Silencing NEDD4L Effectively Inhibits the Malignant Behaviors of Hepatocellular Carcinoma by Dai J, Zhu T, Wan J, Liu R, Song Y, Zhang D, Wang X, Zhang H, Li W, Lin J, Zhu X, Liu Y

“…However, research focusing on its involvement in hepatocellular carcinoma (HCC) remains relatively scarce.Methods: This investigation examined NEDD4L’s expression, survival implications, and regulatory mechanisms of NEDD4L in HCC using RNA-seq and microarray data across multiple databases. …”
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Measuring digital health literacy and its associations with determinants and health outcomes in 13 countries by Diane Levin-Zamir, Diane Levin-Zamir, Stephan Van den Broucke, Éva Bíró, Henrik Bøggild, Lucy Bruton, Saskia Maria De Gani, Saskia Maria De Gani, Hanne Søberg Finbråten, Sarah Gibney, Robert Griebler, Lennert Griese, Øystein Guttersrud, Øystein Guttersrud, Zuzana Klocháňová, Zdenek Kucera, Christopher Le, Christopher Le, Thomas Link, Julien Mancini, Dominika Miksova, Doris Schaeffer, Carlota Ribeiro da Silva, Kristine Sørensen, Christa Straßmayr, Miguel Telo de Arriaga, Miguel Telo de Arriaga, Mitja Vrdelja, Jürgen Pelikan

“…In most countries, the data displayed acceptable fit to the unidimensional Rasch partial credit model (PCM). …”
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Incidence of and Risk Factors for Urinary Stones Among Patients with Spinal Cord Injury: A Systematic Review with Meta-analysis by Wei Zhang, Ruoqi Shen, Zhizhong Shang, Ziming Wang, Yangfan Yu, Keni Zhang, Yang Yang, Mao Pang

“…Background and objective: Urinary stones are a significant and common complication among patients with spinal cord injury (SCI), but epidemiological data are scarce and the evidence regarding risk factors remains unclear. …”
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Future Proofing Study: a cluster randomised controlled trial evaluating the effectiveness of a universal school-based cognitive–behavioural programme for adolescent depression by Maree Teesson, Helen Christensen, Svetha Venkatesh, Aliza Werner-Seidler, Lara Johnston, Bridianne O’Dea, Michelle Torok, Katharine Steinbeck, Raghu Lingam, Andrew Mackinnon, Yael Perry, Kit Huckvale, Joanne R Beames, Alison L Calear, Kate Maston, Philip J Batterham, Ju Lee Oei, Mark E Larsen, Jennifer L Hudson, Lyndsay Brown, Hiroko Fujimoto, Alexandra Batholomew, Debopriyo Bal, Susan Rachel Skinner, Katherine M Boydell, Susanne Schweizer

“…Secondary outcomes were change in anxiety, psychological distress and insomnia.Findings 134 schools participated in this study, and baseline data were collected from n=6388 students (n=3266 intervention; n=3122 control). …”
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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates by Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser, Trevor R. F. Smith, Carl Shaia, David B. Weiner, Heinz Feldmann

“…These data have implications for human translation of gene-encoded mAbs for emerging infectious diseases and low dose mAb delivery against COVID-19.…”
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miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages by Carmen Alexandra Neculachi, Evelyn-Gabriela Nastase-Rusu, Laudy Cherry, Catalina Iolanda Marinescu-Colan, Spyros Tastsoglou, Bogdan Paul Cosman, Alina Madalina Popa, Cristina Panciuc, Germana Zaccagnini, Germana Zaccagnini, Sergiu Bogdan Catrina, Sergiu Bogdan Catrina, Maya Simionescu, Fabio Martelli, Fabio Martelli, Mihai Bogdan Preda, Alexandrina Burlacu

“…The fine-tuned involvement of miR-210 in immune responses may have potential implications for chronic inflammation, immune dysfunction, and tissue repair.…”
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Incidence and Clinical Practice of Myopic Macular Neovascularization: A Nationwide Population-Based Cohort Study by Masahiro Akada, MD, Masahiro Miyake, PhD, MPH, Masayuki Hata, MD, PhD, Ai Kido, MD, PhD, Wakako Okayama, MD, Ai Nakata, MD, Shinya Nakao, MD, Kazuya Morino, MD, Shota Yasukura, MD, Yuki Mori, MD, PhD, Hiroshi Tamura, PhD, ScM, Akitaka Tsujikawa, MD, PhD

“…Methods: This study utilized data from the national claims database managed by the Japan Ministry of Health, Labour and Welfare. …”
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Trends, outcomes and knowledge gaps in mobile apps for reproductive endocrinology and infertility: a scoping review protocol by Alba Regina de Abreu Lima, Emerson Roberto dos Santos, Aline Russomano de Gouvêa, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Daniel de Souza Menezes, Matheus Querino da Silva, Helena Landin Gonçalves Cristóvão, Cíntia Canato Martins, Jéssica Gisleine de Oliveira, Patrícia da Silva Fucuta, Alexandre Lins Werneck, Gerardo Maria de Araújo Filho, Heloisa Cristina Caldas, Vânia Maria Sabadoto Brienze, Júlio César André, Antônio Hélio Oliani

“…Two independent reviewers will carry out the study selection using Covidence software. Data extraction will follow a standardised format and will be synthesised narratively using tables and graphs. …”
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Integrative review of artificial intelligence applications in nursing: education, clinical practice, workload management, and professional perceptions by Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken, Ahmed Ghannam, Fuad H. Abuadas, Joel Somerville, Joel Somerville, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair

“…These efficiencies allowed nursing teams to devote more time to direct patient care and were associated with reductions in burnout and improved workplace morale.Nursing perceptionsAcross practice settings, nursing students and practicing nurses broadly welcomed AI’s ability to streamline workflows and support decision-making, recognizing its potential to elevate patient care and professional practice.Ethical implicationsSimultaneously, nurses voiced significant ethical concerns—chiefly around safeguarding patient data privacy, mitigating algorithmic bias, and preserving the compassionate, human-centered essence of nursing in an increasingly automated environment.Framework and recommendationsThe Nursing AI Integration Roadmap (NAIIR) was developed, emphasizing transformational education, advanced clinical integration, ethical governance, robust organizational infrastructure, participatory design, and rigorous economic evaluation. …”
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Plastic additive bisphenol S induces depression by promoting AZU1/CTSD proteins to mediate plasma-related proteins and metabolites: A comprehensive multi-omics analysis by Ni-ren Li, Pai Xie, Yi-xuan Zeng, Bing-ying Deng, Si-fan Lu, Yu-feng Gu, Yanhong Ma, Chao-hua Luo, Yi Liu

“…Using MR, molecular docking, MD simulations, and clinical data validation, we demonstrated that BPS stably binds to its target proteins, AZU1 and CTSD, and exhibits a significant causal relationship with depressive symptoms. …”
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High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus by Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean-Baptiste Julla, Jean-Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. Barrett, Kirsty R. Short

“…Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.…”
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Changing age profile and incidence of injecting drug use initiation among people in Australia who inject drugs: evidence from two national repeated cross-sectional studiesResearch... by Olivia Price, Lisa Maher, Amy Peacock, Farzaneh Zolala, Louisa Degenhardt, Paul Dietze, Sarah Larney, Seraina Agramunt, Samantha Colledge-Frisby, Bradley Mathers, Dan Lewer, Rachel Sutherland

“…We aimed to explore trends in the age of people injecting and recently starting to inject drugs in Australia, and to model incidence of initiation over time. Methods: We obtained data from the Illicit Drug Reporting System (IDRS) and the Australian Needle Syringe Program Survey (ANSPS), which comprise annual cross-sectional surveys with people who inject drugs (2000–2019). …”
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Designing a model of effective marketing capabilities based on communication by Yoones Banisaeed, Ghanbar Amirnejad, Morteza mousakhani, Leila Andervazh

“…Coding was used in the data analysis of the qualitative part, and SPSS and Lisrel software were used in the quantitative part. …”
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The proposed model of the body of knowledge of digital transformation for the Central Bank of the Islamic Republic of Iran by Samira Tahmasebi Ashtiani, Mohammad Hasanzadeh, Atefeh Sharif, Mostafa Amini

“…After distributing and collecting the data from the questionnaire, confirmatory factor analysis was used with the help of SMART PLS software to estimate the parameters and all calculations. …”
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Prevalence and correlates of anxiety, depression, and symptoms of trauma among Palestinian adults in Gaza after a year of war: a cross-sectional study by Mohamed R. Zughbur, Yaser Hamam, Ashraf Kagee, Majd Hamam, Yara M. Hijazi, Mohammed Hamam, Ola Abuolwan, Shameq Sayeed, Guido Veronese

“…This study aims to offer a comprehensive perspective on the mental health challenges experienced by the people of Gaza. Data collection was carried out between November 10, 2024, and January 10, 2025. …”
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Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…The stylus profilometer data corroborated these findings, with rising Ra values as the degree of staining intensified, highlighting the topographical alterations caused by tobacco exposure. …”
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Genetic variation in NSP4 of type 1 porcine reproductive and respiratory syndrome virus in China by Huiyang Sha, Xiaolin Lan, Zhiyu Yang, Chen Lv, Hang Zhang, Qin Luo, Yajie Zheng, Gan Li, Weili Kong, Liangzong Huang, Jun Ma, Mengmeng Zhao

“…To investigate the prevalence and genetic variation of NSP4, a key gene in the regulation of host immunity, in PRRSV-1 in China, publicly available whole-genome sequence data and NSP4 sequences were obtained for analyses of nucleotide and amino acid homology, substitutions, and phylogenetic relationships. …”
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Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study by Xiaofan Zhang, Fangxu Guan, Wanglong Gou, Qi Wang, Shufa Du, Chang Su, Jiguo Zhang, Ju-Sheng Zheng, Huijun Wang, Bing Zhang

“…The inclusion of relevant microbiome and metabolite data improved the model’s predictive capacity for the risk of dyslipidemia, with ROC values increasing from 0.655 to 0.875. …”
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Clinical Predictors and Risk Factors of Gleason Score Upgrade: A Retrospective Cohort Analysis by Carmine Sciorio, Riccardo Giannella, Lorenzo Romano, Benito Fabio Mirto, Antonio Di Girolamo, Antonio Ruffo, Giuseppe Romeo, Fabio Esposito, Felice Crocetto, Luigi Napolitano, Raffaele Balsamo, Francesco Trama, Francesco Bottone, Carmelo Quattrone, Vittorio Imperatore, Lorenzo Spirito

“…<b>Methods:</b> Data from 779 patients diagnosed with histologically confirmed PCa who underwent robot-assisted radical prostatectomy at a single tertiary care institution between January 2005 and December 2020 were examined. …”
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Examining Caregiver Practices During Adolescent Outpatient Alcohol Use and Co-Occurring Mental Health Treatment: Protocol for a Dyadic Ecological Momentary Assessment Study by Samuel N Meisel, Aaron Hogue, John F Kelly, Elizabeth McQuaid, Robert Miranda Jr

“…Some benchmarks were met during this study (eg, ≥80% caregiver retention rate), although most benchmarks were not (eg, adolescent [772/1622, 47.6%] and caregiver [1331/1881, 70.76%] random prompt compliance was below the ≥80% target). Data collection is anticipated to begin in December of 2024. …”
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