Review of therapeutic agents for burns pruritus and protocols for management in adult and paediatric patients using the GRADE classification by Goutos Ioannis, Clarke Maria, Upson Clara, Richardson Patricia, Ghosh Sudip

“…To review the current evidence on therapeutic agents for burns pruritus and use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) classification to propose therapeutic protocols for adult and paediatric patients. …”
Get full text

Interactive Media Using Articulate Storyline 3 for Fifth Grade Elementary Students to Enhance Speaking Skills by I Gede Agus Sudiantara, I Wayan Widiana, I Made Suarjana

“…The objectives of this study include the development of a prototype of interactive media based on audiovisual using articulate storyline 3, analysis of the validity of the media content, students' responses to the media, and analysis of its effectiveness on the speaking skills of fifth grade elementary school students. …”
Get full text

Evaluating the Uncertainty and Predictive Performance of Probabilistic Models Devised for Grade Estimation in a Porphyry Copper Deposit by Raymond Leung, Alexander Lowe, Arman Melkumyan

“…One problem is the lack of industry guidelines for evaluating the uncertainty and predictive performance of probabilistic ore grade models. This paper aims to bridge this gap by developing a holistic approach that is autonomous, scalable and transferable across domains. …”
Get full text

Delayed-onset hearing loss in first-grade students who previously passed the newborn hearing screening by Reem Elbeltagy, Waad AlObayed, Shatha Mashbri, Robina Alrasheed, Renad Albakiri, Munira Almulayfi, Rania Alkahtani

“…However, some children may develop delayed-onset hearing loss, which can go undetected without ongoing monitoring. …”
Get full text

Impact of sympathetic nervous system on immune evasion in high-grade serous ovarian cancer: a review by Ruiyuan Yu, Yumeng Li, Runze Jiang, Chunxiao Dang, Fengting Zhai, Fengting Zhai

“…As the most frequent and aggressive subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC) often advances unnoticed due to its subtle early symptoms, which in turn leads to a significantly low five-year survival rate. …”
Get full text

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate by Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama

“…In vivo mutagenicity was evaluated following the Organisation for Economic Co-operation and Development Test Guideline 488 (OECD TG488). MutaMouse females were orally dosed with TDI at 0 (corn oil; vehicle control), 250, 500, or 1,000 mg/kg/day for 28 days. …”
Get full text

Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores by Rongwu Lai, Rongwu Lai, Jian Jiang, Jian Jiang, Yi Huo, Hao Wang, Sergei Bosiakov, Yongtao Lyu, Yongtao Lyu, Lei Li

“…BackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-functional pores onto Triply Periodic Minimal Surface (TPMS) structures through topology optimization of unit cell. …”
Get full text

Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix by Patrícia Mendonça Ventura, Isabel Cristina Chulvis do Val Guimarães, Luis Guillermo Coca Velarde, Susana Cristina Aidé Viviani Fialho, Douglas Guedes Ferreira, Matheus Madureira Fernandes, Rafael Augusto Chaves Machado

“…The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. …”
Get full text

Experimental analysis of the damping characteristics of longmaxi shale under graded cyclic loading with different confining pressures by Jiajun Shu, Tao Li, Yue Li, Bingni Wu, Zhengding Deng, Jingzhu Huang, Fausto Molina-Gómez, Rubén Galindo

“…Abstract In the process of shale gas field development, the surrounding rock has been in a three-way high-pressure stress state for a long period of time and has undergone complex cyclic loading during hydraulic fracturing and high-pressure fracturing fluid return, and its mechanical response and mechanism of action have important impacts on the stability of the reservoir. …”
Get full text

Review of therapeutic agents for burns pruritus and protocols for management in adult and paediatric patients using the GRADE classification by Ioannis Goutos, Maria Clarke, Clara Upson, Patricia M. Richardson, Sudip J. Ghosh

“…To review the current evidence on therapeutic agents for burns pruritus and use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) classification to propose therapeutic protocols for adult and paediatric patients. …”
Get full text

mtGrasp: Streamlined reference‐grade mitochondrial genome assembly and standardization to enhance metazoan mitogenome resources by Mark Louie D. Lopez, Cecilia L. Yang, Lauren Coombe, René L. Warren, Michael J. Allison, Jacob J. Imbery, Inanc Birol, Caren C. Helbing

“…We expect the reference‐grade mitogenomes generated with freely available mtGrasp to advance the development of robust, high‐quality eDNA tools and aid in a variety of comparative genomic analyses.…”
Get full text

A multi-faceted review on industrial grade nanolubricants: Applications and rheological insights with global market forecast by Gaurab Kumar Ghosh, Sikta Panda, Niranjan Kumar, Subrata Kumar Ghosh, Ankit Kotia, Jayant Giri, Mohammad Kanan, T. Sathish

Get full text

Apple Watercore Grade Classification Method Based on ConvNeXt and Visible/Near-Infrared Spectroscopy by Chunlin Zhao, Zhipeng Yin, Yushuo Tan, Wenbin Zhang, Panpan Guo, Yaxing Ma, Haijian Wu, Ding Hu, Quan Lu

Get full text

Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall by Hideyuki Kinoshita, Toshinori Tsukanishi, Takeshi Ishii, Hiroto Kamoda, Yoko Hagiwara, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Tsukasa Yonemoto

“…Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive, soft tissue sarcoma that is often fatal. …”
Get full text

Thermodynamic Work of High-Grade Uterine Prolapse Patients Undergoing Transvaginal Mesh Repair with Total Hysterectomy by Hui-Hsuan Lau, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsien-Yu Peng, Dylan Chou, Tsung-Hsien Su, Jie-Jen Lee, Tzer-Bin Lin

Get full text

Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants by Vanessa Monteil, Brett Eaton, Elena Postnikova, Michael Murphy, Benedict Braunsfeld, Ian Crozier, Franz Kricek, Janine Niederhöfer, Alice Schwarzböck, Helene Breid, Stephanie Devignot, Jonas Klingström, Charlotte Thålin, Max J Kellner, Wanda Christ, Sebastian Havervall, Stefan Mereiter, Sylvia Knapp, Anna Sanchez Jimenez, Agnes Bugajska‐Schretter, Alexander Dohnal, Christine Ruf, Romana Gugenberger, Astrid Hagelkruys, Nuria Montserrat, Ivona Kozieradzki, Omar Hasan Ali, Johannes Stadlmann, Michael R Holbrook, Connie Schmaljohn, Chris Oostenbrink, Robert H Shoemaker, Ali Mirazimi, Gerald Wirnsberger, Josef M Penninger

“…It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS‐CoV‐2 variants. …”
Get full text

Efficient and Non-Invasive Grading of Chinese Mitten Crab Based on Fatness Estimated by Combing Machine Vision and Deep Learning by Jiangtao Li, Hongbao Ye, Chengquan Zhou, Xiaolian Yang, Zhuo Li, Qiquan Wei, Chen Li, Dawei Sun

“…This study could aid in developing precise and non-destructive grading systems for the aquaculture and food industries.…”
Get full text

EfficientNetB0-Based End-to-End Diagnostic System for Diabetic Retinopathy Grading and Macular Edema Detection by Long X, Gan F, Fan H, Qin W, Li X, Ma R, Wang L, Hu R, Xie Y, Chen L, Cao J, Shao Y, Liu K, You Z

“…The system not only automates the grading of FFA images but also detects DME, significantly reducing the time required for image interpretation by clinicians and providing an effective tool to improve the efficiency and accuracy of DR diagnosis.Plain Language Summary: This study developed an automated deep learning-based diagnostic system for diabetic retinopathy (DR) and diabetic macular edema (DME) using fluorescein angiography (FFA) images, enabling rapid and accurate diagnosis. …”
Get full text

A Standardized Validation Framework for Clinically Actionable Healthcare Machine Learning with Knee Osteoarthritis Grading as a Case Study by Daniel Nasef, Demarcus Nasef, Michael Sher, Milan Toma

“…Methods: We apply this framework to a case study in knee osteoarthritis grading, demonstrating how overfitting, data leakage, and inadequate validation can lead to deceptively high accuracy that fails to translate into clinical reliability. …”
Get full text

Do explainable AI (XAI) methods improve the acceptance of AI in clinical practice? An evaluation of XAI methods on Gleason grading by Robin Manz, Jonas Bäcker, Samantha Cramer, Philip Meyer, Dominik Müller, Anna Muzalyova, Lukas Rentschler, Christoph Wengenmayr, Ludwig Christian Hinske, Ralf Huss, Johannes Raffler, Iñaki Soto‐Rey

“…The evaluation was conducted on a tool developed in‐house with different visualization approaches to the AI‐generated Gleason grade and the corresponding XAI explanations on top of the original slide. …”
Get full text