Prognostic nomogram for recurrence of hepatocellular carcinoma after liver transplantation for decision making on postoperative adjuvant therapy by Chen-Hao Gao, Qi-Jian Yu, Xing-Yu Luo, Zhao-Xin Shang, Kai-Wun Chang, Shuo Wang, Jian-Peng Liu, Jian-Hua Li, Ji-Zhou Wang, Shu-Sen Zheng, Zhe Yang

“…Accordingly, there is an urgent need to develop and validate an improved model for predicting hepatocellular carcinoma post-liver transplantation. …”
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Matrix metalloproteinases and heat shock proteins on extracellular vesicles in colorectal cancer patients: association with metabolic status by N. V. Yunusova, D. A. Svarovsky, E. E. Dandarova, D. N. Kostromitsky, A. A. Dimcha, O. V. Cheremisina, S. G. Afanasiev, A. I. Konovalov, Z. A. Startseva, I. V. Kondakova, M. R. Patysheva, A. E. Grigor'eva, L. V. Spirina

“…In most patients with colorectal cancer (CRC), the tumor develops against the background of metabolically healthy obesity or metabolic syndrome (more than 60 % of patients), the key pathogenetic moment of which is developing hyperinsulinemia. …”
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Mortality trends in Serbia during the 1990s by Penev Goran D.

“…It is, in relation to the state at the beginning of the period (6.2%), even increased, and considerably higher than in the most developed countries (about 1%). This points to the unsatisfactory quality of data on mortality, but also to the need to use the results of the analysis of mortality according to deaths by cause with caution.…”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…The International Society of Liquid Biopsy (ISLB) established the Quality Control and Accreditation Committee to develop consensus-based minimal standards for ctDNA analysis in oncology. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…A total of 23 NMP representatives from 13 Asia–Pacific countries participated in facilitated discussions. Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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Application of a deep learning algorithm for the diagnosis of HCC by Philip Leung Ho Yu, Keith Wan-Hang Chiu, Jianliang Lu, Gilbert C.S. Lui, Jian Zhou, Ho-Ming Cheng, Xianhua Mao, Juan Wu, Xin-Ping Shen, King Ming Kwok, Wai Kuen Kan, Y.C. Ho, Hung Tat Chan, Peng Xiao, Lung-Yi Mak, Vivien W.M. Tsui, Cynthia Hui, Pui Mei Lam, Zijie Deng, Jiaqi Guo, Li Ni, Jinhua Huang, Sarah Yu, Chengzhi Peng, Wai Keung Li, Man-Fung Yuen, Wai-Kay Seto

“…The Liver Imaging Reporting and Data System (LI-RADS) results in a considerable number of indeterminate observations, rendering an accurate diagnosis difficult. …”
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Polymyalgia rheumatica and giant cell arteritis following COVID-19 vaccination: Results from a nationwide survey by Pierre-André Jarrot, Adrien Mirouse, Sébastien Ottaviani, Simon Cadiou, Jean-Hugues Salmon, Eric Liozon, Simon Parreau, Martin Michaud, Benjamin Terrier, Pierre-Edouard Gavand, Ludovic Trefond, Virginie Lavoiepierre, Jeremy Keraen, Daniel Rekassa, Bastien Bouldoires, Thierry Weitten, Damien Roche, Antoine Poulet, Caroline Charpin, Vincent Grobost, Marion Hermet, Magali Pallure, Chloe Wackenheim, Ludovic Karkowski, Pierre Grumet, Thomas Rogier, Nabil Belkefi, Vincent Pestre, Emilie Broquet, Amélie Leurs, Sophie Gautier, Valérie Gras, Pierre Gilet, Jan Holubar, Nadia Sivova, Nicolas Schleinitz, Jean-Marc Durand, Brice Castel, Alexandre Petrier, Robin Arcani, Baptiste Gramont, Philippe Guilpain, Hubert Lepidi, Pierre-Jean Weiller, Joelle Micallef, David Saadoun, Gilles Kaplanski

“…We then conducted a nationwide survey to gather clinical profiles, therapeutic management, and follow-up data from individuals registered in the pharmacovigilance study. …”
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The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma by Jiesong Wang, Junlei Jia, Jingwei Yu, Jing Liu, Meng Gao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Bin Meng, Wenchen Gong, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Our analysis revealed that the age ≥70 was a significant independent predictor for both OS and PFS. …”
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Mapping barriers, enablers and implementation determinants to shared models of care for physical health and sexual wellbeing among young people with mental health difficulties usin... by Allyson J Gallant, Karen O'Connor, John Paul Lyne, Donal O'Keeffe, Shaakya Anand-Vembar, Yulia Kartalova- O'Doherty, Caroline Wilson, Agnes Higgins, Mary Cannon, Greg Sheaf, Louise Doyle, Rebecca Murphy, David McEvoy, Leona Ryan, Olivia Longe, David Cotter, Sara Burke, Colm McDonald, Gary Donohoe, Catherine D Darker

“…Two independent reviewers will screen titles, abstracts and full texts, followed by data extraction and critical appraisal of included studies. …”
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Deep learning radiomics of elastography for diagnosing compensated advanced chronic liver disease: an international multicenter study by Xue Lu, Haoyan Zhang, Hidekatsu Kuroda, Matteo Garcovich, Victor de Ledinghen, Ivica Grgurević, Runze Linghu, Hong Ding, Jiandong Chang, Min Wu, Cheng Feng, Xinping Ren, Changzhu Liu, Tao Song, Fankun Meng, Yao Zhang, Ye Fang, Sumei Ma, Jinfen Wang, Xiaolong Qi, Jie Tian, Xin Yang, Jie Ren, Ping Liang, Kun Wang

“…Abstract Accurate, noninvasive diagnosis of compensated advanced chronic liver disease (cACLD) is essential for effective clinical management but remains challenging. This study aimed to develop a deep learning-based radiomics model using international multicenter data and to evaluate its performance by comparing it to the two-dimensional shear wave elastography (2D-SWE) cut-off method covering multiple countries or regions, etiologies, and ultrasound device manufacturers. …”
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Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial by Mark Howard, Wendyl D’Souza, Emma Foster, Patrick Carney, Zanfina Ademi, Patrick Kwan, David N Vaughan, James Lee, Clare Stapleton, Zongyuan Ge, Zhibin Chen, Natasha A Lannin, Udaya Seneviratne, Robert Sparrow, Piero Perucca, Armin Nikpour, Chong Wong, John-Paul Nicolo, Michelle Kiley, Terence O’Brien, Jacqui-Lyn Saw, Dean Jones, David Reutens, Sandra Reeder, Richard Shek-kwan Chang, Ernest Somerville, Tania Farrar, Daniel Thom, Lata Vadlamudi

“…Introduction Selection of antiseizure medications (ASMs) for newly diagnosed epilepsy remains largely a trial-and-error process. We have developed a machine learning (ML) model using retrospective data collected from five international cohorts that predicts response to different ASMs as the initial treatment for individual adults with new-onset epilepsy. …”
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Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination by Cancan Qi, Zhaoli Liu, Gizem Kilic, Andrei S. Sarlea, Priya A. Debisarun, Xuan Liu, Yonatan Ayalew Mekonnen, Wenchao Li, Martin Grasshoff, Ahmed Alaswad, Apostolos Petkoglou, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu

“…Interestingly, by integrating with genetic, epigenetic, and cytokine response data from the same individuals, mediation analysis demonstrated that most of the identified DNA methylation changes played a mediating role between genetic variants and cytokine responses; for example, the changes of cg21375332 near SLC12 A3 gene mediated the regulation of genetic variants on IFN-γ changes after BCG vaccination. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy. Methods RNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. …”
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Prospective observational study to assess the performance accuracy of clinical decision rules in children presenting to emergency departments with possible cervical spine injuries:... by Franz E Babl, Simon Craig, Susan M Donath, Meredith L Borland, Natalie Phillips, Amit Kochar, Gavin A Davis, Shane George, Stuart Dalziel, Arjun Rao, Nathan Kuppermann, Stacy Goergen, Sarah Watson, Amanda Williams, Eunicia Tan, Catherine L Wilson, Michelle Davison, Blessy John-Denny, Sonia Singh, Sharon O’Brien, Geoffrey N Askin, Chris J Selman, Julie C Leonard

“…Data will be collected on presenting features (history, injury mechanism, physical examination findings) and management (diagnostic imaging, admission, interventions, outcomes). …”
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Echocardiographic Tissue Characterization Using Radiomics in Patients With Transthyretin-Related Cardiac Amyloidosis by Sara Mori, MD, Noemi Montobbio, MSc, Maria Pia. Sormani, MSc, PhD, Cristina Campi, MSc, PhD, Carlotta Mazzoni, MD, Alessia Argirò, MD, PhD, Giulia Elena Mandoli, MD, Francesca Rubina Ginetti, MD, Margherita Zanoletti, MD, Pier Filippo Vianello, MD, Valeria Rella, MD, Lia Crotti, MD, PhD, Michele Piana, MSc, PhD, Matteo Cameli, MD, PhD, Francesco Cappelli, MD, PhD, Italo Porto, MD, PhD, Luigi Paolo Badano, MD, PhD, Marco Canepa, MD, PhD

“…Objectives: This study aimed to develop a radiomic model for characterizing ATTR-infiltrated myocardium via echocardiography. …”
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Failure Risk Investigation of Transmission Tower-line System Under Sequential Earthquake Considering Input Directionality by LIU Juncai, DONG You

“…A substantial amount of historical seismic data has indicated that ground motion generally occurs in the form of sequences, with randomness and multi-dimensional characteristics. …”
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Identification and pathogenicity of Colletotrichum species associated with Guanximiyou pomelo anthracnose by DAI Ruiqing, ZENG Tianbao, CHEN Shumei, PAN Yonghong, HE Yunyan, LAI Baochun

“…In the edge, tip or middle of damaged leaves develop brown spots, which form a “V” shape then withering and falling off after the diseased leaves die. …”
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High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities. by Junior George Pakoa, Marie-Estelle Soupé-Gilbert, Dominique Girault, Dexter Takau, Justina Gaviga, Ann-Claire Gourinat, Arnaud Tarantola, Cyrille Goarant

“…The MAT serology pointing to serogroup Australis as well as exposure history suggest that livestock animals largely contribute to the burden of human leptospirosis in Vanuatu. The analysis of residential and travel data suggests that the risk might even be higher in other islands of the Vanuatu archipelago. …”
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Probing Autism and ADHD subtypes using cortical signatures of the T1w/T2w-ratio and morphometry by Linn B. Norbom, Bilal Syed, Rikka Kjelkenes, Jaroslav Rokicki, Antoine Beauchamp, Stener Nerland, Azadeh Kushki, Evdokia Anagnostou, Paul Arnold, Jennifer Crosbie, Elizabeth Kelley, Robert Nicolson, Russell Schachar, Margot J. Taylor, Lars T. Westlye, Christian K. Tamnes, Jason P. Lerch

“…Moreover, cortical variability arises from numerous biological pathways, and multimodal approaches can integrate cortical metrics into a single network. We analyzed data from 310 individuals aged 2.6–23.6 years, obtained from the Province of Ontario Neurodevelopmental (POND) Network consisting of individuals diagnosed with ASD (n = 136), ADHD (n = 100), and typically developing (TD) individuals (n = 74). …”
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Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum by Endrit Shahini, Donatello Marziliano, Francesco Losito, Marianna Zappimbulso, Elisabetta Cavalcanti, Raffaele Armentano, Fabio Fucilli, Raffaele Cozzolongo, Giuseppe Ingravallo, Fabrizio Pappagallo, Roberta Iatta, Vanessa Desantis, Annalisa Saracino, Angelo Vacca, Antonio Giovanni Solimando

“…A holistic re-assessment of the patient’s clinical presentation, developmental history, and laboratory, radiologic, and pathological data led to the definitive diagnosis. …”
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