Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators by Siyuan Liu, Fan Li, Yunjia Cai, Lin Sun, Linan Ren, Mengsha Yin, Huijuan Cui, Yujie Pan, Xiaokun Gang, Guixia Wang

“…While hyperuricemia’s association with MASLD is established, the specific connection between gout and MASLD remains less explored. Using data from the UK Biobank, the study employs COX proportional hazard models, multi-state survival analysis, and Mendelian randomization to assess the independent and mutual risks of gout and MASLD. …”
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RER1 regulates lipid metabolism in monocytes and macrophages by Yanxia Liu, Sandra Theil, Mohamed H. Yaghmour, Anja Kerksiek, Peng Chen, Ingo G.H. Schmidt-Wolf, Rebecca Barker, Eva Bartok, Dieter Lütjohann, Christoph Thiele, Jochen Walter

“…Recently, RER1 was implicated in the assembly and subcellular transport of the TREM2-DAP12 immune receptor complex, and its function in intracellular signaling and phagocytosis. …”
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Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus by Lisa Traunmüller, Erin E. Duffy, Hanqing Liu, Stella Sanalidou, Sebastian Krüttner, Elena G. Assad, Senmiao Sun, Naeem S. Pajarillo, Nancy Niu, Eric C. Griffith, Michael E. Greenberg

“…We identified thousands of cell-type-specific chromatin accessibility changes, with coordinated expression and accessibility patterns implicating FOS/AP-1 as a key regulator. These data provide a rich resource of chromatin accessibility and gene expression profiles across hippocampal cell types in response to NE, a physiological stimulus affecting learning and memory.…”
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Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases by Haipeng Jie, Jingjing Zhang, Shuzhen Wu, Luyao Yu, Shengnan Li, Bo Dong, Feng Yan

“…Sustained production of reactive oxygen species (ROS) and an imbalance in the antioxidant system have been implicated in the development of cardiovascular diseases (CVD), especially when combined with diabetes, hypercholesterolemia, and other metabolic disorders. …”
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MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease by Young Cheul Chung, Yoon-Seong Kim, Eugene Bok, Tae Young Yune, Sungho Maeng, Byung Kwan Jin

“…This neuroprotective effect afforded by MMP-3 deletion was associated with the suppression of BBB disruption and a decrease in the number of ED-1- and CD-3-immunopositive cells in the SN. These data suggest that MMP-3 could play a crucial role in neurodegenerative diseases such as PD in which BBB damage and neuroinflammation are implicated.…”
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The phosphoproteome of toll‐like receptor‐activated macrophages by Gabriele Weintz, Jesper V Olsen, Katja Frühauf, Magdalena Niedzielska, Ido Amit, Jonathan Jantsch, Jörg Mages, Cornelie Frech, Lars Dölken, Matthias Mann, Roland Lang

“…Finally, weaving together phosphoproteome and nascent transcriptome data by in silico promoter analysis, we implicated several phosphorylated TFs in primary LPS‐controlled gene expression.…”
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P‐Wave Duration Is Associated With Aging Patterns in Structural Brain Networks by Elizabeth Haddad, William Matloff, Gilsoon Park, Mengting Liu, Neda Jahanshad, Ho Sung Kim

“…Cardiac arrhythmias, including atrial fibrillation, are implicated in clinical and subclinical brain injuries. …”
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IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia by Sofia Horn, Mareike Schmid, Ivan Berest, Federica Piattini, Jing Zhang, Katrien de Bock, Olivier Devuyst, Stellor Nlandu Khodo, Jan Kisielow, Manfred Kopf

“…Single-nucleus-RNA-sequencing data implicates excessive metabolic activity and oxidative phosphorylation across all cell types in the kidney of Il1r1-deficient mice within a few hours upon infection, with associated, localized hypoxia at infection foci. …”
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Metabolomic Insights into Attention Deficit Hyperactivity Disorder: A Scoping Review by Maria Jose Muñoz-Zabaleta, Nicolás Garzón Rodríguez, Luis Eduardo Díaz-Barrera, Maria Fernanda Quiroz-Padilla

“…Fifty-five studies were eligible for data extraction, of which fifteen met the criteria for inclusion in the review. …”
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The Dual Pathogen <i>Fusarium</i>: Diseases, Incidence, Azole Resistance, and Biofilms by Dongmei Li, Kincer Amburgey-Crovetti, Emilie Applebach, Tomoko Y. Steen, Richard Calderone

“…In this review, part of our Special Interest (SI) series, we discuss the spectrum of human diseases caused by <i>Fusarium</i>. While incidence data are better established for human keratitis and onychomycosis, invasive fusariosis remains globally underreported. …”
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In and out: factors influencing two decades of straying and homing by Pacific salmon within the Columbia River basin by Peter A. H. Westley, Andrew H. Dittman, Benjamin W. Nelson, Morgan H. Bond, Molly Payne, Thomas P. Quinn

“…This work suggests that dispersal rates may increase in a warming world, which in turn has implication for the flow of both individuals and, potentially, beneficial or deleterious genes.…”
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Efficacy of Intravenous Immunoglobulins and Other Immunotherapies in Neurological Disorders and Immunological Mechanisms Involved by Angel Justiz-Vaillant, Sachin Soodeen, Odalis Asin-Milan, Julio Morales-Esquivel, Rodolfo Arozarena-Fundora

“…Emerging clinical evidence supports expanding these treatments to other conditions where autoimmunity is implicated. By integrating immunological insights with clinical trial data, this review offers a comprehensive perspective on how immunotherapies may be tailored to target autoimmune contributors to neuropsychiatric disease.…”
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Development and validation of the learning schedule adherence scale (LSAS) for university students by Shakira Khatun, Mim Mariha Nisha Mridha, Md. Minhaz Uddin, Abdul Muktadir, Anika Tarannum, Md. Romiz Uddin Rudro, Mohd. Ashik Shahrier

“…To validate the factor structure, confirmatory factor analysis was run, and the data showed an excellent model fit to the single-factor solution. …”
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Secreted Phosphoprotein 1 in Lung Diseases by Hongli Liu, Cristian Coarfa, Arzoo N. Charania, Jennifer L. Larson-Casey, Ivan O. Rosas, Chao He

“…The role of SPP1 in interstitial lung diseases (ILDs) has become an area of increasing interest, given its elevated expression in various ILDs such as idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD (CTD-ILD), and pneumoconiosis, especially with recent data derived from single-cell RNA sequencing. In addition to ILDs, SPP1 has been implicated in infectious granulomatous lung diseases, lung and pleural malignancies, airway diseases, and COVID-19. …”
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Voxel-Based Lesion Analysis of Ideomotor Apraxia by Giovanna Oliveira Santos, Analía L. Arévalo, Timothy J. Herron, Brian C. Curran, Guilherme Lepski, Nina F. Dronkers, Juliana V. Baldo

“…Neuroimaging and lesion studies have implicated several brain regions in praxis and apraxia, but most studies have described (sub)acute patients. …”
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Molecular architecture and catalytic mechanism of human glycogen debranching enzyme by Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

“…Dysfunction of GDE leads to the accumulation of limit dextrin and is implicated in the pathogenesis of Glycogen Storage Disease Type III (GSD III). …”
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Economic recovery and growth plan, economic sustainability plan and national development plan (2021-2025): The Nigerian experience under President Muhammadu Buhari by Bassey Ekpenyong Anam, Uno Agbor Ijim, Virginia Emmanuel Ironbar, Abang Pius Otu, Otu Offiong Duke, Maxwell-Borjor Achuk Eba

“…This is desk research. Data are obtained from secondary sources and analyzed through content analysis. …”
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NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib by Sheng-Mou Hou, Ching-Yuan Cheng, Wei-Li Chen, En-Ming Chang, Chih-Yang Lin

“…Analysis of GEO (GSE16088) data identified five angiogenesis markers significantly upregulated in OS tissues. …”
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Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature by Daniel D Seaton, Robert W Smith, Young Hun Song, Dana R MacGregor, Kelly Stewart, Gavin Steel, Julia Foreman, Steven Penfield, Takato Imaizumi, Andrew J Millar, Karen J Halliday

“…In flowering, the model predicted regulatory links from the clock to CYCLING DOF FACTOR 1 (CDF1) and FLAVIN‐BINDING, KELCH REPEAT, F‐BOX 1 (FKF1) transcription. Physical interaction data support these links, which create threefold feed‐forward motifs from two clock components to the floral regulator FT. …”
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Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas by Paulo Linhares, Marta Viana-Pereira, Mónica Ferreira, Júlia Amorim, Rui Nabiço, Filipe Pinto, Sandra Costa, Rui Vaz, Rui Manuel Reis

“…VEGF polymorphisms are thought to modulate vascular endothelial growth factor plasma levels and therefore may be implicated in glioma risk. We aimed to clarify the role of VEGF and von Willebrand factor polymorphisms in glioma susceptibility and prognosis. …”
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