Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT by Jagadish Chandra, Junaid Ahmed, K. M. Veena, M. Vijayakumar, Nandita Shenoy, Nanditha Sujir

“…The CBCT scan revealed evidence of moth-eaten appearance of maxilla with destruction of medial and lateral walls and floor of maxillary sinus. …”
Get full text

Mise en scène du paysage montagnard et valorisation sélective des patrimoines dans une vallée pyrénéenne en reconversion économique by Pierre Dérioz, Philippe Bachimon, Maud Loireau

“…This heritage part of the strategy is intended for the residents, the owners of secondary residences, and for tourists in the strict sense of the term: proof of this is in how the promotion of the industrial heritage has been accompanied the disappearance of its physical evidence in the landscape (destruction of the factory), the shift to the reconstruction of a memory being considered as a means of more effectively breaking with this industrial past.…”
Get full text

A Rare Case of Malignant Tumor of the Larynx with Good Prognosis: Laryngeal Chondrosarcoma by Abderrahim Elktaibi, Issam Rharrassi, Nabil Hammoune, Youssef Darouassi, Mohammed Amine Hanine, Haddou Ammar

“…Endoscopic and radiological examinations showed a mass of the wall of his larynx with displaced structures, airway obstruction, and destruction of the cartilage. The patient underwent total laryngectomy. …”
Get full text

Th1 Cytokine-Secreting Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and Prospective Use in Immunotherapy of Bladder Cancer by Yi Luo, Jonathan Henning, Michael A. O'Donnell

“…However, BCG therapy is ineffective in approximately 30–40% of cases. Since evidence supports the T helper type 1 (Th1) response to be essential in BCG-induced tumor destruction, studies have focused on enhancing BCG induction of Th1 immune responses. …”
Get full text

PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections by Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

“…Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA). …”
Get full text

The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment by Delia Nelson, Scott Fisher, Bruce Robinson

“…However, the key to its success is the design of a sound rational approach based on evidence. There is compelling preclinical data for local immunotherapy approaches in tumor immunology. …”
Get full text

Human Oral Keratinocytes Challenged by Streptococcus sanguinis and Porphyromonas gingivalis Differentially Affect the Chemotactic Activity of THP-1 Monocytes by Huajing Li, Chaminda Jayampath Seneviratne, Lijian Jin

“…Periodontal diseases are initiated by the shift from microbe-host symbiosis to dysbiosis, and the disrupted host response predominantly contributes to tissue destruction. This study investigated whether and to what extent human oral keratinocytes (HOKs) challenged by a periodontal commensal or pathogen could differentially affect the chemotactic activity of THP-1 monocytes. …”
Get full text

Analysis of Veterinary and Sanitary Inspection in Russian Federation Subjects by A. М. Selyanin, M. A. Shibayev, A. V. Belchikhina, A. K. Karaulov

“…The study results indicate that 39% of the laboratories are not equipped with the necessary laboratory equipment; 8% of the laboratories perform tests using non-calibrated laboratory equipment, and only 2/3 of the laboratories are covered by the regular internal audits. Evidence of insufficient control over the attestation of the veterinarians involved in the veterinary and sanitary expertise was identified. …”
Get full text

Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 by Aziz Alami Chentoufi, Simon Gaudreau, Alex Nguyen, Mahmoud Sabha, Abdelaziz Amrani, Geyhad ElGhazali

“…Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. …”
Get full text

LAND USE CHANGES AND LAND DEGRADATION IN POST-SOCIALIST ROMANIA by DAN BĂLTEANU, ELENA-ANA POPOVICI

“…En même temps, on constate une dégradationaccentuée des terrains, comme résultat d’une utilisation irrationnelle du fonds foncier, de l’abandon on destruction des systèmes d’amélioration et de la faible fertilisation des terrains agricoles. …”
Get full text

Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes by Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, Shi-Yann Cheng, Horng-Chaung Hsu, Chih-Hsin Tang

“…Our results provide evidence that thrombin acts through the PAR1/PAR3 receptors and activates PKCδ and c-Src, resulting in EGFR transactivation and activation of PI3K, Akt, and finally AP-1 on the MMP-13 promoter, thereby contributing to cartilage destruction during arthritis.…”
Get full text

ENVIRONMENTAL RESOURCES CLIMATE CHANGE: AN EXPOSITION OF HERDSMEN TERRORISM IN TIVLAND OF BENUE STATE by GABRIEL T. TYUNGU, PETER MEMGA KERTYO

“…The paper is informed by the fact that since the beginning of the 21st century, there has been an astronomic increase in the number of herdsmenactivitiesthat have resultantly led to the destruction of lives and properties. Scholars have identified a lot of factors that must inform the wanton destruction of villages and communities by maundering herdsmen in Nigeria. …”
Get full text

The Role of PPARs in Lung Fibrosis by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime

“…Pulmonary fibrosis is a group of disorders characterized by accumulation of scar tissue in the lung interstitium, resulting in loss of alveolar function, destruction of normal lung architecture, and respiratory distress. …”
Get full text

How and why small volcanic ocean islands collapse and move vertically up and down by Fernando O. Marques, Luísa P. Ribeiro, Christian Hübscher, Ana C. G. Costa, Anthony Hildenbrand

“…What if the mass is much smaller, and there is good evidence that the vertical movement is more complex than simple loading-related subsidence? …”
Get full text

Scoping review of the societal impacts of compound climate events by Caroline A. Fehlman, Sophia C. Ryan, Kristen G. Lysne, Quinn M. Rundgren, Taylin J. Spurlock, Rustyn O. Orbison, Jennifer D. Runkle, Margaret M. Sugg

“…Despite the projected increase in the frequency of compound climate events and the adoption of compound event terminology, few studies identify climate extremes as compound climate events and little evidence exists on the societal impacts of these compound climate events. …”
Get full text

Giant Cell Tumor of the Temporal Bone with Direct Invasion into the Middle Ear and Skull Base: A Case Report by Takashi Iizuka, Masayuki Furukawa, Hisato Ishii, Misato Kasai, Chieri Hayashi, Hajime Arai, Katsuhisa Ikeda

“…No clinical or radiological evidence of tumor recurrence was detected for 4 years.…”
Get full text

Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo by Thai Van Thanh Le, Huy Ngoc Phan, Tran Ngoc Dang, Le Duy Pham

“…The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. …”
Get full text

The Coincidence of Newly Diagnosed Type 1 Diabetes Mellitus with IgM Antibody Positivity to Enteroviruses and Respiratory Tract Viruses by Murat Karaoglan, Fahriye Eksi

“…Viruses trigger and promote islet cell destruction and cause type 1 diabetes mellitus (T1DM). …”
Get full text

UPGRADED SCIENTIFIC ORHODONTIC SIMULATOR WITH TEMPERATURE CONTROL AND THERMOCHAMBER by Radu Mircea Pisc, Anne Marie Rauten, Roxana Marinescu, Horia Octavian Manolea

“…We assessed the upgraded electrodonts with the new configuration and the results were evaluated by Orthodontic Specialist and dental technician, without any evidence of melting wax and the treatment was continuous. …”
Get full text

Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment by Antonio Brú, Juan-Carlos Souto, Sonia Alcolea, Rosa Antón, Angel Remacha, Mercedes Camacho, Marta Soler, Isabel Brú, Amelia Porres, Luis Vila

“…There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. …”
Get full text