Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients by Juergen Grafeneder, Wisse van Os, Iris K. Minichmayr, Katarina D. Kovacevic Miljevic, Birgit Reiter, Marcus D. Säemann, Veronika Machold-Fabrizii, Amro Ahmed, Paul Spechtl, Haris Omic, Raute Sunder-Plaßmann, Bernd Jilma, Christian Schoergenhofer, Farsad Eskandary

“…Pantoprazole terminal half-life was ∼1.7-fold higher in HDPs compared to HVs. Conclusion: Our data demonstrate an altered metabolism of clopidogrel in HDPs in the context of lower CYP2C19 activity, with potential implications for other substances metabolized by this enzyme.…”
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Communication and relationships: how patients perceive informational and interactional organizational justice can improve patient-centered care, a study with samples from Spain and... by Diana Pérez-Arechaederra, Elena Briones, Luis García-Ortiz

“…We outline specific implications for improving healthcare quality and patient-centered care.…”
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A novel germline (c.314T>A) SDHB variant in metastatic paraganglioma: case report and literature review by Stella Bernardi, Stella Bernardi, Stefania Zovato, Gianmaria Pennelli, Marco Cavallaro, Matteo Rovina, Chiara Dobrinja, Chiara Dobrinja, Alessandra Guglielmi, Fabrizio Zanconati, Fabrizio Zanconati, Daniela Mazzà, Alberto Nieri, Mirco Bartolomei, Francesca Schiavi

“…Identifying germline succinate dehydrogenase B (SDHB) pathogenic variant has important management implications. Here we report a novel germline variant in the SDHB gene in a patient with metastatic paraganglioma and his response to available treatments.Case presentationa 37-year-old Serbian man was admitted to hospital due to hypertension, tachycardia and hyperhidrosis. …”
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The role of hypoxia-senescence co-related molecular subtypes and prognostic characteristics in hepatocellular carcinoma by Fuqing Chen, Yifan Cai, Xiangmei Chen, Changzhou Chen, Qinliang Fang, Jianming Liu, Yibin Zhang, Jianyin Zhou

“…Transcriptome data and clinical information were obtained from patients with HCC using the Cancer Genome Atlas, GSE76427, and International Cancer Genome Consortium (ICGC). …”
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Consistent improvements in liver histology across subgroups in a post hoc analysis of the SYNERGY-NASH trial with tirzepatide by Mark L. Hartman, Rohit Loomba, Eric J. Lawitz, Raj Vuppalanchi, Jérôme Boursier, Elisabetta Bugianesi, Masato Yoneda, Yuanyuan Tang, Bram Brouwers, Mathijs C. Bunck, Axel Haupt, Arun J. Sanyal

“…In these post hoc analyses, we show that tirzepatide was consistently associated with improved MASH resolution without worsening of fibrosis across subgroups defined by demographics, histology, serum biomarkers, and imaging tests. These data support further investigation of tirzepatide in larger studies of participants with MASH including representation from diverse populations.…”
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Estimation of the aboveground carbon stocks based on tree species identification in Saihanba plantation forest by Ao Zhang, Xiaohong Wang, Xin Gu, Xiangyao Xu, Xintong Gao, Linlin Jiao

“…In this study, based on the multi-temporal Sentinel-2 remote sensing image data, five classification schemes were devised to identify the dominant tree species of all forest patches or sub-compartments in the Saihanba Mechanical Forestry using the Random Forest algorithm. …”
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Person-Specific Analyses of Smartphone Use and Mental Health: Intensive Longitudinal Study by Merve Cerit, Angela Y Lee, Jeffrey Hancock, Adam Miner, Mu-Jung Cho, Daniel Muise, Anna-Angelina Garròn Torres, Nick Haber, Nilam Ram, Thomas N Robinson, Byron Reeves

“…This study highlights the potential for granular, longitudinal data to reveal person-specific patterns that can inform theory development, personalized screening, diagnosis, and interventions in mental health.…”
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The effects of perfluoroalkyl substance pollution on microbial community and key metabolic pathways in the Pearl River Estuary by Wei Lin, Junlin Zhao, Xingqi Wu, Jiakun Jiang, Chunyang Zhou, Jiating Zheng, Cheng Zhang, Ying Guo, Li Wang, How Yong Ng, Song Li, Shengrui Wang

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Comparative analysis of white matter signal alterations in dementia with Lewy bodies and Alzheimer's disease: a systematic review and meta-analysis by Asad Abdi, Asad Abdi, Milad Alipour, Milad Ghanikolahloo, Amin Magsudy, Fatemeh HojjatiPour, Ali Gholamrezanezhad, Ali Gholamrezanezhad, Mehran Ilaghi, Mehran Anjomrooz, Fatemeh Sayehmiri, Ramtin Hajibeygi, Ramtin Hajibeygi, Mobina Fathi, Reza Assadsangabi

“…Stata version 15 US is used to analyze the extracted data.ResultsTwelve studies with 906 AD and 499 DLB patients were considered in this analysis. …”
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Cell‐to‐cell and type‐to‐type heterogeneity of signaling networks: insights from the crowd by Attila Gabor, Marco Tognetti, Alice Driessen, Jovan Tanevski, Baosen Guo, Wencai Cao, He Shen, Thomas Yu, Verena Chung, Single Cell Signaling in Breast Cancer DREAM Consortium members, Bernd Bodenmiller, Julio Saez‐Rodriguez, Augustinas Prusokas, Alidivinas Prusokas, Renata Retkute, Anand Rajasekar, Karthik Raman, Malvika Sudhakar, Raghunathan Rengaswamy, Edward S.C. Shih, Min‐jeong Kim, Changje Cho, Dohyang Kim, Hyeju Oh, Jinseub Hwang, Kim Jongtae, Yeongeun Nam, Sanghoo Yoon, Taeyong Kwon, Kyeongjun Lee, Sarika Chaudhary, Nehal Sharma, Shreya Bande, Gao Gao fan zhu Cankut Cubuk, Pelin Gundogdu, Joaquin Dopazo, Kinza Rian, Carlos Loucera, Matias M Falco, Martin Garrido‐Rodriguez, Maria Peña‐Chilet, Huiyuan Chen, Gabor Turu, Laszlo Hunyadi, Adam Misak, Baosen Guo, Wencai Cao, He Shen, Lisheng Zhou, Xiaoqing Jiang, Pieta Zhang, Aakansha Rai, Rintu Kutum, Sadhna Rana, Rajgopal Srinivasan, Swatantra Pradhan, James Li, Vladimir Bajic, Christophe Van Neste, Didier Barradas‐bautista, Somayah Abdullah Albarade, Igor Nikolskiy, Musalula Sinkala, Duc Tran, Hung Nguyen, Tin Nguyen, Alexander Wu, Benjamin DeMeo, Brian Hie, Rohit Singh, Jiwei Liu, Xueer Chen, Leonor Saiz, Jose M. G Vilar, Peng Qiu, Akash Gosain, Anjali Dhall, Dinesh Bajaj, Harpreet Kaur, Krishna Bagaria, Mayank Chauhan, Neelam Sharma, Gajendra Raghava, Sumeet Patiyal, Jianye Hao, Jiajie Peng, Shangyi Ning, Yi Ma, Zhongyu Wei, Atte Aalto, Jorge Goncalves, Laurent Mombaerts, Xinnan Dai, Jie Zheng, Piyushkumar Mundra, Fan Xu, Jie Wang, Krishna Kant Singh, Mingyu Lee

“…This opens the way to understand the heterogeneity of complex multi‐signaling networks across cells and cell types, with important implications to understand and treat diseases such as cancer. …”
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Health‐Seeking Behavior of Patients With Dental Abscesses: A Cross‐Sectional Study by Kwame Adu Okyere Boadu, Richard Okyere Boadu, Abigail Achiaa Nyarko, Esther Priscilla Biamah Danquah, Victor Wireko Adu, Nana Atuahene Oti, John Billy Owusu Quarshie, Nana Bempong Owusu‐ Ankomah

“…Methods A cross‐sectional quantitative design was used to collect data from 100 participants through purposive sampling. …”
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Coinfection of Mycoplasma suis and porcine circovirus type 3 is linked to reproductive failure in pig farms by Tram Ngoc Thi Ngo, Nam Minh Nguyen, Roongroje Thanawongnuwech, Le Minh Thong, Trang Phuong Thi Nguyen, Toan Tat Nguyen, Duy Tien Do

“…Our findings warrant further investigations of the pathogenic potential and economic implications of M. suis and PCV3 in pigs with reproductive failure in Vietnam.…”
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Associations of greenhouse gases, air pollutants and dynamics of scrub typhus incidence in China: a nationwide time-series study by Haoyue Cao, Jianqiang Han, Weiming Hou, Juxiang Yuan

“…These findings may have important implications for guiding effective public health interventions in the future. …”
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An explainable-by-design end-to-end AI framework based on prototypical part learning for lesion detection and classification in Digital Breast Tomosynthesis images by Andrea Berti, Camilla Scapicchio, Chiara Iacconi, Charlotte Marguerite Lucille Trombadori, Maria Evelina Fantacci, Alessandra Retico, Sara Colantonio

“…Digital Breast Tomosynthesis (DBT) is an advanced radiographic technique that enhances clarity over traditional mammography by compiling multiple X-ray images into a 3D reconstruction, thereby improving cancer detection rates. However, the large data volume of DBT poses a challenge for timely analysis. …”
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Circulating Tumor DNA Combining with Imaging Analysis for Lesion Detection of Langerhans Cell Histiocytosis in Children by Siying Liu, Yongbing Zhu, Yu Chen, Yaqin Wang, Dedong Zhang, Jiasi Zhang, Yao Wang, Ai Zhang, Qun Hu, Aiguo Liu

“…Conclusions: In summary, these findings enhanced and supplemented the implications of ctDNA and imaging analysis application in children with LCH.…”
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From transition management towards just transition and place-based governance. Τhe case of Western Macedonia in Greece by Lefteris Topaloglou, Lefteris Ioannidis

“…The validity of the research findings is strengthened by using multiple sources of evidence and data triangulation. The analysis at the empirical research level focuses on Western Macedonia in Greece. …”
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Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children by Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim

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Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome by Carlo Sorrentino, Paola Lanuti, Emma Di Carlo, Alice Turdo, Matilde Todaro, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni

“…TCGA PanCancer and Oncomine databases provided gene expression data from 1084 and 75 hBC samples, respectively, and immunostaining unveiled the BCSC microenvironment.Results hBCSCs constitutively expressed IL30 as a membrane-anchored glycoprotein. …”
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Study of the Role of the Tumor Microenvironment in Ovarian Cancer (MICO): A Prospective Monocentric Trial by Martina Arcieri, Eleonora Capezzali, Stefano Restaino, Sara Pregnolato, Laura Mariuzzi, Alessandro Mangogna, Maria Orsaria, Angelica Tulisso, Silvia Tonon, Maria De Martino, Miriam Isola, Lorenza Driul, Carlo Pucillo, Giovanni Scambia, Barbara Frossi, Giuseppe Vizzielli

“…The comparison of molecular profiles, in vitro response to drugs, and clinical‐pathological data will allow the definition of a pattern capable of predicting the response of the primary tumor for the identification of those patients who may benefit from specific treatment. …”
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Cost-Effectiveness of Oral Nutritional Supplements in Malnourished or at Risk of Disease-Related Malnutrition Cancer Patients in North Macedonia by Kapedanovska Nestorovska A, Sterjev Z

“…Only direct supportive care costs, estimated from publicly available data, were considered. Quality-adjusted life-years (QALYs) gained per patient and associated costs were calculated, with outcomes and costs discounted at 3.0% annually. …”
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