first graders by Olga V. Romanova

“…Objective. To develop, justify, and experimentally test pedagogical conditions for ensuring continuity in the development of coherent speech in older preschoolers and first-graders. …”
Get full text

PERSONALIZED LEARNING IN THE AVIATION INDUSTRY: DEVELOPMENT OF AIRPORT AND HELIPORT TEACHING MATERIALS BASED ON BLENDED LEARNING by Irfan Irfan, Suhanto Suhanto, Irwan Jaya, Sukarwoto Sukarwoto

“…Methodology – The research used the Research and Development (R&D) model. However, only the first three stages are worked on: define, design, and develop. …”
Get full text

Development and validation of a nomogram model for predicting low muscle mass in patients undergoing hemodialysis by Rongrong Tian, Liyang Chang, Ying Zhang, Hongmei Zhang

“…The training set was used to develop the nomogram model, and the validation set was used to validate the developed model. …”
Get full text

Developing Students’ Movement Independence: Internalizing Physical Literacy in Project-based Physical Education Learning by Mashud Mashud, Syamsul Arifin, Herita Warni, Aryadi Rachman, Amka Amka, Muhammad Fadillah, Pebriyandi Pebriyandi, Miftah Fariz Prima Putra, Wahyu Indra Bayu, Novi Yanti

“…This study examines the urgency of developing students’ movement independence through internalizing physical literacy in physical education learning according to Project-Based Learning (PBL). …”
Get full text

SURGICAL TREATMENT OF MULTIFOCAL ATHEROSCLEROSIS: CORONARY AND BRACHIOCEPHALIC PATHOLOGY AND PREDICTORS OF EARLY ADVERSE EVENTS DEVELOPMENT by R. S. Tarasov, A. N. Kazantsev, S. V. Ivanov, N. N. Burkov, A. I. Anufriev, L S. Barbarash

“…The results can be applied in algorithms development for selection of surgical tactics in multifocal atherosclerosis patients.…”
Get full text

Development of iSpring Suite 11 to train students’ numeracy literacy through problem posing by Depi Setialesmana, Sinta Verawati Dewi, Linda Herawati, Dedi Nurjamil

“…Among the 70 participating seventh-grade students, 21 exhibited high numeracy literacy, 31 were categorized as medium, and 18 were identified as low. …”
Get full text

Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice. by Laura E Pascal, Junkui Ai, Khalid Z Masoodi, Yujuan Wang, Dan Wang, Kurtis Eisermann, Lora H Rigatti, Katherine J O'Malley, Hei M Ma, Xinhui Wang, Javid A Dar, Anil V Parwani, Brian W Simons, Michael M Ittman, Luyuan Li, Benjamin J Davies, Zhou Wang

“…EAF2 knockout mice on a 129P2/OLA-C57BL/6J background developed late-onset lung adenocarcinoma, hepatocellular carcinoma, B-cell lymphoma and high-grade prostatic intraepithelial neoplasia. …”
Get full text

The Current Status and Development Demand Analysis of Certified Reference Materials for Strategic Critical Metal Minerals by Huizhong SUN, Ziyi AN, Chunxue XU, Zongding CHEN

“…Although the number and production techniques of critical metal ore CRMs have improved in recent years, they still have limitations: (1) CRMs for boundary and minimum industrial grades non-ferrous metal ore (such as tungsten ore, tin ore, and cobalt ore) are incomplete. (2) Only a few types and quantities of CRMs are available for the analysis of rare, rare earth and dispersed elements, which is unable to meet the demand. (3) The theoretical basis of the development of CRMs such as chemical phase analysis, in situ analysis, and field on site analysis is relatively weak. …”
Get full text

Development and Sensory Evaluation of Omega-3-Rich Nile Perch Fish Oil-Fortified Yogurt by Margaret W. Murage, Edward K. Muge, Betty N. Mbatia, Mercy W. Mwaniki

“…This study is aimed at developing an omega-3-rich functional yoghurt and evaluating its quality and acceptability. …”
Get full text

DEVELOPING SCIENCE LEARNING INSTRUMENTS BASED ON LOCAL WISDOM TO IMPROVE STUDENT’S CRITICAL THINKING SKILLS by S. Wahyuni

“…This study is a Research and Development by using analysis, desaign, development, implementation and evaluation (ADDIE) method. …”
Get full text

Development and characterization of patient-derived xenograft models of colorectal cancer for testing new pharmacological substances by A. S. Goncharova, E. N. Kolesnikov, G. Yu. Egorov, A. Yu. Maksimov, A. N. Shevchenko, E. M. Nepomnyashchaya, D. Yu. Gvaldin, L. Z. Kurbanova, D. V. Khodakova, S. O. Kit, O. Yu. Kaymakchi, A. V. Snezhko

“…The model reproduced the histotype, grade and mutational status of the KRAS, NRAS, and BRAF genes, as well as microsatellite instability of the donor tumor.Conclusion. …”
Get full text

Harmful working conditions as a risk factor for the development of occupational morbidity in auxiliary professions workers by A. I. Sevalniev, L. P. Sharavara

“…The preventive measures aimed at reducing the risks of occupational diseases development in workers have been proposed.…”
Get full text

Development and assessment of the AE-RADS standardized grid for specifically evaluating adverse events in diagnostic radiology and teleradiology by Jean-François Bergerot, Amandine Crombé, Mylène Seux, Basile Porta, Vanessa Fyon, Samuel Le Nivet, Nicolas Lippa, Rémi Peyre, Paul Etchart, Frédérique Gay, Guillaume Gorincour

“…Abstract Background A specific grid for analyzing and grading adverse events in diagnostic radiology is lacking. …”
Get full text

Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model by Su Y, Wang Z, Chang H, Zhu S, Zhou Y, Cao Z, Ma L, Yuan Y, Xie Y, Niu X, Lu C, Zhang Y, Liu H, Shao N, Yin L, Si C, Ren X, Shi Y

“…Age-specific prediction models were developed for preschool children (AUC of 0.769 [95% CI: 0.725– 0.814]), for school-aged children (AUC of 0.854 [95% CI: 0.812– 0.895]).Conclusion: Our study findings support the important role of craniofacial structures such as the hyoid, maxilla, mandible, and soft palate in pediatric OSA. …”
Get full text

IMPACT OF POLYMORPHISM OF CARDIOVASCULAR RISK GENES ON ARTERIAL REMODELLING DEVELOPMENT DEPENDING ON PRESENCE OF SYSTEMIC HYPERTENSION by A. I. Chernyavina, M. V. Surovtseva

“…The study witness on the fact that cardiovascular risk shaping and the development of arterial stiffness depend not only on blood pressure level, but patient’s genotype. …”
Get full text

PENGEMBANGAN PERANGKAT PMR DAN PENGARUHNYA TERHADAP HASIL BELAJAR MATEMATIKA PADA SISWA KELAS VIII SMP KATOLIK AMBON by Helena Mataheru

“…This study was an experiment research initialized by conducting development research to produce learning material oriented to realistic mathematic learning for flat space solid edge material at VIII grade. …”
Get full text

Development of Interactive Animation Videos for Civics Learning to Improve the Critical Thinking Abilities of Elementary School Students by Atiya Ningsih, Tamsik Udin, Ahmad Arifuddin, Maulana Arafat Lubis

“…This study aims to develop valid and practical interactive animated video media to improve critical thinking skills of grade IV elementary school students. …”
Get full text

Learning Craft From Children’s Authors by Sarah Dyer

“…Throughout I model from my own essay, sharing the strategies I learned about using animal companions to develop the protagonist in Middle Grade novels. I end with one example of how I have applied what I learned to my current manuscript. …”
Get full text