Knowledge Families Hold: Co‐Production and Co‐Research With Mental Health Family Carers in Understanding Experiences During the COVID‐19 Pandemic by Caroline Walters, Eileen McDonald, Carli Sheers, Kerry Hawkins, Hayley Solich, JulieAnne Anderson, Nevena Simic, Danielle Moore, Tony Stevenson, Sharon Lawn, Melinda Goodyear, Marcelo Maghidman, Melissa Petrakis

“…The academic partners advised on the possible processes for data collection, and the lived experience experts decided on the methodology based on that advice. …”
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The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…In this work, we have uncovered novel findings that have significant implications. We determined the transcriptional expression of aroX and npsA, the first genes of each tilimycin (TM)/tilivalline (TV) biosynthetic operon in K. oxytoca MIT 09-7231 wild-type and its derivatives Δlrp mutant and complemented strains. …”
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Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aura... by Elisa Benini, Eliana Musmeci, Serena Busti, Elena Biagi, Sara Ciulli, Enrico Volpe, Francesca Errani, Åge Oterhals, Odd Helge Romarheim, Tone Aspevik, Francesco Dondi, Giulio Zanaroli, Pier Paolo Gatta, Alessio Bonaldo, Luca Parma

“…Furthermore, when singularly correlating gut microbiome and plasma analyses, data showed that higher presence of Stenotrophomonas and Acinetobacter families were positively related to higher lactate hematic concentration, suggesting a physiological distress caused by the inclusion of 10 % of BP in seabream diet exacerbated by adverse environmental conditions. …”
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Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China by Yuzhu Shi, Yuzhu Shi, Yuchen Xie, Yuchen Xie, Ying Chen, Li Yang, Huixia Gao, Yun Guo, Fumin Feng, Jianhua Lu, Erhei Dai

“…However, epidemiological data on HBV/HEV coinfection in the Hebei region are scarce, necessitating further investigation.MethodsWe conducted a multicenter cross-sectional study for infectious diseases across six tertiary hospitals. …”
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Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis by Zahra Moradpour, Amin Barik, Goljamal Jorjani, Mohammad Reza Taherian, Sepideh Tousizadeh, Sepideh Tousizadeh, Aram Halimi, Aram Halimi, Yaser Soleimani, Mobina Karimian, Tina Khavari, Fateme Azizi Kalankari, Fatemeh Asadipour, Mojtaba Azari, Niloofar Yousefzadeh Shakouri, Saeideh Karamian, Nasser Bahari, Alireza Mosavi Jarrahi

“…Inclusion criteria encompassed studies reporting on the association between MWF exposure and prostate cancer incidence or mortality. Data extraction and risk of bias assessment were performed independently by two reviewers, with discrepancies resolved by a third reviewer. …”
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Deep learning can predict cardiovascular events from liver imaging by Gregory Patrick Veldhuizen, Tim Lenz, Didem Cifci, Marko van Treeck, Jan Clusmann, Yazhou Chen, Carolin V. Schneider, Tom Luedde, Peter W. de Leeuw, Ali El-Armouche, Daniel Truhn, Jakob Nikolas Kather

“…This study explores the use of transformer neural networks on liver magnetic resonance imaging (MRI) data to enhance cardiovascular risk prediction. Methods: Using the extensive collection of liver MRIs in the UK Biobank, we developed a feature extractor with a vision transformer backbone trained in a self-supervised manner. …”
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Zika Virus Infection Modulates Extracellular Vesicle Biogenesis and Morphology in Human Umbilical Cord Endothelial Cells: A Proteomic and Microscopic Analysis by Manuel Adrián Velázquez-Cervantes, Arturo Flores-Pliego, Yazmín Rocío Benitez-Zeferino, Victor Javier Cruz-Holguín, Luis Herrera Moro-Huitron, Addy Cecilia Helguera-Repetto, David Eduardo Meza-Sánchez, José Luis Maravillas-Montero, Nicolás Cayetano-Castro, Javier Mancilla-Ramírez, Aurora Casarrubias-Betancourt, Guadalupe León-Reyes, Macario Martínez-Castillo, Isabel Wong-Baeza, Luis Adrián De Jesús-González, María Isabel Baeza-Ramírez, Moisés León-Juárez

“…Future studies aimed at the proteomic and lipidomic composition analyses of these EVs are needed to understand the biological implications in vertical infection.…”
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Risk of hepatocellular carcinoma in Asian patients with primary biliary cholangitis: A nationwide and hospital cohort study by Jihye Lim, Ye-Jee Kim, Sehee Kim, Jonggi Choi

“…This study aimed to evaluate the incidence of HCC and its risk factors in a nationwide cohort. Methods: The data of 4,882 patients with PBC and 38,603 matched controls were extracted from the Korean National Health Insurance Service (2007–2020) and analyzed. …”
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Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia by Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer

“…There were strong correlations between levels of synaptic proteins and established Alzheimer pathology markers, with subtle differences in the association pattern between disorders.Discussion Our data suggest that SNAP-25, NRXN3 and NRGN versus beta-amyloid and phosphorylated tau protein 181 (ptau) are regulated differentially across psychiatric disorders and that SNAP-25 has a moderate diagnostic potential for MDD and SCZ. …”
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Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis by Martina Lepore Signorile, Elisabetta Di Nicola, Giovanna Forte, Paola Sanese, Candida Fasano, Vittoria Disciglio, Katia De Marco, Marialaura Latrofa, Loris De Cecco, Marica Ficorilli, Marta Lucchetta, Erica Torchia, Chiara Dossena, Giusy Bianco, Vito Spilotro, Claudia Ferroni, Nicoletta Labarile, Raffaele Armentano, Francesco Albano, Anna Mestice, Gianluigi Gigante, Valerio Lantone, Giuliano Lantone, Leonardo Vincenti, Alberto Del Rio, Greta Varchi, Valentina Grossi, Cristiano Simone

“…Specifically, we showed that SMYD3 interacts with and methylates c-MYC at K158 and K163, thereby modulating its transcriptional activity, which is implicated in stemness and colorectal malignancy. Our in vitro data suggest that SMYD3 pharmacological inhibition or its stable genetic ablation affects the clonogenic and self-renewal potential of patient-derived CRC-SCs and organoids by altering their molecular signature. …”
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Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation by Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

“…Through systematic analysis of the long‐term effects of virus infection‐induced epigenetic reprogramming in HCC development and progression, combined with multi‐omics data to construct HCC risk prediction models, our findings provide scientific evidence for the development of early screening and precision treatment strategies. …”
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Comparison of Perioperative Outcomes of Holmium Laser Enucleation of the Prostate for Standard (≤149 ml) Versus Very Large (≥150 ml) Prostate Glands: Retrospective Analysis of a Pr... by Jacob Schmidt, Jorien Krediet, Holger Beutel, Ayoub Hidayat Allah, Nella Gagel, Isabel Lichy, Bernhard Ralla, Maha Ullmann, Robert Peters, Frank Friedersdorff, Martin Kanne

“…Methods: We retrospectively analyzed data for 1815 adult patients who underwent HoLEP at Evangelisches Krankenhaus Königin Elisabeth Herzberge, Berlin, between January 2019 and May 2024. …”
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5hmC-profiles in Puerto Rican Hispanic/Latino men with aggressive prostate cancer by Manishkumar S. Patel, Mousa Almubarak, Jaime Matta, Carmen Ortiz-Sanchez, Jarline Encarnacion, Gilberto Ruiz-Deya, Julie Dutil, Jasreman Dhillon, Kosj Yamoah, Anders Berglund, Hyun Park, Deepak Kilari, Yoganand Balagurunathan, Liang Wang, Jong Y. Park

“…Since 5hmC abundance positively correlates with gene expression levels, we further investigated 808 DMGs in TCGA PCa gene expression data. Further, we identified 59 DMGs with significant gene expression changes in the same direction. …”
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أثر إدارة المراسم والاتيكيت في تحقيق النجاح الاستراتيجي لمنظمات الضيافة by نوفل عبد الرضا الكمري, عماد حسين سعود

“…The value of the study: It tries to reach the intellectual and philosophical rooting of the nature of the study variables in order to clarify the practical steps and how to address the current reality and look to the future with a strategic perspective through which the hospitality organizations can formulate policies to adapt to the global environmental changes, The present study used the questionnaire as a main tool for collecting information and data, in an effort to test six key hypotheses with sub-hypotheses arising from them and related to correlation and impact relationships and using the statistical program (SPSS-V22) ) To reach the results.  …”
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The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. by Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal

“…Use of eGFRcys did not improve risk prediction in this population and was associated with increased cost. Our data therefore do not support implementation of these recommendations in primary care. …”
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Results from an Australopithecus africanus dental enamel fragment confirm the potential of palaeoproteomics for South African Plio-Pleistocene fossil sites by Palesa P. Madupe, Fazeelah Munir, Marc Dickinson, Alberto J. Taurozzi, Meaghan Mackie, Mirriam Tawane, Catherine Mollereau, Nomawethu Hlazo, Kirsty Penkman, Lauren Schroeder, Clément Zanolli, Jesper V. Olsen, Rebecca R. Ackermann, Enrico Cappellini

“…Open data set : http://proteomecentral.proteomexchange.org (identifier PXD054431)   …”
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Characterization of Epithelial–Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7 by Hendrik Ungefroren, Juliane von der Ohe, Rüdiger Braun, Yola Gätje, Olha Lapshyna, Jörg Schrader, Hendrik Lehnert, Jens-Uwe Marquardt, Björn Konukiewitz, Ralf Hass

“…We conclude that in PDAC-derived tumor cells, NED is closely linked to EMT and TGF-β signaling, which may have implications for the therapeutic use of TGF-β inhibitors in PDAC management.…”
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Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis by Gabriel C. Barsotti, Randy Luciano, Ashwani Kumar, Kristin Meliambro, Vijayakumar Kakade, Joji Tokita, Abhijit Naik, Jia Fu, Elizabeth Peck, John Pell, Anand Reghuvaran, E.M. Tanvir, Prashant Patel, Weijia Zhang, Fan Li, Gilbert Moeckel, Sudhir Perincheri, Lloyd Cantley, Dennis G. Moledina, F. Perry Wilson, John C. He, Madhav C. Menon

“…By repurposing an inexpensive agent, our results will have implications for FSGS treatment in resource-poor settings.…”
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Width evolution of channel belts as a random walk by J. M. Turowski, J. M. Turowski, F. McNab, A. Bufe, A. Bufe, S. Tofelde

“…Model predictions compare well to data of sediment age distributions measured at field sites and the temporal evolution of channel belts observed in flume experiments. …”
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Fetal birthweight and maternal urinary incontinence in Chinese primiparas: a population-based study by Yanrong Du, Peicheng Wang, Yanhua Chen, Qing Liu, Luwen Wang, Hangmei Jin, Liyan Gong, Jingyan Xie, Ting Lai, Aiyang Li, Lubin Liu, Lifei Zhou, Yanqiu Luan, Lin Wang, Xiaoli Li, Xiping Luo, Yingjie Fu, Jumin Niu, Wen Zhao, Qiming Liu, Renfeng Zhao, Haiyu Pang, Jiming Zhu, Lan Zhu

“…Methods Cross-sectional data from 54,346 women aged 20 years and above were obtained from the 2019–2021 National Urinary Incontinence Survey. …”
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