Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma by Chen Ni, Rulin Hua, Yuanyuan Yang, Jialu Liang, Wentao Liu, Linlin Wang, Xiaohan Yao, Anqi Li, Long Yu, Ruo Feng, Dekang Lv, Zhihai Qin, Wenlong Zhai

“…By assessing the expression levels of marker genes in bRNA-seq data, the correlation of stromal cell clusters with survival was explored. …”
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Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

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Trends in the use and nonmedical use of sedatives-hypnotics in the population aged 12 to 64 years in Taiwan: a comparative analysis of the national surveys in 2014 and 2018 by Wei-Yi Tsay, Lian-Yu Chen, Shang-Chi Wu, Po-Chang Hsiao, Te-Tien Ting, Cheng-Fang Yen, Shu-Sen Chang, Chung-Yi Li, Hao-Jan Yang, Chia-Feng Yen, Chuan-Yu Chen, Jiun-Hau Huang, Yu-Kang Tu, Wei J. Chen

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A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients by Matthew A. Bergens, John T. Bokman, Ernaya J. Johnson, Matthew L. Braun, Yan Li, Amy T. Bush, Lauren Hill, Jolien Van Opstal, Alessandro Racioppi, Rebecca Fan, Sejal Kaushik, Edwin Alyea, Nelson Chao, Taewoong Choi, Cristina Gasparetto, Mitchell Horwitz, Richard Lopez, Sendhilnathan Ramalingam, Keith Sullivan, Paul Wischmeyer, Anthony D. Sung

“…We analyzed 10 years of data (January 2010 to May 2020), including 105 patients who received a BB for more than four days before and after HCT, and 669 control patients who did not receive a BB. …”
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Texture and physicochemical analysis of Creole beef at different aging times: Differences between sex and age by José Américo Saucedo-Uriarte, Segundo M. Portocarrero-Villegas, Nancy Saldaña Gálvez, Hugo Frias, William Bardales, Luis Murga, Yander M. Briceño-Mendoza, Wigoberto Alvarado Chuqui, Gleni Tatiana Segura Portocarrero, Ilse Silvia Cayo-Colca

“…Despite the variability in the data, the studied indicators fall within the ranges reported for specialized breeds. …”
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ProstaPilot: A Comparative Study of Biparametric Magnetic Resonance Imaging Versus Prostate-specific Antigen as a Screening Test for Prostate Cancer by Michal Staník, Michal Standara, David Miklánek, Kateřina Hejcmanová, Miloš Pacal, Roman Hrabec, Ondřej Ngo, Karel Hejduk, Jan Křístek, Michal Uher, Ondřej Májek, Alexandr Poprach

“…Conclusions and clinical implications: In a highly prescreened population, bpMRI may increase the csPC detection rate while reducing the number of biopsies needed in comparison to PSA-based diagnosis. …”
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Differential vasoproliferative traits of Bartonella henselae strains associated with autotransporter BafA variants by Yuka Kondo, Masahiro Suzuki, Shingo Sato, Soichi Maruyama, Akiko Sei, Xingyan Ma, Kota Nakano, Yohei Doi, Kentaro Tsukamoto

“…A core genome SNP analysis of strains using whole genome sequencing data divided B. henselae strains into four clades, with each clade corresponding to BafA variants 1–4. …”
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Soil N2O emissions after perennial legume termination in an alfalfa-wheat crop rotation system under Mediterranean conditions by Laura Trozzo, Matteo Francioni, Ayaka Wenhong Kishimoto-Mo, Lucia Foresi, Michele Bianchelli, Nora Baldoni, Paride D'Ottavio, Marco Toderi

“…Perennial legumes such as alfalfa (Medicago sativa L.) have potential roles for reduction of soil GHG emissions as part of crop rotation systems. However, the implications of perennial legume termination by tillage and subsequent soil incorporation of the residues for reduced GHG emissions have been poorly examined in Mediterranean environments. …”
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Parental influence on Chinese childhood cancer survivors’ physical activity: a mixed methods study by Fengjiao Xu, Danni Lv, Jie Zhou, Zhonghai Guan, Jieni Xiong, Jingyi Yun, Xiaojun Xu, Junqing Mao, Zhipeng Shen, Libin Jin, Yunxia Liu, Haiyan Xing, Jinhu Wang, Hongmei Wang

“…A qualitative investigation using the thematic descriptive phenomenological approach analyzed data concerning the parents of 9-18-year-old childhood cancer survivors who had completed hospitalized treatment for at least three months. …”
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Clinicopathological characterization of Switch/Sucrose-non-fermentable (Swi/Snf) complex (ARID1A, SMARCA2, SMARCA4)-deficient endocervical adenocarcinoma by Chao Cao, Zi-Yun Wu, Wei Liao, Li-Jun Wei, Hao-Yu Liang, Xia Yang, Rong-Zhen Luo, Li-Li Liu

“…However, their prevalence and clinical implications in endocervical adenocarcinoma (ECA) remain unclear. …”
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Polar Ocean Mixing by Internal Tsunamis (POLOMINTS) by Michael Meredith, Katharine Hendry, E. Povl Abrahamsen, J. Alexander Brearley, Emma Young, David Munday, Hugh Venables, Anna Hogg, Benjamin Wallis, Katrien Van Landeghem, Filipa Carvalho, Andrew Yool, Amber Annett, Alberto Naveira Garabato, Mark Inall, Katy Sheen, Andrew Fleming, Estelle Dumont, Oskar Głowacki, Carlos Moffat, Neil Fraser, Sarah Gille, Matthew Alford, Rebecca Jackson, Katherine Retallick

“…By redistributing heat in the ocean, it exerts strong influences on the Antarctic Ice Sheet, with implications for sea level rise globally. Similarly, the redistribution of ocean heat affects the production of sea ice in winter and its melt in summer, with consequences for climate. …”
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Aerosol particle number concentration, ultrafine particle number fraction, and new particle formation measurements near the international airports in Berlin, Germany – First result... by Simonas Kecorius, Susanne Sues, Leizel Madueño, Alfred Wiedensohler, Ulf Winkler, Andreas Held, Sabine Lüchtrath, David C. Beddows, Roy M. Harrison, Mario Lovric, Vanessa Soppa, Barbara Hoffmann, Miriam Wiese-Posselt, Andreas Kerschbaumer, Josef Cyrys

“…The analysis of particle number size distribution data showed that UFP number fraction exhibit seasonal variations, with higher values in spring and autumn. …”
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92 Prevalence of heteroresistance in urinary Escherichia coli in Metropolitan Atlanta, Georgia by Sarah Blaine, Sarah Kathryn Blaine, Sarah Lohsen, Julia A Van Riel, Madeleine Boulis, Alexandra Rio, D’Ante Gooden, Gillian Smith, David Weiss, Jessica Howard-Anderson, Sarah Satola

“…Antibiotic susceptibility data were missing from 5(1.4%) and 11(3%) of isolates for nitrofurantoin and trimethoprim-sulfamethoxazole, respectively. …”
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Electronic Implementation of Patient-Reported Outcome Measures in Primary Health Care: Mixed Methods Systematic Review by Maxime Sasseville, Wilfried Supper, Jean-Baptiste Gartner, Géraldine Layani, Samira Amil, Peter Sheffield, Marie-Pierre Gagnon, Catherine Hudon, Sylvie Lambert, Eugène Attisso, Steven Ouellet, Mylaine Breton, Marie-Eve Poitras, Pierre-Henri Roux-Lévy, James Plaisimond, Frédéric Bergeron, Rachelle Ashcroft, Sabrina T. Wong, Antoine Groulx, Jean-Sébastien Paquette, Natasha D'Anjou, Sylviane Langlois, Annie LeBlanc

“…We included studies that implemented ePROMs among adults for chronic disease management in PHC. The extracted data included patient health outcomes, provider workflow implications, implementation factors, and cost considerations. …”
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Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis by Gaoyan Tang, Xuelei Cao, Jiaqi Chen, Fu Hui, Na Xu, Yiqing Jiang, Hongmin Lu, Haifeng Xiao, Xiuming Liang, Mingzhe Ma, Yu Qian, Dongli Liu, Zhenlu Wang, Shuzhen Liu, Guohua Yu, Lei Sun

“…Furthermore, immunohistochemical (IHC) analysis of an NSCLC tissue microarray confirmed a strong positive correlation between p-p38 and NOXA expression. Clinical data analysis further suggested that the p-p38/NOXA axis might be a potential prognostic biomarker for overall survival (OS) in NSCLC patients.…”
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Safety and efficacy of tranexamic acid in paediatric cardiac surgery: study protocol for a double-blind randomised controlled trial by Yang Wang, Xu Wang, Rong Wang, Yu Zhang, Zhe Zhang, Yuan Jia, Jia Shi, Su Yuan, Jinping Liu, Jun Ran, Yuchen Zhao, Zhongdong Hua, Shoujun Li, Zhe Zheng, Shengshou Hu, Fuxia Yan

“…The pragmatic study will provide important implications for paediatric cardiac surgery.Methods and analysis This will be a single-centre prospective, double-blind randomised controlled trial. …”
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Dolphin Pituitary Gland: Immunohistochemistry and Ultrastructural Cell Characterization Following a Novel Anatomical Dissection Protocol and Non-Invasive Imaging (MRI) by Paula Alonso-Almorox, Alfonso Blanco, Carla Fiorito, Eva Sierra, Cristian Suárez-Santana, Francesco Consolli, Manuel Arbelo, Raiden Grandía Guzmán, Ignacio Molpeceres-Diego, Antonio Fernández Gómez, Javier Almunia, Ayoze Castro-Alonso, Antonio Fernández

“…This study presents the first immunolabelling of thyrotrophs in cetacean adenohypophysis and the first detailed ultrastructural characterization of adenohypophyseal cells in cetaceans, providing baseline data for future research. By integrating multidisciplinary techniques, it advances the understanding of dolphin neuroendocrinology and highlights broader implications for cetacean health, welfare, and conservation.…”
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Nutritional status and intestinal parasitism determinants of cognitive performance among secondary school students in South-East Nigeria by Uzochukwu G. Ekeleme, Uchechukwu M. Chukwuocha, Christopher Chike A. Okereke, Chidinma O. Akanazu, Queeneth C. Onuoha, Ijeoma G. Chukwuemeka, Chiamaka C. Ogujiuba, Chigozie C. Ukachukwu, Chinwendu L. Opara, Amarachi B. Nwokoro

“…Summary: Adolescents represent a critical population in public health research because their well-being has significant implications for future societal outcomes. This study focuses on the nutritional status and intestinal parasitism determinants of cognitive performance among secondary school students in South-East Nigeria. …”
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A cryptic elapid snake persists in the wake of catastrophic wildfires by Mitchell J. Hodgson, Alexandra K. Ross, Yingyod Lapwong, Santiago Cuartas, Bridget Roberts, Owen Price, Jonathan Webb, Nicola Sentinella, Joshua Lee, Shawn W. Laffan, Hugh M. Burley, Finlay McIntosh, Mike Letnic

“…Although conclusions regarding the effects of fire on D. rhodogaster are limited because of the lack of baseline data, it is evident that the species has persisted across the landscape in the wake of extensive bushfires. …”
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Monkeypox virus (MPXV) isolation from longitudinal samples of 11 patients to infer risk of onwards transmission by Dr Helen Callaby, Dr Janie Olver, Ms Kirsty Emery, Dr Kevin Richards, Dr Marian Killip, Dr Natalie Groves, Dr Jake Dunning, Professor Malcolm G Semple, Professor J Kenneth Baillie, Dr Tommy Rampling, Dr Catherine F Houlihan

“…Discussion: The duration of the infectious period of MPXV during clinical mpox is currently unclear with a paucity of robust longitudinal culture data, particularly from hospitalised patients. The median time of isolation of 11.5 days would fit within the known threshold but was far exceeded in a single immunocompromised patient at 109 days. …”
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