Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor su... by Elliot H. H. Famili-Youth, Aryana Famili-Youth, Dongfang Yang, Ayesha Siddique, Elizabeth Y. Wu, Wenguang Liu, Murray B. Resnick, Qian Chen, Alexander S. Brodsky

“…Data processing and statistical analysis was performed using R and various publicly-available computational tools. …”
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Ecological and human use traits shape lemur-tree interaction networks across human-modified landscapesGitHub by Camille M.M. DeSisto, Roméo Bezaralahy, Candidier Dimbiarijaonina, Razara Emerancine, Telesy Feno, Edouard Mahazandry, Jeantauné Njakandrina, Charles L. Nunn, Edgar Rabevao, Mamy Omega Raharizafinirina, Sidonie Olivia Rakotoarisoa, William Ramalanjaona, Dominique Randrianasolo, Jean Randrianasy, Manadina Rasolofo, George Raveloson, Marie Rolande Soazafy, Jean Tiamanana, Eric Tsilanizara, Zico Zandry, Franclin Zerimanana, John R. Poulsen, James P. Herrera

“…Our results highlight the importance of combining research-based observations with ethnobiological data to advance our understanding of the trait-based functioning of ecological networks. …”
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Differential Spatiotemporal Patterns of Major Ions and Dissolved Organic Carbon Variations from Non-Permafrost to Permafrost Arctic Basins: Insights from the Severnaya Dvina, Pecho... by Yuanyuan Yang, Ping Wang, Chunnuan Deng, Shiqi Liu, Dan Chen, Ruixin Wang

“…However, our understanding of chemical export from Arctic basins to oceans remains limited due to scarce data, particularly in permafrost-dominated regions. …”
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Anti-sperm Antibody Positivity in Men with Varicocele: A Systematic Review and Meta-Analysis by Marco Falcone, Kadir Bocu, Hakan Keskin, Jesus Fernando Solorzano Vazquez, Ravi Banthia, Tara Mahendran, Muslim Dogan Deger, Vinod Kv, Preto Mirko, Ahmed M. Harraz, Ramadan Saleh, Rupin Shah, Ashok Agarwal

“…Conclusions: This SRMA indicates that ASA positivity is significantly higher among men with varicocele when tested by direct method (MAR) or indirect method (ELISA). This data suggests an immunological pathology in infertile men with varicocele and may have implications for the management of these patients.…”

Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in ch... by Sacha Stelzer-Braid, Michael Doumit, Michael J Coffey, Isabelle R McKay, Sandra Chuang, Susan Adams, Shafagh A Waters, Nadine A Kasparian, Torsten Thomas, Tamarah Katz, Chee Y Ooi

“…Alterations in diet and intestinal and respiratory microbiomes may have important implications for physical and psychosocial health. Diet influences the intestinal microbiome and should be considered when exploring disease-specific alterations. …”
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Longitudinal Trends in Pediatric Survival by Congenital Heart Defect in Texas, 1999 to 2017 by Sara B. Stephens, PhD, MPH, Shaine A. Morris, MD, MPH, Renata H. Benjamin, PhD, Mark A. Canfield, PhD, Charles J. Shumate, DrPH, Ruosha Li, PhD, Cecilia Cazaban-Ganduglia, MD, DrPH, A.J. Agopian, PhD

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Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls by Orsolya I. Gaal, Megan Leask, Valentin Nica, Georgiana Cabău, Medeea Badii, Ioana Hotea, Dennis M de Graaf, Zhenhua Zhang, Yang Li, Cristina Pamfil, Simona Rednic, Tony R. Merriman, Tania O. Crișan, Leo A.B. Joosten

“…We assess the functional implications of IL1RN rs9973741, the lead gout-associated variant. …”
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Engage for equity plus: Transforming academic health centers to sustain patient/community engaged research structures, policies, and practices by Shannon Sanchez-Youngman, Belkis Jacquez, Prajakta Adsul, Elizabeth Dickson, Tabia Henry Akintobi, LaShawn Hoffman, Lisa G. Rosas, Starla Gay, Jason A. Mendoza, Diane Mapes, John Oetzel, Donald Nease, Nina Wallerstein

“…Conclusion: We discuss the overall implications for E2 PLUS for other AHCs working toward sustainable community/patient engaged research policies and practices. …”
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A novel classification for aseptic femoral shaft nonunion after intramedullary nailing: a retrospective study by Zhi Zhang, Xiong Wang, Qirong Zhou, Xingwen Xu, Jin Cui, Wenqiang Wei, Liehu Cao

“…Furthermore, we sought to explore the new classification’s clinical significance and management implications. Methods This retrospective study involved the analysis of clinical data collected from 82 patients with aseptic bone nonunion after intramedullary nailing of femoral shaft fractures between 2010 and 2022. …”
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Factors affecting urban households’ participation in home gardens: the case of Mekelle City, Tigray Region, Ethiopia by Aregawi Beyene, Azeb Gebreegziabher, Zenebe Abraha, Tsahaynesh Hagos, Yohansu Girmay

“…The collected data were analysed using descriptive statistics, and a probit model was used to identify the factors affecting the participation of urban households in home gardening practice. …”
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Hubungan Antara Cache, Energy Consumption dan Runtime Performance pada Progressive Web Apps by Wakhid Kurniawan, Agung Fatwanto

“…Perancangan eksperimen ini memiliki variabel Cache, Energy Consumption dan Runtime Performance dengan perilaku pengumpulan data ketika Cache kosong dan Cache terisi yang selanjutnya akan di analisis dengan analisis Pearson Correlation. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Finally, the study explores how DAS influences ageism both directly and indirectly through life satisfaction, gratitude, and prosociality.Design and Settings: A cross-sectional study conducted at 11 higher education institutions in Jiangxi, China.Participants: A total of 1,213 undergraduates participated in the study between July and August 2024. Following data cleaning, 1174 responses were included for analysis.Methods: Data were collected using online questionnaires. …”
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Artificial intelligence in vaccine research and development: an umbrella review by Rabie Adel El Arab, May Alkhunaizi, May Alkhunaizi, Yousef N. Alhashem, Alissar Al Khatib, Munirah Bubsheet, Salwa Hassanein, Salwa Hassanein

“…Nonetheless, persistent challenges emerged—data heterogeneity, algorithmic bias, limited regulatory frameworks, and ethical concerns over transparency and equity.Discussion and implicationsThese findings illustrate AI’s transformative potential across the vaccine lifecycle but underscore that translating promise into practice demands five targeted action areas: robust data governance and multi‑omics consortia to harmonize and share high‑quality datasets; comprehensive regulatory and ethical frameworks featuring transparent model explainability, standardized performance metrics, and interdisciplinary ethics committees for ongoing oversight; the adoption of adaptive trial designs and manufacturing simulations that enable real‑time safety monitoring and in silico process modeling; AI‑enhanced public engagement strategies—such as routinely audited chatbots, real‑time sentiment dashboards, and culturally tailored messaging—to mitigate vaccine hesitancy; and a concerted focus on global equity and pandemic preparedness through capacity building, digital infrastructure expansion, routine bias audits, and sustained funding in low‑resource settings.ConclusionThis umbrella review confirms AI’s pivotal role in accelerating vaccine development, enhancing efficacy and safety, and bolstering public acceptance. …”
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Analysing gender disparities in youth sports coaching: an international survey (FEMCoach project) by Vanessa Dias, Julio Calleja-Gonzalez, Víctor López-Ros, Raquel Font-Lladó, Jorge Arede, Leonardo Cunha, Stella Douka, Bruno Rosa, Graça Pinto, Graça Pinto, Nuno Leite, Nuno Leite

“…IntroductionThe issue of gender inequality has a significant impact on the sporting world, with a range of implications and consequences. In the field of coaching, women are confronted with inequity throughout their careers, which frequently has a detrimental impact. …”
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Time series analysis of the impact of air pollutants on influenza-like illness in Changchun, China by Yang Pan, Laishun Yao, Biao Huang, Yinghua He, Changxi Xu, Xianda Yang, Yingying Ma, Zhidi Wang, Xingyu Wang, Hong Zhu, Man Wang, Lijun Song, Xiao Liu, Guiping Yu, Lin Ye, Liting Zhou

“…Methods ILI surveillance data from Changchun were extracted from “China Influenza Surveillance Network” and the ambient air quality monitoring data of the city were collected from 2017 to 2022. …”
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Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity by Aino Heikkinen, Vivienne F. C. Esser, Seung Hyuk T. Lee, Sara Lundgren, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Sini Heinonen, Sergio Villicaña, Jordana T. Bell, Alice Maguolo, Emma Nilsson, Charlotte Ling, Allan Vaag, Päivi Pajukanta, Jaakko Kaprio, Kirsi H. Pietiläinen, Shuai Li, Miina Ollikainen

“…Our findings underscore the impact of mitochondrial DNA quantity on DNA methylation and expression of the SH3BP4 gene within adipose tissue, with potential implications for obesity.…”
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Single‐cell RNA‐sequencing and spatial transcriptomic analysis reveal a distinct population of APOE− cells yielding pathological lymph node metastasis in papillary thyroid cancer... by Guohui Xiao, Rongli Xie, Jianhua Gu, Yishu Huang, Min Ding, Dongjie Shen, Jiqi Yan, Jianming Yuan, Qiong Yang, Wen He, Siyu Xiao, Haizhen Chen, Dan Xu, Jian Wu, Jian Fei

“…We established a machine learning‐based scRNA‐seq data, 13‐gene signature predictive of lymph node metastasis. …”
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The potential effects of widespread community transmission of SARS-CoV-2 infection in the World Health Organization African Region: a predictive model by Francis Chisaka Kasolo, Ambrose Talisuna, Michel Yao, Zabulon Yoti, Joseph Waogodo Cabore, Humphrey Cyprian Karamagi, Hillary Kipruto, James Avoka Asamani, Benson Droti, Aminata Binetou Wahebine Seydi, Regina Titi-Ofei, Benido Impouma, Felicitas Zawaira, Prosper Tumusiime, Matshidiso R Moeti

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Depressive symptoms mediate the association between sleep disorders and gallstone disease: a causal mediation analysis of NHANES 2017–2020 by Yisen Hou, Rui Li, Zhen Xu, Wenhao Chen, Zhiwen Li, Weirong Jiang, Yong Meng, Jianli Han

“…Depression, often accompanying sleep disorders, may play a mediating role in this relationship. This study uses data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) to explore the potential mediating role of depression in the association between sleep disorders and gallstones.MethodsWe analyzed data from 7,868 adults aged 20 and older from NHANES 2017–2020. …”
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Developmental patterns of white matter functional networks in neonates by Yuhan Wang, Ningning Pan, Zhuoshuo Li, Yating Wang, Ruoqing Chen, Zhicong Fang, Minmin Pan, Hongzhuang Li, Ke Fang, Xiaorui Wu, Mengting Liu, Xinting Ge

“…This study systematically explores the developmental characteristics of white matter (WM) functional networks in neonates. Utilizing data from the third release of the Developing Human Connectome Project (dHCP), we analyzed resting-state functional magnetic resonance imaging (rs-fMRI) data from 730 full-term and 157 preterm neonates. …”
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