Exercise‐induced dynamic mitral regurgitation is associated with outcomes in patients with ischaemic cardiomyopathy by Maximilian Spieker, Jonas Sidabras, Hannah Lagarden, Lucas Christian, Niklas Günther, Stephan Angendohr, Alexandru Bejinariu, P. Christian Schulze, Roman Pfister, Can Öztürk, Ralf Westenfeld, Patrick Horn, Amin Polzin, Malte Kelm, Obaida Rana

“…Multivariate analysis identified MR severity during exercise [HR 1.998 (1.367–2.938)] and exercise TAPSE [HR 0.913 (0.853–0.973)] as predictors of the combined endpoint. …”
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Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus by A. V. Rudakova, N. I. Briko, Yu. V. Lobzin, I. S. Namazova-Baranova, S. N. Avdeev, V. A. Korshunov, M. P. Kostinov, G. I. Ignatova, E. V. Blinova, A. V. Kontsevaya, R. V. Shepel, I. Yu. Drozdova, O. M. Drapkina

“…Patients with diabetes mellitus have an increased risk of developing various infections, including those of the lower respiratory tract. …”
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An atomistical elucidation of the 6FDA-durene-based mixed matrix membrane and ionic liquid mixed matrix membrane for CO2/CH4 separation by Jia Cheng Loh, Serene Sow Mun Lock, Bobby Kwong Yii Lee, Mehtab Ali Darban, Dun-Yen Kang, Mohd Hafiz Dzarfan Othman, Zhen Hong Ban

“…Validation against experimental data showed a mean averaged relative deviation (MARD) below 0.1362. …”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…The interviews were conducted by two researchers who have extensive experience interviewing KOA patients, and data were gathered through face-to-face, semi-structured interviews to ensure a high level of information power. …”
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Interventions to improve the quality of cataract services: protocol for a global scoping review by Nathan Congdon, João M Furtado, Matthew J Burton, Jacqueline Ramke, Stephen Gichuhi, Helen Burn, Iris Gordon, William H Dean, John Buchan, Ada Aghaji, Miho Yoshizaki, Ana P Marques

“…For included articles, data regarding publication characteristics, study details and quality-related outcomes will be extracted by two reviewers independently. …”
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Effects of community action on animal vaccination uptake, antimicrobial usage, and farmers’ wellbeing in Ghana: study protocol for a cluster-randomized controlled trial by Francis Sena Nuvey, Günther Fink, Jan Hattendorf, Daniel T. Haydon, Gilbert Fokou, Kennedy Kwasi Addo, Jakob Zinsstag, Clemence Esse-Dibby, Bassirou Bonfoh

“…Approximately 10 households per community will be sampled for data collection at baseline, and at 6 and 12 months post-intervention, following prevailing vaccination schedules. …”
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Construction of an anaplastic thyroid cancer stratification signature to guide immune therapy selection and validation of the pivotal gene HLF through in vitro experiments by Li Pengping, Yin Kexin, Xie Yuwei, Sun Ke, Li Rongguo, Wang Zhenyu, Jin Haigang, Wang Shaowen, Huang Yuqing

“…Our study aims to identify ATC patients who might bene t from immunotherapy.MethodsOur study uses multiple algorithms by R4.2.0, and gene expression and clinical data are collected from TCGA, GEO and local cohort. …”
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Detection of risk for depression among adolescents in diverse global settings: protocol for the IDEA qualitative study in Brazil, Nepal, Nigeria and the UK by Christian Kieling, Brandon A Kohrt, Syed Shabab Wahid, Gloria A. Pedersen, Katherine Ottman, Abigail Burgess, Kamal Gautam, Thais Martini, Anna Viduani, Olufisayo Momodu, Crystal Lam, Helen L. Fisher, Abiodun O Adewuya, Valeria Mondelli

“…This is a multisite qualitative study being conducted in Brazil, Nepal, Nigeria and the UK.Methods and analysis A systematic set of qualitative methods will be used in this study. …”
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Postoperative atrial arrhythmias after bilateral lung transplantation with intraoperative V-A extracorporeal membrane oxygenation: a single-center experience by Annalisa Boscolo, Annalisa Boscolo, Nicolò Sella, Francesco Zarantonello, Raimondo Pittorru, Giulia Mormando, Carlo Alberto Bertoncello, Elena Curmaci, Roberta Ceccato, Valentina Fincati, Paola Masetti Zannini, Angela Bianco, Giordana Coniglio, Elisa Pistollato, Alessandro Zambianchi, Mustaj Sindi, Sabrina Congedi, Gabriella Roca, Arianna Peralta, Luisa Muraro, Giorgia Pacchiarini, Federico Migliore, Manuel De Lazzari, Tommaso Pettenuzzo, Federico Rea, Martina Perazzolo Marra

“…Although AAs are frequently observed in the early postoperative period, data regarding their incidence and impact on outcomes are scarce. …”
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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer by Sarah Alexandrou, Christine S. Lee, Kristine J. Fernandez, Celine E. Wiharja, Leila Eshraghi, John Reeves, Daniel A. Reed, Neil Portman, Zoe Phan, Heloisa H. Milioli, Iva Nikolic, Antonia L. Cadell, David R. Croucher, Kaylene J. Simpson, Elgene Lim, Theresa E. Hickey, Ewan K. A. Millar, Carla L. Alves, Henrik J. Ditzel, C. Elizabeth Caldon

“…Overall, we demonstrate that suppression of JNK signalling enables persistent growth during combined endocrine therapy and CDK4/6 inhibition. Our data provides the pre-clinical rationale to stratify patients based on JNK pathway activity prior to receiving combination endocrine therapy and CDK4/6 inhibition.…”
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A review of altimetry waveform retracking for inland water levels by Xinyuan Deng, Linghong Ke, Liguang Jiang, Karina Nielsen, Xiaomei Fan, Jida Wang, Chunqiao Song

“…Considering the selection of different data and retrackers in varying scenarios, a synthesis analysis is conducted based on results reported in previous literature. …”
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Influence of Peptide Conjugation Sites on Lunatin–Alumina Nanoparticles: Implications for Membrane Interaction and Antimicrobial Activity by Carolina Silva Ferreira, Lívia Mara Fontes Costa, Lúcio Otávio Nunes, Kelton Rodrigues de Souza, Giovanna Paula Araújo, Evgeniy S. Salnikov, Kelly Cristina Kato, Helen Rodrigues Martins, Adriano Monteiro de Castro Pimenta, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…Functionalization at the N-terminal significantly influenced both antibacterial activity and peptide conformation compared to C-terminal attachment. Biophysical data demonstrated stronger membrane interaction and greater membrane disruption when lun-1 was conjugated at the N-terminal. …”
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Artificial Intelligence in Breast Cancer Diagnosis and Treatment: Advances in Imaging, Pathology, and Personalized Care by Petar Uchikov, Usman Khalid, Granit Harris Dedaj-Salad, Dibya Ghale, Harney Rajadurai, Maria Kraeva, Krasimir Kraev, Bozhidar Hristov, Mladen Doykov, Vanya Mitova, Maria Bozhkova, Stoyan Markov, Pavel Stanchev

“…However, challenges include data variability, ethical concerns, and real-world validation. …”
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Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

“…Independent recurrence‐related risk factors were analyzed by logistic regression analysis. New logistic regression models were further developed to predict the probability of recurrence. …”
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Clinical-radiomics hybrid modeling outperforms conventional models: machine learning enhances stratification of adverse prognostic features in prostate cancer by Minghan Jiang, Minghan Jiang, Zeyang Miao, Run Xu, Mengyao Guo, Xuefeng Li, Guanwu Li, Peng Luo, Su Hu, Su Hu

“…ObjectiveThis study aimed to develop MRI-based radiomics machine learning models for predicting adverse pathological prognostic features in prostate cancer and to explore the feasibility of integrating radiomics with clinical characteristics to improve preoperative risk stratification, addressing the limitations of conventional clinical models.MethodsA retrospective cohort of 137 prostate cancer patients between January 2021 and April 2023 with preoperative MRI and postoperative pathology data was divided into adverse-feature-positive (n=85) and negative (n=52) groups. …”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…However, there are currently no available prospective data on the impact of bridging period and there is a lack of research on the effects of neoadjuvant chemotherapy during the bridging period. …”
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Clinical Efficacy and Pain Perception with Novel Chemomechanical Caries Removal Agent and Conventional Method in Primary Molars: A Randomized Controlled Study by Seema Bargale, Sejal Jain, Anshula N Deshpande, Poonacha K S, Saylee Deshmukh, Charmi Shah

“…Clinical efficacy and the Wong–Baker Pain Rating Scale (WBPRS) were used as the two parameters. The obtained data analysis was done using an independent <italic>t</italic>-test and Mann–Whitney <italic>U</italic> test. …”
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Efficacy of prehospital National Early Warning Score to predict outpatient disposition at an emergency department of a Japanese tertiary hospital: a retrospective study by Jumpei Tsukuda, Shigeki Fujitani, Kenichiro Morisawa, Nobuhiko Shimozawa, Yasuhiko Taira, Tomohiro Shinozaki, Takuro Endo, Toru Yoshida, Takako Motohashi, Hsiang-Chin Hsu, Shunsuke Fukuda, Takaki Naito

“…Objectives The National Early Warning Score (NEWS) was originally developed to assess hospitalised patients in the UK. …”
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Ketoanalogue use is associated with a lower risk of worsening frailty among patients with diabetic kidney disease of advanced stage: A retrospective cohort study by Jui Wang, Szu-Ying Lee, Chia-Ter Chao, Jenq-Wen Huang, Kuo-Liong Chien

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An evidence-based tailored eHealth patient education tool for patients with knee osteoarthritis: A randomized controlled trial by Chong Li, Chuanmei Zhu, Kangping Song, Xiaona Xiang, Xiaoyi Wang, Jing Hu, Zhao Li, Yi Deng, Daoxin Jiang, Lixin Guo, Ting Ren, Luwen Zhu, Haibo Ai, Shaojun Zhang, Zhongliang Liu, Yonghong Yang, Siyi Zhu, Chengqi He

“…Patients who received eHealth education perceived it as a valuable tool for education. The analysis of follow-up data showed that the knowledge level of the eHealth group was higher than that of the control group at 6 months ( F  = 0.727, P  = 0.471), but there was no significant difference. …”
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