Interplay of PAK1 and CAMKII in Pancreatic Beta Cell Insulin Secretion by Nely Gisela López-Desiderio, Genaro Patiño-López, Citlaltépetl Salinas-Lara, Carlos Sánchez-Garibay, Olga Villamar-Cruz, Alonso Vilches-Flores, José de Jesús Peralta-Romero, Leonel Armas-López, Jazmín García-Machorro, Luis Enrique Arias-Romero, Héctor Iván Saldívar-Cerón

“…Additionally, bioinformatic analysis of publicly available RNA sequencing (RNA-Seq) data from human islets of healthy donors, prediabetic individuals, and T2DM patients provided translational validation. …”
Get full text

Pollution affects Arabian and Saharan dust optical properties in the eastern Mediterranean by M. Teri, M. Teri, J. Gasteiger, J. Gasteiger, K. Heimerl, K. Heimerl, M. Dollner, M. Schöberl, M. Schöberl, P. Seibert, P. Seibert, A. Tipka, A. Tipka, T. Müller, S. Aryasree, K. Kandler, B. Weinzierl

Get full text

Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures by Michael J. Luna, Peter O. Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S. Shell, Thomas R. Ioerger, Sarah M. Fortune, Maha R. Farhat, Christopher M. Sassetti

“…Understanding how this pathogen adapts to the varied environmental pressures imposed by host immunity and antibiotics has important implications for the design of more effective therapies. …”
Get full text

Evaluación formativa, autorregulación, feedback y herramientas digitales: uso de Socrative en educación superior (Formative assessment, self-regulation, feedback and digital tools... by Juan Fraile, Patricia Ruiz-Bravo, David Zamorano-Sande, Daniel Orgaz-Rincón

“…Learning and self-regulation were encouraged through four forms of feedback. Data were collected on the perception of the tool by 30 students who used it on several occasions throughout the course. …”
Get full text

Urban Hierarchy Migration Model and Impact Mechanism of Graduates Admitted to the Guangdong Provincial Civil Service Examination by Wu Jinghao, Liu Ye, Tang Honglin

“…This study has significant implications for local governments in formulating scientific and reasonable civil service recruitment policies tailored to local conditions, and guiding newly graduated university students to make informed and rational decisions when applying for civil service positions.…”
Get full text

Neuropsychological and psychosocial assessment of small and non-small lung cancer patients: a study protocol by Benedetta Capetti, Lorenzo Conti, Chiara Marzorati, Chiara Marzorati, Vincenzo Bagnardi, Matteo Chiari, Monica Casiraghi, Monica Casiraghi, Monica Casiraghi, Roberto Grasso, Roberto Grasso, Gabriella Pravettoni, Gabriella Pravettoni

“…However, there is little data in the literature concerning such adverse effects in patients with lung cancer. …”
Get full text

Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance M... by Zeid Kuzbari, Charlie F. Rowlands, Isaac Wade, Alice Garrett, Chey Loveday, Subin Choi, Beth Torr, Kevin Litchfield, Alison Reid, Robert Huddart, Peter Broderick, Richard S. Houlston, Clare Turnbull

“…Methods: This study is a case-control meta-analysis of whole-exome sequencing data from three datasets (Institute of Cancer Research, The Cancer Genome Atlas, and UK Biobank). …”
Get full text

Prevalence of Obesity and Its Associated Comorbidities in Adults with Asthma: A Single-Center Study in Saudi Arabia by Abdulrhman S. Alghamdi, Khalid S. Alwadeai, Mohammed A. Almeshari, Saad A. Alhammad, Sulaiman S. Alsaif, Wael A. Alshehri, Mushabbab A. Alahmari, Turki M. Alanazi, Rayan A. Siraj, Fahad Abuguyan, Tareq F. Alotaibi, Saleh S. Algarni

“…Data were collected from King Khalid University Hospital in Saudi Arabia between July 2023 and December 2023. …”
Get full text

M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds by Cristina Bertasio, Valentina Carta, Giovanni Parisio, Mariagrazia Zanoni, Marco Tamba, Laura Mazzera, Erika Scaltriti, Maria Lodovica Pacciarini, Giovanni Loris Alborali, Daniel Polzer, Annette Nigsch, Romana Steinparzer, Maria Beatrice Boniotti

“…The complex approach of integrating WGS data with epidemiological information proved to be useful in delineating likely transmission chains and identifying the possible sources of infection, showing how NGS is a powerful tool to support epidemiological investigations.…”
Get full text

The novel diagnostic markers for systemic lupus erythematosus and periodontal disease by Xuedi Cheng, Jinfeng Zhang, Jiali Hou, Xiaocui Han, Bin Han, Jun Zhou, Zhongjun Wang, Junzheng Wang

“…This study aims to explore common genetic markers in SLE and PD that hold diagnostic and therapeutic implications.MethodsMicroarray datasets for systemic lupus erythematosus (SLE) and periodontal disease (PD) were obtained from the Gene Expression Omnibus (GEO) database. …”
Get full text

Nomophobia and its Relationship with Depression, Anxiety and Stress among Undergraduate Medical Students in a District of West Bengal: A Cross-sectional Study by Tousif Ahamed, Ritu Ghosh, Malay Kumar Das, Dilip Kumar Das

“…Introduction: Nomophobia is the fear or anxiety that individuals experience when they are without their smartphones or unable to use them. The implications of nomophobia among undergraduate medical students could be significant, as medical education is demanding and stressful. …”
Get full text

Diarrhea Prevalence and Sociodemographic Factors among Under-Five Children in Rural Areas of North Gondar Zone, Northwest Ethiopia by Atalay Getachew, Tadesse Guadu, Alebachew Tadie, Zemichael Gizaw, Mulat Gebrehiwot, Daniel Haile Cherkos, Martha Alemayehu Menberu, Teklay Gebrecherkos

“…Risk factors for diarrhea vary by settings and have important implications for developing intervention strategies to reduce the burden of the disease. …”
Get full text

Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in JapanAJOG Global Reports at a Glance by Mitsutoshi Yamada, MD, PhD, Kenji Ezoe, PhD, Satoshi Ueno, PhD, Osamu Yoshino, MD, PhD, Toshifumi Takahashi, MD, PhD

“…The existing literature has not yet comprehensively examined how TLT data are utilized to optimize ART outcomes, particularly in Japan, where ART practices are highly prevalent. …”
Get full text

“QUANDO PARLO ITALIANO SENTO DI ESSERE ABBRACCIATO SPESSO” – “WHEN I SPEAK ITALIAN, I FEEL LIKE I’M BEING HUGGED”. A JOURNEY ACROSS LOTE MOTIVATION AND PERSISTENCE by Elvira Carlotti, Gholam Najafi Fusaro

“…For this reason, this study uses Participative Narrative Inquiry to capture the complexities of the lived experience of Gholam. Data were generated through in depth biographical semi-structured interviews, one written reflection and several informal conversations between the authors. …”
Get full text

Enhancing emotional intelligence in medical education: a systematic review of interventions by Sabyasachi Maity, Samantha Michelle De Filippis, Alexander Aldanese, Melissa A. McCulloch, Alexis P. Sandor, Jan E. Perez Cajigas, Yiorgos Antoniadis, Te-keila D. T. Rochester, Lauren Elizabeth Carter, Alexander M. Preisig, Julia Ali Kobeissi, Narendra Nayak, Jaime E. Mendoza, Samal Nauhria

“…Although a meta-analysis was initially planned, substantial heterogeneity across the studies limited the pooling of quantitative data. Using an inductive coding approach, eight major themes were identified: Narrative and Storytelling Interventions, Reflective Practices and Writing, Communication Skills Training, Emotional Intelligence Enhancement, Experiential Learning and Patient Exposure, Stress, Burnout, and Coping Interventions, Assessment Tools and Structural Interventions, and Personalized Interventions and Diversity Considerations. …”
Get full text

Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention by Alexandra Philipsen, Thomas Frodl, Georg Schomerus, Michael Bauer, Martin Lambert, Jürgen Gallinat, Lisa Tlach, Frank Jessen, Gerd Schulte-Körne, Uwe Herwig, Andreas J Fallgatter, Andrea Pfennig, Tobias Banaschewski, Christiane Woopen, Michael Huss, Tobias Renner, Hans-Henning Flechtner, Christoph Correll, Marcel Romanos, Juliane Köberlein-Neu, Johann Steiner, Natalia Wege, Andreas Heinz, Irene Neuner, Stefan Borgwardt, Eva Meisenzahl, Nikolaos Koutsouleris, Alkomiet Hasan, Sebastian Walther, Georg Juckel, Andreas Meyer-Lindenberg, Barbara Hutz, Stephan Bender, Stefanie J Schmidt, Joseph Kambeitz, Maximilian Schneider, Trutz Bommhardt, Jens Peschl, Frauke Schultze-Lutter, Jule Sauer, Jannike Zimmermann, Sarah Shishechian, Jenny Spahlholz, Christian Sander, Barbara Kranenburg, Thomas Jaschinski-Weber, Marcus Hoppe, Jürgen Medenbach, Sonja Botterweck, Martina Deiß, Britt Kilian, Katrin Knopp, Ursula Leyens, Inga Meyhöfer, Viviane Wolf, Milenko Kujovic, Devin Mollamehmetoglu, Naweed Osman, Christian Theisen, Marius Wrulich, Volker Reissner, Miriam Frings, Marija Nikolic, Santiago Cabrera, Andreas Stöhr, Amke Smid, Sarah Brauckmann, Nadja Drusenheimer, Daniela Lieberz, Christian Calles, Andreas Hippe, Alessa Grand, Puyan Heindl, Lenka Krcmar, Natalie Matti, Lisa-Maria Neuner, Caroline Plett, Anne Ruef, Jana von Trott zu Solz, Clara Weyer, Christopher Eberle, Richard Gaus, Selina Mandl, Lana Kambeitz-Ilankovic, Amelie Conrad, Marleen Gersie, Paula Mengelkamp Vera Lennartz, Sophie Müller, Marlene Rosen, Susanne Inanloo-Shavikloo, Alexia Synetou, Julian Wenzel, Elena Borovik, Johanna Loy, Johanna Kim, Heidrun Lioba Wunram, Janina Michel, Hanna Schwinde, Henrik Rohner, Sven Wasserthal, Chiara van der Coelen, Jule Daniels, Luisa Jung, Martin Gladbach, Maximilian Huppertz, Ulf Thiemann, Sandra Hackler, Darja Gesell, Nele Bijlard, Udo Dannlowski, Antonia Böthig, Janik Goltermann, Dominik Grotegerd, Georg Romer, Linda Meredith Bonnekoh, Robert Göder, Ellen Quant, Fanny Wiesner, Manuel Munz, Mareike Euent, Jan-Henrik Rieck, Christina Andreou, Marco Heide, Sofia Eickhoff, Petra Reiring, Kris Sievert, Leon Franzen, Oliver Soyka, Michael Lipp, Mareike Kallmeyer, Mara Johannsen, Sarah Kittel-Schneider, Matthias Nieberler, Georg Ziegler, Catherina Klüpfel, Melanie Schroll, Larissa Schulz, Christiane Rieß, Hans-Christoph Aster, Julia Geissler, Florian Schlagenhauf, Niuscha Ramona Arlt, Zahra Assadi, Esther Quinlivan, Teresa Katthagen, Jakob Kaminski, Paul Jasper Wirsching, Peter J Uhlhaas, Lilith Becher, Philine Köln, Anastassia von Lingen, Clara Naujoks, Fabiola Henrike Heuer, Antonia Wasserscheid, Enise Irem Incesoy, Sophia Götze, Claudia Rehe, Anne Strehlow, Sandra Weigand, Miriam Wiegel, Stefanie Seidenbecher, Rico Krämer, Anett Riedel, Jessica Kesik, Aila Katharina Rau, Antonia Ritters, Oliver Dohrn, Gereon Schnellbächer, Knut Hoffmann, Vera-Estelle Daly, Rena Sophie Birner, Emese Bori-Kovács, Lisann Cöppicus, Carla Lenders, Katharina Meister, Daniela Alejandra Guzmán Vega, Johannes Gabriel, Abdul Rahman Ghanam, Christopher Gramsch, Thomas Jedamzik, Marc Wahl, Dusan Hirjak, Désirée Fink, Camila Malkewitz, Sandra Franco Palacio, Emanuel Schwarz, Sebastian Volkmer, Jonas Daub, Kathrin Becker, Alexander Häge, Paul Palm, Medea Eleftheriadis, Bettina Klos, Christoph Gerth, Julia Boettcher, Saskia Neumann, Florianne Sammoum, Laura Seefeldt, Niklas Feil, Stefan Klingberg, Magdalena Haupt, Svenja Unsöld, Anne Rau, Laura Krüger, Patrick Steinwand, Gottfried Maria Barth, Janina Fausel, Theresa Huber, Elena Müller, Melinda Mroß, Eusebia Schäfer, Daniela Mier, Sarah Stumpp, Ludwig Bley, Peter Diedrich, Alexander Wolber, María Zoll, Simon Senner, Anja Christine Rohenkohl, Alicia Balzar, Schirin Gellert, Pia Sowada, Sarah Hohmann, Marie Mey, Ruth Pöll, Eva Mennigen, Ilka Boehm, Kyra Bröckel-Bundt, Mareen Gliemann, Cathleen Köpke, Birgit Maicher, Christina Berndt, Fabian Huth, Andreas Bechdolf, Karolina Leopold, Dilek Genccagj, Laura van Hardenberg, Laura Holzner, Sibel Kanlidere, Nora Schumacher, Olga Shmuilovich, Anja Baumgartner, Sophie-Kathrin Greiner, Noa Stella Niemann, Sarah Riedlinger, Anna Martina Strasser, Thomas Görlitz, Wolfgang Strube

“…Further, the initial economic logic model will be refined using trial data and expert interviews. This comprehensive approach aims to provide decision-makers not only with evidence on the cost-effectiveness of CARE, but also with a broader understanding of the implications of the intervention.Ethics and dissemination The study has received ethical approval and plans to disseminate its findings through publication in a peer-reviewed journal and conference presentations.Trial registration number NCT05813080.…”
Get full text

Phenomenological Analysis of Lived Experience of Cancer: A Case Study of Patients at Ayatollah Kashani Hospital in Shahrekord by Hedari Arman, Sayedeh Sapideh Hashemi

“…Consequently, a non-random, purposeful sampling method was employed. Data collection involved two primary techniques: comprehensive observation and semi-structured interviews. …”
Get full text

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression by Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm

“…For validation, we compared an external transcriptome data set of liver biopsies from people with PSC (n = 73) with different fibrosis stages (baseline samples from NCT01672853). …”
Get full text

Preliminary Results in the Investigation of In Vivo Iliac and Coronary Flow Collision, Vortex Formation, and Disorganized Flow Degeneration: Insights from Invasive Cardiology Based... by Thach Nguyen, Hieu D. Nguyen, Hoang V. K. Dinh, Tien H. T. Dinh, Khiem Ngo, Hieu H. Truong, Hien Q. Nguyen, Vu Tri Loc, Thien Le, Nhi Vo, Trung Q. T. Le, Tam Tran, Chau Dang, Vy Le, Dat Q. Ha, Hadrian Tran, Mihas Kodenchery, Marco Zuin, Gianluca Rigatelli, Miguel Antunes, Quynh T. N. Nguyen, Aravinda Nanjundappa, C. Michael Gibson

“…The results comprised quantitative data (prevalence of laminar flows, collisions, and retrograde flows) and qualitative data (morphological characteristics of antegrade laminar flow, retrograde contrast flow, and instances of flow collision). …”
Get full text

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis by Tingli Liu, Guiting Pu, Liqun Wang, Ziyu Ye, Hong Li, Rui Li, Yanping Li, Xiaola Guo, William C. Cho, Hong Yin, Yadong Zheng, Xuenong Luo

Get full text